[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"postoperative-pain-management\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:postoperative-pain-management":28},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,38,0,25,[9,46,79,112,140,169,204,233,264,289,311,342,370,394,418,441,469,508,531,562,591,618,643,670,694],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":4,"eligibilityCriteria":16,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":23,"studyType":24,"phases":4,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100618118","ultrasound-guided-transversus-abdominis-plane-block-versus-epidural-block-for-umbilical-hernia-analgesia-100618118",false,"NCT07327463","Ultrasound-Guided Transversus Abdominis Plane Block Versus Epidural Block for Umbilical Hernia Analgesia","Comparison of the Analgesic Efficacy of Ultrasound-guided Transversus Abdominis Plane Block and Single-dose Epidural Block in Patients Undergoing Umbilical Hernia Surgery.","Inclusion Criteria:\n\n* Patients aged 18 to 65 years\n* Patients scheduled for elective umbilical hernia surgery\n* ASA physical status I or II\n* Patients who undergo surgery under either: Single-dose epidural anesthesia, or general anesthesia with postoperative ultrasound-guided transversus abdominis plane (TAP) block, as part of routine clinical practice\n* Ability to understand and use the Visual Analog Scale (VAS)\n* Provision of written informed consent\n\nExclusion Criteria:\n\n* ASA physical status III or higher\n* Known allergy or contraindication to local anesthetic agents\n* Coagulopathy or ongoing anticoagulant\u002Fantiplatelet therapy contraindicating regional anesthesia\n* Infection at the site of epidural or TAP block application\n* History of chronic pain, long-term opioid use, or chronic analgesic consumption\n* Neurological disorders affecting pain perception or assessment\n* Severe hepatic or renal disease\n* Pregnancy or lactation\n* Inability to cooperate with postoperative pain assessment or inability to use VAS\n* Emergency surgery","ALL","18 Years","65 Years",{"count":21,"type":22},30,"ESTIMATED","1 Day","OBSERVATIONAL","This observational study aims to compare the postoperative analgesic effectiveness of ultrasound-guided transversus abdominis plane (TAP) block and single-dose epidural anesthesia in patients undergoing umbilical hernia surgery. Pain intensity will be assessed using the Visual Analog Scale (VAS) at predefined postoperative time points. The study seeks to determine which analgesic approach provides superior pain control and patient satisfaction in the postoperative period.",[27,28],"Umbilical Hernia","Postoperative Pain Management",[30,31,28,32],"Single-Dose Epidural Analgesia","Transversus Abdominis Plane Block","Umbilical Hernia Surgery","RECRUITING","2026-06-23",{"date":36,"type":37},"2026-06-24","ACTUAL",{"date":39,"type":37},"2026-01-15",{"date":41,"type":22},"2026-06-20",{"name":43,"class":44},"Sakarya University","OTHER",1,{"id":47,"slug":48,"hasResults":12,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":54,"enrollmentInfo":55,"targetDuration":4,"studyType":57,"phases":58,"briefSummary":60,"conditions":61,"keywords":65,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":41,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":4},"100611303","transversalis-fascia-plane-block-versus-surgical-wound-infiltration-for-postoperative-analgesia-in-open-inguinal-hernia-repair-100611303","NCT07238829","Transversalis Fascia Plane Block Versus Surgical Wound Infiltration for Postoperative Analgesia in Open Inguinal Hernia Repair","Analgesic Efficacy of Ultrasound-Guided Transversalis Fascia Plane Block Versus Surgical Wound Infiltration After Open Inguinal Hernia Surgery: A Randomized Controlled Trial","TFPB-WIN","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Scheduled for elective unilateral open inguinal hernia repair\n* Planned anesthesia: spinal anesthesia\n* American Society of Anesthesiologists (ASA) physical status I-II\n* Able to understand the study procedures and provide written informed consent\n\nExclusion Criteria:\n\n* Body mass index (BMI) \\> 35 kg\u002Fm²\n* Known hypersensitivity to local anesthetics used in the study (e.g., bupivacaine) or to analgesic medications\n* Coagulopathy\n* Infection or hematoma at the planned block site\n* Significant systemic disease (such as chronic kidney disease, hepatic failure, chronic obstructive pulmonary disease, etc.)