[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"postoperative-pain-following-knee-arthroplasty\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:postoperative-pain-following-knee-arthroplasty":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,48,77],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":31,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100642144","biceps-femoris-short-head-bifes-block-and-adductor-canal-block-for-postoperative-analgesia-following-total-knee-arthroplasty-100642144",false,"NCT07577869","Biceps Femoris Short Head (BiFeS) Block and Adductor Canal Block for Postoperative Analgesia Following Total Knee Arthroplasty","A Comparison of the Effects of Biceps Femoris Short Head Block and Adductor Canal Block in Total Knee Arthroplasty on Postoperative Analgesia Using Multimodal Analgesia Methods","BiFeS Adductor","Inclusion Criteria:\n\n* Patients aged 18 and older\n* ASA I-III\n* Patients scheduled for elective unilateral knee replacement\n* Eligibility for and consent to spinal anesthesia\n\nExclusion Criteria:\n\n* History of allergy or anaphylaxis to local anesthetics, animal gelatin, or chlorhexidine\n* Bleeding diathesis\u002Finability to discontinue anticoagulants\n* Infection (at the injection site\u002Fsepsis)\n* Neurological disorders or cognitive impairment affecting pain perception\n* Pregnancy, breastfeeding\n* Patients under 18 years of age",true,"ALL","18 Years","80 Years",{"count":22,"type":23},60,"ESTIMATED","INTERVENTIONAL",[26],"NA","This prospective randomized controlled study aims to evaluate the effect of ultrasound-guided Biceps Femoris Short Head (BiFeS) block combined with adductor canal block on postoperative opioid consumption and pain control in patients undergoing elective total knee arthroplasty under spinal anesthesia.\n\nA total of 60 patients aged 18-80 years with ASA physical status I-III scheduled for unilateral elective total knee arthroplasty will be randomized into two groups. The intervention group will receive spinal anesthesia followed by BiFeS block and adductor canal block before surgery, in addition to standard multimodal analgesia and postoperative morphine patient-controlled analgesia (PCA). The control group will receive spinal anesthesia and standard multimodal analgesia with postoperative morphine PCA without peripheral nerve block.\n\nThe primary outcome is total morphine consumption during the first 24 postoperative hours. Secondary outcomes include postoperative pain scores assessed by Numeric Rating Scale (NRS), time to first analgesic requirement, time to first foot movement, and Quality of Recovery-15 (QoR-15) scores.",[29,30],"Postoperative Pain Following Knee Arthroplasty","Total Knee Arthroplasty",[32,33,34],"Postoperative Pain","BiFeS","BiFeS and Adductor Canal Block","RECRUITING","2026-06-10",{"date":38,"type":39},"2026-06-12","ACTUAL",{"date":41,"type":39},"2026-06-02",{"date":43,"type":23},"2027-07-02",{"name":45,"class":46},"Ömer Kayar","OTHER_GOV",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":56,"targetDuration":4,"studyType":24,"phases":58,"briefSummary":59,"conditions":60,"keywords":61,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":47},"100599161","the-effect-of-distal-versus-proximal-ipack-on-pain-after-total-knee-arthroplasty-100599161","NCT07080892","The Effect of Distal Versus Proximal iPACK on Pain After Total Knee Arthroplasty","The Effect of Distal Versus Proximal Approach to the Interspace Between the Popliteal Artery and the Posterior Capsule of the Knee (iPACK) on Pain After Total Knee Arthroplasty","eDIPACK","Inclusion Criteria:\n\n* Age between 18 and 80 years\n* Patients undergoing primary unilateral total knee arthroplasty (TKA) for osteoarthritis\n* Ability to understand and sign informed consent\n* American Society of Anesthesiologists (ASA) classification I-III\n* Ability to cooperate and participate in postoperative pain assessments (e.g., VAS)\n\nExclusion Criteria:\n\n* Refusal to participate or failure to sign informed consent\n* Bilateral or revision TKA\n* Partial or unicondylar knee replacement\n* Severe knee deformity (flexion, varus, or valgus \\>30°)\n* Diagnosis other than osteoarthritis (e.g., rheumatoid arthritis, septic arthritis, post-traumatic arthritis)\n* Allergy to local anesthetics