[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"postoperative-pain-management-in-total-knee-arthroplasty\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:postoperative-pain-management-in-total-knee-arthroplasty":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,44,66],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100607700","efficacy-of-an-afcn-proxy-block-in-post-tka-multimodal-pain-management-100607700",false,"NCT07191964","Efficacy of an AFCN Proxy Block in Post-TKA Multimodal Pain Management","Efficacy Assessment of Supra-Sartorial Subcutaneous Infiltration (SSSI) as an Anterior Femoral Cutaneous Nerve Proxy Block in the Multimodal Pain Management After Total Knee Arthroplasty: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Adults aged 45-90 undergoing unilateral primary TKA for osteoarthritis.\n* American Society of Anesthesiologists (ASA) physical status I-III.\n* Able to provide informed consent and use NRS pain scales.\n* Surgery scheduled to start before noon to standardize spinal anesthesia recovery.\n\nExclusion Criteria:\n\n* Bilateral or revision TKA.\n* Contraindications to regional anesthesia (e.g., coagulopathy, infection at injection site).\n* Chronic opioid use (\\>30 mg morphine equivalents\u002Fday) or preoperative NRS \\>4.\n* Pre-existing neurological deficits in lower extremities or AFCN-related neuropathy.\n* Allergy to ropivacaine.\n* Pregnancy, breastfeeding, or cognitive impairment affecting assessments.","ALL","45 Years","90 Years",{"count":20,"type":21},90,"ESTIMATED","INTERVENTIONAL",[24],"NA","This randomized controlled trial evaluates the additive effect of Supra-Sartorial Subcutaneous Infiltration (SSSI) when performed in combination with intermittent adductor canal block (iACB) and posterior capsule local infiltration analgesia (PC-LIA) for pain management after total knee arthroplasty (TKA). SSSI, an easy-to-perform tentative proxy block to targeted anterior femoral cutaneous nerve (AFCN) block, is tested in 90 adults (45-90 years) randomized into two arms: active SSSI versus sham SSSI. Primary outcome is pain scores at rest and during movement on postoperative day 0; secondary outcomes include daily pain trajectory at rest and during movement, functional recovery scores, rescue analgesic doses over days 0-3, and quality of recovery assessment on day 4.",[27],"Postoperative Pain Management in Total Knee Arthroplasty",[29,30],"Anterior Femoral Cutaneous Nerve Block","Total Knee Arthroplasty","NOT_YET_RECRUITING","2026-06-29",{"date":34,"type":35},"2026-07-01","ACTUAL",{"date":37,"type":21},"2026-08-01",{"date":39,"type":21},"2027-09-01",{"name":41,"class":42},"Taipei Medical University WanFang Hospital","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":16,"minAge":51,"maxAge":52,"enrollmentInfo":53,"targetDuration":4,"studyType":22,"phases":55,"briefSummary":56,"conditions":57,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":58,"lastUpdatePostDateStruct":59,"startDateStruct":61,"completionDateStruct":62,"leadSponsor":64,"locationsCount":4},"100606159","genicular-vs-ipack-block-for-analgesia-in-knee-arthroplasty-100606159","NCT07171931","Genicular vs IPACK Block for Analgesia in Knee Arthroplasty","Comparison of the Postoperative Analgesic Efficacy of Genicular Block and IPACK Block in Addition to Adductor Canal Block in Knee Arthroplasty","Inclusion Criteria:\n\n* Patients undergoing unilateral total knee arthroplasty\n* ASA physical status I-III\n\nExclusion Criteria:\n\n* BMI \\> 35\n* Patients \\\u003C 50 kg\n* Allergy to study medications","18 Years","70 Years",{"count":54,"type":21},72,[24],"Total knee arthroplasty (TKA) is one of the most frequently performed orthopedic procedures, and with the aging population, the global number of TKA cases is expected to increase sixfold within the next decade. Postoperative pain following TKA is often severe and difficult to manage, which may increase the risk of developing chronic pain. Effective pain control is therefore a major concern, and multimodal analgesia is recommended to enhance analgesia, reduce opioid consumption, and minimize opioid-related side effects.