[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"postoperative-neurocognitive-disorder\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:postoperative-neurocognitive-disorder":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,8,0,[8,53,88,111,140,170,198,222],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":22,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":35,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":41,"lastUpdatePostDateStruct":42,"startDateStruct":45,"completionDateStruct":47,"leadSponsor":49,"locationsCount":52},"100643122","the-effects-of-anesthesia-on-postoperative-cognitive-functions-in-patients-undergoing-sleeve-gastrectomy-100643122",false,"NCT07637357","The Effects of Anesthesia on Postoperative Cognitive Functions in Patients Undergoing Sleeve Gastrectomy","The Effects of Total Intravenous Anesthesia and Inhalational Anesthesia on Postoperative Cognitive Functions in Patients Undergoing Sleeve Gastrectomy","Inclusion Criteria:\n\nPatients of both sexes, Patients Aged between 18 and 65 years, Patients classified as ASA(American Society of Anesthesiologists) physical status I- III, Patients with a BMI (Body Mass Index) between 35 and 50 kg\u002Fm² scheduled to undergo sleeve gastrectomy as a type of bariatric surgery for the first time.\n\nExclusion Criteria:\n\nPatients classified as ASA physical status 4 or high, Patients with known allergy to any of the drugs used in the study, Patients with bleeding disorders, Patients with serum creatinine levels \\>2 mg\u002FdL, Patients with severe arrhythmias and EF\\\u003C30%, Patients with a known history of drug abuse are excluded.","ALL","18 Years","65 Years",{"count":20,"type":21},60,"ESTIMATED","3 Months","OBSERVATIONAL","In this study, the investigators want to examine the effects of intravenous anesthetic drugs and gases on cognitive functions in the postoperative period in individuals who will undergo surgery for obesity. The investigators believe that the anesthesia method we apply with inhalation gases is also as reliable method as total intravenous anesthesia for postoperative cognitive functions in these patients who undergoe sleeve gastrectomy.\n\nThe anesthesia method applied intravenously and with inahalational gases have been applied safely for many years. Comparisons between these two anesthesia technics in obese individuals and for postoperative cognitive dysfunctions are limited.\n\nStudies on the examination of cognitive functions in postoperative patients have gained momentum with the use of neuropsychiatric tests performed on patients who have undergone cardiac surgery and these tests have also been performed on individuals who have undergone non-cardiac surgery. And yet, similar declines in cognitive functions have been observed. For these reasons, the effects of surgery itself and anesthesia methods on cognitive functions have been studied up to date.\n\nIn this study, the investigators plan to evaluate patients who will undergo obesity surgery in both anesthesia methods by the recovery times from anesthesia and the residual effects of anesthesia, and after awakening they plan to evaluate their cognitive functions with neuropsychiatric tests that will be performed at certain intervals.",[26,27,28,29,30,31,32,33,34],"POCD - Postoperative Cognitive Dysfunction","Recovery Time","Postoperative Neurocognitive Disorder","Postoperative Delirium","Bariatric Sleeve Gastrectomy","Delayed Neurocognitive Recovery","Total Intravenous Anesthesia","Inhalational Anesthesia","Cognitive Functions",[36,37,38,39],"total intravenous anesthesia","inhalational anesthesia","sleeve gastrectomy","postoperative cognitive dysfunctions","RECRUITING","2026-06-04",{"date":43,"type":44},"2026-06-09","ACTUAL",{"date":46,"type":44},"2025-09-30",{"date":48,"type":21},"2026-07-30",{"name":50,"class":51},"Sehit Prof. Dr. Ilhan Varank Sancaktepe Training and Research Hospital","OTHER",1,{"id":54,"slug":55,"hasResults":11,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":4,"eligibilityCriteria":59,"healthyVolunteers":11,"sex":16,"minAge":18,"maxAge":4,"enrollmentInfo":60,"targetDuration":4,"studyType":62,"phases":63,"briefSummary":65,"conditions":66,"keywords":72,"overallStatus":78,"whyStopped":4,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":87},"100519351","prediction-and-prevention-of-postoperative-mortality-and-morbidity-100519351","NCT06042413","Prediction