[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"postoperative-morbidity\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:postoperative-morbidity":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,45,78,106,131,157],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":28,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100502592","risk-factors-for-postoperative-complications-in-major-non-cardiac-surgery-post-hoc-analysis-of-the-ophique-multicentre-study-100502592",false,"NCT05824260","Risk Factors for Postoperative Complications in Major Non-cardiac Surgery: Post-hoc Analysis of the OPHIQUE Multicentre Study","MULTIPAS","Inclusion Criteria:\n\n* Abdominal, orthopaedic or vascular surgery under general anaesthesia and with an estimated duration of surgery \\> 2 hours\n* Adult patients (age ≥ 18 years)\n* ASA score ≥ II\n* Patient with at least two of the following comorbidities: age \\> 50 years, high blood pressure (HTA), heart failure, ECG abnormality, smoking, stroke, transient ischemic attack (TIA), peripheral arterial disease (PAD), insulin-dependent or non-insulin-dependent diabetes mellitus (NIDDM), ascites, chronic renal failure (CRF)\n* Signature of the consent form\n* Affiliation to a social security scheme\n\nExclusion Criteria:\n\n* Severe untreated or unbalanced hypertension\n* Preoperative renal failure on dialysis\n* Acute heart failure\n* Acute coronary insufficiency\n* Vascular surgery with renal plasty\n* Cardiac surgery\n* Permanent laparoscopy\n* Chronic respiratory failure with home oxygen therapy\n* Acute respiratory distress syndrome with FiO2\\>60%.\n* Preoperative shock\n* Surgery under spinal anaesthesia and epidural only\n* Refusal to participate by the patient\n* Pregnant, parturient or breastfeeding women\n* Patients under guardianship or curators, under court protection or deprived of public rights\n* The patient already included in another therapeutic trial with an experimental molecule\n* Emergency surgery\n* Patients who do not want their personal data to be used in the framework of the research","ALL","18 Years",{"count":19,"type":20},350,"ESTIMATED","OBSERVATIONAL","Post-operative morbidity and mortality is related to many factors related to the patient's condition, the intra-operative period and the optimisation of intra-operative haemodynamic and respiratory parameters. Many studies have looked at the determinants and factors that increase postoperative complications. However, these have been randomised studies looking at one parameter in particular.\n\nThis analysis would be the first to investigate the determinants of postoperative complications in a large population of patients undergoing major non-cardiac surgery. This is a post-hoc analysis of patients included in the OPHIQUE study, whose main objective was to evaluate intraoperative haemodynamic management guided by a marker of tissue hypoperfusion (the respiratory quotient).",[24,25,26,27],"Goal Directed Therapy","Postoperative Morbidity","Individualised Target","Postopera Mortality",[29,30,31],"Goal directed therapy","postoperative morbi-mortality","individualised target","RECRUITING","2026-06-12",{"date":35,"type":36},"2026-06-15","ACTUAL",{"date":38,"type":36},"2022-06-23",{"date":40,"type":20},"2026-06",{"name":42,"class":43},"Centre Hospitalier Universitaire, Amiens","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":53,"enrollmentInfo":54,"targetDuration":4,"studyType":56,"phases":57,"briefSummary":59,"conditions":60,"keywords":63,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":44},"100608186","the-effect-of-different-flap-closure-techniques-on-postoperative-morbidity-in-impacted-third-molar-surgery-100608186","NCT07198282","The Effect of Different Flap Closure Techniques on Postoperative Morbidity in Impacted Third Molar Surgery","The Effect of Different Flap Closure Techniques on Postoperative Morbidity: A Randomized Controlled Trial for Impacted Third Molar Surgery","GMC02","Inclusion Criteria:\n\n* Patients aged 18-40 years.\n* Patients with no systemic diseases (ASA I).\n* Patients with impacted mandibular third molars indicated for extraction, with bone and\u002For mucosal retention, in similar positions (Pell \\& Gregory Class 2, Position B; Winter classification vertical or mesioangular).\n\nExclusion Criteria:\n\n* Patients classified as ASA II, III, or IV.\n* Known allergy to anesthetic solutions.\n* Allergy to acrylate.\n* Pregnant or breastfeeding women.\n* Individuals with tobacco use ≥10 cigarettes\u002Fday.\n* Alcohol users.\n* Patients using antiplatelet agents.