[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"postoperative-cognitive-dysfunction\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:postoperative-cognitive-dysfunction":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,23,0,[8,46,77,113,139,165,193,219,240,260,282,310,343,366,393,414,441,462,489,510,535,557,579],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":27,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100645294","palmitoylethanolamideluteolin-supplementation-in-older-adults-undergoing-cardiac-surgery-100645294",false,"NCT07681063","Palmitoylethanolamide\u002FLuteolin Supplementation in Older Adults Undergoing Cardiac Surgery","Palmitoylethanolamide\u002FLuteolin for the Maintenance of Cognitive Performance in Older Adults Undergoing Cardiac Surgery","Inclusion Criteria:\n\n* Age ≥ 65 years\n* Both genders\n* Undergoing elective aortic or mitral valve replacement\u002Freconstruction with or without coronary artery bypass grafting (CABG), at the Cardiac Surgery Unit of IRCCS San Gerardo dei Tintori Foundation (Monza, Italy)\n* Prognosis quoad vitam ≥ 3 months\n* Availability of a formal or informal caregiver who can assist the participant in taking the prescribed dose and following the visit schedule\n* Any concomitant therapy should be stable\n* Written informed consent obtained prior to randomization (from the participant or caregiver if the participant is unable to sign but clearly expresses the will to participate)\n\nExclusion Criteria:\n\n* Severe dementia diagnosis\n* Preoperative clinical diagnosis of delirium\n* Other treatments\u002Fmedications that may improve cognition\n* Current treatment with m\u002FumPEA or PEALut (Glialia®), or its use within 90 days prior to enrollment\n* Contraindications to the use of PEALut, including allergy to excipients contained in the supplement and previous adverse reactions to PEALut\n* Other clinical conditions or situations that could interfere with the study or prevent optimal participation, as judged by the researchers","ALL","65 Years",{"count":19,"type":20},100,"ESTIMATED","INTERVENTIONAL",[23],"NA","Postoperative Cognitive Dysfunction (POCD) is a common complication after surgery, particularly among older adults. It is characterized by cognitive impairment, reduced functional independence, and decreased quality of life. Growing evidence suggests that neuroinflammation plays a relevant role in POCD development and persistence.\n\nPalmitoylethanolamide (PEA) is an endogenous lipid mediator involved in the regulation of neuroinflammatory processes through the modulation of non-neuronal cells, while luteolin is a flavonoid with well-known antioxidant properties. Under conditions of prolonged neuroinflammation, endogenous PEA levels may be insufficient to adequately counteract pro-inflammatory signaling, making exogenous administration necessary.\n\nIn this context, exogenous micronized and ultramicronized PEA (mPEA and umPEA) supplementation has been shown to modulate cognitive and executive functions, working memory, language, and activities of daily living. Moreover, the combination of umPEA and luteolin (PEALut) may produce synergistic effects by modulating neuroinflammation and supporting neuronal function.\n\nThis study aims to evaluate whether postoperative administration of co-ultramicronized PEA and luteolin (700 mg + 70 mg in 10 mL), added to standard of care, may contribute to the mitigation of POCD in older adults undergoing elective cardiac surgery, compared to standard care alone.",[26],"Postoperative Cognitive Dysfunction",[28,29,30,26,31,32],"Neuroinflammation","Palmitoylethanolamide","Luteolin","Cardiac Surgery","Cognitive Impairment","NOT_YET_RECRUITING","2026-06-26",{"date":36,"type":37},"2026-07-02","ACTUAL",{"date":39,"type":20},"2026-06",{"date":41,"type":20},"2028-06",{"name":43,"class":44},"Fondazione IRCCS San Gerardo dei Tintori","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":54,"sex":16,"minAge":55,"maxAge":56,"enrollmentInfo":57,"targetDuration":4,"studyType":21,"phases":59,"briefSummary":60,"conditions":61,"keywords":4,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":45},"100519373","kids-with-iron-deficiency-and-scoliosis-100519373","NCT06042699","Kids With Iron Deficiency and Scoliosis","Kids With Iron Deficiency and Scoliosis (KIDS) Study","KIDS","Inclusion Criteria:\n\n1. 10-26 years old;\n2. diagnosis of scoliosis or kyphosis;\n3. self-reported ability to swallow a tablet;\n4. spinal fusion procedure planned approximately 6 to 24 weeks from an orthopedic surgical clinic visit at which patient agrees to phlebotomy for screening blood work;\n5. serum ferritin less than or equal to 25 µg\u002FL.\n\nExclusion Criteria:\n\n1. taking or planning to take iron-containing supplement on patient's own volition, and not willing to stop for duration of study;\n2. taking or planning to take iron-containing supplement as prescribed or recommended under the care of a physician;\n3. Hg \\\u003C10mg\u002FdL if post-menarchal, Hg \\\u003C 11 if premenarchal or male\n4. C-reactive protein \\> 10 mg\u002FL\n5. receiving nutritional support by report in the medical chart;\n6. self-reported history of hypersensitivity reaction to iron-containing supplements;\n7. self-reported history of or suspected non-iron deficient hematologic disorder;\n8. self-reported history of iron overloaded state such as hereditary hemochromatosis or hemosiderosis;\n9. objection to receiving red blood cell transfusions;\n10. current pregnancy (by self-report);\n11. prisoners;\n12. patient or parent decides against study participation.",true,"10 Years","26 Years",{"count":58,"type":20},275,[23],"This study is a randomized controlled trial of preoperative oral iron supplementation, to identify whether iron deficiency is a modifiable risk factor for adverse surgical outcomes such as red blood cell transfusion and diminished postoperative cognitive and physical capacity in adolescents undergoing scoliosis surgery.\n\nResearch Question(s)\u002FHypothesis(es):\n\nPrimary\n\n* Iron supplementation will reduce the incidence of perioperative RBC transfusion in iron deficient scoliosis patients undergoing spinal fusion.\n\nSecondary\n\n* Iron supplementation will reduce postoperative neurocognitive functional declines in iron deficient scoliosis patients undergoing spinal fusion.\n* Iron supplementation will improve patient-reported physical functioning in iron deficient scoliosis patients undergoing spinal fusion.",[62,63,64,65,66,67,26],"Adolescent Idiopathic Scoliosis","Neuromuscular Scoliosis","Perioperative\u002FPostoperative Complications","Iron Deficiencies","Anemia","Spinal Fusion","RECRUITING","2026-06-25",{"date":34,"type":37},{"date":72,"type":37},"2024-01-11",{"date":74,"type":20},"2028-02-01",{"name":76,"class":44},"Columbia University",{"id":78,"slug":79,"hasResults":11,"nctId":80,"briefTitle":81,"officialTitle":82,"acronym":83,"eligibilityCriteria":84,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":85,"targetDuration":4,"studyType":87,"phases":4,"briefSummary":88,"conditions":89,"keywords":92,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":104,"startDateStruct":106,"completionDateStruct":108,"leadSponsor":110,"locationsCount":112},"100485045","impact-of-personalised-cardiac-anaesthesia-and-cerebral-autoregulation-on-neurological-outcomes-in-patients-undergoing-cardiac-surgery-100485045","NCT05595954","Impact of Personalised Cardiac Anaesthesia and Cerebral Autoregulation on Neurological Outcomes in Patients Undergoing Cardiac Surgery","Impact of Personalised Cardiac Anaesthesia and Cerebral Autoregulation on Neurological Outcomes in Patients Undergoing Cardiac Surgery (PRECISION)","PRECISION","Inclusion Criteria:\n\n* Elective primary or reoperative coronary artery bypass graft and\u002For valvular and\u002For ascending aorta surgery requiring cardiopulmonary bypass.\n\nExclusion Criteria:\n\n* Surgery requiring moderate (28-31.9ºC) or deep (\\\u003C28ºC) hypothermic circulatory arrest;\n* Heart and\u002For lung transplantation;\n* Urgent (within 24 hours) and emergency surgery;\n* Inability to follow procedures or insufficient knowledge in English, German or French;\n* Inability to give consent.