[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"postoperative-cognitive-dysfunction-pocd\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:postoperative-cognitive-dysfunction-pocd":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,7,0,[8,54,83,114,137,173,195],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":21,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":29,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":42,"lastUpdatePostDateStruct":43,"startDateStruct":46,"completionDateStruct":48,"leadSponsor":50,"locationsCount":53},"100641778","early-cognitive-changes-after-same-day-discharge-hip-and-knee-arthroplasty-100641778",false,"NCT07598552","Early Cognitive Changes After Same-day Discharge Hip and Knee Arthroplasty","Early Cognitive Changes in Patients Aged 70 Years or Older After Same-day Discharge Hip and Knee Arthroplasty: A Prospective Cohort Study","Inclusion Criteria:\n\n* Unilateral elective primary Total Hip Arthroplasty, Total Knee Arthroplasty, or Unicompartmental Knee\n* Native Danish speaker\n* Spinal anesthesia\n\nExclusion Criteria:\n\n* Inability or unwillingness to provide informed consent\n* Inability to comply with virtual study procedures or follow-up sessions, including because of visual or hearing impairment\n* Known dementia or other diagnosed cognitive disorders or Brief Assessment of Impaired Cognition (BASIC)≤20\n* Parkinson's disease or other neurological conditions causing functional impairment\n* History of alcohol abuse (≥35 units per week)\n* Daily use of anxiolytics or hypnotics\n* Not discharged on the day of surgery","ALL","70 Years",{"count":19,"type":20},48,"ESTIMATED","7 Days","OBSERVATIONAL","The goal of this observational study is to explore early cognitive changes in patients aged 70 years or older undergoing same-day discharge after hip or knee replacement surgery. The main question it aims to answer is:\n\nDoes patients experience cognitive changes in cognitive test performance from before surgery to the first day after surgery?\n\nParticipants will:\n\n* Complete a cognitive test battery virtually about 14 days before surgery, and on the first and seventh day after their operation.\n* Record pain levels and pain medicine use during the first week after surgery",[25,26,27,28],"Postoperative Cognitive Dysfunction (POCD)","Cognitive Change","Total Knee Arthroplasty","Unicompartmental Knee Arthroplasty",[30,31,32,33,34,35,36,37,38,39,40],"Same-day discharge","Fast-track surgery","Hip arthroplasty","Knee arthroplasty","Unicompartmental knee arthroplasty","Cognitive function","SDMT","Stroop test","Verbal fluency","Older adults","recovery","RECRUITING","2026-06-17",{"date":44,"type":45},"2026-06-22","ACTUAL",{"date":47,"type":45},"2026-05-18",{"date":49,"type":20},"2026-11-30",{"name":51,"class":52},"Odense University Hospital","OTHER",1,{"id":55,"slug":56,"hasResults":11,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":60,"eligibilityCriteria":61,"healthyVolunteers":11,"sex":16,"minAge":62,"maxAge":4,"enrollmentInfo":63,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":65,"conditions":66,"keywords":67,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":53},"100643371","cohort-study-of-postoperative-cognitive-dysfunction-after-off-pump-coronary-artery-bypass-grafting-100643371","NCT07643194","Cohort Study of Postoperative Cognitive Dysfunction After Off-Pump Coronary Artery Bypass Grafting","Risk of Postoperative Cognitive Dysfunction After Off-Pump Coronary Artery Bypass Grafting: A Prospective Cohort Study","OPCAB-POCD","Inclusion Criteria:\n\n* Age 18 years or older\n* Scheduled to undergo elective off-pump coronary artery bypass grafting\n* American Society of Anesthesiologists physical status classification I to IV\n* Able to complete preoperative cognitive assessments, including the Mini-Mental State Examination and the Montreal Cognitive Assessment\n* Written informed consent provided by the patient or family member\n\nExclusion Criteria:\n\n* Emergency surgery\n* Pre-existing diagnosed cognitive impairment or history of psychiatric disease\n* Preoperative cognitive impairment\n* Severe neurological disease, such as sequelae of stroke, that may interfere with cognitive assessment\n* Severe visual or hearing impairment that prevents completion of cognitive assessment\n* Inability to understand Chinese or presence of language communication barriers","18 Years",{"count":64,"type":20},600,"This prospective cohort study aims to investigate postoperative cognitive dysfunction in patients undergoing off-pump coronary artery bypass grafting. Eligible patients will be enrolled