[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"postoperative-nausea\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:postoperative-nausea":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,10,0,[8,41,69,99,126,161,192,217,240,267],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":20,"targetDuration":23,"studyType":24,"phases":4,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":36,"leadSponsor":38,"locationsCount":4},"100620005","autonomic-neural-field-block-for-visceral-pain-in-minimally-invasive-left-sided-colectomy-100620005",false,"NCT07351994","Autonomic Neural Field Block for Visceral Pain in Minimally Invasive Left-Sided Colectomy","Autonomic Neural Field Block for Visceral Pain Control in Minimally Invasive Left-Sided Colorectal Resections","ANfiELD","Inclusion Criteria:\n\n* Age ≥ 18 years.\n* Scheduled for elective minimally invasive (laparoscopic or robotic) left-sided colonic or rectal resection with primary anastomosis constructed above the peritoneal reflection (e.g., sigmoid colectomy, left colectomy, anterior resection\u002Frectosigmoid resection with intraperitoneal anastomosis).\n* Planned intraoperative administration of autonomic neural field block targeting the superior hypogastric plexus and\u002For inferior mesenteric plexus, performed under direct visualization, as part of routine operative workflow.\n* Managed perioperatively under an institutional standard analgesic pathway (e.g., ERAS or equivalent), with postoperative opioid administration recorded in the medical record.\n* Ability to provide informed consent\n\nExclusion Criteria:\n\n* Emergency\u002Furgent colorectal surgery (e.g., perforation, uncontrolled bleeding, toxic megacolon, obstructing cancer requiring urgent operation).\n* Planned open left-sided colectomy\u002Frectal resection (minimally invasive approach not intended).\n* Procedures in which no primary anastomosis is created (e.g., Hartmann's procedure, end colostomy, permanent diversion without anastomosis).\n* Planned low pelvic\u002Fextra-peritoneal anastomosis (e.g., low anterior resection with anastomosis at or below the peritoneal reflection) or planned handsewn coloanal anastomosis.\n* Known allergy or contraindication to the local anesthetic agents used for the block (or inability to receive local anesthetic for clinical reasons).\n* Inability to reliably capture outcome data for the primary endpoint (e.g., anticipated transfer to another facility within 24 hours post-op, incomplete medication administration records).\n* Pregnancy\n* Prisoners or other protected populations where participation is restricted\n* Chronic opioid therapy at baseline defined as daily opioid use for \\> 30 days preoperatively, or baseline opioid dose \\> 30 MME\u002Fday\n* Planned use of neuraxial analgesia (epidural\u002Fspinal) intended for postoperative analgesia",true,"ALL","18 Years",{"count":21,"type":22},400,"ESTIMATED","6 Months","OBSERVATIONAL","Effective postoperative pain control is a core component of enhanced recovery after surgery (ERAS) pathways in colorectal surgery; however, postoperative pain following minimally invasive left-sided colectomy remains a persistent clinical challenge. Standard multimodal analgesic strategies primarily target somatic pain pathways and may inadequately address visceral postoperative pain, which is mediated through autonomic afferent neural pathways. Residual visceral pain is associated with increased opioid consumption, postoperative nausea and vomiting, delayed recovery, and prolonged length of stay.