\n\nParticipants who undergo cardiac surgery under minimal extracorporeal circulation will also be excluded.",{"count":86,"type":20},500,"OBSERVATIONAL","This international, multicentre prospective cohort study will assess whether perioperative duration and magnitude of mean arterial pressure (MAP) outside of an individual's cerebral autoregulation (CA) limits using near-infrared spectroscopy (NIRS) and transcranial Doppler (TCD) are associated with adverse neurological events. It is to investigate whether patients with a higher burden of cerebral haemodynamic insults have an increased incidence or poorer neurological outcomes. Associations between neurologic outcomes, neurobiomarkers and genetic tests will be explored.",[90,91,26],"Postoperative Delirium","Postoperative Stroke",[93,94,95,96,97,98,99,100,101,102,103],"cerebral autoregulation","hypotension","neurological outcomes","adverse neurological events","postoperative delirium","postoperative stroke","postoperative cognitive decline","personalised cardiac anaesthesia","cardiac surgery","near-infrared spectroscopy","transcranial Doppler",{"date":105,"type":37},"2026-06-30",{"date":107,"type":37},"2023-01-23",{"date":109,"type":20},"2027-06",{"name":111,"class":44},"University Hospital, Basel, Switzerland",4,{"id":114,"slug":115,"hasResults":11,"nctId":116,"briefTitle":117,"officialTitle":118,"acronym":119,"eligibilityCriteria":120,"healthyVolunteers":11,"sex":121,"minAge":122,"maxAge":4,"enrollmentInfo":123,"targetDuration":4,"studyType":87,"phases":4,"briefSummary":125,"conditions":126,"keywords":128,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":129,"lastUpdatePostDateStruct":130,"startDateStruct":132,"completionDateStruct":134,"leadSponsor":136,"locationsCount":45},"100642483","pocd-after-major-gynecologic-surgery-100642483","NCT07589348","POCD After Major Gynecologic Surgery","Early Postoperative Cognitive Dysfunction After Major Gynecological Surgery: Incidence and Perioperative Risk Factors in a Prospective Cohort Study","POCD-GYN","Inclusion Criteria:\n\n* Female patients aged ≥18 years\n* Scheduled for elective major gynecological surgery under general anesthesia\n* Total abdominal hysterectomy and\u002For bilateral salpingo-oophorectomy\n* Open or laparoscopic surgical approach\n* Ability to complete the Turkish version of the Montreal Cognitive Assessment (MoCA)\n* Ability to understand and provide written informed consen\n\nExclusion Criteria:\n\n* Pre-existing dementia or major neurocognitive disorder\n* History of cerebrovascular event within the previous 3 months\n* Severe visual or hearing impairment preventing cognitive assessment\n* Emergency or hemodynamically unstable surgery\n* Planned postoperative sedation or mechanical ventilation longer than 72 hours\n* Postoperative delirium detected during assessment\n* Inability to communicate or cooperate\n* Refusal to participate","FEMALE","18 Years",{"count":124,"type":20},72,"This prospective observational cohort study aims to determine the incidence of early postoperative cognitive dysfunction (POCD) in patients undergoing major gynecological surgery. Cognitive function will be assessed using the Montreal Cognitive Assessment (MoCA) preoperatively and on postoperative day 3. POCD will be defined as a ≥20% relative decline or ≥2-point decrease in MoCA score. The study will also evaluate the association between POCD and perioperative clinical, surgical, and inflammatory parameters.",[26,127],"Perioperative Neurocognitive Disorder",[26,127],"2026-06-11",{"date":131,"type":37},"2026-06-12",{"date":133,"type":37},"2026-05-06",{"date":135,"type":20},"2026-09-15",{"name":137,"class":138},"Fatihhan Zeytun","OTHER_GOV",{"id":140,"slug":141,"hasResults":11,"nctId":142,"briefTitle":143,"officialTitle":144,"acronym":145,"eligibilityCriteria":146,"healthyVolunteers":11,"sex":16,"minAge":122,"maxAge":147,"enrollmentInfo":148,"targetDuration":149,"studyType":87,"phases":4,"briefSummary":150,"conditions":151,"keywords":152,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":156,"lastUpdatePostDateStruct":157,"startDateStruct":159,"completionDateStruct":161,"leadSponsor":163,"locationsCount":45},"100627725","optic-nerve-sheath-diameter-and-cognitive-outcomes-in-bentall-surgery-100627725","NCT07452367","Optic Nerve Sheath Diameter and Cognitive Outcomes in Bentall Surgery","Evaluation of the Relationship Between Bilateral Optic Nerve Sheath Diameter (ONSD) Measurements and Postoperative Cognitive Functions in Bentall Surgeries: A Prospective Observational Study","ONCOB","Inclusion Criteria:\n\n* Age between 18 and 80 years\n* Scheduled for elective Bentall procedure\n* Requiring cardiopulmonary bypass (CPB)\n* Willing to participate and able to provide informed consent\n* Able to complete the MoCA cognitive assessment test\n\nExclusion Criteria:\n\n* Age below 18 or above 80 years\n* Emergency Bentall surgery\n* Pre-existing diagnosed cognitive impairment or dementia\n* History of prior stroke or neurological disease\n* Significant carotid artery stenosis\n* Inability to complete the MoCA test (language barrier, illiteracy, visual or hearing impairment)\n* Refusal to participate or inability to provide informed consent\n* Patients with known psychiatric disorders\n* Reoperation (redo surgery)\n* Patients with severe renal or hepatic failure","80 Years",{"count":19,"type":20},"1 Month","Bentall surgery is a major cardiac procedure involving replacement of the ascending aorta, aortic root, and aortic valve, typically requiring cardiopulmonary bypass (CPB) and sometimes deep hypothermic circulatory arrest (DHCA). Due to its complexity, it carries a significant risk of postoperative neurological complications including stroke and postoperative cognitive dysfunction (POCD).\n\nThis prospective observational study aims to evaluate the relationship between perioperative bilateral optic nerve sheath diameter (ONSD) measurements obtained by ultrasound and postoperative cognitive functions in patients undergoing elective Bentall surgery. ONSD is a non-invasive surrogate marker of intracranial pressure that can be measured at the bedside using ultrasound.\n\nIn addition to routine hemodynamic monitoring and cerebral oximetry (NIRS), bilateral ONSD will be measured at predefined intraoperative and postoperative time points. Cognitive function will be assessed using the Montreal Cognitive Assessment (MoCA) test preoperatively and postoperatively, and delirium will be evaluated using the CAM-ICU scale during ICU stay. The association between perioperative ONSD values and postoperative cognitive outcomes, extubation time, ICU stay, and neurological complications will be analyzed.",[26],[153,154,155],"Bentall surgery","Optic nerve sheath diameter","Postoperative cognitive dysfunction","2026-03-05",{"date":158,"type":37},"2026-03-06",{"date":160,"type":37},"2025-08-30",{"date":162,"type":20},"2026-08-30",{"name":164,"class":138},"Bursa Yuksek Ihtisas Training and Research Hospital",{"id":166,"slug":167,"hasResults":11,"nctId":168,"briefTitle":169,"officialTitle":170,"acronym":4,"eligibilityCriteria":171,"healthyVolunteers":11,"sex":16,"minAge":122,"maxAge":172,"enrollmentInfo":173,"targetDuration":4,"studyType":87,"phases":4,"briefSummary":175,"conditions":176,"keywords":178,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":184,"lastUpdatePostDateStruct":185,"startDateStruct":187,"completionDateStruct":189,"leadSponsor":191,"locationsCount":45},"100592978","transcranial-doppler-as-a-predictor-of-postoperative-cognitive-dysfunction-following-cardiopulmonary-bypass-100592978","NCT07000461","Transcranial Doppler as a Predictor of Postoperative Cognitive Dysfunction Following Cardiopulmonary Bypass","Can Transcranial Doppler Predict Postoperative Cognitive Dysfunction After Cardiopulmonary Bypass","Inclusion Criteria:\n\n* Patients aged 18-70\n* Patients scheduled for isolated elective cardiopulmonary bypass surgery\n\nExclusion Criteria:\n\n* Patients with carotid stenosis ≥50%\n* Emergency patients or those with a history of reoperation\n* Patients with a history of cerebrovascular events\n* Patients who do not provide consent\n* Patients with temporal window failure\n* Patients with an ejection fraction (EF) \\\u003C40%\n* Patients with a Mini-Mental State Examination (MMSE) score \\\u003C23\n* Patients who require mechanical ventilation for more than 24 hours or those who are reintubated","70 Years",{"count":174,"type":20},106,"Neurological dysfunction either transient or permanent is a major cause of morbidity and mortality after cardiopulmonary bypass, and cognitive dysfunction is more frequent in cardiac surgery than in non-cardiac procedures. Variations in cerebral blood flow and oxygen extraction are considered key contributing factors. Although pulsatile flow during bypass has shown benefits for renal function and recovery, its effects on postoperative neurological dysfunction and delirium remain unclear due to limited research. This study aims to evaluate the impact of pulsatile versus non-pulsatile cardiopulmonary bypass flow on POCD in adult CABG patients by measuring middle cerebral artery (MCA) flow using transcranial Doppler.",[26,177],"Delirium, Postoperative",[179,180,181,182,183],"transcranial doppler","delirium","POCD","cerebral perfusion","CABG","2026-02-13",{"date":186,"type":37},"2026-02-17",{"date":188,"type":37},"2025-04-17",{"date":190,"type":20},"2026-04-30",{"name":192,"class":138},"Bakirkoy Dr. Sadi Konuk Research and Training Hospital",{"id":194,"slug":195,"hasResults":11,"nctId":196,"briefTitle":197,"officialTitle":198,"acronym":199,"eligibilityCriteria":200,"healthyVolunteers":11,"sex":16,"minAge":122,"maxAge":4,"enrollmentInfo":201,"targetDuration":4,"studyType":21,"phases":203,"briefSummary":204,"conditions":205,"keywords":207,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":184,"lastUpdatePostDateStruct":212,"startDateStruct":213,"completionDateStruct":215,"leadSponsor":217,"locationsCount":45},"100442065","decreasing-preoperative-stress-to-prevent-postoperative-delirium-and-postoperative-cognitive-decline-in-cardiac-surgical-patients-100442065","NCT05036538","Decreasing Preoperative Stress to Prevent Postoperative Delirium and Postoperative Cognitive Decline in Cardiac Surgical Patients.","Decreasing Preoperative Stress to Prevent Postoperative Delirium and Postoperative Cognitive Decline in Cardiac Surgical Patients. A Randomized Controlled Trial on Relaxation Interventions Via Virtual Reality and Binaural Beats.","DESTRESS-SURG","Inclusion Criteria:\n\n1. Elective cardiac surgery (coronary artery bypass surgery, aortic or mitral valve replacement\u002Freconstruction, or combination surgery) with standardized extracorporeal circulation.