[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"postoperative-cough\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:postoperative-cough":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,49,73],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100633286","effects-of-energy-versus-mechanical-surgical-devices-on-postoperative-cough-100633286",false,"NCT07524712","Effects of Energy Versus Mechanical Surgical Devices on Postoperative Cough","Preliminary Study on the Associated Mechanisms Between Surgical Instruments and Postoperative Cough","ENERGY-COUGH","Inclusion Criteria:\n\n* Adult patients scheduled to undergo elective video-assisted thoracoscopic surgery (VATS) for partial resection of the right lung and lymph node sampling between 2025 and 2026;\n* Preoperative examination shows that the maximum diameter of the pulmonary lesion is 2 cm or less (T1), with no hilar or mediastinal lymph node metastasis and no evidence of distant metastasis (M0);\n* ASA grade I-III.\n\nExclusion Criteria:\n\n* With a respiratory infection in the past 4 weeks, and with a history of chronic cough, chronic bronchitis, bronchiectasis, asthma, rhinitis, gastroesophageal reflux disease, or allergic rhinitis syndrome;\n* Using angiotensin-converting enzyme inhibitors (ACEI);\n* Severe heart disease;\n* Having a history of lung surgery.","ALL","18 Years",{"count":20,"type":21},248,"ESTIMATED","INTERVENTIONAL",[24],"NA","Numerous current studies have indicated that transecting the pulmonary plexus nerve as a routine step in radical lung cancer surgery is an independent risk factor for cough hypersensitivity (CH). However, there are significant disagreements in the thoracic surgery community regarding the strategy for managing the vagus pulmonary plexus, primarily because key clinical issues remain unresolved: How do surgical procedures affect the occurrence and development of CH? And how can these procedures be improved?\n\nA large number of published studies have only analyzed \"where to cut\" while neglecting the surgical issue of \"how to cut\". Even with a high level of evidence, the conclusions remain contradictory. This is because doctors' preferences and changes in supply conditions can influence the selection of instruments. Differences in the energy of the instruments can lead to varying degrees and scopes of vagus nerve degeneration and collateral damage to the sympathetic pulmonary plexus, while CH is regulated by both the sympathetic and parasympathetic nervous systems.\n\nThis project intends to explore the correlation between the selection of surgical instruments and the occurrence and development of postoperative CH at the clinical level, providing a reference for optimizing surgical methods and preventing and treating postoperative CH after lung surgery.\n\nThe specific research objectives are: to clarify the correlation through a randomized controlled trial, comparing the patterns and changes in the occurrence and development of postoperative CH between two groups of patients whose autonomic nerve pulmonary plexus was transected using energy-based instruments versus mechanical methods.\n\nOptimize the surgical procedure: Based on the above results, propose a safe, effective, and feasible surgical method to reduce intraoperative damage, prevent postoperative CH, and improve patients' quality of life.\n\nKey problems to be solved: How do surgical operations affect the occurrence and development of CH? How can improvements be made?\n\n1. Clinical issues:\n\n   ① Do energy-based instruments (causing thermal damage, etc.) and mechanical transection (causing physical damage), which lead to varying degrees of vagus nerve injury and collateral sympathetic nerve damage, affect the occurrence and development of postoperative cough hypersensitivity (CH)?\n\n   ② How to optimize surgical operations to reduce the incidence of postoperative CH and improve patients' quality of life?\n2. Correlation mechanisms: How do different instruments and energy modes affect the pathophysiology of nerve injury, degeneration, and repair, and what are the correlation patterns and mechanisms between these and the occurrence and development of CH?",[27,28],"Postoperative Cough","Cough Hypersensitivity Syndrome",[30,31,32,33,34,35],"postoperative cough","persistent cough","surgical instruments","cough hypersensitivity","vagus pulmonary plexus","vagus nerve","NOT_YET_RECRUITING","2026-05-02",{"date":39,"type":40},"2026-05-07","ACTUAL",{"date":42,"type":21},"2026-09-01",{"date":44,"type":21},"2028-09-01",{"name":46,"class":47},"Tongji Hospital","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":4,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":56,"enrollmentInfo":57,"targetDuration":4,"studyType":22,"phases":59,"briefSummary":60,"conditions":61,"keywords":4,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":48},"100558253","effect-of-transcutaneous-acupoint-electrical-stimulation-taes-on-postoperative-cough-in-lung-cancer-100558253","NCT06548711","Effect of Transcutaneous Acupoint Electrical Stimulation (TAES) on Postoperative Cough in Lung Cancer","Director of Oncology Department, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine","Inclusion Criteria:\n\n* Age between 18 and 80 years old - Surgery performed under general anesthesia for radical resection of lung cancer or lung cancer resection combined with lymph node dissection.