or any medications used in the study\n* Contraindications to regional anesthesia (e.g., infection at the injection site, coagulopathy, therapeutic anticoagulation)\n* BMI \\> 40 kg\u002Fm²\n* Severe renal impairment (KDIGO stage G4 or higher) or liver failure (Child-Pugh score ≥ 10)\n* Prior surgery or vascular procedure on the femoral vessels of the operated limb\n* Language barrier or inability to assess pain using the VAS\n* Planned outpatient (same-day discharge) procedure",{"count":57,"type":23},120,[26],"Total knee arthroplasty (TKA) often results in significant postoperative pain, which can hinder recovery despite advances in surgical and anesthetic techniques. Traditional pain management methods like femoral nerve blocks may impair motor function, delaying rehabilitation. The iPACK block, targeting the posterior knee without affecting motor control, offers a promising alternative. This study aims to compare the effectiveness of two iPACK block approaches-proximal (at the distal femoral shaft) and distal (between the femoral condyles)-in managing postoperative pain in TKA patients. In a double-blind, randomized controlled trial with 120 participants, pain scores, opioid use, and time to rescue analgesia will be assessed. The hypothesis is that the distal iPACK block provides superior pain relief, potentially improving patient outcomes and recovery.",[29],[62,63,64,65,66],"pain","postoperative pain","arthroplasty","peripheral nerve block","iPACK","2026-02-02",{"date":69,"type":39},"2026-02-04",{"date":71,"type":39},"2025-02-12",{"date":73,"type":23},"2027-05-30",{"name":75,"class":76},"Comenius University","OTHER",{"id":78,"slug":79,"hasResults":11,"nctId":80,"briefTitle":81,"officialTitle":82,"acronym":4,"eligibilityCriteria":83,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":84,"targetDuration":4,"studyType":24,"phases":86,"briefSummary":88,"conditions":89,"keywords":90,"overallStatus":95,"whyStopped":4,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":4},"100620419","phase-3-evaluating-suzetrigine-for-pain-control-following-tka-100620419","NCT07357376","Evaluating Suzetrigine for Pain Control Following TKA","Evaluating a Non-Opioid Analgesic Strategy for Enhanced Recovery After Total Knee Arthroplasty: A Randomized Controlled Trial of Suzetrigine","Inclusion Criteria:\n\n* Age 18 years or older\n* Scheduled for elective, unilateral primary total knee arthroplasty\n* Able to tolerate oral medications after surgery\n\nExclusion Criteria:\n\n* Revision or bilateral total knee arthroplasty\n* American Society of Anesthesiologists (ASA) physical status classification greater than 3\n* Severe renal impairment (estimated glomerular filtration rate less than 15 mL\u002Fmin\u002F1.73 m²)\n* Severe hepatic impairment (Child-Pugh Class C)\n* Chronic opioid use of 30 morphine milligram equivalents per day or greater for more than 3 months\n* Pregnancy or breastfeeding\n* Seizure disorder or known hypersensitivity to suzetrigine\n* Use of medications contraindicated with CYP3A metabolism\n* Active gastrointestinal ulcer or bleeding",{"count":85,"type":23},210,[87],"PHASE3","The goal of this clinical trial is to learn if a non-opioid pain medicine called suzetrigine works to treat pain after total knee replacement surgery in adults. It will also learn about the safety of suzetrigine. The main questions it aims to answer are:\n\nDoes suzetrigine lower the amount of opioid pain medicine participants use after surgery?\n\nDoes suzetrigine have any effect on postoperative patient-reported outcomes, including pain scores, range of motion, length of stay, and KOOS\u002FPROMIS surveys?\n\nResearchers will compare suzetrigine to a placebo to see if suzetrigine works to treat pain after total knee replacement surgery.\n\nParticipants will:\n\nTake suzetrigine or a placebo by mouth for 14 days after surgery\n\nReceive standard pain care, including opioid pain medicine only if needed\n\nReport their pain levels using short daily surveys\n\nAttend routine follow-up visits after surgery",[29],[30,32,91,92,93,94],"Journavx","Suzetrigine","Opioid","Enhanced Recovery","NOT_YET_RECRUITING","2026-01-20",{"date":98,"type":39},"2026-01-22",{"date":100,"type":23},"2026-03-01",{"date":102,"type":23},"2026-08-01",{"name":104,"class":76},"AdventHealth"]