[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"postoperative-pain-chronic\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:postoperative-pain-chronic":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,47],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":31,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100533156","recovering-from-bariatric-surgery-the-effects-of-early-initiated-and-supervised-mobilization-100533156",false,"NCT06222151","Recovering From Bariatric Surgery: the Effects of Early Initiated and Supervised Mobilization","Inclusion Criteria:\n\n* The ability to read and understand the Danish language\n\nExclusion Criteria:\n\n* Preoperative dependence of walking aids\n* Vision impairment\n* Previous syncopes or epilepsy\n* Admission to the intensive care unit after surgery\n* Acute complications during hospital admission\n* Patients are excluded at baseline if they have an oxygen saturation below 90% or a systolic blood pressure above 180 mmHg","ALL","18 Years","70 Years",{"count":19,"type":20},112,"ESTIMATED","INTERVENTIONAL",[23],"NA","The aim is to investigate the effect of early initiated and supervised mobilization continued after discharge as management of postoperative pain and recovery following obesity surgery, including patient experiences, pain coping, physical functionality and quality of life.",[26,27,28,29,30],"Postoperative Pain, Acute","Postoperative Pain, Chronic","Bariatric Surgery","Mobilization","Physical Activity",[32,28,33,30,29],"Pain Coping","Postoperative Pain","RECRUITING","2026-05-18",{"date":37,"type":38},"2026-05-20","ACTUAL",{"date":40,"type":38},"2024-04-22",{"date":42,"type":20},"2027-12-26",{"name":44,"class":45},"Esbjerg Hospital - University Hospital of Southern Denmark","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":54,"enrollmentInfo":55,"targetDuration":4,"studyType":21,"phases":57,"briefSummary":59,"conditions":60,"keywords":66,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":46},"100452533","phase-4-opioid-free-anaesthesia-analgesia-strategy-on-surgical-stress-and-immunomodulation-in-elective-vats-lobectomy-for-nsclc-100452533","NCT05172739","Opioid Free Anaesthesia-Analgesia Strategy on Surgical Stress and Immunomodulation in Elective VATS-Lobectomy for NSCLC","Effect of a Perioperative Opioid Free Anaesthesia-Analgesia (OFA-A) Strategy on Surgical Stress Response and Immunomodulation in Elective VATS Lobectomy for NSCLC Lung Cancer: A Prospective Randomized Study","Inclusion Criteria:\n\n* patients undergoing elective VATS lobectomy\n* early stage NSCLC (up to T3N1M0)\n\nExclusion Criteria:\n\n* Immunocompromised patients\n* previous lung surgery\n* preoperative corticosteroid or immunosuppressive drug use\n* uncontrolled Diabetes Mellitus\n* cardiac failure (NYHA 3 and 4)\n* preoperative infection (CRP \\>5mg\u002Fml, WBC \\>10x10\\^9\u002FL)\n* preoperative anemia (Hb\\\u003C12g\u002Fdl)\n* chronic inflammatory diseases\n* inflammatory bowel disease\n\nGroup-specific exclusion criteria:\n\n* OFA-Α: perioperative opioid administration, within the study period\n* OBA-Α: perioperative dexmedetomidine or lidocaine infusion, ketamine, gabapentinoid or corticosteroid administration within the study period","80 Years",{"count":56,"type":20},70,[58],"PHASE4","Lobectomy is a major, high-risk surgical procedure that in addition to one-lung ventilation (OLV) exerts a potent surgical stress response. An overwhelming immune cell recruitment may lead to excessive tissue damage, peripheral organ injury and immunoparesis. The effect of anesthesia on the immune system is modest, compared to the effects induced by major surgery. However, to an immunocompromised patient, due to cancer and\u002For other comorbidities, the immunosuppressive effects of anesthesia may increase the incidence of post-operative infections, morbidity, and mortality. Exogenous opioids have been correlated with immunosuppression, opioid-induced hyperalgesia, and respiratory depression, with deleterious outcomes. An Opioid-Free Anaesthesia-Analgesia (OFA-A) strategy is based on the administration of a variety of anaesthetic\u002Fanalgesic and other pharmacological agents with different mechanisms of action, including immunomodulating and anti-inflammatory effects. Our basic hypothesis is that the implementation of a perioperative multimodal OFA-A strategy, will lead to an attenuated surgical stress response and attenuated immunosuppression, compared to a conventional Opioid-Based Anaesthesia-Analgesia (OBA-A) strategy. The aforementioned effects, are presumed to be associated with equal or improved analgesia and decreased incidence of postoperative infections compared to a perioperative OBA-A technique.",[61,26,27,62,63,64,65],"Systemic Inflammatory Response Syndrome","Infections Postoperative","Opioid Use","Anesthesia","Non-small Cell Lung Cancer",[67,68,69,70,71,72,73,74,75],"Opioid-free Anesthesia-Analgesia","Opioid-based Anesthesia-Analgesia","Cytokines","NSCLC","Hemodynamic stability","Immunomodulation","Inflammatory markers","Acute postoperative pain","Chronic postoperative pain","2021-12-10",{"date":78,"type":38},"2021-12-29",{"date":80,"type":38},"2021-10-01",{"date":82,"type":20},"2026-11-01",{"name":84,"class":45},"University of Crete"]