\n* Patients using anticoagulants.\n* Patients with coagulation disorders.\n* Patients with immunosuppressive diseases or receiving immunosuppressive therapy.\n\nPatients with acute pain or local infection at the surgical site.","40 Years",{"count":55,"type":20},148,"INTERVENTIONAL",[58],"NA","1\\. ABSTRACT This study is a randomized controlled trial comparing the clinical efficacy and safety of four different flap closure techniques in reducing postoperative morbidity (pain, swelling, trismus, wound healing) and improving patient quality of life (GOHAI) following impacted mandibular third molar extraction. The methods include conventional suturing, sutureless technique, surgical drain, and cyanoacrylate tissue adhesive, which are commonly used in oral surgery practice. The study aims to scientifically evaluate the effects of each method on patients and to determine the most appropriate clinical approach.",[61,25,62],"Impacted Mandibular Third Molar","Oral Surgery",[64,65,66,67,68],"Impacted third molar","Flap closure techniques","Cyanoacrylate","Sutureless technique","Surgical drain","2026-06-08",{"date":71,"type":36},"2026-06-09",{"date":73,"type":36},"2026-05-08",{"date":75,"type":20},"2026-08-30",{"name":77,"class":43},"Recep Tayyip Erdogan University",{"id":79,"slug":80,"hasResults":11,"nctId":81,"briefTitle":82,"officialTitle":83,"acronym":4,"eligibilityCriteria":84,"healthyVolunteers":85,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":86,"targetDuration":4,"studyType":56,"phases":88,"briefSummary":89,"conditions":90,"keywords":93,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":104,"locationsCount":44},"100624433","palatal-wound-healing-after-free-gingival-graft-surgery-100624433","NCT07409571","Palatal Wound Healing After Free Gingival Graft Surgery","Impact of Topical Triamcinolone Acetonide on Palatal Wound Healing, Patient Morbidity, and Quality of Life After Free Gingival Graft Surgery: A Randomized Clinical Trial","Inclusion Criteria:\n\n* Adults aged 18 years and older\n* Patients presenting with insufficient attached gingiva and\u002For gingival recession requiring free gingival graft surgery\n* Systemically healthy individuals (ASA I)\n* Full-mouth plaque score (FMPS) \\\u003C 15% and full-mouth bleeding score (FMBS) \\\u003C 15% at the time of surgery\n* Ability and willingness to provide written informed consent and comply with study procedures\n\nExclusion Criteria:\n\n* Presence of systemic diseases that may affect wound healing (e.g., diabetes mellitus, immunological disorders)\n* Use of systemic corticosteroids, immunosuppressive drugs, or anti-inflammatory medications within the last 3 months\n* Current smokers or tobacco users\n* Pregnancy or lactation\n* History of periodontal surgery at the palatal donor site\n* Presence of active infection, ulceration, or pathological lesions at the palatal donor area\n* Known allergy or hypersensitivity to corticosteroids, collagen materials, or study-related medications",true,{"count":87,"type":20},55,[58],"This randomized controlled clinical trial aims to evaluate the effects of topical triamcinolone acetonide application on wound healing and patient-reported outcomes at the palatal donor site following free gingival graft (FGG) surgery. A total of 55 patients with mucogingival deficiencies requiring FGG will be randomly assigned to either a control group receiving a collagen membrane or a test group receiving topical triamcinolone acetonide at the donor site. All palatal donor areas will be protected with a periodontal dressing. Clinical assessments will be performed on postoperative days 3, 7, 14, and 30. Wound epithelialization will be evaluated using the hydrogen peroxide bubbling test, while wound healing and scar formation will be assessed using the Landry, Turnbull, and Howley index and the modified Manchester Scar Scale, respectively. Patient-centered outcomes, including postoperative pain, discomfort, analgesic consumption, and oral health-related quality of life, will be assessed using visual analog scales and the Oral Health Impact Profile-14 questionnaire. The findings of this study are expected to provide evidence regarding the potential benefits of topical corticosteroid use in reducing palatal donor site morbidity following FGG surgery.",[91,25,92],"Gingival Recession, Localized","Palatal Donor Site Wound Healing",[94,95,96,97],"Free Gingival Graft","Palatal Donor Site","Wound Healing","Triamcinolone Acetonide","2026-05-20",{"date":100,"type":36},"2026-05-22",{"date":102,"type":36},"2025-10-16",{"date":98,"type":20},{"name":105,"class":43},"Kahramanmaras