\n* History of chronic pain or long-term analgesic use\n* Inability to use the patient-controlled analgesia system\n* Presence of psychiatric disorders\n* Refusal to participate in the study.\n* Cases with a surgical duration shorter than 30 minutes or longer than 180 minutes were excluded.","80 Years",{"count":56,"type":22},104,"INTERVENTIONAL",[59],"NA","The purpose of this clinical trial is to evaluate whether two different analgesic techniques - ultrasound-guided Transversalis Fascia Plane Block (TFPB) and surgical wound infiltration - can improve postoperative pain control in adult patients undergoing open inguinal hernia repair.\n\nThe key questions that this study aims to answer are:\n\nDoes TFPB reduce total intravenous opioid consumption within the first 24 postoperative hours compared with wound infiltration?\n\nDoes TFPB improve postoperative pain scores at rest and during movement compared with wound infiltration?\n\nDoes TFPB improve patient satisfaction, reduce the need for rescue analgesics, and enhance overall postoperative recovery quality?\n\nIf there is a comparison group:\n\nThe investigators will compare the effects of TFPB with wound infiltration to determine whether either technique provides superior postoperative analgesia and reduces opioid requirements.\n\nParticipants will be asked to:\n\nUndergo open inguinal hernia repair under spinal anesthesia.\n\nBe randomly assigned to one of two groups:\n\nTFPB Group: Receive an ultrasound-guided transversalis fascia plane block with local anesthetic.\n\nWound Infiltration Group: Receive local anesthetic infiltration performed by the surgeon along the incision line.\n\nPostoperatively:\n\nReport pain scores at defined intervals.\n\nReceive standardized IV analgesia with documentation of opioid consumption.\n\nAllow assessment of rescue analgesic requirement.\n\nBe monitored for adverse events and recovery outcomes.",[62,28,63,64],"Inguinal Hernia Unilateral","Regional Anaesthesia","Transversalis Fascia Plane Block",[66,67,68,69],"transversalis fascia plane block","regional anaesthesia","inguinal hernia","analgesia","NOT_YET_RECRUITING",{"date":72,"type":37},"2026-06-25",{"date":74,"type":22},"2027-01-01",{"date":76,"type":22},"2027-04-01",{"name":78,"class":44},"Ondokuz Mayıs University",{"id":80,"slug":81,"hasResults":12,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":85,"eligibilityCriteria":86,"healthyVolunteers":12,"sex":87,"minAge":18,"maxAge":88,"enrollmentInfo":89,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":91,"conditions":92,"keywords":95,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":103,"lastUpdatePostDateStruct":104,"startDateStruct":106,"completionDateStruct":108,"leadSponsor":110,"locationsCount":45},"100604138","effect-of-bilateral-ultrasound-guided-tap-block-on-quality-of-recovery-in-cesarean-delivery-patients-receiving-intrathecal-morphine-100604138","NCT07145619","Effect of Bilateral Ultrasound-Guided TAP Block on Quality of Recovery in Cesarean Delivery Patients Receiving Intrathecal Morphine","Effect of Bilateral Ultrasound-Guided Transversus Abdominis Plane Block on Quality of Recovery in Cesarean Delivery Patients Receiving Intrathecal Morphine: A Prospective Observational Cohort Study","QoR-TAP","Inclusion Criteria:\n\n* Female patients