[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"postoperative-neuronal-injury\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:postoperative-neuronal-injury":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":34,"leadSponsor":36,"locationsCount":5},"100625247","remote-ischemic-preconditioning-and-postoperative-neuronal-injury-100625247",false,"NCT07420153","Remote Ischemic Preconditioning and Postoperative Neuronal Injury","Remote Ischemic Preconditioning and Postoperative Neuronal Injury in Non-Cardiac Surgery Patients: A Randomized Trial","SHIELD","Inclusion criteria:\n\n* patients (≥50 years) scheduled for elective non-cardiac surgery with general anesthesia\n* patients at risk for postoperative delirium, defined as the presence of ≥2 of the following established risk factors: age ≥65 years, American Society of Anesthesiologists physical status classification of ≥III, Charlson Comorbidity, planned surgical duration \\>180 minutes, polypharmacy (regular intake of more than five medications), symptoms of depression (Patient Health Questionnaire-9 ≥10 points)\n\nExclusion criteria:\n\n* patients in whom RIPC cannot be safely applied due to relevant peripheral arterial disease (defined as Fontaine stage ≥II), lymphedema, recent upper-arm surgery, trauma, or skin lesions at the arm\n* patients with acute coronary syndrome (within the past month)\n* patients with surgery in the previous month\n* patients with intracranial surgery\n* patients with pre-existing delirium\n* patients with severe cognitive impairment preventing reliable delirium assessment\n* patients with current treatment with sulfonamides due to potential interference with ischemic preconditioning mechanisms\n* patients with previous participation in the SHIELD trial","ALL","50 Years",{"count":20,"type":21},216,"ESTIMATED","INTERVENTIONAL",[24],"NA","The SHIELD trial is a single-center, randomized, controlled, parallel-group, single-blinded clinical trial investigating whether performing RIPC one day before surgery-compared to not performing RIPC-reduces postoperative neuronal injury, as reflected by the maximum serum NfL concentration within the first 2 postoperative days, in non-cardiac surgery patients at risk for postoperative delirium.",[27],"Postoperative Neuronal Injury","RECRUITING","2026-03-02",{"date":31,"type":32},"2026-03-04","ACTUAL",{"date":29,"type":32},{"date":35,"type":21},"2027-09",{"name":37,"class":38},"University of Hamburg-Eppendorf","OTHER"]