\n2. A sufficiently good knowledge of German is necessary as neuropsychological tests are language-dependent.\n\nExclusion Criteria:\n\n1. History of acute clinically relevant cognitive impairment of any cause (e.g., dementia, depression, stroke, multiple sclerosis) that may impair neuropsychological evaluation.\n2. Contraindications to the presentation of binaural beats or visual stimuli (e.g., epilepsy),\n3. Significant hearing loss or astigmatism, which may interfere with optimal perception of auditory and visual stimuli.\n4. Taking sedatives on the day of surgery.\n5. Unwilling to participate in the relaxation procedure or neuropsychological testing due to deteriorating health, lack of motivation, or other reasons.\n6. Participation in interventions that aim to change cognitive or emotional functioning which cannot be systematically controlled by our study team.\n7. Participation in an interventional study according to AMG\u002FMPG will also be excluded.\n8. Patients with missing informed consent.",{"count":202,"type":20},125,[23],"Patients undergoing cardiac surgery often complain of anxiety before a major operation and the resulting stress. This circumstance is a risk factor for mental problems that may occur after the operation (e.g., delirium or memory deficits). This study aims to prevent these discomforts by a preoperative relaxation intervention.",[206,26,90],"Preoperative Stress",[31,208,90,206,209,210,211],"Postoperative Cognitive Decline","Relaxation Intervention","Virtual Reality","Binaural Beats",{"date":186,"type":37},{"date":214,"type":37},"2023-07-27",{"date":216,"type":20},"2028-11",{"name":218,"class":44},"Heart and Brain Research Group, Germany",{"id":220,"slug":221,"hasResults":11,"nctId":222,"briefTitle":223,"officialTitle":224,"acronym":225,"eligibilityCriteria":226,"healthyVolunteers":11,"sex":16,"minAge":122,"maxAge":4,"enrollmentInfo":227,"targetDuration":4,"studyType":21,"phases":228,"briefSummary":229,"conditions":230,"keywords":231,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":184,"lastUpdatePostDateStruct":234,"startDateStruct":235,"completionDateStruct":237,"leadSponsor":239,"locationsCount":45},"100400420","increasing-preoperative-cognitive-reserve-to-prevent-postoperative-cognitive-dysfunction-in-cardiac-surgical-patients-100400420","NCT04493996","Increasing Preoperative Cognitive Reserve to Prevent Postoperative Cognitive Dysfunction in Cardiac Surgical Patients","Increasing Preoperative Cognitive Reserve to Prevent Postoperative Delirium and Postoperative Cognitive Decline in Cardiac Surgical Patients. A Randomized Controlled Trial on Cognitive Training","INCORE","Inclusion Criteria:\n\n* Elective cardiac surgery (coronary artery bypass surgery, aortic or mitral valve replacement\u002Freconstruction, or combination surgery) with standardized extracorporeal circulation\n* A sufficiently good knowledge of German is necessary as cognitive training and neuropsychological tests are language-dependent\n\nExclusion Criteria:\n\n* History of stroke and preexisting psychiatric or neurological disorders that may impair the neuropsychological performance",{"count":19,"type":20},[23],"Postoperative delirium (POD) and postoperative cognitive decline (POCD) can be observed after cardiosurgical interventions. Taken together, these postoperative neurocognitive dysfunctions contribute to increased morbidity and mortality and higher economic costs. Preoperative risk factors of postoperative neurocognitive dysfunctions, such as decreased neuropsychometric performance or decreased cognitive daily activities, can be interpreted as reduced cognitive reserve. The aim of this study is to build up cognitive reserves to protect against the development of POD and POCD through preoperative, home-based, cognitive training.",[208,90,26],[31,208,90,232,233,26],"Cognitive Training","Cognitive Reserve",{"date":186,"type":37},{"date":236,"type":37},"2020-08-14",{"date":238,"type":20},"2026-03",{"name":218,"class":44},{"id":241,"slug":242,"hasResults":11,"nctId":243,"briefTitle":244,"officialTitle":245,"acronym":4,"eligibilityCriteria":246,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":247,"targetDuration":4,"studyType":87,"phases":4,"briefSummary":249,"conditions":250,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":251,"lastUpdatePostDateStruct":252,"startDateStruct":254,"completionDateStruct":256,"leadSponsor":258,"locationsCount":4},"100623146","postoperative-cognitive-dysfunction-in-elderly-and-its-relation-with-sleep-disorders-and-melanin-concentrating-hormone-100623146","NCT07392840","Postoperative Cognitive Dysfunction in Elderly and it's Relation With Sleep Disorders and Melanin Concentrating Hormone","Postoperative Delayed Neurocognitive Recovery in Elderly Patients Undergoing Spinal Anesthesia: Assessment of Its Prevalence and Correlation With Preoperative Sleep Disorders and Melanin Concentrating Hormone.","Inclusion Criteria:\n\n* Patients of both genders ageing 65 years or above.\n* ASA grade I to III.\n* Undergo elective lower limb surgery under spinal anesthesia\n* Agree to collect one's own CSF and blood samples\n\nExclusion Criteria:\n\n* Past history of depression,anxiety,delirium and schizophrenia .\n* Past history of drug dependence.\n* Past history of dementia,including Alzheimer disease(AD).\n* Preoperative Montreal Cognitive Assessment (MoCA) score \\\u003C26.\n* Inability to understand or cooperate with the evaluation scale or questionnaire.\n* Refuse collecting one's own CSF and blood samples.",{"count":248,"type":20},50,"The aim of this study is to explore the relationship between preoperative sleep disorders, melanin-concentrating hormone (MCH), and delayed neurocognitive recovery early after surgery in older adult patients undergoing spinal anesthesia.",[26],"2026-02-06",{"date":253,"type":37},"2026-02-10",{"date":255,"type":20},"2026-02-01",{"date":257,"type":20},"2027-04-01",{"name":259,"class":44},"Minia University",{"id":261,"slug":262,"hasResults":11,"nctId":263,"briefTitle":264,"officialTitle":265,"acronym":4,"eligibilityCriteria":266,"healthyVolunteers":54,"sex":16,"minAge":122,"maxAge":267,"enrollmentInfo":268,"targetDuration":4,"studyType":87,"phases":4,"briefSummary":270,"conditions":271,"keywords":4,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":272,"lastUpdatePostDateStruct":273,"startDateStruct":275,"completionDateStruct":277,"leadSponsor":279,"locationsCount":281},"100272899","retrospective-evaluation-of-pocd-data-of-studies-from-kai-charit---universittsmedizin-berlin-100272899","NCT02832193","Retrospective Evaluation of POCD Data of Studies From KAI, Charité - Universitätsmedizin Berlin","Retrospective Evaluation of POCD Data of Studies From the Department of Anesthesiology and Operative Intensive Care Medicine (CCM, CVK) Charité - Universitätsmedizin Berlin","Study Group\n\nInclusion Criteria:\n\n* Age 18 -100 years\n* Male or female patients undergoing elective surgery expected to last at least 60 min, screened at the Department of Anesthesiology and Operative Intensive Care Medicine (CCM, CVK), Charité - Universitätsmedizin Berlin, Berlin, Germany\n* Written informed consent to participate after having been properly instructed\n\nExclusion Criteria:\n\n* Lacking willingness to take part in the study, or to have relevant study data collected, saved and analyzed for the purpose of the study\n* Accommodation in an institution due to an official or judicial order\n* Insufficient knowledge of German language\n* Members of the hospital staff\n* Homelessness or other conditions that disable reachability for postoperative assessment by post or telephone\n* Illiteracy\n* Patients who had a history of neurologic deficits (e.g. stroke, history of seizures, etc.)\n* Hearing impairment that severely affects the neuropsychological testing.\n* Visual impairment that severely affects the neuropsychological testing.