aged 18-45 years\n* Singleton pregnancy\n* ASA physical status II-III\n* Scheduled elective lower segment cesarean delivery under spinal anesthesia with intrathecal morphine (ITM) as standard care\n* Able to understand study procedures, provide written informed consent, and reliably use IV PCA\n* Able to complete ObsQoR-10-T assessments (with trained assistance if needed)\n\nExclusion Criteria:\n\n* Contraindication to spinal anesthesia or TAP block (e.g., infection at injection site, coagulopathy, allergy to local anesthetics)\n* Chronic opioid use or opioid\u002Falfa-2 agonist intolerance\n* Severe preeclampsia, HELLP syndrome, significant hepatic or renal impairment\n* Urgent or emergent cesarean section (Category 1)\n* Cognitive impairment or communication difficulty preventing accurate assessment\n* Prior major abdominal surgery (other than previous cesarean delivery)\n* Body mass index (BMI) \\> 40 kg\u002Fm²\n* Major psychiatric illness (e.g., major depressive disorder, generalized anxiety disorder, psychosis) that may affect pain perception or quality of recovery","FEMALE","45 Years",{"count":90,"type":22},150,"This prospective, assessor-blinded observational cohort study will investigate the effect of adding bilateral ultrasound-guided transversus abdominis plane (TAP) block to standard intrathecal morphine (ITM) analgesia on the quality of recovery in women undergoing elective cesarean delivery under spinal anesthesia. All participants will receive ITM as part of routine spinal anesthesia. The TAP group will receive an additional bilateral ultrasound-guided TAP block at the end of surgery, while the control group will not receive any additional block. Both groups will receive standardized postoperative analgesia with intravenous patient-controlled analgesia (IV PCA). The primary outcome is the quality of recovery at 24 hours postoperatively, measured using the validated Obstetric Quality of Recovery-10 (ObsQoR-10) questionnaire. Secondary outcomes include Numerical Rating Scale (NRS) pain scores, time to first breastfeeding, time to mobilization, time to hospital discharge, and total opioid consumption in the first 24 hours after surgery. Outcome assessors will be blinded to group allocation. The study aims to determine whether TAP block enhances functional recovery, reduces pain, and decreases analgesic requirements when used alongside ITM in cesarean delivery patients.",[28,93,94],"Obstetric Anesthesia","Recovery From Anesthesia",[96,97,98,99,100,101,102],"Cesarean delivery","Spinal anesthesia","Intrathecal morphine","Transversus abdominis plane block","Postoperative pain","Obstetric anesthesia","Quality of recovery","2026-06-13",{"date":105,"type":37},"2026-06-16",{"date":107,"type":37},"2025-09-01",{"date":109,"type":22},"2026-07-30",{"name":111,"class":44},"MEHMET GÖKHAN TAFLAN",{"id":113,"slug":114,"hasResults":12,"nctId":115,"briefTitle":116,"officialTitle":117,"acronym":4,"eligibilityCriteria":118,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":119,"targetDuration":4,"studyType":57,"phases":121,"briefSummary":122,"conditions":123,"keywords":124,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":130,"lastUpdatePostDateStruct":131,"startDateStruct":133,"completionDateStruct":135,"leadSponsor":137,"locationsCount":139},"100633283","comprasion-of-spsip-and-rhomboid-intercostal-plan-blocks-on-vats-100633283","NCT07524673","Comprasion of SPSIP and Rhomboid Intercostal Plan Blocks on VATS","Comparison of the Analgesic Efficacy of Rhomboid Intercostal Plane Block and Serratus Posterior Superior Intercostal Plane Block on Postoperative Pain in Patients Undergoing Video-Assisted Thoracoscopic Surgery","Inclusion Criteria:\n\n* Forty adult patients scheduled for elective wedge resection or biopsy under VATS, classified as American Society of Anesthesiologists (ASA) physical status I-III, were enrolled after providing written informed consent.