Sutcu Imam University",{"id":107,"slug":108,"hasResults":11,"nctId":109,"briefTitle":110,"officialTitle":110,"acronym":4,"eligibilityCriteria":111,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":112,"targetDuration":114,"studyType":21,"phases":4,"briefSummary":115,"conditions":116,"keywords":4,"overallStatus":121,"whyStopped":4,"lastUpdateSubmitDate":122,"lastUpdatePostDateStruct":123,"startDateStruct":125,"completionDateStruct":127,"leadSponsor":129,"locationsCount":4},"100632209","value-of-the-time-weighted-average-twa-of-mean-arterial-pressure-map-and-cerebral-oximetry-rso-as-predictors-of-postoperative-tissue-perfusion-impairment-in-patients-undergoing-cardiac-surgery-100632209","NCT07510711","Value of the Time-Weighted Average (TWA) of Mean Arterial Pressure (MAP) and Cerebral Oximetry (rSO₂) as Predictors of Postoperative Tissue Perfusion Impairment in Patients Undergoing Cardiac Surgery","Inclusion Criteria:\n\n* Age \\>18 years\n* Undergoing cardiac surgery, with or without cardiopulmonary bypass\n* Written informed consent\n* Preoperative cognitive status: Glasgow Coma Scale score of 15; no history of dementia; no evidence of cognitive impairment on baseline assessment; patient oriented and cooperative prior to surgery\n* Continuous intraoperative monitoring of mean arterial pressure (MAP) and cerebral regional oxygen saturation (rSO₂)\n\nExclusion Criteria:\n\n* History of dementia or cognitive impairment\n* Emergency surgeries",{"count":113,"type":20},120,"3 Months","Neurological problems after heart surgery are common and include confusion, memory loss, and difficulty thinking clearly. These issues may appear hours or days after surgery and can negatively affect recovery.\n\nDuring heart surgery, blood flow and oxygen delivery to the brain may decrease, causing changes in blood pressure and cerebral oxygenation. Previous studies suggest that prolonged drops in mean arterial pressure (MAP) or cerebral oxygenation (rSO₂) are linked to worse postoperative outcomes. Continuous monitoring of blood pressure and cerebral oxygenation is standard in cardiac surgery.\n\nThis study aims to evaluate the duration and severity of intraoperative drops in MAP and cerebral oxygenation. These measures may provide a more accurate assessment of neurological risk than isolated measurements.\n\nThe primary objective is to determine whether decreases in MAP and cerebral oxygenation, as well as their duration and intensity during surgery, are associated with postoperative neurological complications.\n\nThis is a prospective, observational study in adult patients undergoing cardiac surgery, with or without cardiopulmonary bypass (CPB). CPB diverts blood through a machine that performs the work of the heart and lungs while the heart is operated on. All patients will receive standard monitoring, including continuous MAP and cerebral oxygenation measurements. No additional interventions will be performed.\n\nNeurological status will be assessed using validated clinical scales before and after surgery. Other outcomes include kidney function, ICU and hospital stay length, postoperative complications, and in-hospital mortality.\n\nValidating these measures as a predictive tool could enable early identification of patients at higher risk of neurological injury and allow more individualized intraoperative management to reduce morbidity, hospital stay, and healthcare costs.",[117,118,119,25,120],"Delirium - Postoperative","Postoperative Cognitive Dysfunction (POCD)","Postoperative Acute Kidney Injury","Intensity Care Unit Length of Stay","NOT_YET_RECRUITING","2026-03-30",{"date":124,"type":36},"2026-04-03",{"date":126,"type":20},"2026-05-01",{"date":128,"type":20},"2027-11",{"name":130,"class":43},"Hospital Universitari Vall d'Hebron Research Institute",{"id":132,"slug":133,"hasResults":11,"nctId":134,"briefTitle":135,"officialTitle":136,"acronym":4,"eligibilityCriteria":137,"healthyVolunteers":11,"sex":16,"minAge":138,"maxAge":4,"enrollmentInfo":139,"targetDuration":140,"studyType":21,"phases":4,"briefSummary":141,"conditions":142,"keywords":145,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":148,"lastUpdatePostDateStruct":149,"startDateStruct":151,"completionDateStruct":153,"leadSponsor":155,"locationsCount":44},"100627894","preoperative-cardiac-power-output-and-p-possum-score-100627894","NCT07454564","Preoperative Cardiac Power Output and P-POSSUM Score","Investigation of the Relationship Between Preoperative Cardiac Power Output and P-POSSUM Score","Inclusion Criteria: Being 65 years of age or older,\n\n* Undergoing abdominal surgery in general surgery practice (including elective and emergency procedures),\n* ASA (American Society of Anesthesiologists) class I-III,\n* Adequate recording with transthoracic echocardiography,\n* Having given informed consent.