[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"postoperative-cognitive-decline\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:postoperative-cognitive-decline":31},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,51,82],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":32,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100519351","prediction-and-prevention-of-postoperative-mortality-and-morbidity-100519351",false,"NCT06042413","Prediction and Prevention of Postoperative Mortality and Morbidity","Real-world and Innovative Multimodal Prediction and Prevention of Postoperative Mortality and Multi-morbidities","Part I Inclusion Criteria:\n\n* 65 years of age and older\n* Identified as higher risk (≥2.5%) for 30-day mortality and MACCE based on the UPMC's Perioperative Model (EHR risk prediction algorithm)\n* Scheduled for major cardiac surgeries including coronary artery bypass and valvular repair and\u002For vascular surgeries including carotid endarterectomy, aortic aneurysm repair, and major vascular surgeries\n* RAI score ≥ 30\n* Informed consent\n* English speaking patients\n\nPart II Inclusion Criteria:\n\n* Enrolled in Aim 1 \u002F Part I Preoperative Intervention Trial\n* Scheduled for high-risk, cardiac or vascular surgery requiring intraoperative neurophysiological monitoring (IONM)\n* Moderate and high risk for mortality based on Society of Thoracic Surgery score (score \\>4)\n\nPart I Exclusion Criteria:\n\n* Children (\\\u003C18 years)\n* Patients unable to provide consent\n* Participants undergoing same day procedures or operations (discharged same day)\n* Patients with severe preoperative medical diseases such as blindness or significant visual impairment, unresolved motor weakness, or any other perioperative events or complications that would have a bearing on the patient's ability to perform study tasks, neuropsychological tests, and proposed interventions\n\nPart II Exclusion Criteria:\n\n* Pregnant women\n* Patients do not provide consent.\n* Patients are unable to participate in cognitive and other behavioral assessment due to physical limitations\n* Patients refuse any blood transfusions during surgery","ALL","65 Years",{"count":19,"type":20},1200,"ESTIMATED","INTERVENTIONAL",[23],"NA","This study will contribute to creating a prospective and automated preoperative risk assessment algorithm for predicting 30-day mortality, major adverse cardiac and cerebrovascular events (MACCE), and postoperative neurocognitive outcomes following elective cardiac and vascular surgery in older adults. It will evaluate associations between perioperative factors and longer-term neurocognitive outcomes, including postoperative neurocognitive disorder and dementia. In addition, this study will assess scalable, multimodal preoperative and intraoperative interventions to improve perioperative outcomes.\n\nThis study will explore two main hypotheses:\n\n1. Preoperative personalized prehabilitation with proactive cognitive and behavioral interventions will improve postoperative cognitive outcomes, morbidity, and mortality in high-risk elderly surgical patients.\n2. Proactive bundled intraoperative interventions are superior to reactive standard of care in reducing postoperative cognitive outcomes, MACCE, and mortality.\n\nExpected Outcome: Improved EHR algorithm will have higher predictive accuracy for MACCE and mortality while predicting postoperative cognitive outcomes.",[26,27,28,29,30,31],"Dementia","Postoperative Delirium (POD)","Postoperative Neurocognitive Disorder","Major Adverse Cardiac and Cerebrovascular Events","Perioperative Complications","Postoperative Cognitive Decline",[33,34,35,36,37],"MACCE","Cognitive decline","Perioperative brain health","Neurocognitive disorder","Postoperative delirium","NOT_YET_RECRUITING","2026-06-02",{"date":41,"type":42},"2026-06-04","ACTUAL",{"date":44,"type":20},"2026-06",{"date":46,"type":20},"2027-06",{"name":48,"class":49},"University of Pittsburgh","OTHER",5,{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":57,"eligibilityCriteria":58,"healthyVolunteers":11,"sex":16,"minAge":59,"maxAge":4,"enrollmentInfo":60,"targetDuration":4,"studyType":21,"phases":62,"briefSummary":63,"conditions":64,"keywords":67,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":81},"100400420","increasing-preoperative-cognitive-reserve-to-prevent-postoperative-cognitive-dysfunction-in-cardiac-surgical-patients-100400420","NCT04493996","Increasing Preoperative Cognitive Reserve to Prevent Postoperative Cognitive Dysfunction in Cardiac Surgical Patients","Increasing Preoperative Cognitive Reserve to Prevent Postoperative Delirium and Postoperative Cognitive Decline in Cardiac Surgical Patients. A Randomized Controlled Trial on Cognitive Training","INCORE","Inclusion Criteria:\n\n* Elective cardiac surgery (coronary artery bypass