\n\nExclusion Criteria:\n\n* ASA class IV or higher,\n* morbid obesity (BMI \\> 40 kg\u002Fm²),\n* body weight ≤ 50 kg,\n* skin infection at the block site,\n* refusal to participate,\n* inability to cooperate during postoperative pain assessment,\n* conversion to open surgery,\n* preexisting pain,\n* known allergy to any study medication,\n* coagulopathy.",{"count":120,"type":22},40,[59],"This study aimed to compare rhomboid intercostal plane block and serratus posterior superior intercostal plane block (SPSIPB) to determine the most suitable technique for maintaining postoperative analgesia in video-assisted thoracoscopic surgeries (VATS).",[28],[125,126,127,128,129],"rhomboid intercostal plane block","serratus posterior superior intercostal plane block","vats","video-assisted thoracoscopic surgery","postoperative pain","2026-06-02",{"date":132,"type":37},"2026-06-03",{"date":134,"type":37},"2026-03-12",{"date":136,"type":22},"2026-12",{"name":138,"class":44},"Cumhuriyet University",2,{"id":141,"slug":142,"hasResults":12,"nctId":143,"briefTitle":144,"officialTitle":145,"acronym":4,"eligibilityCriteria":146,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":147,"enrollmentInfo":148,"targetDuration":4,"studyType":57,"phases":150,"briefSummary":152,"conditions":153,"keywords":154,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":160,"lastUpdatePostDateStruct":161,"startDateStruct":163,"completionDateStruct":165,"leadSponsor":167,"locationsCount":45},"100610335","phase-4-methadone-pharmacokinetics-in-cardiac-surgery-100610335","NCT07226245","Methadone Pharmacokinetics in Cardiac Surgery","Evaluating Pharmacokinetics of Three Methadone Dosing Strategies During Cardiac Surgery With Cardiopulmonary Bypass","Inclusion Criteria:\n\n* Elective cardiac surgery requiring median sternotomy and cardiopulmonary bypass (CABG, valve, combined CABG\u002Fvalve surgeries)\n* Anticipated extubation within 12 hours postoperatively\n* No prior opioid use within 30 days of surgery\n* Ability to provide informed consent\n\nExclusion Criteria:\n\n* Severe liver or kidney dysfunction (Child-Pugh class B\u002FC, eGFR \\\u003C30 mL\u002Fmin\u002F1.73m², creatinine \\>2 mg\u002FdL, dialysis)\n* Allergy to methadone or fentanyl\n* Use of CYP3A4 inducers (rifampin, phenytoin, carbamazepine), CYP3A4 inhibitors (ketoconazole, erythromycin, clarithromycin, itraconazole), SSRIs (fluoxetine, sertraline, paroxetine, citalopram, escitalopram, fluvoxamine)\n* Body mass index \\>40 kg\u002Fm²\n* Corrected QT interval interval \\>500 milliseconds\n* Intubation anticipated \\>12 hours\n* History of illicit drug use or alcohol or opioid abuse use disorder within last 12 months\n* Mechanical circulatory support, heart transplant, deep hypothermic circulatory arrest procedures\n* Left Ventricular Ejection Fraction \\\u003C30%\n* Pulmonary disease requiring oxygen therapy\n* Preoperative inotropic support or intra-aortic balloon pump\n* Emergency surgery\n* Postoperative regional anesthesia\n* Hemofiltration during cardiopulmonary bypass","70 Years",{"count":149,"type":22},69,[151],"PHASE4","Cardiac surgery frequently leads to significant postoperative pain, with multiple different drug regimens being utilized (both opioid and non-opioid) in an attempt to alleviate this surgical pain. Methadone is currently one of the drugs that is being utilized to help control the pain. It can be given during and\u002For after surgery. This study hopes to identify the optimal dose of methadone to use to treat this surgical pain.",[28],[155,156,157,158,159],"methadone pharmacokinetics","cardiac surgery","pain management","cardiac surgery recovery","methadone","2026-05-22",{"date":162,"type":37},"2026-05-26",{"date":164,"type":22},"2026-09",{"date":166,"type":22},"2026-12-30",{"name":168,"class":44},"Wake Forest University Health