\n\nThis prospective, multicenter observational registry evaluates the feasibility and real-world outcomes of an intraoperative autonomic neural field block targeting the superior hypogastric and inferior mesenteric plexuses during minimally invasive left-sided colectomy. The technique is performed under direct visualization as an adjunct to standard ERAS-based analgesic care. The primary outcome is postoperative opioid consumption within the first 24 hours after surgery. Secondary outcomes include opioid use through 48 hours, postoperative nausea and vomiting, antiemetic use, pain scores, length of stay, and readiness for discharge. Data from this registry will inform future comparative studies and help define the role of autonomic neural modulation in perioperative pain management for colorectal surgery.",[27,28,29],"Postoperative Pain","Postoperative Nausea","Opioid Use","NOT_YET_RECRUITING","2026-01-10",{"date":33,"type":34},"2026-01-20","ACTUAL",{"date":33,"type":22},{"date":37,"type":22},"2026-09-01",{"name":39,"class":40},"Antonio Caycedo, MD","OTHER",{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":45,"acronym":46,"eligibilityCriteria":47,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":48,"targetDuration":4,"studyType":50,"phases":51,"briefSummary":53,"conditions":54,"keywords":56,"overallStatus":58,"whyStopped":4,"lastUpdateSubmitDate":59,"lastUpdatePostDateStruct":60,"startDateStruct":62,"completionDateStruct":64,"leadSponsor":66,"locationsCount":68},"100604648","advancing-strategies-to-optimize-the-perioperative-management-of-postoperative-nausea-and-vomiting-aspire-ponv-trial-100604648","NCT07152249","Advancing Strategies to Optimize the PerIopeRativE Management of PostOperative Nausea and Vomiting (ASPIRE-PONV) Trial","ASPIRE-PONV","Adult Inclusion Criteria\n\n* Age ≥ 18 years\n* Planned surgery with general anesthesia with endotracheal intubation or laryngeal mask airway\n* Meet zero or more risk factors for PONV ( history of motion sickness or postoperative nausea and vomiting, non-smoker, female sex, duration of inhalation anesthesia greater than 1 hour, undergoing high risk surgical procedure (cholecystectomy, laparoscopy, gynecologic), and perioperative opioid use)\n\nAdult Exclusion Criteria\n\n* ASA 6 including organ procurement,\n* Patients anticipated to be transferred directly to the intensive care unit intubated,\n* Procedure types:\n\n  * Electroconvulsive therapy,\n  * Intubation only cases,\n  * labor epidurals,\n  * transesophageal echocardiography (TEE)\u002Fcardioversion,\n  * surgery duration \\\u003C 30 minutes.\n\nOperating Room Anaesthesia Provider Inclusion Criteria\n\nAny operating room anaesthesia provider of eligible patients will be included.",{"count":49,"type":22},19480,"INTERVENTIONAL",[52],"NA","The goal of this prospective, unblinded, pragmatic and repeated crossover trial is to learn if clinical decision support alerts will impact postoperative nausea and vomiting (PONV) prophylaxis and reduce PONV rates in adult patients who have planned surgery with general anesthesia. The main aim is to improve PONV, establishing a scalable Clinical Decision Support (CDS) Tool for personalized PONV prevention.\n\nThe primary hypothesis is that, compared with standard care, the Anesthesia Workflow-Driven Clinical Decision Support Tool for Personalized PONV Prevention will be associated with a significant improvement in the rate of appropriate administration of PONV prophylaxis and a significant decrease in the incidence of PONV.\n\nThis study will evaluate a new clinical decision support (CDS) tool designed to improve how and when PONV prevention strategies are used. Unlike traditional tools that provide generic, one-time alerts, this new system is integrated into the electronic health record (EHR) and delivers timely, targeted reminders to anesthesia providers at key moments during a patient's surgical care-such as before surgery begins, after anesthesia is given, and before the patient wakes up. These alerts are based on each patient's individual risk for PONV and are intended to support, not replace, clinical judgment. The study will use a crossover design over 12 months, alternating between periods when the tool is active and when it is not. The goal is to determine whether this time-sensitive, workflow-integrated tool can lead to better adherence to best practices and improved patient outcomes.",[28,55],"Postoperative Vomiting",[57],"clinical decision