\n* Participation in other prospective clinical interventional trials\n\nControl Group\n\nInclusion Criteria:\n\n* Age 18 - 100 years\n* Male or female patients (ASA Status I, II+III)\n* No planned surgery during the next 3 months\n* No surgery during the past 6 months before study inclusion\n* Written informed consent to participate after having been properly instructed\n\nExclusion Criteria:\n\n* Insufficient knowledge of German language Lacking willingness to take part in the study, or to have relevant study data collected, saved and analyzed for the purpose of the study\n* Neuropsychiatric conditions that severely affect the neuropsychological testing\n* Hearing impairment that severely affects the neuropsychological testing\n* Visual impairment that severely affects the neuropsychological testing","100 Years",{"count":269,"type":20},5000,"Data on prevention of perioperative neurocognitive disorders (pNCDs) are limited. The purpose of this monocentric parallel - grouped observational registry is to collect study data from studies with pNCDs as primary or secondary endpoint to estimate prevalence and incidence of pNCDs.",[26],"2025-11-25",{"date":274,"type":37},"2025-11-26",{"date":276,"type":37},"2009-03",{"date":278,"type":20},"2027-12",{"name":280,"class":44},"Charite University, Berlin, Germany",2,{"id":283,"slug":284,"hasResults":11,"nctId":285,"briefTitle":286,"officialTitle":287,"acronym":288,"eligibilityCriteria":289,"healthyVolunteers":54,"sex":16,"minAge":290,"maxAge":4,"enrollmentInfo":291,"targetDuration":4,"studyType":87,"phases":4,"briefSummary":292,"conditions":293,"keywords":297,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":301,"lastUpdatePostDateStruct":302,"startDateStruct":304,"completionDateStruct":306,"leadSponsor":308,"locationsCount":45},"100526369","cerebral-autoregulation-in-non-cardiac-surgery-and-relationship-to-postoperative-delirium-state-100526369","NCT06133842","CEReBral AutorEgulation in Non-cardiac SuRgery and Relationship to Postoperative DeliriUm State","CEReBral AutorEgulation in Non-cardiac SuRgery and Relationship to Postoperative DeliriUm State - CERBERUS Trial","CERBERUS","Inclusion Criteria:\n\n* Age ≥ 60 years\n* Undergoing any non-cardiac surgeries including but not limited to vascular, hepatobiliary, or complex spine surgeries requiring general anesthesia with arterial catheterization for monitoring\n\nExclusion Criteria:\n\n1. Non-English speaking (Justification: cognitive assessment instruments are not validated in a sufficient range of languages, and the research team lacks polylingual capabilities or the financial resources to hire interpreters for the duration of all proposed assessments.)\n2. Cognitive impairment as defined by total MoCA score \\\u003C 10 (justification: baseline cognitive dysfunction will confound primary outcome measure)\n3. Significant visual impairment (justification: will be difficult for patients to draw individual components in MOCA score)\n4. Emergent surgery (justification: insufficient time to initiate intervention)\n5. History of stroke within the last 3 months (justification: cognitive dysfunction secondary to stroke can confound outcome measures","60 Years",{"count":19,"type":20},"The goal of this observational study is to learn the how to determine the mean arterial pressure(MAP) or blood pressure level to be maintained during non-cardiac surgery for optimal brain health in patients above the age of 60 undergoing major non-cardiac surgery. The main question\\[s\\] it aims to answer are:\n\n* Is there a way to tailor the blood pressure to be maintained in such patients during surgery for optimal brain health using non-invasive monitors that check the brains electrical activity, the electroencephalogram(EEG) monitor, and the brain's blood oxygen levels, the cerebral oximetry(CO) monitor?\n* How much does this optimal blood pressure level vary between patients?\n\nParticipants will be asked to:\n\n* Complete a questionnaire at the time they enroll into the study, as well as a daily questionnaire to help determine their level of thinking and brain health. This questionnaire will be administered by a member of the study team.\n* They will also have an EEG and CO monitoring sticker placed on their foreheads. This will be connected to a monitor that will collect this data just before, during, and after their surgery. The data collected through these monitors will help us with our study goals.",[64,26,90,294,295,296],"EEG With Periodic Abnormalities","Intraoperative Hypotension","Cerebral Hypoperfusion",[298,299,300],"EEG","Cerebral Autoregulation","Intraoperative Monitoring","2025-10-27",{"date":303,"type":37},"2025-10-28",{"date":305,"type":37},"2024-04-17",{"date":307,"type":20},"2027-07",{"name":309,"class":44},"Beth Israel Deaconess Medical Center",{"id":311,"slug":312,"hasResults":11,"nctId":313,"briefTitle":314,"officialTitle":315,"acronym":316,"eligibilityCriteria":317,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":318,"targetDuration":4,"studyType":21,"phases":320,"briefSummary":322,"conditions":323,"keywords":327,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":335,"lastUpdatePostDateStruct":336,"startDateStruct":338,"completionDateStruct":339,"leadSponsor":341,"locationsCount":45},"100601668","phase-3-remimazolam-vs-midazolam-for-sedation-and-cognitive-outcomes-in-orthopedic-surgery-100601668","NCT07113483","Remimazolam vs. Midazolam for Sedation and Cognitive Outcomes in Orthopedic Surgery","Randomized, Double-Blind, 2x2 Factorial Trial of Remimazolam vs. Midazolam on Sedation and Early Cognitive Outcomes in Patients Undergoing Traumatic or Non-Traumatic Orthopedic Surgery With Regional Anesthesia","REMIND-ORTHO","Inclusion Criteria:\n\n* Adults aged 65 years or older.\n* Scheduled for traumatic or non-traumatic orthopedic surgery under regional anesthesia.\n* Able to provide informed consent or have a legally authorized representative provide consent.\n\nExclusion Criteria:\n\n* Patient refusal to participate.\n* Mini-Cog score less than 3 (indicative of significant cognitive impairment).\n* Severe hepatic or renal failure.\n* Known allergy to benzodiazepines or propofol.\n* History of benzodiazepine dependence.",{"count":319,"type":20},120,[321],"PHASE3","This study aims to compare two medications, Remimazolam and Midazolam, used for sedation during orthopedic surgeries performed under regional anesthesia. We want to find out which medication provides better sedation during the procedure and which one affects early recovery of brain function after surgery.\n\nOlder adults (65 years and above) undergoing surgery for bone injuries or conditions will participate. We will monitor their sedation levels, blood pressure, heart rate, side effects, and how quickly they recover after surgery. We also want to see if either medication causes fewer problems with thinking and memory shortly after surgery.\n\nThe study is designed so neither the patients nor the medical staff know which medication is being given, to ensure unbiased results. Participants will be randomly assigned to receive either Remimazolam or Midazolam.\n\nThe information gathered will help doctors choose the safest and most effective sedative for older patients undergoing orthopedic surgeries, potentially improving patient comfort and recovery.",[26,324,325,326],"Orthopedic Procedures","Postoperative Pain Management","Hip Fracture",[328,329,330,331,332,333,334],"Remimazolam","Midazolam","Regional Anesthesia","Sedation","Cognitive dysfunction","Elderly patients","Trauma","2025-09-26",{"date":337,"type":37},"2025-10-01",{"date":337,"type":20},{"date":340,"type":20},"2026-02-15",{"name":342,"class":44},"Romanian Society for Enteral and Parenteral Nutrition",{"id":344,"slug":345,"hasResults":11,"nctId":346,"briefTitle":347,"officialTitle":348,"acronym":4,"eligibilityCriteria":349,"healthyVolunteers":11,"sex":16,"minAge":350,"maxAge":351,"enrollmentInfo":352,"targetDuration":4,"studyType":21,"phases":354,"briefSummary":355,"conditions":356,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":357,"lastUpdatePostDateStruct":358,"startDateStruct":360,"completionDateStruct":362,"leadSponsor":364,"locationsCount":4},"100607745","perioperative-gdnf-as-a-predictive-factor-for-postoperative-delirium-and-adverse-neurological-outcomes-in-pediatric-surgery-100607745","NCT07192549","Perioperative GDNF as a Predictive Factor for Postoperative Delirium and Adverse Neurological Outcomes in Pediatric Surgery","Perioperative GDNF as a Predictive Factor for Postoperative Delirium and Adverse Neurological Outcomes in Pediatric Surgery:a Single-center, Prospective, Randomized Controlled Study","Inclusion Criteria:\n\n* (1) Aged 1-3 years; (2) American Society of Anesthesiologists (ASA) Physical Status Classification I-II; (3) Body Mass Index (BMI) 18-35 kg\u002Fm²; (4) Agreement to participate in the study and signed informed consent form.