and Prevention of Postoperative Mortality and Morbidity","Real-world and Innovative Multimodal Prediction and Prevention of Postoperative Mortality and Multi-morbidities","Part I Inclusion Criteria:\n\n* 65 years of age and older\n* Identified as higher risk (≥2.5%) for 30-day mortality and MACCE based on the UPMC's Perioperative Model (EHR risk prediction algorithm)\n* Scheduled for major cardiac surgeries including coronary artery bypass and valvular repair and\u002For vascular surgeries including carotid endarterectomy, aortic aneurysm repair, and major vascular surgeries\n* RAI score ≥ 30\n* Informed consent\n* English speaking patients\n\nPart II Inclusion Criteria:\n\n* Enrolled in Aim 1 \u002F Part I Preoperative Intervention Trial\n* Scheduled for high-risk, cardiac or vascular surgery requiring intraoperative neurophysiological monitoring (IONM)\n* Moderate and high risk for mortality based on Society of Thoracic Surgery score (score \\>4)\n\nPart I Exclusion Criteria:\n\n* Children (\\\u003C18 years)\n* Patients unable to provide consent\n* Participants undergoing same day procedures or operations (discharged same day)\n* Patients with severe preoperative medical diseases such as blindness or significant visual impairment, unresolved motor weakness, or any other perioperative events or complications that would have a bearing on the patient's ability to perform study tasks, neuropsychological tests, and proposed interventions\n\nPart II Exclusion Criteria:\n\n* Pregnant women\n* Patients do not provide consent.\n* Patients are unable to participate in cognitive and other behavioral assessment due to physical limitations\n* Patients refuse any blood transfusions during surgery",{"count":61,"type":21},1200,"INTERVENTIONAL",[64],"NA","This study will contribute to creating a prospective and automated preoperative risk assessment algorithm for predicting 30-day mortality, major adverse cardiac and cerebrovascular events (MACCE), and postoperative neurocognitive outcomes following elective cardiac and vascular surgery in older adults. It will evaluate associations between perioperative factors and longer-term neurocognitive outcomes, including postoperative neurocognitive disorder and dementia. In addition, this study will assess scalable, multimodal preoperative and intraoperative interventions to improve perioperative outcomes.\n\nThis study will explore two main hypotheses:\n\n1. Preoperative personalized prehabilitation with proactive cognitive and behavioral interventions will improve postoperative cognitive outcomes, morbidity, and mortality in high-risk elderly surgical patients.\n2. Proactive bundled intraoperative interventions are superior to reactive standard of care in reducing postoperative cognitive outcomes, MACCE, and mortality.\n\nExpected Outcome: Improved EHR algorithm will have higher predictive accuracy for MACCE and mortality while predicting postoperative cognitive outcomes.",[67,68,28,69,70,71],"Dementia","Postoperative Delirium (POD)","Major Adverse Cardiac and Cerebrovascular Events","Perioperative Complications","Postoperative Cognitive Decline",[73,74,75,76,77],"MACCE","Cognitive decline","Perioperative brain health","Neurocognitive disorder","Postoperative delirium","NOT_YET_RECRUITING","2026-06-02",{"date":41,"type":44},{"date":82,"type":21},"2026-06",{"date":84,"type":21},"2027-06",{"name":86,"class":51},"University of Pittsburgh",5,{"id":89,"slug":90,"hasResults":11,"nctId":91,"briefTitle":92,"officialTitle":93,"acronym":94,"eligibilityCriteria":95,"healthyVolunteers":11,"sex":16,"minAge":18,"maxAge":4,"enrollmentInfo":96,"targetDuration":4,"studyType":62,"phases":98,"briefSummary":99,"conditions":100,"keywords":4,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":102,"lastUpdatePostDateStruct":103,"startDateStruct":105,"completionDateStruct":107,"leadSponsor":109,"locationsCount":52},"100544928","digital-sleep-optimization-for-brain-health-outcomes-in-older-surgical-patients-100544928","NCT06375265","Digital Sleep Optimization for Brain Health Outcomes in Older Surgical Patients","A Pilot Study of Digital Sleep Optimization for Brain Health Outcomes in Older Surgical Patients (SLEEP-BOOST)","SLEEP-BOOST","Inclusion Criteria:\n\n1. Adults ≥ 65 years old\n2. Scheduled for an elective orthopedic total joint replacement procedure (knee\u002Fhip)\n3. At least mild insomnia (ISI score of ≥10 on telephone screening or RedCap screening questionnaire)\n\n5\\. Own a smart phone 6. Willingness to use the dCBT-I app and actigraphy.