\n* Pathological confirmation of primary lung cancer after surgery.\n* Duration of persistent dry cough after lung surgery ≥2 weeks.\n* Consciousness, ability to express opinions clearly, and voluntary signing of informed consent.\n\nExclusion Criteria:\n\n* Patients diagnosed with acute respiratory system diseases within 1 month.\n* Patients diagnosed with pneumonia based on chest X-ray.\n* Patients with a history of asthma or tuberculosis.\n* Patients with uncontrolled hyperthyroidism, severe hypertension, heart disease, systemic infection, coagulation disorders (hypercoagulable state or bleeding tendency), or other severe systemic diseases.\n* Patients who have used steroid drugs within the past 3 months.\n* Patients who have taken angiotensin-converting enzyme inhibitors (ACEIs) within the past 6 months.\n* Patients with surgical incisions, skin allergies, wounds, or infections in the treatment area.\n* Patients who cannot tolerate transcutaneous acupoint electrical stimulation or withdraw during the procedure.\n* Patients with contraindications to transcutaneous electrical stimulation or implanted electrophysiological devices.\n* Patients who are pregnant or breastfeeding.","80 Years",{"count":58,"type":21},84,[24],"Observation and exploration of the improvement in cough symptoms in postoperative lung cancer patients with Transcutaneous Acupoint Electrical Stimulation (TAES), the change in Cough Symptom Score (CSS) compared to baseline, the change in Visual Analog Scale (VAS) score for cough symptoms compared to baseline, the change in total score of Leicester Cough Questionnaire-Mandarin Chinese version (LCQ-MC) compared to baseline, and overall evaluation of treatment effectiveness by patients. A total of 84 postoperative lung cancer patients with cough were strictly selected according to the inclusion\u002Fexclusion criteria and treated and followed up according to the research plan requirements. Clinical observation forms were completed and clinical data were recorded in the database. Statistical analysis was performed on relevant clinical observation indicators to report research results and write related papers.",[27,62],"Lung Cancer","RECRUITING","2025-09-02",{"date":66,"type":40},"2025-09-08",{"date":68,"type":40},"2024-04-17",{"date":70,"type":21},"2026-06-17",{"name":72,"class":47},"Kong Fanming",{"id":74,"slug":75,"hasResults":11,"nctId":76,"briefTitle":77,"officialTitle":78,"acronym":4,"eligibilityCriteria":79,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":80,"enrollmentInfo":81,"targetDuration":4,"studyType":22,"phases":83,"briefSummary":84,"conditions":85,"keywords":90,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":48},"100554581","effects-of-vagus-nerve-pulmonary-branch-block-on-postoperative-cough-after-vats-lung-resection-100554581","NCT06500949","Effects of Vagus Nerve Pulmonary Branch Block on Postoperative Cough After VATS Lung Resection","Effects of Vagus Nerve Pulmonary Branch Block on Postoperative Cough After Thoracoscopic Lung Resection","Inclusion Criteria:\n\n* Age between 18 and 70 years old.\n* BMI between 18 and 30 kilograms per square meter (kg\u002Fm²).\n* ASA Physical Status Classification of I, II, or III.\n* Preoperative pulmonary imaging demonstrating peripheral lesions, with clinical staging T≤2, N≤1, M0.\n* Undergone thoracoscopic lung resection surgery.\n* Patients managed by the same lead surgeon's team.\n* Obtained informed consent, with patients agreeing and signing the informed consent document.\n\nExclusion Criteria:\n\n* Patients with a history of chemotherapy or previous pulmonary surgery.\n* Presence of chronic cough due to respiratory infectious diseases, pharyngitis, rhinitis, COPD, asthma, post-nasal drip syndrome, etc.\n* Individuals exhibiting ECG abnormalities such as atrial fibrillation, bundle branch block, frequent ventricular premature beats, pre-excitation syndrome, etc.\n* Currently using ACE inhibitor medications.\n* Presence of preoperative hoarseness.","70 Years",{"count":82,"type":21},104,[24],"Postoperative cough after pulmonary resection is a common issue seen after thoracic surgeries, hindering patients' recovery and affecting their postoperative quality of life. While vagus nerve pulmonary branch block has been known to reduce intraoperative coughing, its impact on postoperative cough post lung resection is uncertain. This study aims to assess the effects of vagus nerve pulmonary branch block on postoperative cough after VATS lung resection. A randomized controlled trial involving 104 thoracoscopic lung resection patients will assign them randomly to a vagus nerve pulmonary branch block group or a control group. The primary outcome measure is the postoperative cough incidence 3 weeks after lung resection. The secondary outcomes include assessing hoarseness in PACU, peak expiratory flow (PEF) on the first post-op day, NRS scores for cough, and LCQ-MC scores at 3 weeks post-surgery, as well as cough occurrence, NRS scores, and LCQ-MC scores at 8 weeks post-procedure.",[27,86,87,88,89],"Thoracoscopy","Pulmonary Resection","Vagus","Nerve Block",[91,92,93,94,88],"Chronic cough","Postoperative cough","Thoracoscopy or Video-assisted thoracoscopic surgery","Pulmonary resection or Lung resection","2024-07-25",{"date":97,"type":40},"2024-07-29",{"date":99,"type":40},"2024-07-15",{"date":101,"type":21},"2025-07",{"name":103,"class":47},"Second Affiliated Hospital, School of Medicine, Zhejiang University"]