before surgery and followed after surgery. Cognitive function will be assessed using the Montreal Cognitive Assessment before surgery and at predefined postoperative time points. Perioperative clinical information, including preoperative assessment data, intraoperative monitoring parameters, and postoperative clinical data, will be collected. The study will evaluate the occurrence of postoperative cognitive dysfunction and explore its association with perioperative factors.",[25],[68,69,70,71,72],"Postoperative Cognitive Dysfunction","Off-Pump Coronary Artery Bypass Grafting","OPCABG","Montreal Cognitive Assessment","Prospective Cohort Study","NOT_YET_RECRUITING","2026-06-09",{"date":76,"type":45},"2026-06-11",{"date":78,"type":20},"2026-05-24",{"date":80,"type":20},"2026-12-15",{"name":82,"class":52},"Beijing Anzhen Hospital",{"id":84,"slug":85,"hasResults":11,"nctId":86,"briefTitle":87,"officialTitle":87,"acronym":88,"eligibilityCriteria":89,"healthyVolunteers":11,"sex":16,"minAge":62,"maxAge":4,"enrollmentInfo":90,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":92,"conditions":93,"keywords":97,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":105,"lastUpdatePostDateStruct":106,"startDateStruct":108,"completionDateStruct":110,"leadSponsor":112,"locationsCount":4},"100639710","prospective-neuropsychological-evaluation-of-the-implementation-of-a-heart-valve-unit-hvu-neuro-100639710","NCT07626567","Prospective Neuropsychological Evaluation of the Implementation of a Heart Valve Unit (HVU-NEURO)","HVU-NEURO","Inclusion Criteria:\n\n* Severe aortic valve stenosis\n* Indication for transcatheter valve therapy according to current guideline recommendations and\u002For Heart-Team consensus\n* Sufficient German language proficiency, as study-related tests, questionnaires, and instructions are administered in German\n* Age ≥18 years\n* Willingness to participate voluntarily with written informed consent\n\nExclusion Criteria:\n\n* Known pregnancy at the time of study inclusion\n* Life expectancy \\\u003C1 year due to non-cardiac disease\n* Pre-interventional psychiatric and neurological disorders (known and diagnosed dementia, depression, history of stroke or transient ischemic attack \\[TIA\\], migraine, epilepsy) with acute symptoms that may interfere with data collection",{"count":91,"type":20},500,"Transcatheter aortic valve implantation (TAVI) is an established treatment for severe aortic stenosis. Despite improved procedural outcomes, neurocognitive complications such as postoperative delirium (POD) and postoperative cognitive decline (POCD) remain clinically relevant.\n\nHeart Valve Units (HVU) are specialized interdisciplinary care structures designed to improve treatment pathways and healthcare quality. However, their impact on neuropsychological outcomes has not been sufficiently investigated.\n\nHVU-NEURO is a prospective observational cohort study evaluating neuropsychological outcomes before and after implementation of an HVU. Approximately 500 patients undergoing transcatheter valve therapy will be included.\n\nNeurocognitive function will be assessed before intervention, at hospital discharge, and three months after intervention. POD will be assessed using the Intensive Care Delirium Screening Checklist (ICDSC). The primary objective is to evaluate the effect of HVU implementation on postoperative cognitive decline at discharge from acute hospital care.",[94,25,95,96],"Aortic Valve Stenosis","Delirium - Postoperative","Neurocognitive Disorders",[98,99,100,101,102,103,104],"TAVI","HVU","Postoperative Cognitive Decline","Postoperative Delirium","Neuropsychology","Transcatheter Aortic Valve Implantation","Intensive Care Delirium Screening Checklist","2026-05-29",{"date":107,"type":45},"2026-06-04",{"date":109,"type":20},"2026-05-25",{"date":111,"type":20},"2028-02",{"name":113,"class":52},"Heart and Brain Research Group, Germany",{"id":115,"slug":116,"hasResults":11,"nctId":117,"briefTitle":118,"officialTitle":118,"acronym":4,"eligibilityCriteria":119,"healthyVolunteers":11,"sex":16,"minAge":62,"maxAge":4,"enrollmentInfo":120,"targetDuration":122,"studyType":22,"phases":4,"briefSummary":123,"conditions":124,"keywords":4,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":128,"lastUpdatePostDateStruct":129,"startDateStruct":131,"completionDateStruct":133,"leadSponsor":135,"locationsCount":4},"100632209","value-of-the-time-weighted-average-twa-of-mean-arterial-pressure-map-and-cerebral-oximetry-rso-as-predictors-of-postoperative-tissue-perfusion-impairment-in-patients-undergoing-cardiac-surgery-100632209","NCT07510711","Value of the