\n\nExclusion Criteria:\n\n1. Current or previous CBT-I exposure in the last 6 months prior to the start of the study\n2. Rapidly progressive illnesses\u002Flife expectancy \\\u003C6 months\n3. Active psychosis\u002Fsuicidal ideation\n4. Irregular shift work\u002Fsleep patterns\n5. Moderate-severe sleep apnea (apnea\u002Fhypopnea index ≥15) without CPAP compliance per chart review\n6. Sleep disorders other than insomnia or apnea\n7. Cognitive impairment (diagnosis of dementia)\n8. Initiation, discontinuation, or dose change of sleep-affecting prescription medications within 1 month prior to study start or during the intervention period; not excluded if stable sleep-affecting medications in the prior month (by clinical review)\n9. No surgery within 12 months of consented, eligibility will be reassessed if surgery is delayed by more than 3 months",{"count":97,"type":21},50,[64],"The Sleep Optimization for Brain Health Outcomes in Older Surgical Patients (SLEEP-BOOST) is a pilot randomized, controlled, singled-blinded (participant) trial in major orthopedic joint surgery patients that will build on a previously clinically tested cognitive behavioral therapy for insomnia (CBT-I) mobile application paired with a wearable device (wrist actigraphy).",[101,29,31,28],"Insomnia","2026-05-11",{"date":104,"type":44},"2026-05-14",{"date":106,"type":44},"2025-01-15",{"date":108,"type":21},"2026-12-31",{"name":110,"class":51},"Massachusetts General Hospital",{"id":112,"slug":113,"hasResults":11,"nctId":114,"briefTitle":115,"officialTitle":116,"acronym":117,"eligibilityCriteria":118,"healthyVolunteers":11,"sex":16,"minAge":119,"maxAge":4,"enrollmentInfo":120,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":122,"conditions":123,"keywords":4,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":131,"lastUpdatePostDateStruct":132,"startDateStruct":134,"completionDateStruct":136,"leadSponsor":138,"locationsCount":52},"100608374","the-role-of-neuroinflammation-on-neurocognitive-outcome-in-cardiac-surgery-100608374","NCT07200726","The Role of Neuroinflammation on Neurocognitive Outcome in Cardiac Surgery","The Role of Neuroinflammation on Neurocognitive Outcome in Cardiac Surgery: INOCS Study","INOCS","Inclusion Criteria:\n\n* aged 60 years or older;\n* scheduled for cardiac surgery.\n\nExclusion Criteria:\n\n* dementia, as diagnosed by a specialist, since this would make detection of PNCD impossible;\n* urgent, not elective surgery.","60 Years",{"count":121,"type":21},80,"RATIONALE: Postoperative cognitive changes are common after cardiac surgery and can be categorised into three main types: postoperative delirium (POD), delayed neurocognitive recovery (DNCR) and postoperative neurocognitive disorder (PNCD). DNCR is diagnosed until postoperative day 30 and PNCD is diagnosed at least 30 days after the operation. Both conditions can be mild or major, and can affect the quality of life of these patients.\n\nThe incidence of PNCD in cardiac surgery is around 40%. Despite this high incidence, screening for PNCD is absent in current postoperative care since the diagnosis of PNCD is difficult and very time intensive. Furthermore, the underlying pathogenesis is incompletely understood.\n\nThe identification of a biomarker and\u002For validated short diagnostic instrument would be of paramount importance to easily identify patients at risk, or to diagnose patients with PNCD in order to identify therapeutical pathways for this disease.\n\nOBJECTIVES: The main objective of this prospective clinical trial is to evaluate the performance of the short NPA and\u002For biochemical markers for the diagnosis of DNCR and PNCD in cardiac surgery patients aged 60 years or older.\n\nSTUDY DESIGN: Single-centre interventional observational study\n\nSTUDY INTERVENTIONS: Patients will undergo a neurophysiological assessment (NPA) pre-operatively and at two timepoints post-operatively, namely 6 (+\u002F-1) days and 40 (+\u002F- 10) days after surgery. During the stay at the intensive care unit, they will be screened daily for delirium, using the CAM-ICU and 3D-CAM.