\n\nPeripheral nerve blocks (PNBs) are an integral part of multimodal regimens. Among them, the adductor canal block (ACB), which provides analgesia to the anteromedial aspect of the knee while preserving motor function, is widely used. The optimal analgesic strategy for TKA should not only ensure adequate pain relief but also maintain quadriceps strength to allow early mobilization. Motor-sparing blocks combined with multimodal analgesia have become increasingly popular because they facilitate early rehabilitation, decrease opioid requirements, and improve recovery outcomes.\n\nThe knee joint has a complex innervation, receiving contributions from the femoral, sciatic, and obturator nerves. For this reason, combining different PNBs may provide superior analgesia compared to a single block (2). The genicular nerves, consisting of branches from the femoral, common peroneal, saphenous, tibial, and obturator nerves, innervate the knee capsule. Genicular nerve block specifically targets these branches and has been used to manage postoperative pain in TKA patients.\n\nAnother motor-sparing option is the interspace between the popliteal artery and posterior capsule of the knee (IPACK) block, which provides analgesia to the posterior aspect of the knee. Using ultrasound guidance, local anesthetic is deposited between the posterior capsule and the popliteal artery. This approach spares the main trunks of the tibial and common peroneal nerves while effectively blocking the terminal branches innervating the posterior capsule, including the genicular nerves and the popliteal plexus.\n\nHowever, there are no studies in the literature directly comparing IPACK and genicular blocks. With this study, the investigators aim to compare the efficacy of these two blocks in patients undergoing TKA.",[27],"2025-09-10",{"date":60,"type":35},"2025-09-15",{"date":60,"type":21},{"date":63,"type":21},"2026-04-01",{"name":65,"class":42},"Kocaeli University",{"id":67,"slug":68,"hasResults":11,"nctId":69,"briefTitle":70,"officialTitle":71,"acronym":4,"eligibilityCriteria":72,"healthyVolunteers":11,"sex":16,"minAge":51,"maxAge":73,"enrollmentInfo":74,"targetDuration":4,"studyType":22,"phases":76,"briefSummary":78,"conditions":79,"keywords":80,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":43},"100606477","phase-4-dexmedetomidine-as-an-adjunct-to-periarticular-ropivacaine-in-total-knee-replacement-a-pilot-randomised-controlled-trial-100606477","NCT07176065","Dexmedetomidine as an Adjunct to Periarticular Ropivacaine in Total Knee Replacement: A Pilot Randomised Controlled Trial","A Pilot Randomized Controlled Trial Assessing the Impact of Dexmedetomidine as an Adjunct to Periarticular Ropivacaine Infiltration on Postoperative Pain and Recovery in Patients Undergoing Total Knee Replacement","Inclusion Criteria:\n\n* Aged ≥18 years\n* Undergoing elective unilateral total knee replacement\n* ASA physical status I-III\n* No known allergy to local anaesthetics or dexmedetomidine\n* No opioid use \\>24 hours preoperatively\n* Provided informed consent\n\nExclusion Criteria:\n\n* Known allergy to study drugs\n* Chronic pain or neurological conditions\n* Bilateral or revision TKR\n* Significant deformity affecting function\n* Substance abuse history\n* Day-case surgery","100 Years",{"count":75,"type":21},60,[77],"PHASE4","This study aims to evaluate whether adding dexmedetomidine to ropivacaine-based periarticular infiltration (PAI) improves postoperative pain control in patients undergoing total knee replacement (TKR). Despite standard pain management, many patients continue to experience moderate-to-severe pain after surgery. Dexmedetomidine, a sedative and analgesic agent, may help prolong the effect of local anaesthetics. A total of 60 patients will be randomly assigned to receive either ropivacaine alone or ropivacaine with dexmedetomidine. Pain scores, opioid use, side effects, and recovery time will be monitored for 24 hours. The goal is to determine if this method is more effective and safer for improving recovery after knee surgery.",[27],[81,82,83,84,85,86,87,88,89],"Total Knee Replacement","TKR","Periarticular Infiltration","Ropivacaine","Dexmedetomidine","Postoperative Pain","Opioid Consumption","Regional Anaesthesia","Adductor Canal Block","2025-09-08",{"date":92,"type":35},"2025-09-16",{"date":94,"type":21},"2025-10",{"date":96,"type":21},"2028-12",{"name":98,"class":42},"University of Malaya"]