Time-Weighted Average (TWA) of Mean Arterial Pressure (MAP) and Cerebral Oximetry (rSO₂) as Predictors of Postoperative Tissue Perfusion Impairment in Patients Undergoing Cardiac Surgery","Inclusion Criteria:\n\n* Age \\>18 years\n* Undergoing cardiac surgery, with or without cardiopulmonary bypass\n* Written informed consent\n* Preoperative cognitive status: Glasgow Coma Scale score of 15; no history of dementia; no evidence of cognitive impairment on baseline assessment; patient oriented and cooperative prior to surgery\n* Continuous intraoperative monitoring of mean arterial pressure (MAP) and cerebral regional oxygen saturation (rSO₂)\n\nExclusion Criteria:\n\n* History of dementia or cognitive impairment\n* Emergency surgeries",{"count":121,"type":20},120,"3 Months","Neurological problems after heart surgery are common and include confusion, memory loss, and difficulty thinking clearly. These issues may appear hours or days after surgery and can negatively affect recovery.\n\nDuring heart surgery, blood flow and oxygen delivery to the brain may decrease, causing changes in blood pressure and cerebral oxygenation. Previous studies suggest that prolonged drops in mean arterial pressure (MAP) or cerebral oxygenation (rSO₂) are linked to worse postoperative outcomes. Continuous monitoring of blood pressure and cerebral oxygenation is standard in cardiac surgery.\n\nThis study aims to evaluate the duration and severity of intraoperative drops in MAP and cerebral oxygenation. These measures may provide a more accurate assessment of neurological risk than isolated measurements.\n\nThe primary objective is to determine whether decreases in MAP and cerebral oxygenation, as well as their duration and intensity during surgery, are associated with postoperative neurological complications.\n\nThis is a prospective, observational study in adult patients undergoing cardiac surgery, with or without cardiopulmonary bypass (CPB). CPB diverts blood through a machine that performs the work of the heart and lungs while the heart is operated on. All patients will receive standard monitoring, including continuous MAP and cerebral oxygenation measurements. No additional interventions will be performed.\n\nNeurological status will be assessed using validated clinical scales before and after surgery. Other outcomes include kidney function, ICU and hospital stay length, postoperative complications, and in-hospital mortality.\n\nValidating these measures as a predictive tool could enable early identification of patients at higher risk of neurological injury and allow more individualized intraoperative management to reduce morbidity, hospital stay, and healthcare costs.",[95,25,125,126,127],"Postoperative Acute Kidney Injury","Postoperative Morbidity","Intensity Care Unit Length of Stay","2026-03-30",{"date":130,"type":45},"2026-04-03",{"date":132,"type":20},"2026-05-01",{"date":134,"type":20},"2027-11",{"name":136,"class":52},"Hospital Universitari Vall d'Hebron Research Institute",{"id":138,"slug":139,"hasResults":11,"nctId":140,"briefTitle":141,"officialTitle":142,"acronym":143,"eligibilityCriteria":144,"healthyVolunteers":11,"sex":16,"minAge":145,"maxAge":4,"enrollmentInfo":146,"targetDuration":4,"studyType":148,"phases":149,"briefSummary":151,"conditions":152,"keywords":155,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":163,"lastUpdatePostDateStruct":164,"startDateStruct":166,"completionDateStruct":168,"leadSponsor":170,"locationsCount":172},"100630335","awareness-neuraxial-versus-general-anesthesia-in-frail-patients-undergoing-laparoscopic-or-robotic-abdominopelvic-surgery-100630335","NCT07486336","Awareness Neuraxial Versus General Anesthesia in Frail Patients Undergoing Laparoscopic or Robotic Abdominopelvic Surgery.","Neuraxial Anesthesia Awareness Versus General Anesthesia in Frail Patients Undergoing Elective Laparoscopic or Robotic Abdominopelvic Surgery: A Pilot Randomized Controlled Trial.","SAFE-AWARENESS","Inclusion Criteria:\n\n* Age \\> 60 years\n* Willingness to participate in the study and written informed consent\n* ASA physical status \\> 2\n* Frailty score \\> 5 and\u002For AMT-10 \\\u003C 6\n* Laparoscopic or robotic major elective abdominopelvic surgery\n\nExclusion Criteria:\n\n* Patients undergoing open (laparotomic) or emergency surgery, or presenting contraindications to central locoregional (neuraxial) anesthesia, specifically:\n\n  * coagulation disorders\n  * severe spinal deformities\n  * known allergy to local anesthetics\n  * severe aortic stenosis\n  * systemic sepsis\n  * infection at the puncture site\n* Any systemic disease that, in the investigator's judgment, is not compatible with participation in the study","60 Years",{"count":147,"type":20},100,"INTERVENTIONAL",[150],"NA","This is a bicentric, prospective, non-pharmacological, randomized study designed to compare the efficacy and safety of awake neuraxial anesthesia with sedation versus general anesthesia in frail patients undergoing elective major laparoscopic or robotic abdominopelvic surgery.