\n\nExclusion Criteria:\n\n* (1) Surgical duration exceeding 4 hours; (2) Patients with language or hearing impairments hindering effective communication; (3) Patients with postoperative infections or perioperative cardiopulmonary complications; (4) Patients with preoperative psychiatric disorders.","1 Year","3 Years",{"count":353,"type":20},200,[23],"To observe the dynamic changes in serum levels of inflammatory cytokines (e.g., IL-6, TNF-α), Brain-Derived Neurotrophic Factor (BDNF), and Glial Cell Line-Derived Neurotrophic Factor (GDNF) during the perioperative period in pediatric patients undergoing Scheduled Laparoscopic Hernia Repair surgery, and to investigate their relationship with the occurrence of postoperative delirium (POD) and postoperative cognitive dysfunction (POCD),and to compare the different influence between propofol and sevoflurane . The aim is to provide insights into the neurobiological mechanisms underlying these complications and to identify potential biomarkers for risk stratification.",[26,90],"2025-09-17",{"date":359,"type":37},"2025-09-25",{"date":361,"type":20},"2025-09-15",{"date":363,"type":20},"2030-12-01",{"name":365,"class":44},"General Hospital of Ningxia Medical University",{"id":367,"slug":368,"hasResults":11,"nctId":369,"briefTitle":370,"officialTitle":371,"acronym":4,"eligibilityCriteria":372,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":373,"enrollmentInfo":374,"targetDuration":4,"studyType":21,"phases":376,"briefSummary":379,"conditions":380,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":384,"lastUpdatePostDateStruct":385,"startDateStruct":387,"completionDateStruct":389,"leadSponsor":391,"locationsCount":45},"100599624","phase-1-the-impact-of-remimazolam-tosilate-on-oxygenation-and-postoperative-cognitive-function-in-elderly-patients-undergoing-thoracoscopic-lobectomy-100599624","NCT07086911","The Impact of Remimazolam Tosilate on Oxygenation and Postoperative Cognitive Function in Elderly Patients Undergoing Thoracoscopic Lobectomy","The Impact of Tosylate Remimazolam on Oxygenation and Postoperative Cognitive Function in Elderly Patients Undergoing Thoracoscopic Lobectomy","Inclusion Criteria:\n\n* Patients scheduled for thoracoscopic surgery under general anesthesia at the First Affiliated Hospital of Kunming Medical University;\n* Age 65 to 75 years old;\n* BMI18-30 kg\u002Fm ²;\n* ASA grades I to III;\n* There are no contraindications to any related drugs;\n* Both the patient and their family members agreed to participate in this study and signed the informed consent form\n\nExclusion Criteria:\n\n* Patients with severe sinus bradycardia (heart rate \\\u003C50 beats per minute) and atrioventricular block;\n* Respiratory tract infection and the use of non-steroidal anti-inflammatory drugs or hormone drugs within 2 weeks before the operation;\n* Those with central nervous system and psychological disorders;\n* Have taken anticholinergic drugs, anticonvulsants, anti-anxiety drugs, antidepressants, etc. in the past half year;\n* Severe liver and kidney dysfunction and immune system diseases, uncontrolled hypertension and diabetes;\n* History of preoperative radiotherapy and chemotherapy;\n* Patients with communication barriers who are unable to cooperate to complete the test;\n* The OLV \\\u003C 60 min or interim thoracotomy patients;\n* Intraoperative blood loss \\> 1500ml;\n* Patients transferred to the ICU ward after the operation.","75 Years",{"count":375,"type":20},150,[377,378],"PHASE1","PHASE2","Background: During thoracoscopic lobectomy in elderly patients, one-lung ventilation (OLV) is a common procedure. However, this process is prone to cause hypoxemia and postoperative cognitive dysfunction (POCD), which seriously affect the postoperative recovery and prognosis of patients. At present, there is still a need for further exploration and optimization of effective anesthetic drugs and regimens to improve intraoperative oxygenation and reduce the occurrence of POCD in such patients. Remimazolam besylate, as a novel anesthetic drug, has not yet had its advantages in thoracoscopic surgery in elderly patients fully clarified. This study is conducted to explore its effects on oxygenation and postoperative cognitive function in this specific surgical setting, so as to provide new references for clinical drug use and improve the perioperative management and postoperative outcomes of elderly patients.\n\nObjective:To mainly investigate the effects of remimazolam besylate on oxygenation and intrapulmonary shunting during one-lung ventilation in elderly patients undergoing thoracoscopic surgery, as well as its impact on postoperative cognitive dysfunction.\n\nResearch Content:The research content includes the observation and evaluation of oxygenation index, shunt fraction, cognitive function status, intraoperative conditions (such as OLV duration, blood loss, etc.),hemodynamic indicators, blood gas analysis indicators, serum indicators, and postoperative recovery status (such as postoperative sedation, pain, adverse reactions, pulmonary complications, hospital stay duration, etc.) in elderly patients undergoing thoracoscopic lobectomy.\n\nResearch Methods:\n\nStudy Design: A randomized controlled study will be adopted. Case Selection: Inclusion Criteria: Patients aged 65-75 years old, with a BMI of 18-30 kg\u002Fm², ASA classification of I-III, no contraindications to related drugs, and consent from the patient and their family to participate in the study and sign the informed consent form, who are scheduled for thoracoscopic surgery under general anesthesia at the First Affiliated Hospital of Kunming Medical University from December 2024 to December 2025, will be selected. Exclusion Criteria: Patients with severe arrhythmias, preoperative respiratory tract infections, central nervous system diseases, hepatic or renal insufficiency, immune system diseases, a history of preoperative radiotherapy or chemotherapy, communication barriers, etc., will be excluded. Exclusion Criteria: Patients with OLV duration less than 60 minutes or conversion to thoracotomy, intraoperative blood loss greater than 1000 ml, and those transferred to the ICU after surgery will be excluded.\n\nGrouping and Anesthesia Methods: Patients will be randomly divided into three groups: Remimazolam Group (R Group), Propofol Group (P Group), and Remimazolam Combined with Propofol Group (C Group), with 50 cases in each group. After anesthesia induction, the three groups will be maintained with different drugs and doses until 10 minutes before the end of the surgery, while remifentanil will be combined, and the infusion rate of the drugs will be adjusted according to the BIS value.\n\nData Collection: Detailed records will be kept of the patient's general information, intraoperative conditions, perioperative cardiovascular reactions, blood gas analysis indicators, serum indicators, as well as postoperative cognitive function assessment, sedation and pain assessment, adverse reactions, and complications.\n\nSample Size Calculation: Based on the oxygenation index at 60 minutes of OLV, which is the primary endpoint, and in combination with relevant literature and statistical requirements, the sample size for each group is calculated to be 58. Considering the dropout and withdrawal rates, the final sample size for each group is determined to be 70.\n\nStatistical Analysis: SPSS 27.0 software will be used. Normal distribution measurement data, non-normal distribution measurement data, and count data will be analyzed using independent sample t-test, Wilcoxon rank-sum test, and chi-square test or Fisher's exact probability method, respectively. A P value less than 0.05 will be considered statistically significant.