support","RECRUITING","2026-01-09",{"date":61,"type":34},"2026-01-12",{"date":63,"type":34},"2025-09-03",{"date":65,"type":22},"2026-09",{"name":67,"class":40},"Vanderbilt University Medical Center",1,{"id":70,"slug":71,"hasResults":11,"nctId":72,"briefTitle":73,"officialTitle":74,"acronym":4,"eligibilityCriteria":75,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":76,"enrollmentInfo":77,"targetDuration":4,"studyType":50,"phases":79,"briefSummary":80,"conditions":81,"keywords":84,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":68},"100607321","methylprednisolone-vs-dexamethasone-effects-on-sugammadex-reversal-pain-and-nausea-in-adults-100607321","NCT07187037","Methylprednisolone vs Dexamethasone: Effects on Sugammadex Reversal, Pain, and Nausea in Adults","Comparison of the Effects of the Interaction of Methylprednisolone and Dexamethasone With Sugammadex on Rocuronium Reversal Time, Postoperative Pain, and Nausea in Adult Patients","Inclusion Criteria:\n\n* Adult patients aged 18-65 years\n* American Society of Anesthesiologists (ASA) physical status I-II\n* Scheduled for elective septoplasty or rhinoplasty under general anesthesia\n* Written informed consent obtained\n\nExclusion Criteria:\n\n* ASA physical status ≥ III\n* Emergency surgery\n* Known allergy or contraindication to rocuronium, sugammadex, or corticosteroids\n* Chronic or recent (within 3 months) systemic corticosteroid therapy\n* Concomitant use of drugs that may interact with sugammadex (e.g., toremifene, flucloxacillin, fusidic acid)\n* Neuromuscular disorders (e.g., myasthenia gravis, muscular dystrophy)\n\n  * Significant hepatic, renal, respiratory, or cardiac dysfunction\n* Anticipated difficult airway or history of difficult intubation\n* Nasopharyngeal or oropharyngeal anomalies interfering with airway management\n* Developmental or cognitive impairment interfering with informed consent or cooperation","65 Years",{"count":78,"type":22},130,[52],"This randomized controlled trial aims to compare the effects of intravenous methylprednisolone and dexamethasone on the reversal time of rocuronium by sugammadex in adult patients undergoing elective septoplasty or rhinoplasty. The primary outcome is the time from sugammadex administration to recovery of a train-of-four (TOF) ratio of 0.9. Secondary outcomes include extubation time, postoperative nausea and vomiting (PONV), pain scores, complications in the post-anesthesia care unit (PACU), and intraoperative hemodynamic parameters. The study will provide new evidence on whether perioperative corticosteroid choice modifies the efficacy of sugammadex and influences postoperative recovery.",[82,83,28],"Neuromuscular Block, Residual","Pain",[85,86,87,88,89],"sugammadex","dexamethasone","methylprednisolone","postoperative nausea","postoperative pain","2025-09-18",{"date":92,"type":34},"2025-09-22",{"date":94,"type":22},"2025-10-01",{"date":96,"type":22},"2026-04-30",{"name":98,"class":40},"Konya City Hospital",{"id":100,"slug":101,"hasResults":11,"nctId":102,"briefTitle":103,"officialTitle":104,"acronym":4,"eligibilityCriteria":105,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":76,"enrollmentInfo":106,"targetDuration":4,"studyType":50,"phases":108,"briefSummary":109,"conditions":110,"keywords":112,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":116,"lastUpdatePostDateStruct":117,"startDateStruct":119,"completionDateStruct":121,"leadSponsor":123,"locationsCount":68},"100605477","comparison-of-two-plane-blocks-used-in-open-ventral-hernia-repair-operations-100605477","NCT07163026","Comparison of Two Plane Blocks Used in Open Ventral Hernia Repair Operations","Comparison of Analgesic Efficacy of Erector Spinae Plane Block and External Oblique-Intercostal Plane Block in Patients Undergoing Open Ventral Hernia Repair","Inclusion Criteria:\n\n* Patients scheduled for open ventral hernia repair under general anesthesia\n* Patients with ASA scores (American Society of Anesthesiologists) 1 and 2\n* Patients with a body mass index between 18.5 and 34.9\n\nExclusion Criteria:\n\n* Patients scheduled for open ventral hernia repair under spinal or epidural anesthesia\n* Patients who have previously undergone spine surgery.