\n\nTo evaluate whether the development of DNCR or POD has an important effect on quality of recovery , the quality of recovery scale 15 (QOR-15), muscle strength (handgrip strength) and the Chalder fatigue score will be scored post-operative (postop day 1, 3 and 5). To evaluate whether PNCD has an effect on quality of live the EQ5D5L score will be measured at 40 (+\u002F- 10) days after surgery, compared to preoperative values.\n\nOn several time points, blood samples will be drawn to measure markers of neuroinflammation. The time points will be preoperatively, at the moment of arrival on ICU, postoperative day 1, 2 and 3, if still on ICU. Two repeat blood sample will be taken at the moment of NPA performed after 6 (+\u002F- 1) days and 40 (+\u002F- 10) days after surgery, if the patient is willing (not obligatory).\n\nSTUDY POPULATION:\n\nPatients aged 60 years or older who are scheduled for cardiac surgery.\n\nInclusion criteria:\n\n* aged 60 years or older;\n* scheduled for cardiac surgery.\n\nExclusion criteria:\n\n* dementia, as diagnosed by a neurologist;\n* urgent, not elective surgery.\n\nMAIN STUDY ENDPOINTS:\n\nPrimary outcome PNCD defined as a decline of \\> 1 SD on \\> 2 tests in one or more cognitive domains or a decline of \\> 1 SD on total cognitive domain score.\n\nSecondary outcomes Postoperative delirium - CAM-ICU will be evaluated twice daily (morning and evening) on every day when the patient is awake (not intubated) on the ICU. This is standard of care and is part of the routine clinical care in the hospital. Furthermore, once daily a 3D-CAM will be performed on day 1, 3 and 5.\n\nQuality of recovery\n\n* QOR-15, a validated measurement of quality of recovery in the short term postoperative recovery, will be evaluated pre-operatively and postoperatively day 1, 3 and 5.\n* EQ5D5L, a validated measurement of quality of recovery in the long term postoperative recovery, will be evaluated preoperatively and at the moment of the third NPA measurement.\n* Postoperative muscle function (upper extremity, by hand grip strength) on day 1, 3 and 5 after surgery and at the moment of the second and third NPA measurement (being day 6 (+\u002F-1) and day 40 (+\u002F-10) postoperatively), as compared to preoperative values.\n* Chalder Fatigue questionnaire on day 1, 3 and day 5 and on the second and third NPA measurement, as compared to preoperative.\n\nBiochemical analysis\n\n\\- Blood samples will be drawn for analysis before induction of anaesthesia (preoperatively), at the end of the operation (immediately postoperatively on arrival in ICU), on day 1, 2 and 3 postoperatively (if still at the ICU) and at the time of the postoperative follow-up visits with the NPA testing (day 6 (+\u002F-1) and day 40 (+\u002F-10) days post-surgery).\n\nAt each time point, markers of neuroinflammation and -degeneration will be determined.\n\nTertiary outcomes\n\n* Length of CPB\n* Duration of mechanical ventilation\n* Administered anaesthetic drugs during surgery\n* Transfusion need\n* Length of ICU stay (days)\n* Length of in-hospital stay (days)\n* Readmission to ICU or hospital within 28 days after surgery\n* Cardiovascular outcome: atrial fibrillation, , thrombo-embolic events, myocardial injury, myocardial infarction, cardiac arrest, cardiac death\n* Pulmonary outcome: postoperative pulmonary complications, postoperative pneumonia, postoperative respiratory failure\n* Postoperative infection within 28 days after surgery",[124,28,125,126,127,128,129,130],"Postoperative Neurocognitive Dysfunction","Cardiac Surgery","Major Surgery Under General Anesthesia","Major Surgery in Adult Patients","Postoperative Fatigue","Elderly Patients","Quality of Recovery","2026-04-07",{"date":133,"type":44},"2026-04-08",{"date":135,"type":44},"2025-10-21",{"date":137,"type":21},"2026-10",{"name":139,"class":51},"Ziekenhuis Oost-Limburg",{"id":141,"slug":142,"hasResults":11,"nctId":143,"briefTitle":144,"officialTitle":145,"acronym":4,"eligibilityCriteria":146,"healthyVolunteers":11,"sex":16,"minAge":18,"maxAge":4,"enrollmentInfo":147,"targetDuration":4,"studyType":62,"phases":149,"briefSummary":150,"conditions":151,"keywords":155,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":161,"lastUpdatePostDateStruct":162,"startDateStruct":164,"completionDateStruct":165,"leadSponsor":167,"locationsCount":169},"100553181","repetitive-transcranial-magnetic-stimulation-and-postoperative-neurocognitive-recovery-100553181","NCT06482749","Repetitive Transcranial Magnetic Stimulation and Postoperative Neurocognitive Recovery","Impact of Repetitive Transcranial Magnetic Stimulation on Postoperative Neurocognitive Recovery in Older Patients With Preoperative Cognitive Impairment: A Randomized, Double-blinded, Sham-controlled Trial","Inclusion Criteria:\n\n1. Aged ≥65 years;\n2. Patients with preoperative mild to moderate cognitive impairment, defined as 9\\\u003CMontreal Cognitive Assessment (MoCA)\\\u003C26;\n3. Scheduled for elective non-cardiac surgery under general anesthesia, with an expected surgical duration of \\>2 hours;\n4. Expected to stay in hospital for at least 5 days after surgery.