\n\nTechnical and Feasibility Assurance: Relying on the clinical resources and technical platform of the First Affiliated Hospital of Kunming Medical University, as well as the research team's proficiency in thoracic anesthesia techniques and the operation of related equipment, the smooth conduct of the study will be ensured.",[381,382,383,26],"Remimazolam Besylate","Thoracoscopic Lobectomy","Oxygenation","2025-07-17",{"date":386,"type":37},"2025-07-25",{"date":388,"type":20},"2025-08",{"date":390,"type":20},"2026-12",{"name":392,"class":44},"Jinqiao Qian",{"id":394,"slug":395,"hasResults":11,"nctId":396,"briefTitle":397,"officialTitle":398,"acronym":4,"eligibilityCriteria":399,"healthyVolunteers":11,"sex":16,"minAge":122,"maxAge":267,"enrollmentInfo":400,"targetDuration":4,"studyType":21,"phases":402,"briefSummary":403,"conditions":404,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":405,"lastUpdatePostDateStruct":406,"startDateStruct":408,"completionDateStruct":410,"leadSponsor":412,"locationsCount":45},"100590121","ketamine-and-dexmedetomidine-for-delirium-in-joint-arthroplasty-100590121","NCT06963294","Ketamine and Dexmedetomidine for Delirium in Joint Arthroplasty","The Effect of Intraoperative Ketamine and Dexmedetomidine Use on Postoperative Delirium and Cognitive Dysfunction in Patients Undergoing Total Joint Arthroplasty","Inclusion Criteria:\n\n* Scheduled for elective total joint arthroplasty (hip or knee)\n* ASA physical status I-III\n* Age between 18 and 100 years\n* Ability to provide informed consent and comply with cognitive assessments\n\nExclusion Criteria:\n\n* Pre-existing cognitive dysfunction or diagnosed neurodegenerative disease\n* Hearing or language impairment interfering with MMSE\u002FCAM evaluation\n* Known allergy to ketamine or dexmedetomidine\n* Significant cardiac arrhythmia (e.g., supraventricular tachycardia, 2nd or 3rd degree AV block)\n* Renal insufficiency (GFR \\\u003C30 mL\u002Fmin\u002F1.73 m²)\n* Severe hepatic dysfunction",{"count":401,"type":20},80,[23],"This prospective, randomized, double-blind, placebo-controlled clinical trial aims to evaluate the effects of intraoperative ketamine and dexmedetomidine on the incidence of postoperative delirium (POD) and postoperative cognitive dysfunction (POCD) in patients undergoing total joint arthroplasty. Given the high incidence of neurocognitive complications in elderly patients following major orthopedic surgeries, neuroprotective strategies during anesthesia are of growing interest. Both ketamine and dexmedetomidine have shown potential in reducing neuroinflammation and improving postoperative cognitive outcomes in previous studies.\n\nEighty adult patients (ASA I-III, aged 18-100) scheduled for elective total hip or knee arthroplasty under spinal anesthesia will be randomized into four groups: control (saline infusion), ketamine infusion, dexmedetomidine infusion, and combined ketamine + dexmedetomidine. Cognitive assessments will be performed preoperatively and on postoperative days 2 and 15 using the Mini Mental State Examination (MMSE). Delirium assessments will be conducted using the Confusion Assessment Method (CAM) postoperatively on days 1, 3, and 15.\n\nSecondary outcomes include perioperative levels of cortisol, CRP, and fibrinogen, as well as postoperative pain scores (VAS) and analgesic consumption. The results are expected to clarify whether intraoperative administration of ketamine or dexmedetomidine can reduce the incidence of POD\u002FPOCD and improve postoperative recovery.",[90,26],"2025-04-30",{"date":407,"type":37},"2025-05-09",{"date":409,"type":20},"2026-05-05",{"date":411,"type":20},"2026-07-15",{"name":413,"class":44},"Istinye University",{"id":415,"slug":416,"hasResults":11,"nctId":417,"briefTitle":418,"officialTitle":419,"acronym":420,"eligibilityCriteria":421,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":422,"targetDuration":4,"studyType":21,"phases":424,"briefSummary":426,"conditions":427,"keywords":429,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":433,"lastUpdatePostDateStruct":434,"startDateStruct":435,"completionDateStruct":437,"leadSponsor":439,"locationsCount":281},"100515383","phase-4-the-effect-of-desflurane-versus-sevoflurane-versus-propofol-on-postoperative-delirium-100515383","NCT05990790","The Effect of Desflurane Versus Sevoflurane Versus Propofol on Postoperative Delirium","The Effect of Desflurane Versus Sevoflurane Versus Propofol on Postoperative Delirium in Elderly Patients Undergoing Moderate- to High-risk Major Noncardiac Surgery - a Prospective, Observer-blinded, Randomized, Clinical Trial","RAPID-II","Inclusion Criteria:\n\n* Provide written informed consent\n* ≥65 years of age\n* Scheduled for elective major noncardiac surgery with estimated time of surgery ≥ 2 hours\n\nExclusion Criteria:\n\n* Patients undergoing emergency surgery\n* BMI \\> 45 kg\u002Fm\\^2\n* History of diagnosed dementia\n* Language, vision, or hearing impairments that may compromise cognitive assessments\n* History of malignant hyperthermia\n* History of structural muscle disease\n* History of organ transplantation (kidney, liver, lung, heart)\n* Patients undergoing hyperthermic intraperitoneal chemotherapy\n* ICU patients undergoing surgery",{"count":423,"type":20},1332,[425],"PHASE4","Patients over the age of 65 years are at increased risk for developing delirium after noncardiac surgeries, resulting in increased morbidity and mortality. The prevention of postoperative delirium has been classified as a public health priority. However, so far data regarding possible intraoperative interventions to reduce the incidence of postoperative delirium is very scarce. Due to the more rapid wash-in and wash-out times of desflurane as compared to sevoflurane or propofol it seems reasonable that desflurane might be beneficial for the prevention of postoperative delirium. Therefore, we evaluate the effect of maintenance of anesthesia using desflurane, sevoflurane or propofol on postoperative delirium in elderly patients undergoing moderate- to high-risk major noncardiac surgery.",[90,428,26],"Major Noncardiac Surgery",[430,431,432],"Propofol","Sevoflurane","Desflurane","2025-04-27",{"date":405,"type":37},{"date":436,"type":37},"2023-09-03",{"date":438,"type":20},"2028-12-31",{"name":440,"class":44},"Medical University of Vienna",{"id":442,"slug":443,"hasResults":11,"nctId":444,"briefTitle":445,"officialTitle":445,"acronym":446,"eligibilityCriteria":447,"healthyVolunteers":11,"sex":16,"minAge":290,"maxAge":4,"enrollmentInfo":448,"targetDuration":4,"studyType":87,"phases":4,"briefSummary":450,"conditions":451,"keywords":4,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":454,"lastUpdatePostDateStruct":455,"startDateStruct":457,"completionDateStruct":459,"leadSponsor":461,"locationsCount":45},"100313467","development-of-a-prediction-model-for-delirium-after-cardiac-surgery-using-a-novel-self-administered-preoperative-cognitive-assessment-tool-100313467","NCT03360838","Development of a Prediction Model for Delirium After Cardiac Surgery Using a Novel Self-Administered Preoperative Cognitive Assessment Tool","CogCheck-Valid","Inclusion Criteria:\n\n* Elective cardiac surgery\n* Age ≥60 years\n* Good knowledge of the German language\n* Written informed consent\n\nExclusion Criteria:\n\n* Emergency surgery\n* Medical instability limiting preoperative assessment\n* Surgical procedures without the use of cardiopulmonary bypass\n* Procedures involving deep hypothermic circulatory arrest\n* Concurrent carotid surgical procedures\n* Participation in an interventional trial with POD or POCD as primary endpoint",{"count":449,"type":20},475,"This observational cohort study is designed to validate the CogCheck application as a risk prediction tool for postoperative delirium in patients undergoing cardiac surgery.",[90,26,452,32,453,31],"Cognitive Decline","Cognition Disorders","2025-01-22",{"date":456,"type":37},"2025-01-27",{"date":458,"type":37},"2018-04-16",{"date":460,"type":20},"2025-12",{"name":111,"class":44},{"id":463,"slug":464,"hasResults":11,"nctId":465,"briefTitle":466,"officialTitle":467,"acronym":468,"eligibilityCriteria":469,"healthyVolunteers":11,"sex":16,"minAge":122,"maxAge":470,"enrollmentInfo":471,"targetDuration":473,"studyType":87,"phases":4,"briefSummary":474,"conditions":475,"keywords":476,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":481,"lastUpdatePostDateStruct":482,"startDateStruct":484,"completionDateStruct":486,"leadSponsor":487,"locationsCount":45},"100574614","bilateral-bispectral-index-asymmetries-and-post-operative-delirium-100574614","NCT06761573","Bilateral Bispectral Index, Asymmetries and Post-operative Delirium","Bilateral Bispectral Index and Asymmetries in High Risk Patients for Posteoperative Delirium: An Observational, Prospective, Exploratory Study","DELBIS","Inclusion Criteria:\n\n-Patients, undergoing head\\&neck surgery, who have at least 3 of the following criteria (to establish \"a priori\" increased risk of POD):\n\n* Age\\> 70;\n* Male sex; or ASA III;\n* Smoker;\n* High blood pressure;\n\nExclusion Criteria:\n\n* ASA IV, V or ASA IE, IIE, IIIE (patients with anesthetic risk ASA\\>III and those undergoing urgent-emergency surgery will be excluded from the study);\n* Past positive medical history for:\n\n  * Stroke;\n  * Dementia;\n  * Cerebral aneurysm;\n  * Intracranial mass;\n  * Head trauma;\n  * Epilepsy;\n  * Diabetes mellitus;\n  * Previous neurosurgical intervention;\n  * Psychiatric illnesses requiring chronic treatment;\n* Patients undergoing surgery in the previous two weeks;\n* Patients whose hospitalization duration is estimated to be less than five days;\n* Lack of understanding of the Italian language or English;\n* Age \\\u003C18 years.","90 Years",{"count":472,"type":20},84,"90 Days","The primary objective of the study is to describe the value of interhemispheric asymmetry (ASYM), during the different intra- and peri-operative phases, in those patients who develop or do not develop post-operative delirium (POD) during the first 30 post-operative days and postoperative cognitive disfunction (POCD) in the first 90 