\n* Patients with known local anesthetic allergy\n* Pregnant women\n* Mentally uncooperative patients\n* Patients with a history of chronic analgesic use",{"count":107,"type":22},50,[52],"The aim of this study is to compare the postoperative analgesic efficacy of bilateral erector spinae plane block and bilateral external oblique-intercostal plane block in patients undergoing open ventral hernia repair.",[111,27,28,55],"Ventral Hernia",[113,114,115],"erector spinae plane block","external oblique intercostal plane block","bupivacain","2025-09-14",{"date":118,"type":34},"2025-09-16",{"date":120,"type":22},"2025-09-30",{"date":122,"type":22},"2025-12-15",{"name":124,"class":125},"Ankara Ataturk Sanatorium Training and Research Hospital","OTHER_GOV",{"id":127,"slug":128,"hasResults":11,"nctId":129,"briefTitle":130,"officialTitle":131,"acronym":132,"eligibilityCriteria":133,"healthyVolunteers":11,"sex":18,"minAge":134,"maxAge":135,"enrollmentInfo":136,"targetDuration":4,"studyType":50,"phases":138,"briefSummary":140,"conditions":141,"keywords":146,"overallStatus":58,"whyStopped":4,"lastUpdateSubmitDate":152,"lastUpdatePostDateStruct":153,"startDateStruct":155,"completionDateStruct":157,"leadSponsor":159,"locationsCount":68},"100575859","phase-4-comparison-of-remimazolam-and-propofol-in-endoscopic-examinations-and-treatments-100575859","NCT06777758","Comparison of Remimazolam and Propofol in Endoscopic Examinations and Treatments","The Comparison of Remimazolam or Propofol Used Alone Versus in Combination for Moderate Sedation During Endoscopic Examination and Treatment.","Remimazolam","Inclusion Criteria:\n\n* Subjects are between 20-80 years old.\n* Anesthesiologists rated ASA as between I and III.\n* Patients undergoing upper gastrointestinal endoscopic examination or therapy.\n\nExclusion Criteria:\n\n* Allergy to Propofol, Remimazolam, or opioid medications.\n* Emergency surgery.\n* Pregnancy.\n* History of malignant hyperthermia.\n* Impaired liver or kidney function.\n* Airway difficulties due to pharyngeal tumors.\n* Refusal to participate.","20 Years","80 Years",{"count":137,"type":22},90,[139],"PHASE4","This study aims to evaluate the efficacy and safety of Remimazolam, either used alone or in combination with Propofol, for moderate sedation anesthesia during endoscopic therapies or examinations. Additionally, it seeks to explore whether their combination can further enhance the quality of patient anesthesia and recovery outcomes.",[142,143,28,144,145],"Postoperative Complications","Respiratory Depression","Vomiting","Constipation",[147,148,149,150,151],"endoscope","Respiratory depression","Remimazolam、","Sedation","BYFAVO","2025-05-06",{"date":154,"type":34},"2025-05-08",{"date":156,"type":34},"2025-02-12",{"date":158,"type":22},"2026-12-31",{"name":160,"class":40},"Kaohsiung Veterans General Hospital.",{"id":162,"slug":163,"hasResults":11,"nctId":164,"briefTitle":165,"officialTitle":166,"acronym":167,"eligibilityCriteria":168,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":169,"targetDuration":4,"studyType":50,"phases":171,"briefSummary":172,"conditions":173,"keywords":176,"overallStatus":58,"whyStopped":4,"lastUpdateSubmitDate":182,"lastUpdatePostDateStruct":183,"startDateStruct":185,"completionDateStruct":187,"leadSponsor":189,"locationsCount":191},"100573993","phase-4-intraoperative-autonomic-blockade-for-laparoscopic-cholecystectomy-100573993","NCT06753500","Intraoperative Autonomic Blockade for Laparoscopic Cholecystectomy","Intraoperative Autonomic Blockade to Prevent Early Postoperative Pain After Laparoscopic Cholecystectomy: A Double-Blind, Randomized Controlled Trial","ANB","Inclusion Criteria:\n\n* Elective or emergency laparoscopic cholecystectomy for cholelithiasis with or without cholecystitis.