\n\nA total of 100 frail patients aged over 60 years, with ASA physical status \\>2 and evidence of frailty and\u002For cognitive vulnerability, will be randomized to receive either standard general anesthesia with mechanical ventilation or thoracic neuraxial anesthesia combined with non-GABAergic sedation while maintaining spontaneous breathing.\n\nThe primary objective is to evaluate the feasibility in terms of recruitment of a RCT conducted in a population of frail or cognitively impaired patients undergoing major laparoscopic abdominal surgery, randomized to a neuraxial or general anesthetic approach in which the effects on the onset of postoperative delirium and postoperative cognitive dysfunction (POCD) will be determined. Secondary outcomes include the occurrence of postoperative organ dysfunction (respiratory, cardiovascular, renal, and metabolic), length of hospital stay, time to recovery after surgery, and postoperative mortality.\n\nPatients will undergo comprehensive perioperative clinical, laboratory, and ultrasound assessments, including lung and renal ultrasound evaluations. Neurological and functional status will be assessed during hospitalization, at 1 month, and via telephone follow-up at 1 year after surgery.\n\nThe aim of the study is to evaluate the feasibility and safety of performing two different anesthetic techniques on fragile patients.",[153,154,25],"Fraily","Abdominal Surgery",[156,157,158,159,160,161,162],"neuraxial anesthesia","awake surgery","frailty","postoperative delirium","cognitive outcomes","perioperative medicine","enhanced recovery after surgery","2026-03-17",{"date":165,"type":45},"2026-03-20",{"date":167,"type":20},"2026-09-01",{"date":169,"type":20},"2029-01-01",{"name":171,"class":52},"Ente Ospedaliero Ospedali Galliera",2,{"id":174,"slug":175,"hasResults":11,"nctId":176,"briefTitle":177,"officialTitle":177,"acronym":4,"eligibilityCriteria":178,"healthyVolunteers":11,"sex":16,"minAge":179,"maxAge":4,"enrollmentInfo":180,"targetDuration":182,"studyType":22,"phases":4,"briefSummary":183,"conditions":184,"keywords":4,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":186,"lastUpdatePostDateStruct":187,"startDateStruct":189,"completionDateStruct":191,"leadSponsor":193,"locationsCount":53},"100630082","prediction-model-for-postoperative-cognitive-dysfunction-in-elderly-cardiac-patients-a-special-disease-cohort-study-100630082","NCT07483047","Prediction Model for Postoperative Cognitive Dysfunction in Elderly Cardiac Patients: A Special Disease Cohort Study","Inclusion Criteria:\n\n* Subjects aged ≥65 years, with no gender restriction. Patients meet the indications for cardiac surgery (cardiac surgery with cardiopulmonary bypass).\n\nNormal liver and renal function during the screening period. No evidence of active infection during the screening period. Able to cooperate in answering questions related to the MMSE and MoCA cognitive scales during the screening period.\n\nHave signed the informed consent form.\n\nExclusion Criteria:\n\n* The investigator considers that the subject has conditions that may interfere with the study results.\n\nSubjects with evidence of active liver disease (liver function test results: ALT or AST ≥ 2 times the upper limit of normal \\[ULN\\]) or chronic active hepatitis B or C within 1 month.\n\nActive systemic infection requiring antibacterial drugs within 1 week before surgery.\n\nPreoperative low MMSE score (illiterate: \\\u003C17 points; primary school education: \\\u003C20 points; middle school education or above: \\\u003C24 points).