post-operative days, in a population undergoing head\\&neck and plastic surgery with a priori increased probability of POD.",[90,26],[477,478,479,90,26,480],"Bilateral Bispectral Index","Head&Neck Surgery","Plastic Surgery","Interhemispheric asymmetries","2024-12-30",{"date":483,"type":37},"2025-01-07",{"date":485,"type":37},"2020-07-07",{"date":390,"type":20},{"name":488,"class":44},"IRCCS Azienda Ospedaliero-Universitaria di Bologna",{"id":490,"slug":491,"hasResults":11,"nctId":492,"briefTitle":493,"officialTitle":494,"acronym":495,"eligibilityCriteria":496,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":497,"targetDuration":4,"studyType":87,"phases":4,"briefSummary":499,"conditions":500,"keywords":4,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":502,"lastUpdatePostDateStruct":503,"startDateStruct":505,"completionDateStruct":507,"leadSponsor":508,"locationsCount":45},"100552163","older-peoples-neurocognitive-recovery-after-cardiac-surgery-100552163","NCT06469515","Older People's Neurocognitive Recovery After Cardiac Surgery","Enhanced Continuity of Postoperative Care for Older People in Their Neurocognitive Recovery After Cardiac Surgery","ECPON","Inclusion Criteria:\n\n* Scheduled for elective or urgent open-heart surgery or minimally invasive cardiac surgery\n* Resident in the area\u002Fregion for the current thoracic clinic\n* Able to read and understand Swedish\n\nExclusion Criteria:\n\n* Physical, mental, and cognitive difficulties that prevent the individual from completing the cognitive tests\n* Undergone surgery within the last 6 months",{"count":498,"type":20},220,"Society is aging and advantages in anesthesia and surgery allow more complex interventions in older persons. Old age is a significant risk factor for the development of postoperative neurocognitive decline characterized by a gradual decrease in performance in several cognitive domains such as memory, attention, information processing, and executive functions, leading to problems with performing daily activities and maintaining independence and postoperative complications. The purpose of this study is to measure older persons' postoperative neurocognitive function, to detect neurocognitive decline, and to identify risk factors and difficulties in daily living as well as explore close relatives' experiences of it. We will include 220 participants ≥65 years of age undergoing planned cardiac surgery. Cognitive symptoms and signs and neurocognitive function will be assessed up to 6 months after surgery. Risk\u002Faffected factors such as delirium, functional status, recovery, depression, and healthcare-related quality of life, as well as close relative's experiences and burden, will be measured. The results will have immediate relevance for a substantial number of older persons undergoing surgery, and their close relatives, by enhancing knowledge about postoperative cognitive decline and recovery, and subsequently identifying what support needs to be implemented.",[26,501,31],"Postoperative Recovery","2024-11-06",{"date":504,"type":37},"2024-11-07",{"date":506,"type":37},"2024-11-01",{"date":278,"type":20},{"name":509,"class":44},"Karolinska Institutet",{"id":511,"slug":512,"hasResults":11,"nctId":513,"briefTitle":514,"officialTitle":515,"acronym":4,"eligibilityCriteria":516,"healthyVolunteers":11,"sex":16,"minAge":290,"maxAge":517,"enrollmentInfo":518,"targetDuration":4,"studyType":21,"phases":520,"briefSummary":521,"conditions":522,"keywords":523,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":526,"lastUpdatePostDateStruct":527,"startDateStruct":529,"completionDateStruct":531,"leadSponsor":533,"locationsCount":45},"100566714","use-of-transcranial-magnetic-stimulation-in-the-post-operative-cognitive-dysfunction-in-elderly-100566714","NCT06658769","Use of Transcranial Magnetic Stimulation in the Post-Operative Cognitive Dysfunction in Elderly","Use of Transcranial Magnetic Stimulation in the Prevention of Post-Operative Cognitive Dysfunction in Elderly with Mild Neurocognitive Disorder","Inclusion Criteria:\n\n1. Patients over 60 years old\n2. Patients scheduled for elective surgeries of moderate or large scale and candidates for general or spinal anesthesia;\n3. Patients who demonstrate possible or probable cognitive impairment based on pre-operative screening using the 10-CS (10-point cognitive screening) tool; - For Non-surgical Control Intervention Group, only the first and third criteria will be applied.\n\nExclusion Criteria:\n\n1. Contraindications for the use of Transcranial Magnetic Stimulation (metal implants in the head, history of seizures or epilepsy, brain trauma or surgery, intracranial hypertension, and complications from exposure to magnetic fields);\n2. Medical diagnosis of Major Neurocognitive Disorder (any form of dementia, regardless of the stage);\n3. Indication for skull surgery;\n4. Conditions that interfere with cognitive testing (presence of severe hearing and vision loss, inability to understand Portuguese);\n5. Ongoing medication adjustments that affect cortical electrical activity (antidepressants, antipsychotics);\n6. Difficulty attending treatment during the stipulated evaluation and follow-up period, whether due to socioeconomic or clinical reasons;\n7. Anticipation of surgical scheduling;","120 Years",{"count":519,"type":20},12,[23],"Postoperative Cognitive Dysfunction (POCD) is a prevalent condition with significant clinical, social, and financial impacts on patients and healthcare services. The term POCD refers to any signs of new cognitive impairment that exceed the expected time for recovery from the acute effects of surgery and anesthesia. Mild Cognitive Impairment (MCI) is among the main risk factors and is defined as a small cognitive decline from the previous level of performance in one or more cognitive domains, without interfering with daily activities. Considering the aging population linked to an increase in the number of individuals with MCI and a growing demand for surgery, the identification of interventions that can prevent the occurrence of POCD is necessary. Non-invasive brain stimulation (NIBS) techniques such as TMS (Transcranial Magnetic Stimulation) are widely used in research and clinical practice and involve the modulation of excitability and brain activity, potentially improving the individual's cognitive performance. The aim of this study is to assess the efficacy of a Theta Burst rTMS protocol with few sessions in preventing postoperative cognitive dysfunction in elderly individuals with mild neurocognitive disorder. Methodology: This will be a randomized, blinded clinical trial with volunteers aged \\> 60 years, candidates for elective surgeries, who will be randomly allocated into 2 groups: the groups will receive real or sham TBS 15 days before surgery. There will be 3 intervention sessions, with a 72-hour interval between them. Outcome measures will be cognitive psychological assessment and Stroop Test cognitive task performance before and after transcranial magnetic stimulation, after surgery and at the 3-month follow-up. There will be a non-surgical control group with cognitive impairment according to the study inclusion criteria and will receive active stimulation.",[26],[524,26,525],"Transcranial Magnetic Stimulation","Theta Burst Stimulation","2024-10-23",{"date":528,"type":37},"2024-10-26",{"date":530,"type":37},"2024-04-01",{"date":532,"type":20},"2026-12-31",{"name":534,"class":44},"University of Sao Paulo General Hospital",{"id":536,"slug":537,"hasResults":11,"nctId":538,"briefTitle":539,"officialTitle":540,"acronym":541,"eligibilityCriteria":542,"healthyVolunteers":11,"sex":16,"minAge":290,"maxAge":4,"enrollmentInfo":543,"targetDuration":4,"studyType":21,"phases":545,"briefSummary":546,"conditions":547,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":548,"lastUpdatePostDateStruct":549,"startDateStruct":551,"completionDateStruct":553,"leadSponsor":555,"locationsCount":45},"100476326","timing-of-transcutaneous-acupoint-electrical-stimulation-on-postoperative-recovery-in-geriatric-patients-with-gastrointestinal-tumor-100476326","NCT05482477","Timing of Transcutaneous Acupoint Electrical Stimulation on Postoperative Recovery in Geriatric Patients with Gastrointestinal Tumor","Timing of Transcutaneous Acupoint Electrical Stimulation on Postoperative Recovery in Geriatric Patients with Gastrointestinal Tumor：a Protocol of Randomised Controlled Trial","TEAS","Inclusion Criteria:\n\n* Patients aged 60 years or older.\n\n  * Patients diagnosed with gastrointestinal tumor and received radical resection of gastrointestinal tumors under general anesthesia in Subei People's Hospital of Jiangsu province.\n\n    * Patients willing and able to give informed consent and comply with this study protocol.\n\n      * American Society of Anesthesiology (ASA) classification I～III. ⑤ Preoperative Tilburg frailty scale score is less than 5 points. ⑥ Preoperative D-dimer was normal.