\n\nExclusion Criteria:\n\n* Associated biliary pathologies (e.g., biliary pancreatitis, cholangitis).\n\n  * Additional procedures, such as formal bile duct exploration. Conversion to an open approach\n  * Anesthesia or Surgical complications that require intensive care unit\n* Allergies to local anesthetics",{"count":170,"type":22},60,[139],"This study proposes infiltrating the hepatoduodenal ligament and the serosal reflection of the gallbladder cystic plate with a combination of Bupivacaine (a long-acting local anesthetic) and Dexamethasone (a corticosteroid). This technique aims to block the hepatic branches of the celiac plexus to improve visceral pain control and its associated clinical manifestations, reduce analgesic requirements, and lower readmission rates, thereby facilitating recovery.",[174,175,29,28,55],"Visceral Pain","Analgesia",[177,178,88,179,180,181],"autonomic neural blockade,","Visceral pain","Postoperative vomiting","analgesic consumption","opioid use","2025-01-25",{"date":184,"type":34},"2025-01-28",{"date":186,"type":34},"2025-01-15",{"date":188,"type":22},"2025-11-04",{"name":190,"class":40},"Universidad Simón Bolívar",2,{"id":193,"slug":194,"hasResults":11,"nctId":195,"briefTitle":196,"officialTitle":196,"acronym":4,"eligibilityCriteria":197,"healthyVolunteers":17,"sex":18,"minAge":198,"maxAge":4,"enrollmentInfo":199,"targetDuration":4,"studyType":50,"phases":201,"briefSummary":202,"conditions":203,"keywords":204,"overallStatus":58,"whyStopped":4,"lastUpdateSubmitDate":208,"lastUpdatePostDateStruct":209,"startDateStruct":211,"completionDateStruct":213,"leadSponsor":215,"locationsCount":68},"100548576","the-impact-of-nasogastric-tube-gastric-decompression-on-postoperative-nausea-and-vomiting-in-orthognathic-surgery-100548576","NCT06422793","The Impact of Nasogastric Tube Gastric Decompression on Postoperative Nausea and Vomiting in Orthognathic Surgery","Inclusion Criteria:\n\n* Patients over the age of 16 at the time of consent undergoing orthognathic surgery for the correction of dentofacial deformities at the Victoria General Hospital during the study period.\n\nOrthognathic surgery to include:\n\n1. Patients who receive single-jaw surgery (i.e. BSSO \\[Bilateral Sagittal Split Osteotomy\\] only, or LeFort only).\n2. Patients receiving double-jaw surgery (i.e. BSSO and LeFort).\n3. Patients undergoing a functional genioplasty in addition to another osteotomy (i.e. BSSO and\u002For LeFort).\n\nExclusion Criteria:\n\n* Patients will be excluded if they do not meet inclusion criteria or if they have risk factors known to directly impact PONV and\u002For cause delayed gastric emptying:\n\n  1. Patients under the age of 16 at the time of consent.\n  2. Patients contraindicated to undergo elective surgery, including pregnant patients.\n  3. Patients undergoing a functional genioplasty procedure only.\n  4. Patients taking GLP-1 receptor agonists).\n  5. Patients with known gastroparesis.","16 Years",{"count":200,"type":22},92,[52],"This study will compare the incidence of postoperative nausea and vomiting during the first 24 hours following corrective jaw surgery (orthognathic surgery) in patients with and without nasogastric tube gastric decompression.",[28,55],[205,206,207],"nasogastric tube","orthognathic surgery","gastric decompression","2025-01-12",{"date":210,"type":34},"2025-01-14",{"date":212,"type":34},"2024-12-04",{"date":214,"type":22},"2025-12",{"name":216,"class":40},"Nova Scotia Health Authority",{"id":218,"slug":219,"hasResults":11,"nctId":220,"briefTitle":221,"officialTitle":222,"acronym":4,"eligibilityCriteria":223,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":224,"enrollmentInfo":225,"targetDuration":4,"studyType":50,"phases":226,"briefSummary":228,"conditions":229,"keywords":4,"overallStatus":58,"whyStopped":4,"lastUpdateSubmitDate":231,"lastUpdatePostDateStruct":232,"startDateStruct":234,"completionDateStruct":236,"leadSponsor":238,"locationsCount":68},"100448486","phase-3-perioperative-dexamethasone-reduces-postoperative-pain-and-nausea-after-periacetabular-osteotomy-100448486","NCT05120076","Perioperative