Sciences",{"id":170,"slug":171,"hasResults":12,"nctId":172,"briefTitle":173,"officialTitle":174,"acronym":175,"eligibilityCriteria":176,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":177,"enrollmentInfo":178,"targetDuration":4,"studyType":57,"phases":180,"briefSummary":181,"conditions":182,"keywords":185,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":195,"lastUpdatePostDateStruct":196,"startDateStruct":198,"completionDateStruct":200,"leadSponsor":202,"locationsCount":45},"100612014","effect-of-ipack-and-bifes-blocks-on-quality-of-recovery-after-total-knee-arthroplasty-100612014","NCT07248072","Effect of iPACK and BiFeS Blocks on Quality of Recovery After Total Knee Arthroplasty","Effects of iPACK and Biceps Femoris Short Head (BiFeS) Blocks Combined With Adductor Canal Block on Quality of Recovery After Total Knee Arthroplasty: A Prospective, Randomized, Double-Blind Clinical Trial","BiFeS-TKA","Inclusion Criteria:\n\n* Age 18-75 years\n* Scheduled for elective primary unilateral total knee arthroplasty (TKA)\n* Planned spinal anesthesia\n* ASA physical status I-III\n* Ability to understand study procedures and provide written informed consent\n\nExclusion Criteria:\n\n* Known allergy or hypersensitivity to local anesthetics or other study medications\n* Coagulopathy or current anticoagulant therapy\n* Severe hepatic, renal, or cardiac failure\n* History of neuropathic pain\n* Infection at the site of proposed nerve block\n* Pre-existing neuromuscular disorders in the lower extremities\n* Inability to cooperate or refusal to participate in the study\n* Pregnancy","75 Years",{"count":179,"type":22},74,[59],"This prospective, randomized, double-blind clinical trial aims to compare the effects of two different posterior knee analgesia techniques-iPACK block (Interspace Between the Popliteal Artery and the Capsule of the posterior Knee) and the Biceps Femoris Short Head (BiFeS) block-when combined with an adductor canal block (ACB) in patients undergoing elective unilateral total knee arthroplasty (TKA). Effective postoperative analgesia is essential for early mobilization, enhanced recovery, and patient satisfaction after TKA. Although ACB provides good anterior knee analgesia while preserving quadriceps strength, additional posterior knee analgesia is often required.\n\nThe iPACK block is a commonly used technique that targets the posterior knee capsule, whereas the newer BiFeS block aims to provide more selective posterolateral sensory blockade with potentially reduced risk of motor involvement. However, comparative clinical data between these two techniques are limited.\n\nThe primary objective of this study is to evaluate the difference between the iPACK and BiFeS blocks in terms of Quality of Recovery-15 (QoR-15) scores at 24 hours postoperatively. Secondary objectives include comparisons of postoperative pain scores, opioid consumption, time to first analgesic request, quadriceps and anterior tibialis muscle strength, functional test performance, time to mobilization, active range of motion, and the incidence of adverse events.\n\nA total of 74 adult patients scheduled for elective unilateral TKA under spinal anesthesia will be randomized in a 1:1 ratio into two groups: ACB + iPACK block or ACB + BiFeS block. All blocks will be performed under ultrasound guidance by an experienced anesthesiologist. Outcome assessments will be conducted by blinded investigators. The study aims to provide high-quality clinical evidence regarding the effectiveness of the BiFeS block compared to the widely used iPACK technique.",[183,28,184],"Knee Osteoarthritis","Total Knee Arthroplasty",[184,186,187,188,189,190,191,192,193,194],"Knee Replacement","Adductor Canal Block","iPACK Block","BiFeS Block","Regional Anesthesia","Postoperative Analgesia","QoR-15","Posterior Knee Pain","Ultrasound-Guided Nerve