surgery, aortic or mitral valve replacement\u002Freconstruction, or combination surgery) with standardized extracorporeal circulation\n* A sufficiently good knowledge of German is necessary as cognitive training and neuropsychological tests are language-dependent\n\nExclusion Criteria:\n\n* History of stroke and preexisting psychiatric or neurological disorders that may impair the neuropsychological performance","18 Years",{"count":61,"type":20},100,[23],"Postoperative delirium (POD) and postoperative cognitive decline (POCD) can be observed after cardiosurgical interventions. Taken together, these postoperative neurocognitive dysfunctions contribute to increased morbidity and mortality and higher economic costs. Preoperative risk factors of postoperative neurocognitive dysfunctions, such as decreased neuropsychometric performance or decreased cognitive daily activities, can be interpreted as reduced cognitive reserve. The aim of this study is to build up cognitive reserves to protect against the development of POD and POCD through preoperative, home-based, cognitive training.",[31,65,66],"Postoperative Delirium","Postoperative Cognitive Dysfunction",[68,31,65,69,70,66],"Cardiac Surgery","Cognitive Training","Cognitive Reserve","RECRUITING","2026-02-13",{"date":74,"type":42},"2026-02-17",{"date":76,"type":42},"2020-08-14",{"date":78,"type":20},"2026-03",{"name":80,"class":49},"Heart and Brain Research Group, Germany",1,{"id":83,"slug":84,"hasResults":11,"nctId":85,"briefTitle":86,"officialTitle":87,"acronym":4,"eligibilityCriteria":88,"healthyVolunteers":11,"sex":16,"minAge":89,"maxAge":4,"enrollmentInfo":90,"targetDuration":4,"studyType":21,"phases":92,"briefSummary":94,"conditions":95,"keywords":96,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":101,"lastUpdatePostDateStruct":102,"startDateStruct":104,"completionDateStruct":106,"leadSponsor":108,"locationsCount":81},"100609694","phase-2-daridorexant-to-prevent-post-cardiotomy-delirium-100609694","NCT07217912","Daridorexant to Prevent Post-cardiotomy Delirium","Randomized, Double-blind Trial of Daridorexant to Prevent Delirium After Heart Surgery","Inclusion Criteria:\n\n* ≥ 60 yrs;\n* having surgical aortic valve surgery or coronary artery bypass graft surgery at Strong Memorial Hospital;\n* can provide consent;\n* able to speak, read,and write English (as the instruments, including semi-structured interviews, used in this protocol have been validated in English);\n* family member or close friend for collateral.\n\nExclusion Criteria:\n\n* Prior cardiotomy\n* Infectious endocarditis\n* Emergency surgery\n* Delirium at baseline (positive 3D-CAM)\n* Auditory or visual impairment that prevents study procedures\n* Alcohol or substance misuse (CAGE-AID score ≥ 2)\n* Psychotic disorder\n* Dementia-level deficits (TICS \\\u003C 27)\n* Use of a prescription sleep aid at least every other night\n* Use of a strong CYP3A4 inhibitor (e.g., ceritinib, clarithromycin, cobicistat, idelalisib, itraconazole, ketoconazole, nefazodone, nelfinavir, posaconazole, ritonavir, telithromycin, voriconazole)\n* Daridorexant intolerance\n* Severe kidney or liver impairment (Child-Pugh ≥7, Cockcroft-Gault \\\u003C30 mL\u002Fmin, or on dialysis)\n* Narcolepsy\n* Suicidal ideation at baseline\n* Any condition that, in the PI's opinion, compromises patient safety or data quality\n* Additional exclusions for the NLP exploratory aim: history of traumatic brain injury or head concussions with loss of consciousness, use of corticosteroids, or history of major neurological disease or brain surgery","60 Years",{"count":91,"type":20},80,[93],"PHASE2","The goal of this follow-on pilot randomized clinical trial is to obtain additional preliminary data to inform a larger, adequately powered phase 2b trial of daridorexant for the prevention of postoperative delirium after heart surgery. Having demonstrated feasibility in a prior study (RSRB #9841), this study aims to estimate the effect of daridorexant on (1) reducing delirium symptom burden and incidence and (2) improving self-reported sleep quality during the postoperative period, and (3) to assess the feasibility of collecting objective sleep data in the postoperative setting.\n\nParticipants will: complete a baseline visit; take the study drug, either daridorexant or placebo, each of the first three nights after heart surgery; and be evaluated daily for sleep and delirium during the first three postoperative days. Participants will also have the option of wearing a sleep monitor in the hospital each of the first three nights after surgery.",[31,65],[97,98,99,100],"delirium","sleep","cognitive decline","Alzheimer disease and related dementias","2026-01-06",{"date":103,"type":42},"2026-01-07",{"date":105,"type":42},"2025-10-14",{"date":107,"type":20},"2027-11-01",{"name":109,"class":49},"University of Rochester"]