[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"postoperative-cognitive-complications\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:postoperative-cognitive-complications":24},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":29,"overallStatus":45,"whyStopped":4,"lastUpdateSubmitDate":46,"lastUpdatePostDateStruct":47,"startDateStruct":50,"completionDateStruct":52,"leadSponsor":54,"locationsCount":5},"100638143","prospective-observational-multimodal-neuromonitoring-during-high-risk-adult-surgery-100638143",false,"NCT07577726","Prospective Observational Multimodal Neuromonitoring During High-Risk Adult Surgery","Prospective Observational Multimodal Neuromonitoring During High-Risk Adult Surgery: A Single-Center Cohort Study of Quantitative EEG, Noninvasive Intracranial Dynamics, and Perioperative Physiologic Correlates","Inclusion Criteria:\n\n* Age 18 years or older\n* Scheduled to undergo major spine surgery, liver transplantation, on-pump cardiac surgery, major vascular surgery, major thoracic surgery, major abdominal surgery, or neurosurgical craniotomy at UT Southwestern Medical Center\n* Able to provide informed consent (self or legally authorized representative when applicable)\n* Safe and feasible placement of SedLine and\u002For Brain4Care monitoring as determined by the clinical and research teams\n* Anticipated availability of perioperative clinical data needed for study analyses\n\nExclusion Criteria:\n\n* Age younger than 18 years\n* Prisoner status\n* Pregnancy\n* Unable to provide informed consent in English (consent documents available in English only)\n* Declining participation\n* Lack of subject or legally authorized representative consent when required\n* Clinical condition preventing safe or feasible placement of study monitors (e.g., incompatible surgical field location, significant facial or scalp injury, open wounds at intended sensor placement site)\n* Operative workflow or clinical urgency precluding reasonable completion of consent and monitor placement prior to start of surgery\n* Anticipated clinical data capture insufficient for meaningful analysis","ALL","18 Years",{"count":19,"type":20},300,"ESTIMATED","OBSERVATIONAL","This is a prospective observational cohort study of adult patients undergoing high-risk surgery at UT Southwestern Medical Center. The study acquires synchronized multimodal neuromonitoring data - including SedLine quantitative EEG (qEEG) extracted from standard-of-care clinical monitoring and, where deployed, Brain4Care (B4C) noninvasive intracranial dynamics data - and links these data to perioperative hemodynamic, medication, laboratory, procedural, and outcome variables. No alteration of routine clinical care occurs. The primary goal is to characterize associations between monitor-derived features and perioperative clinical variables, and to establish a multimodal dataset supporting future analyses of perioperative brain health in high-risk surgical populations.",[24,25,26,27,28],"Postoperative Cognitive Complications","Delirium","Perioperative\u002FPostoperative Complications","Brain Injuries","Anesthesia",[30,31,32,33,34,35,36,37,38,39,40,41,42,43,44],"quantitative EEG","SedLine","Brain4Care","intracranial dynamics","cerebrovascular reactivity","perioperative neuromonitoring","postoperative delirium","perioperative brain health","cardiac surgery","liver transplantation","spine surgery","Moberg Clinical Platform","cerebral autoregulation","high-risk surgery","intraoperative monitoring","NOT_YET_RECRUITING","2026-05-04",{"date":48,"type":49},"2026-05-11","ACTUAL",{"date":51,"type":20},"2026-07",{"date":53,"type":20},"2028-12",{"name":55,"class":56},"University of Texas Southwestern Medical Center","OTHER"]