Block","2026-05-15",{"date":197,"type":37},"2026-05-18",{"date":199,"type":37},"2025-12-01",{"date":201,"type":22},"2026-07-02",{"name":203,"class":44},"Ataturk University",{"id":205,"slug":206,"hasResults":12,"nctId":207,"briefTitle":208,"officialTitle":209,"acronym":210,"eligibilityCriteria":211,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":212,"targetDuration":4,"studyType":57,"phases":214,"briefSummary":215,"conditions":216,"keywords":218,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":223,"lastUpdatePostDateStruct":224,"startDateStruct":226,"completionDateStruct":228,"leadSponsor":230,"locationsCount":45},"100627309","minimum-effective-volume-of-bupivacaine-for-serratus-posterior-superior-intercostal-plane-block-in-video-assisted-thoracoscopic-surgery-100627309","NCT07446959","Minimum Effective Volume of Bupivacaine for Serratus Posterior Superior Intercostal Plane Block in Video-Assisted Thoracoscopic Surgery","Determination of the Median Effective Volume (ED50) of Bupivacaine for Serratus Posterior Superior Intercostal Plane Block in Patients Undergoing Video-Assisted Thoracoscopic Surgery Using the Dixon Up-and-Down Method","SPSIP-EV50","Inclusion Criteria:\n\n* Age 18 years or older\n* Scheduled for elective video-assisted thoracoscopic surgery (VATS)\n* American Society of Anesthesiologists (ASA) physical status I-III\n* Planned to receive ultrasound-guided serratus posterior superior intercostal plane block for postoperative analgesia\n* Ability to provide written informed consent\n\nExclusion Criteria:\n\n* Refusal to participate in the study\n* Known allergy or contraindication to local anesthetics\n* Infection at the block injection site\n* Coagulation disorders or anticoagulant therapy contraindicating regional anesthesia\n* Severe respiratory insufficiency\n* Chronic opioid use or chronic pain syndrome\n* Pregnancy\n* Inability to cooperate or communicate postoperative pain scores",{"count":213,"type":22},27,[59],"This study aims to determine the minimum effective volume of bupivacaine required for the serratus posterior superior intercostal plane (SPSIP) block in patients undergoing video-assisted thoracoscopic surgery (VATS). The SPSIP block is an ultrasound-guided regional anesthesia technique used to provide postoperative pain relief after thoracic surgery.\n\nUsing a stepwise dose-adjustment method, the volume of local anesthetic will be increased or decreased based on the effectiveness of the block in each patient. The main outcome of the study is to identify the volume that provides effective pain control in 50% of patients. The results may help optimize pain management while minimizing drug exposure.",[28,217],"Video-assisted Thoracoscopic Surgery (VATS)",[219,190,220,221,222],"SPSIP Block","Dose-Finding Study","Dixon Up-and-Down Method","Thoracic Analgesia","2026-05-11",{"date":225,"type":37},"2026-05-12",{"date":227,"type":37},"2026-03-15",{"date":229,"type":22},"2026-07-15",{"name":231,"class":232},"Bursa City Hospital","OTHER_GOV",{"id":234,"slug":235,"hasResults":12,"nctId":236,"briefTitle":237,"officialTitle":238,"acronym":239,"eligibilityCriteria":240,"healthyVolunteers":12,"sex":17,"minAge":88,"maxAge":241,"enrollmentInfo":242,"targetDuration":4,"studyType":57,"phases":244,"briefSummary":245,"conditions":246,"keywords":249,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":255,"lastUpdatePostDateStruct":256,"startDateStruct":258,"completionDateStruct":260,"leadSponsor":262,"locationsCount":45},"100622832","espb-vs-spsip-for-postoperative-analgesia-after-cabg-100622832","NCT07388745","ESPB vs SPSIP for Postoperative Analgesia After CABG","A Randomized Trial Comparing Erector Spinae Plane Block Versus Serratus Posterior Superior Intercostal Plane Block for Postoperative Analgesic Efficacy in Patients Undergoing Coronary Artery Bypass Graft Surgery","ESP-SPSIP-CABG","Inclusion Criteria:\n\n* Age 45-85 