\n\nPatients with one or more of the following diseases:\n\nClassified as obese (body mass index ≥ 30 kg\u002Fm²); Uncontrolled hypertension (defined as systolic blood pressure ≥ 180 mmHg or diastolic blood pressure ≥ 100 mmHg); History of organ transplantation, including corneal transplantation; Any clinically significant uncontrolled respiratory disease, including but not limited to chronic obstructive pulmonary disease, asthma, bronchiectasis, or pleural effusion; Previously diagnosed or suspected demyelinating diseases, including multiple sclerosis, Guillain-Barré syndrome, etc.; Use of any glucocorticoids or immunosuppressive agents; Any disease that significantly affects the nervous system. Participation in other clinical trials.","65 Years",{"count":181,"type":20},634,"6 Months","This is a prospective cohort study aiming to construct a prediction model for postoperative cognitive dysfunction (POCD) in elderly cardiac patients. We plan to enroll elderly patients aged ≥65 years undergoing cardiac surgery. Peripheral blood samples and functional magnetic resonance imaging (fMRI) data will be collected at baseline and key time points post-surgery. The primary objectives are to identify novel peripheral blood protein biomarkers for POCD, explore the correlation between fMRI characteristics and POCD, and establish a reliable early prediction model to improve perioperative management and reduce the incidence of POCD in elderly cardiac surgical patients.",[25,185],"Cardiac Diseases Requiring Surgery","2026-03-15",{"date":188,"type":45},"2026-03-19",{"date":190,"type":45},"2026-03-03",{"date":192,"type":20},"2028-09",{"name":194,"class":52},"Shanghai Geriatric Medical Center",{"id":196,"slug":197,"hasResults":11,"nctId":198,"briefTitle":199,"officialTitle":200,"acronym":4,"eligibilityCriteria":201,"healthyVolunteers":11,"sex":16,"minAge":62,"maxAge":202,"enrollmentInfo":203,"targetDuration":4,"studyType":148,"phases":205,"briefSummary":206,"conditions":207,"keywords":209,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":215,"lastUpdatePostDateStruct":216,"startDateStruct":218,"completionDateStruct":220,"leadSponsor":221,"locationsCount":4},"100623634","effect-of-perioperative-iv-ibuprofen-on-cerebral-oxygenation-and-postoperative-cognition-during-one-lung-ventilation-100623634","NCT07399184","Effect of Perioperative IV Ibuprofen on Cerebral Oxygenation and Postoperative Cognition During One-Lung Ventilation","Comparison of the Effects of Ibuprofen on Cerebral Oxygenation, Postoperative Cognitive Dysfunction, and Delirium in One-Lung Ventilation","Inclusion Criteria:\n\n* Patients aged 18-75 years\n* American Society of Anesthesiologists (ASA) Physical Status Classification System I-III\n* Patients scheduled for lobectomy or segmentectomy via Video-Assisted Thoracic Surgery (VATS ) with one-lung ventilation\n* New York Heart Association (NYHA) class I-II\n* Patients who have been informed about the study and have provided written informed consent will be included.\n\nExclusion Criteria:\n\n* Patients younger than 18 years or older than 75 years\n* History of alcohol or substance abuse\n* Patients with chronic NSAID use and\u002For NSAID use within the last 30 days, or NSAID allergy\n* Allergy to other drugs used in the study (e.g., bupivacaine)\n* ASA Physical Status IV-V\n* Severe hearing, visual, or speech impairment\n* Dementia, Alzheimer's disease, or psychiatric disorders (psychosis, bipolar disorder, schizophrenia)\n* History of previous head trauma\n* Chronic liver disease\n* Pregnancy\n* History of cerebrovascular disease\n* Moderate-to-severe chronic obstructive pulmonary disease (COPD) (predicted FEV₁ \\\u003C50%)\n* GFR \\\u003C60 mL\u002Fmin\u002F1.73 m²\n* Patients who do not provide written informed consent\n* Conditions that may cause inaccurate cerebral oximetry readings (subdural and\u002For extracranial hematoma, intracranial arteriovenous shunts, hyperbilirubinemia)\n* Patients undergoing emergency surgery\n* Patients in whom surgery is initiated as thoracotomy or converted to thoracotomy\n* Patients unable to complete the preoperative MMSE (total score ≤24) will be excluded.","75 Years",{"count":204,"type":20},54,[150],"This study compares the effects of ibuprofen administered during surgery and within the first 24 hours after surgery, versus no ibuprofen, on cerebral oxygenation, postoperative changes in consciousness (postoperative delirium and cognitive dysfunction), length of stay in the intensive care unit, and the incidence of postoperative pain, nausea, vomiting, and pruritus in patients undergoing lung lobectomy or segmentectomy using a closed (video-assisted) method (VATS - video-assisted thoracoscopic surgery), in whom one-lung ventilation is applied.\n\nThe aim of this study is to evaluate the effects of ibuprofen on cerebral oxygenation, postoperative cognitive changes, and delirium in patients undergoing one-lung ventilation.",[101,208,25],"Cerebral Oxygen Saturation",[210,211,212,159,213,214],"cerebral oxygenation","near infrared spectroscopy","thoracic anesthesia","one lung ventilation","ibuprofen","2026-02-08",{"date":217,"type":45},"2026-02-10",{"date":219,"type":20},"2026-02-15",{"date":167,"type":20},{"name":222,"class":52},"Ondokuz Mayıs University"]