Dexamethasone Reduces Postoperative Pain and Nausea After Periacetabular Osteotomy","Perioperative Dexamethasone Reduces Postoperative Pain and Nausea After Periacetabular Osteotomy- a Double-blinded Placebo Controlled RCT","Inclusion Criteria:\n\n* Age ≥ 18 years\n* General anasthesia\n* Elective periacetabular osteotomy for any reason\n* Written informed consent as documented by signature (Appendix Informed Consent Form)\n* Competent German language skills\n\nExclusion Criteria:\n\n* Chronic pain patient, chronic lower back pain\n* Steroid or immunosuppressive drugs used within 6 months of surgery\n* Renal failure, hepatic failure\n* Relevant allergies\n* Pregnancy\u002F Breast feeding\n* Contraindications for Fortecortin treatment according to Swissmedic\n* Previous enrollment into the current study\n* Participation in another study with investigational drug within the 30 days preceding and during the present study\n* Known or suspected non-compliance, drug or alcohol abuse Illness according to \"Warnings and Precautions of Dexamethasone and NaCl\"","99 Years",{"count":170,"type":22},[227],"PHASE3","The purpose of this study is to assess the effect of Dexamethasone on postoperative pain and nausea after periacetabular osteotomy.",[83,28,230],"Amount of Postoperative Opioid Use in Milligrams","2024-08-09",{"date":233,"type":34},"2024-08-12",{"date":235,"type":34},"2021-07-16",{"date":237,"type":22},"2024-08-31",{"name":239,"class":40},"Balgrist University Hospital",{"id":241,"slug":242,"hasResults":11,"nctId":243,"briefTitle":244,"officialTitle":245,"acronym":246,"eligibilityCriteria":247,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":248,"targetDuration":4,"studyType":50,"phases":250,"briefSummary":251,"conditions":252,"keywords":254,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":258,"lastUpdatePostDateStruct":259,"startDateStruct":261,"completionDateStruct":263,"leadSponsor":265,"locationsCount":68},"100306632","protocol-for-accelerated-recovery-in-patients-undergoing-thoracic-surgical-procedures-prosm-study-randomized-comparative-between-the-adoption-of-the-proposed-guidelines-and-the-traditional-method-currently-used-in-the-institution-100306632","NCT03271749","Protocol for Accelerated Recovery in Patients Undergoing Thoracic Surgical Procedures (PROSM). Study Randomized Comparative Between the Adoption of the Proposed Guidelines and the Traditional Method Currently Used in the Institution","Protocol for Accelerated Recovery in Patients Undergoing Thoracic Surgical Procedures Adapted to the Conditions of Santa Marcelina - Itaquera Hospital - São Paulo - Brazil (PROSM). Study Randomized Comparative Between the Adoption of the Proposed Guidelines and the Traditional Method Currently Used in the Institution","PROSM","Inclusion Criteria:\n\n* patients with elective pulmonary resections (segmentectomies, lobectomies or pneumonectomies) to treat neoplastic lung diseases.\n\nExclusion Criteria:\n\n* unable to read, understand and sign informed consent\n* patients with compromised performance status (ECOG greater than 2)\n* body mass below 60 kg or greater than 120 kg\n* allergy to latex\n* patients with a history of allergy to any of the drugs used in anesthesia for PROSM\n* patients with renal dysfunction\n* liver dysfunction\n* severe cardiac dysfunction (cardiac failure)",{"count":249,"type":22},200,[52],"Introduction:\n\nAiming at reducing costs and optimizing the use of these financial resources, several postoperative recovery protocols have emerged that aim to reduce the length of hospital stay by accelerating surgical recovery.1,2 In view of the current Brazilian political and economic scenario allied to the existing scientific knowledge on the subject , the investigators developed a protocol that aims to meet this need using resources already available and offered in brazilian public health system. The investigators called this protocol as Protocol of Operative Recovery Santa Marcelina (PROSM) that had as inspiration the protocols of accelerated postoperative recovery already used in several European health services.