\n\nExclusion Criteria:Advanced heart failure with ejection fraction (EF) \\\u003C30%,\n\n* Severe valvular disease (severe stenosis or insufficiency),\n* Unstable coronary artery disease or recent myocardial infarction (within the last 3 months),\n* Pulmonary hypertension,\n* Severe arrhythmia (uncontrolled atrial fibrillation, ventricular tachycardia, etc.)","65 Years",{"count":113,"type":20},"1 Month","This study aims to investigate the relationship between preoperative Cardiac Power Output (CPO), which reflects the pumping capacity of the heart, and the P-POSSUM score, a widely used surgical risk assessment tool, in patients aged 65 years and older undergoing abdominal surgery. Simple and non-invasive measurements performed in the preoperative period will be used to obtain CPO values and to evaluate whether these measurements are helpful in predicting postoperative morbidity and mortality. No additional procedures beyond routine clinical care will be performed as part of this observational study. The findings of this study may contribute to a more accurate assessment of surgical risk and help improve patient safety in the perioperative period.",[143,144,25],"Surgical Risk Assessment","Postoperative Mortality",[146,147],"p-possum score","cardiac power output","2026-03-18",{"date":150,"type":36},"2026-03-23",{"date":152,"type":36},"2026-03-10",{"date":154,"type":20},"2026-11-30",{"name":156,"class":43},"Necmettin Erbakan University",{"id":158,"slug":159,"hasResults":11,"nctId":160,"briefTitle":161,"officialTitle":162,"acronym":4,"eligibilityCriteria":163,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":138,"enrollmentInfo":164,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":166,"conditions":167,"keywords":169,"overallStatus":121,"whyStopped":4,"lastUpdateSubmitDate":173,"lastUpdatePostDateStruct":174,"startDateStruct":175,"completionDateStruct":177,"leadSponsor":179,"locationsCount":44},"100630477","preoperative-carotid-doppler-ultrasound-parameters-for-prediction-of-post-induction-hypotension-in-elective-non-cardiac-surgery-100630477","NCT07488182","Preoperative Carotid Doppler Ultrasound Parameters for Prediction of Post-Induction Hypotension in Elective Non-Cardiac Surgery","The Value of Preoperative Carotid Doppler Ultrasonography Parameters in Predicting Post-Induction Hypotension in Patients Undergoing Elective Non-Cardiac Surgery","Inclusion Criteria:\n\n* Adult patients aged 18-65 years\n\nAmerican Society of Anesthesiologists (ASA) physical status I-II\n\nScheduled for elective non-cardiac surgery under general anesthesia\n\nPlanned endotracheal intubation\n\nAbility to provide written informed consent\n\nExclusion Criteria:\n\nRefusal to participate in the study\n\nPlanned emergency surgery\n\nPlanned cardiac surgery\n\nPresence of carotid artery stenosis greater than 50%\n\nModerate to severe valvular heart disease\n\nPresence of atrial fibrillation or significant arrhythmia\n\nAdvanced heart failure\n\nPreoperative hypotension or hemodynamic instability\n\nInability to obtain reliable ultrasonographic measurements\n\n\\-",{"count":165,"type":20},110,"This prospective observational study aims to evaluate the predictive value of preoperative carotid Doppler ultrasound parameters, including carotid velocity-time integral (carotid VTI) and corrected carotid flow time (ccFT), for post-induction hypotension in adult patients undergoing elective non-cardiac surgery under general anesthesia. Hemodynamic instability during anesthesia induction is a common and clinically important problem associated with adverse perioperative outcomes. Carotid Doppler ultrasonography provides a rapid and non-invasive method for assessing hemodynamic status at the bedside. In this study, carotid Doppler measurements will be performed in the preoperative period and their association with post-induction hypotension will be analyzed. The results of this study may help identify patients at risk for hypotension and improve perioperative hemodynamic management.",[168,25],"Post Induction Hypotension",[170,171,172],"Doppler Ultrasound","Velocity Time Integral","Anesthesia","2026-03-17",{"date":150,"type":36},{"date":176,"type":20},"2026-09",{"date":178,"type":20},"2027-09",{"name":156,"class":43}]