[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"postoperative-infection\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:postoperative-infection":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,42],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":21,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100610516","biofilm-on-chest-drains-after-thoracic-surgery-clinical-impact-and-antibiotic-resistance-100610516",false,"NCT07228598","Biofilm on Chest Drains After Thoracic Surgery: Clinical Impact and Antibiotic Resistance","Biofilm Formation on Thoracic Drains: Clinical Significance and Association With Antibiotic Resistance","Inclusion Criteria:\n\n* Age 18 years and older\n* Undergoing elective thoracic surgery requiring chest drain placement\n* Able and willing to provide written informed consent\n\nExclusion Criteria:\n\n* Presence of active infection prior to surgery\n* Emergency thoracic surgery\n* Immunosuppressed patients (e.g., neutropenia, advanced malignancy, organ transplantation)\n* Patients receiving systemic antibiotic therapy at the time of drain removal\n* Drainage for empyema or pre-existing pleural infection\n* Presence of extrathoracic infection focus\n* Refusal or inability to provide informed consent","ALL","18 Years",{"count":19,"type":20},180,"ESTIMATED","30 Days","OBSERVATIONAL","This prospective observational study aims to investigate the frequency and clinical significance of biofilm formation on thoracic chest drains used after thoracic surgery. Biofilms are structured bacterial communities that adhere to surfaces and can promote infection and antibiotic resistance. In this study, small samples from the tips of chest drains will be collected under sterile conditions at the time of drain removal and analyzed in the microbiology laboratory.\n\nThe main objectives are to evaluate the relationship between the duration of chest drain placement and the presence of biofilm, and to identify the antibiotic resistance profiles of microorganisms isolated from these biofilms. Secondary outcomes include the association between biofilm formation, postoperative infections (such as empyema or wound infection), and the length of hospital stay.\n\nThis study will be conducted at Ondokuz Mayıs University Faculty of Medicine, Department of Thoracic Surgery, in collaboration with the Department of Microbiology. The findings are expected to contribute to better understanding of optimal drain management and infection prevention strategies after thoracic surgery.",[25,26,27,28],"Biofilms","Thoracic Surgery","Postoperative Infection","Antibiotic Resistance, Bacterial","RECRUITING","2025-11-16",{"date":32,"type":33},"2025-11-19","ACTUAL",{"date":35,"type":33},"2025-10-01",{"date":37,"type":20},"2026-07-01",{"name":39,"class":40},"Caner İşevi, MD","OTHER",1,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":4,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":49,"targetDuration":4,"studyType":51,"phases":52,"briefSummary":54,"conditions":55,"keywords":58,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":70,"locationsCount":41},"100443301","preventive-therapy-of-postoperative-intra-abdominal-infection-based-on-serum-lactate-changes-100443301","NCT05052619","Preventive Therapy of Postoperative Intra-abdominal Infection Based on Serum Lactate Changes","A Prospective, Randomized Clinical Trial to Treat Intra-abdominal Infection Preventively After Pancreatic Surgery Based on Serum Lactate Changes","Inclusion Criteria:\n\n1. treatment by pancreatic resection, including pancreaticoduodenectomy, pancreatosplenectomy, total pancreatectomy, and other variant operations;\n2. revival in the intensive care unit (ICU) with standard serum lactate elution treatments after surgery instead of the operation room or general ward;\n3. availability of complete preoperative, intraoperative, and postoperative data;\n4. the peak serum lactate level in 24 hours after surgery \\>3.250 mmol\u002FL.\n\nExclusion Criteria:\n\n1. a history of surgical treatment of any upper abdominal lesions before the current hospital admission;\n2. the minimum mean arterial pressure \\\u003C65 mmHg during the operation;\n3. without written informed consents for the perioperative situation and related studies.",{"count":50,"type":20},297,"INTERVENTIONAL",[53],"NA","Intra-abdominal infection is one of the most serious complications after pancreatic resection. The preventive use of antibiotics intraoperatively could reduce the incidence rate of postoperative intra-abdominal infection. According to the previous retrospective study, changes of serum lactate level on postoperative day1 could predict the incidence rate of postoperative intra-abdominal infection. This prospective RCT is to further validate and promote the findings and conclusion.",[27,56,57],"Lactate","Antibiotics",[59,60,61,62,63],"Serum lactate","Postoperative intra-abdominal infection","Preventive usage","Advanced antibioties","Strategy","2021-09-21",{"date":66,"type":33},"2021-09-27",{"date":68,"type":33},"2021-07-01",{"date":37,"type":20},{"name":71,"class":40},"Peking Union Medical College Hospital"]