[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"postoperative-pain-after-endodontic-treatment\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:postoperative-pain-after-endodontic-treatment":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,44,72],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100642280","effect-of-niti-systems-and-xp-endo-finisher-on-postoperative-pain-100642280",false,"NCT07642596","EFFECT OF NITI SYSTEMS AND XP-ENDO FINISHER ON POSTOPERATIVE PAIN","EVALUATION OF THE EFFECT OF RECIPROCATING AND ROTARY NICKEL-TITANIUM FILE SYSTEMS USED IN COMBINATION WITH XP-ENDO FINISHER ON POSTOPERATIVE PAIN FOLLOWING ROOT CANAL TREATMENT","Inclusion Criteria:\n\n* Age 18-65 years. Healthy volunteers. Mandibular molar teeth with pulpal necrosis, asymptomatic status, chronic apical periodontitis, and periapical radiolucent lesion.\n\nWritten informed consent.\n\nExclusion Criteria:\n\n* Patients who have taken analgesic or anti-inflammatory drugs within the last 12 hours.\n\nPatients with allergy to non-steroidal anti-inflammatory drugs or local anesthetics.\n\nPregnant or lactating patients. Patients with a history of gastrointestinal diseases. Patients using opioid medications. Teeth with calcified canals, resorptive defects, or complex root canal anatomy. Patients with severe periodontal disease. Patients with acute or chronic apical abscess or signs of systemic infection. Immunosuppressed patients.",true,"ALL","18 Years","65 Years",{"count":21,"type":22},80,"ESTIMATED","INTERVENTIONAL",[25],"NA","Title\n\nEvaluation of the Effect of Reciprocal and Rotational NiTi File Systems and XP-Endo Finisher Combination on Postoperative Pain\n\nClinical Research Protocol Summary Objective\n\nThe aim of this study is to compare the effects of different NiTi file systems (FKG Race Evo and One Reci) and their combination with XP-Endo Finisher on postoperative pain. The study intends to evaluate how these two different file systems and XP-Endo Finisher influence patients' pain levels after endodontic treatment. It is also hypothesized that XP-Endo Finisher may play an important role in reducing postoperative pain by enhancing irrigation efficacy. This study is expected to contribute clinically significant findings to the limited literature on this topic.\n\nBackground\n\nEndodontic treatment is a procedure performed to mechanically shape, disinfect, and hermetically seal teeth with pulpal damage or periapical lesions caused by caries or trauma. The success of treatment depends on proper shaping within biological limits, effective disinfection, preservation of apical constriction, and removal of bacteria from canal walls.\n\nNiTi alloys have improved canal shaping efficiency due to their flexibility and shape memory properties. Rotary and reciprocating NiTi systems each offer different clinical advantages. Rotary systems provide efficient shaping through continuous rotation, while reciprocating systems offer a minimally invasive approach using a single file.\n\nPostoperative pain is a common complication after endodontic treatment and may vary depending on instrumentation technique, irrigation protocol, and clinical conditions.\n\nIrrigation is essential for removing microorganisms and debris from the canal system. Conventional irrigation techniques may be insufficient to reach apical areas effectively. Therefore, advanced systems such as XP-Endo Finisher have been developed to improve irrigant penetration and enhance cleaning efficiency.\n\nFKG Race Evo is a rotary NiTi system with high cyclic fatigue resistance, while One Reci is a reciprocating single-file system that offers safe shaping with reduced procedural errors. This study will evaluate the postoperative pain outcomes of these systems in combination with XP-Endo Finisher.\n\nMaterials and Methods\n\nThe materials used in this study include FKG Race Evo and One Reci NiTi file systems, XP-Endo Finisher, 2.5% sodium hypochlorite (NaOCl), 17% EDTA, and saline solution.\n\nThe study will be conducted on 80 patients attending the Department of Endodontics, Faculty of Dentistry, Eskisehir Osmangazi University. Healthy individuals aged 18-65 years with chronic apical periodontitis or periapical radiolucent lesions will be included. Written informed consent will be obtained from all participants.\n\nPatients will be randomly divided into four groups:\n\nGroup 1: Instrumentation with FKG Race Evo 25\u002F06 Group 2: FKG Race Evo 25\u002F06 followed by XP-Endo Finisher irrigation Group 3: Instrumentation with One Reci 25\u002F06 Group 4: One Reci 25\u002F06 followed by XP-Endo Finisher irrigation\n\nAll procedures will be performed under rubber dam isolation and local anesthesia. Canal shaping will be performed according to the assigned system, with irrigation performed after each file change. Obturation will be completed in the second session.\n\nSample Size Calculation\n\nThe sample size was calculated using G\\*Power software (3.1.9.4; Heinrich Heine University, Düsseldorf, Germany). The calculation was based on a 5% type I error (alpha), 95% power (1-β), and an effect size of 0.587 (f), derived from a previous study. A total of 80 participants was determined to be sufficient to detect statistically significant differences between groups. Each group will include 20 patients.\n\nStatistical Analysis\n\nAll data will be recorded electronically with strict confidentiality. Only authorized researchers will have access to the dataset.\n\nStatistical analysis will be performed using appropriate software. The choice of statistical tests will depend on data distribution.