\n\nExclusion Criteria:\n\n1. Left-handed;\n2. Primary school education level or below;\n3. Comorbid diseases including mental illness, intellectual disability, auditory and visual dysfunction, language impairment, severe neurological disorders, or other diseases that impede the completion of evaluation;\n4. Neurosurgery;\n5. Presence of contraindications to rTMS treatment, including epilepsy, pregnant or lactating women, or with a metal or electric implanted device (e.g., deep brain stimulator, ventriculoperitoneal shunt, aneurysm clip, pacemaker, cochlear implant, or surgical staples on the scalp);\n6. Other situations that are deemed unsuitable for inclusion in the study.",{"count":148,"type":21},568,[64],"Patients with preoperative cognitive impairment are at increased risks of delayed neurocognitive recovery (DNR) and postoperative neurocognitive disorder (POCD). Repetitive transcranial magnetic stimulation (rTMS) has been used to improve cognitive function in patients with cognitive impairement. This trial is designed to compare the effects of rTMS versus sham intervention on postoperative neurocognitive function in patients with preoperative cognitive impairment.",[152,153,154,31,28],"Older Patients","Cognitive Impairment","Repetitive Transcranial Magnetic Stimulation",[156,157,158,159,160],"Older patients","Cognitive impairment","Repetitive transcranial magnetic stimulation","Delayed neurocognitive recovery","Postoperative neurocognitive disorder","2025-07-28",{"date":163,"type":44},"2025-07-31",{"date":161,"type":44},{"date":166,"type":21},"2029-02",{"name":168,"class":51},"Peking University First Hospital",3,{"id":171,"slug":172,"hasResults":11,"nctId":173,"briefTitle":174,"officialTitle":175,"acronym":4,"eligibilityCriteria":176,"healthyVolunteers":11,"sex":16,"minAge":18,"maxAge":177,"enrollmentInfo":178,"targetDuration":180,"studyType":23,"phases":4,"briefSummary":181,"conditions":182,"keywords":184,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":189,"lastUpdatePostDateStruct":190,"startDateStruct":192,"completionDateStruct":194,"leadSponsor":196,"locationsCount":52},"100551900","correlation-analysis-of-pod-and-pncd-in-elderly-patients-with-gastrointestinal-neoplasms-100551900","NCT06466096","Correlation Analysis of POD and pNCD in Elderly Patients With Gastrointestinal Neoplasms","Correlation Analysis of Postoperative Delirium and Postoperative Neurocognitive Disorder in Elderly Patients With Gastrointestinal Neoplasms","Inclusion Criteria:\n\n* Patients ≥65 years of age who have undergone surgical anesthesia of gastrointestinal neoplasms; Sign informed consent.\n\nExclusion Criteria:\n\n* Inability to complete cognitive function assessment; Illiteracy, hearing impairment or visual impairment; He has a history of epilepsy, depression, schizophrenia, Alzheimer's disease and other psychiatric and neurological diseases.","100 Years",{"count":179,"type":21},165,"1 Year","This is a prospective cohort study to explore the differences of serum indicators between elderly gastrointestinal neoplasms patients with postoperative delirium (POD) who either develop or do not develop long-term postoperative neurocognitive disorders (pNCD).",[29,28,183],"Gastrointestinal Surgery",[185,186,187,188],"postoperative delirium","postoperative neurocognitive disorder","serum indicators","gastrointestinal neoplasms surgery","2025-03-30",{"date":191,"type":44},"2025-04-03",{"date":193,"type":44},"2024-10-18",{"date":195,"type":21},"2026-07-01",{"name":197,"class":51},"Xuanwu Hospital, Beijing",{"id":199,"slug":200,"hasResults":11,"nctId":201,"briefTitle":202,"officialTitle":203,"acronym":4,"eligibilityCriteria":204,"healthyVolunteers":11,"sex":16,"minAge":18,"maxAge":177,"enrollmentInfo":205,"targetDuration":180,"studyType":23,"phases":4,"briefSummary":207,"conditions":208,"keywords":210,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":189,"lastUpdatePostDateStruct":216,"startDateStruct":217,"completionDateStruct":219,"leadSponsor":221,"locationsCount":52},"100548634","risk-warning-model-of-postoperative-delirium-and-long-term-cognitive-dysfunction-in-elderly-patients-100548634","NCT06423547","Risk