\n\nExclusion Criteria:\n\n* Preoperative cognitive dysfunction or history of cognitive dysfunction, dementia, and delirium.\n\n  * History of severe depression, schizophrenia, or other mental and nervous system diseases or taking antipsychotic or antidepressant drugs in the past.\n\n    * Patients with severe hearing or visual impairment without assistive tools.\n\n      * Patients who have difficulty in communicating.\n\n        * Male patients average daily pure alcohol intake ≥ 61 g or female patients average daily pure alcohol intake ≥ 41 g.\n\n          * Patients received surgical treatment within 3 months or preoperative hospitalized over 3 months.\n\n            * Patients with severe heart, liver, or renal failure.\n\n              ⑧ Patients with hypoxemia (blood oxygen saturation \\\u003C 94%) more than 10 min during the operation.\n\n              ⑨ Patients admitted to ICU after operation.\n\n              ⑩ Patients who quit or died due to noncooperation or sudden situation.\n\n              ⑪ Patients who already participate in other clinical studies which may influence this study.\n\n              ⑫ Patients who underwent emergency surgery.\n\n              ⑬ Patients who had a history of acupuncture treatment.",{"count":544,"type":20},238,[23],"Postoperative cognitive dysfunction(POCD). is a central nervous system complication in cancer patients with a 8.9-46.1% incidence. It is mainly manifested as impaired memory, descending information handling ability and decline or damage of attention, perception, abstract thinking, executive, language, and body movement. However, it is difficult to identify and it can last for months or years or even become a dementia state, which can severely affect patients' postoperative recovery, prolong the hospitalization time, reduce the quality of life, increase the mortality and the consumption of family and social medical resources, and intensifies the national economic and social burden.\n\nTranscutaneous electrical acupoint stimulation (TEAS) is a new type of acupoint stimulation therapy that inputs low-frequency pulse current into human acupoints through electrodes pasted on the skin surface to achieve therapeutic purposes, which combined the preponderances of both acupuncture and transcutaneous electrical nerve stimulation (TENS). TEAS is non-invasive, easy to operate and acceptable to patients. Study showed that TEAS treatment can reduce the consumption of intraoperative anesthetic and improve postoperative nausea and vomiting (PONV) and postoperative recovery.\n\nAlso, studies have shown that TEAS treatment may improve the cognitive function of geriatric patients. Most studies have shown that TEAS treatment 10\\~30 minutes before operation or from entering the operating room to the end of operation can reduce the incidence of POCD in elderly patients. Some studies showed that preoperative combined with postoperative or simple postoperative TEAS treatment can significantly improve patients' postoperative cognitive function. Our previous research showed that perioperative TEAS treatment can reduce the postoperative inflammatory response and increased the postoperative cognitive function score and decrease the incidence of POCD in geriatric patients with gastrointestinal tumor. Moreover, studies showed that long-term electroacupuncture treatment is easy to cause \"tolerance effect', leading to the activation of the negative feedback mechanism of the body, and reduction of the number of receptors, and the weakening of the treatment effect. So, what is the best time period for TEAS to improve POCD and reduce the use of resources? Therefore, the objective of this study is to discuss different time of TEAS on POCD in geriatric patients with gastrointestinal tumor.",[26],"2024-09-17",{"date":550,"type":37},"2024-09-20",{"date":552,"type":20},"2025-01-01",{"date":554,"type":20},"2026-12-30",{"name":556,"class":44},"Subei People's Hospital of Jiangsu Province",{"id":558,"slug":559,"hasResults":11,"nctId":560,"briefTitle":561,"officialTitle":562,"acronym":4,"eligibilityCriteria":563,"healthyVolunteers":54,"sex":16,"minAge":17,"maxAge":470,"enrollmentInfo":564,"targetDuration":4,"studyType":21,"phases":566,"briefSummary":567,"conditions":568,"keywords":4,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":570,"lastUpdatePostDateStruct":571,"startDateStruct":573,"completionDateStruct":575,"leadSponsor":577,"locationsCount":45},"100529620","impact-of-desflurane-and-sevoflurane-on-postoperative-delirium-in-elderly-patients-100529620","NCT06176144","Impact of Desflurane and Sevoflurane on Postoperative Delirium in Elderly Patients","Impact of Desflurane Versus Sevoflurane Anesthesia Maintenance Methods on Incidence of Postoperative Delirium in Elderly Patients","Inclusion Criteria:\n\n1. Age ≥ 65 years and \\\u003C 90 years;\n2. Scheduled to undergo non-cardiac or non-neurosurgery with an expected duration of 2 hours or more, under general anesthesia;\n3. Agree to participate, and give signed written informed consent.\n\nExclusion Criteria:\n\n1. Preoperative history of schizophrenia, epilepsy, parkinsonism or any diseases of central nervous system;\n2. Inability to communicate in the preoperative period (coma, dementia, language barrier, impaired hearing or vision);\n3. Severe diseases in cardiovascular, respiratory, liver, kidney, or preoperative American Society of Anesthesiologists physical status classification ≥ IV;\n4. Alcoholism and drug dependence;\n5. Other reasons that are considered unsuitable for participation by the responsible surgeons or investigators (reasons must be recorded in the case report form).",{"count":565,"type":20},890,[23],"Advanced age is a consistent risk factor for the incidence of postoperative cognitive decline, which is associated with longer hospital stays, decreased quality of life, and increased mortality. Anaesthetic drugs can also affect postoperative cognition, as their residual effects can alter central nervous system activity. Desflurane and sevoflurane are widely used volatile anesthetics. Choice anesthetics may influence the occurrence of postoperative delirium. However, evidence in this aspect is conflicting.",[569,26],"Delirium","2024-06-01",{"date":572,"type":37},"2024-06-04",{"date":574,"type":37},"2023-09-10",{"date":576,"type":20},"2025-09",{"name":578,"class":44},"West China Hospital",{"id":580,"slug":581,"hasResults":11,"nctId":582,"briefTitle":583,"officialTitle":584,"acronym":585,"eligibilityCriteria":586,"healthyVolunteers":11,"sex":16,"minAge":122,"maxAge":4,"enrollmentInfo":587,"targetDuration":588,"studyType":87,"phases":4,"briefSummary":589,"conditions":590,"keywords":4,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":592,"lastUpdatePostDateStruct":593,"startDateStruct":595,"completionDateStruct":597,"leadSponsor":599,"locationsCount":45},"100402718","trajectory-of-neuroinflammatory-markers-in-cerebrospinal-fluid-prior-to-and-after-thoracic-aortic-surgery-100402718","NCT04523909","Trajectory of Neuroinflammatory Markers in Cerebrospinal Fluid Prior to and After Thoracic Aortic Surgery","Trajectory of Neuroinflammatory Markers in Cerebrospinal Fluid Prior to and After Thoracic Aortic Surgery: the TURBO Study","TURBO","Inclusion Criteria:\n\n* Competent patients ≥ 18 years\n* Patients who will undergo thoracic aortic surgery and will therefore receive an external lumbar drain as a standard of care procedure.\n\nExclusion Criteria:\n\n* Patients with meningitis\u002Fencephalitis\u002Fbrain abscess within the last 6 months\n* Patients with other neurological conditions: brain injury (acute stroke, brain trauma or cerebral haemorrhage) within the last 3 months, known brain tumours, neurodegenerative disease or known pre-existing cognitive impairment (to a degree that would be compatible with mild cognitive impairment or more).\n* Brain or spinal surgery within the last 3 months\n* Active infection \\\u003C2 weeks before surgery\n* Patients who object against storage of their body material for scientific reasons",{"count":19,"type":20},"2 Weeks","Observational prospective pilot study to analyze the trajectory of neuroinflammatory protein expression in cerebrospinal fluid (CSF) in relation to systemic compartment in patients undergoing thoracic aortic surgery.\n\nThe aim of this study is to identify and unravel the biochemical (neuroinflammatory) pathways involved in postoperative delirium.\n\nPatient undergoing thoracic aortic surgery will have an external lumbar drain (ELD) in situ on the day before surgery. This ELD remains in place during and three days after surgery to reduce the risk on periprocedural spinal cord ischemia. Paired measurements of CSF and blood will be analyzed.",[90,26,591],"Thoracic Aortic Aneurysm","2023-03-28",{"date":594,"type":37},"2023-03-31",{"date":596,"type":37},"2017-12-18",{"date":598,"type":20},"2026-12-01",{"name":600,"class":44},"Radboud University Medical Center"]