\n\nGoals:\n\n1. To evaluate the impact of PROSM on the length of hospitalization in days and postoperative pain (visual analog pain scale - VAS) in patients submitted to surgical procedures performed by the thoracic surgery team of the Hospital Santa Marcelina de Itaquera.\n2. Evaluate the impacts of PROSM in reducing the costs (US dollars) of surgical treatment and hospitalization of these patients.\n\nMaterials and methods:\n\nA group of 200 patients with elective pulmonary resections (segmentectomies, lobectomies or pneumonectomies) to treat neoplastic lung diseases will be selected by the investigators.\n\nThe participants will be randomized into two groups (rate of randomization 1\u002F1).\n\nThe first group will be submitted to the standard surgical treatment that is currently used in Santa Marcelina - Itaquera hospital. The second group will be submitted to treatment with the adoption of the PROSM guidelines, which will be detailed later.\n\nInvestigators will evaluate in the two groups: surgical time in minutes, intraoperative complications: intraoperative bleeding in mililiters, need for transfusion of blood products, intraoperative clinical complications. Investigators will also evaluate the need for postoperative recovery in Intensive Care Unit (ICU), medications used to maintain the anesthetic plane during the procedure (amount of drugs in milligrams), medications used for postoperative analgesia, length of hospital stay in days, postoperative clinical complications, need for surgical re-boarding, immediate postoperative pain (VAS), postoperative pain at the time of discharge and the first outpatient return (VAS), the need for opioid analgesics at home after discharge.\n\nAfter the data collection, the investigators will analyze them and make a comparative study of the costs of surgical treatment and hospitalization between the two groups. This data will be obtained from the billing department of the Hospital Santa Marcelina de Itaquera.",[27,142,28,253],"Lung Cancer",[255,256,257],"Fast Track surgical recovery","Surgical recovery","Thoracic surgery","2020-12-17",{"date":260,"type":34},"2020-12-21",{"date":262,"type":22},"2021-07-01",{"date":264,"type":22},"2028-12-31",{"name":266,"class":40},"Igor Renato Louro Bruno de Abreu",{"id":268,"slug":269,"hasResults":11,"nctId":270,"briefTitle":271,"officialTitle":271,"acronym":4,"eligibilityCriteria":272,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":273,"targetDuration":4,"studyType":50,"phases":275,"briefSummary":276,"conditions":277,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":279,"lastUpdatePostDateStruct":280,"startDateStruct":282,"completionDateStruct":284,"leadSponsor":286,"locationsCount":4},"100395681","phase-4-oral-dexamethasone-as-an-intervention-for-postoperative-pain-and-nausea-management-in-total-knee-arthroplasty-100395681","NCT04432259","Oral Dexamethasone as an Intervention for Postoperative Pain and Nausea Management in Total Knee Arthroplasty","Inclusion Criteria:\n\n* adult patients age 18 and older who will be undergoing joint replacement\n\nExclusion Criteria:\n\n* Patients with uncontrolled diabetes ( HbA1C, \\>7.5%), impaired hepatic function (Child class, \\>B), impaired renal failure (Glomerular filtration rate \\\u003C60 mL\u002Fmin\u002F1.73 m2), chronic narcotic use, alcohol and\u002For opioid dependence, patients with a known adverse reaction to corticosteroids, and patients unable to give informed consent.",{"count":274,"type":22},300,[139],"This study aims to determine if oral dexamethasone provides clinically significant improvement in postoperative outcomes, specifically nausea and pain scores.",[278,28,27],"Arthritis Knee","2020-06-12",{"date":281,"type":34},"2020-06-16",{"date":283,"type":22},"2020-07",{"date":285,"type":22},"2022-12",{"name":287,"class":40},"Henry Ford Health System"]