\n\nStudy results may be published in national or international peer-reviewed journals in accordance with ethical and legal requirements. All data will be anonymized to protect participant confidentiality, and secure electronic storage will be used to prevent unauthorized access.",[28],"Postoperative Pain After Endodontic Treatment",[30],"Postoperative pain NiTi rotary files NiTi reciprocating files FKG Race Evo One Reci XP-Endo Finisher","RECRUITING","2026-06-10",{"date":34,"type":35},"2026-06-11","ACTUAL",{"date":37,"type":35},"2026-02-13",{"date":39,"type":22},"2027-04-30",{"name":41,"class":42},"BUSRA OZTURK","OTHER",2,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":50,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":52,"targetDuration":4,"studyType":23,"phases":54,"briefSummary":55,"conditions":56,"keywords":58,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":4},"100613816","postoperative-pain-after-single-vs-multiple-visit-root-canal-treatment-in-diabetic-patients-100613816","NCT07271511","Postoperative Pain After Single vs Multiple-Visit Root Canal Treatment in Diabetic Patients","Comparative Analysis of Postoperative Pain Following Single vs Multiple-Visit Root Canal Therapy in Single-Rooted Teeth of Diabetic Patients: A Randomized Controlled Trial","RCT-DM-Pain","Inclusion Criteria:Patients aged between 12 and 60 years.\n\nDiagnosed with Type 1 or Type 2 Diabetes Mellitus.\n\nIn need of root canal treatment on a single-rooted tooth.\n\nA clinical diagnosis of either irreversible pulpitis or necrotic pulp in the indicated tooth.\n\nWillingness and ability to understand and provide written informed consent (and assent with parental consent for minors).\n\n\\-\n\nExclusion Criteria:\n\n* Pregnancy.\n\nKnown history of allergy to local anesthetics.\n\nPresence of large periapical radiolucent lesions (typically defined as \\>5mm in diameter).\n\nCurrent use of long-term analgesic or anti-inflammatory medication (which could alter pain perception).\n\nTeeth with complex root canal anatomy (e.g., calcified canals, C-shaped canals) that would complicate standard treatment.",{"count":53,"type":22},200,[25],"A short description of the clinical study, including a brief statement of the clinical study's hypothesis, written in language intended for the lay public.",[57,28],"Diabetes Mellitus",[59,60,61],"Single-Visit Endodontics","Multiple-Visit Endodontic","Root canal therapy","NOT_YET_RECRUITING","2026-03-16",{"date":65,"type":35},"2026-03-18",{"date":67,"type":22},"2026-05-15",{"date":69,"type":22},"2026-06-15",{"name":71,"class":42},"College of Physicians and Surgeons Pakistan",{"id":73,"slug":74,"hasResults":11,"nctId":75,"briefTitle":76,"officialTitle":77,"acronym":4,"eligibilityCriteria":78,"healthyVolunteers":11,"sex":79,"minAge":18,"maxAge":80,"enrollmentInfo":81,"targetDuration":4,"studyType":23,"phases":83,"briefSummary":84,"conditions":85,"keywords":89,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":103},"100611355","a-randomized-controlled-trial-evaluating-whether-pre-operative-trinase-reduces-post-operative-pain-in-patients-with-symptomatic-irreversible-pulpitis-compared-to-placebo-using-vas-scores-and-analgesic-intake-over-48-hours-100611355","NCT07239505","A Randomized Controlled Trial Evaluating Whether Pre-operative Trinase Reduces Post-operative Pain in Patients With Symptomatic Irreversible Pulpitis Compared to Placebo, Using VAS Scores and Analgesic Intake Over 48 Hours.","The Role Of Trinase In Reducing Post-Operative Pain For Patients With Symptomatic Irreversible Pulpitis: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Systemically healthy male patients (ASA I or II)\n* Aged 18 to 50 years\n* Presenting with symptomatic irreversible pulpitis in a restorable mandibular molar\n* Preoperative moderate to severe pain (VAS ≥45 mm)\n* Normal periapical tissue (no radiolucency, pocket depth ≤5 mm, mobility ≤ Grade I)\n\nExclusion Criteria:\n\nMedically compromised patients (ASA III or higher)\n\n* History of allergy or intolerance to Trinase or any of its components (trypsin, bromelain, rutin)\n* Vertical root fracture\n* External or internal root resorption\n* Periodontal pocket depth \\>5 mm\n* Tooth mobility Grade II or III\n* Presence of periapical lesion (radiolucency)\n* Female patients (to standardize pain perception and hormonal factors)","MALE","50 Years",{"count":82,"type":22},182,[25],"This study aims to determine whether Trinase, an enzyme-based anti-inflammatory medication, can reduce pain after root canal treatment in patients with symptomatic irreversible pulpitis. A total of 182 male patients aged 18 to 50 years who present with moderate to severe tooth pain will be randomly assigned to receive either a Trinase tablet or a placebo 30 minutes before treatment. All root canal procedures will be performed in a single visit using standard endodontic techniques.\n\nPain levels will be measured on a Visual Analogue Scale (VAS) before treatment and at 6, 12, 24, and 48 hours after treatment. Patients will also record the number of pain-relief tablets they take during the first 48 hours. The goal of the study is to see whether Trinase can lower post-operative pain and reduce the need for analgesic medication compared with placebo. This information may help improve pain management for patients undergoing root canal therapy.",[86,28,87,88],"Symptomatic Irreversible Pulpitis (SIP)","Endodontic Disease","Dental Pain",[90,91,92,93],"Visual Analogue Scale (VAS)","Randomized Controlled Trial","Trinase","Postoperative Pain","2025-11-27",{"date":96,"type":35},"2025-12-01",{"date":98,"type":35},"2025-08-01",{"date":100,"type":22},"2025-12-15",{"name":102,"class":42},"Fayoum University",1]