Warning Model of Postoperative Delirium and Long-term Cognitive Dysfunction in Elderly Patients","Risk Warning Model of Postoperative Delirium and Long-term Cognitive Dysfunction in Elderly Patients Based on Autonomous Evolutionary Neural Network Algorithm","Inclusion Criteria:\n\n* Patients ≥65 years of age who have undergone surgical anesthesia; Sign informed consent\n\nExclusion Criteria:\n\n* Inability to complete cognitive function assessment; Illiteracy, hearing impairment or visual impairment; He has a history of epilepsy, depression, schizophrenia, Alzheimer's disease and other psychiatric and neurological diseases",{"count":206,"type":21},10000,"The incidence of postoperative delirium in elderly patients is high, which can lead to long-term postoperative neurocognitive disorders. Its high risk factors are not yet clear. At present, there is a lack of early diagnosis and alarm technology for perioperative neurocognitive disorders, which can not achieve early intervention and effective treatment. By artificial intelligence and autonomously evolutionary neural network algorithm, relying on multi-source clinical big data, we explored the use of Bayesian network to optimize the anesthesia decision-making system in enhanced recovery after surgery, and established risk prediction model for perioperative critical events. It is expected that this method will also help to establish a risk prediction model for postoperative delirium and long-term postoperative neurocognitive disorders. This project plans to collect the perioperative sensitive parameters of anesthesia machine, multi-parameter monitor, EEG monitor,fMRI and HIS system, to explore the evolution process of data characteristics by feature fusion.We also plan to quickly screen key perioperative risk characteristics of postoperative delirium from massive clinical data through feature selection, to explore the high risk factors of long-term postoperative neurocognitive disorders developing from postoperative delirium. Finally, with multi-center intelligent analysis，the risk prediction model of postoperative delirium and long-term postoperative neurocognitive disorders will be constructed.",[29,28,209],"Surgery",[211,212,213,214,215],"postoperative delirium;","postoperative neurocognitive disorder;","risk prediction model;","artificial intelligence;","evolutionary neural network",{"date":191,"type":44},{"date":218,"type":44},"2024-07-30",{"date":220,"type":21},"2027-12-31",{"name":197,"class":51},{"id":223,"slug":224,"hasResults":11,"nctId":225,"briefTitle":226,"officialTitle":227,"acronym":4,"eligibilityCriteria":228,"healthyVolunteers":11,"sex":16,"minAge":18,"maxAge":177,"enrollmentInfo":229,"targetDuration":180,"studyType":23,"phases":4,"briefSummary":230,"conditions":231,"keywords":233,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":189,"lastUpdatePostDateStruct":236,"startDateStruct":237,"completionDateStruct":239,"leadSponsor":240,"locationsCount":52},"100551899","correlation-analysis-of-pod-and-pncd-in-elderly-spinal-surgery-patients-100551899","NCT06466083","Correlation Analysis of POD and pNCD in Elderly Spinal Surgery Patients","Correlation Analysis of Postoperative Delirium and Postoperative Neurocognitive Disorder in Elderly Spinal Surgery Patients","Inclusion Criteria:\n\n* Patients ≥65 years of age who have undergone spinal surgery anesthesia; Sign informed consent\n\nExclusion Criteria:\n\n* Inability to complete cognitive function assessment; Illiteracy, hearing impairment or visual impairment; He has a history of epilepsy, depression, schizophrenia, Alzheimer's disease and other psychiatric and neurological diseases",{"count":179,"type":21},"This study is a prospective cohort study to investigate the differences in serum indexes between elderly spinal surgery patients with postoperative delirium (POD) who either develop or do not develop long-term postoperative neurocognitive disorders (pNCD).",[29,28,232],"Spinal Surgery",[185,186,234,235],"serum indexes","spinal surgery",{"date":191,"type":44},{"date":238,"type":44},"2025-01-14",{"date":195,"type":21},{"name":197,"class":51}]