years\n* Scheduled for elective coronary artery bypass graft (CABG) surgery\n* American Society of Anesthesiologists (ASA) I-II-III\n* Patients who provide written informed consent and agree to participate in the study\n\nExclusion Criteria:\n\n* Emergency cases\n* ASA IV-V\n* Known allergy to local anesthetics\n* Coagulopathy (platelet count \\\u003C100,000\u002Fmm³, INR \\>1.5, aPTT \\>1.5× normal)\n* Infection at the block injection site\n* Pregnancy\n* Patients who do not provide written informed consent or decline to participate after being informed","85 Years",{"count":243,"type":22},64,[59],"This prospective, randomized, active-controlled, double-blind, parallel-group study compares the postoperative analgesic efficacy and safety of ultrasound-guided bilateral Erector Spinae Plane Block (ESPB) versus bilateral Serratus Posterior Superior Intercostal Plane Block (SPSIPB) in adult patients (45-85 years, ASA I-III) undergoing elective coronary artery bypass graft surgery. The primary outcome is postoperative pain intensity assessed by Numeric Rating Scale (NRS) at 2, 4, 8, 16, 24, and 48 hours after surgery. Secondary outcomes include intraoperative fentanyl\u002Fremifentanil consumption, postoperative morphine consumption, patient-controlled analgesia (PCA) demand\u002Fdelivery parameters (if PCA is used), need for rescue analgesics, extubation and mobilization times, peak inspiratory flow measured by incentive spirometry at predefined time points, ICU and hospital length of stay, recovery quality (QoR-15 at 0, 24, and 48 hours), mortality, and block-related adverse events.",[247,248,28],"Coronary Arterial Disease","Coronary Artery Bypass Grafting (CABG) Surgery",[250,251,252,190,194,253,254],"Coronary Artery Bypass Grafting","Erector Spinae Plane Block","Serratus Posterior Superior Intercostal Plane Block","Postoperative Pain","Numeric Rating Scale","2026-05-10",{"date":257,"type":37},"2026-05-13",{"date":259,"type":37},"2026-03-01",{"date":261,"type":22},"2026-08-31",{"name":263,"class":44},"Kutahya Health Sciences University",{"id":265,"slug":266,"hasResults":12,"nctId":267,"briefTitle":268,"officialTitle":269,"acronym":4,"eligibilityCriteria":270,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":271,"targetDuration":4,"studyType":57,"phases":273,"briefSummary":274,"conditions":275,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":280,"lastUpdatePostDateStruct":281,"startDateStruct":283,"completionDateStruct":285,"leadSponsor":287,"locationsCount":45},"100590197","iliopsoas-ipb-and-pericapsular-nerve-group-peng-blocks-comparison-on-analgesia-and-recovery-after-total-hip-arthroplasty-100590197","NCT06964282","Iliopsoas (IPB) and Pericapsular Nerve Group (PENG) Blocks Comparison on Analgesia and Recovery After Total Hip Arthroplasty","Comparison Between Iliopsoas Block (IPB) and Pericapsular Nerve Group (PENG) Block on Postoperative Analgesia and Functional Recovery After Total Hip Arthroplasty Surgery: a Double-blinded Randomized Clinical Trial","Inclusion Criteria:\n\nAdult patients (age \\>18 years) ASA physical status classification I-III Scheduled for elective posterior approach total hip arthroplasty (THA) under spinal anesthesia\n\nExclusion Criteria:\n\nPregnancy (confirmed by beta-HCG test if applicable) Known peripheral neuropathy or major neurological disease Chronic pain syndromes or long-term opioid use (\\>20 mg oral morphine equivalents\u002Fday) Severe hepatic or renal insufficiency Allergy to local anesthetics Major coagulopathies Vulnerable patients (e.g., minors, legally protected individuals)",{"count":272,"type":22},118,[59],"Background:\n\nIn recent years, regional anesthesia has become more popular because it can reduce pain and the need for strong pain medications like morphine. For hip surgery, the PENG block is already known to be effective. A newer method, called the iliopsoas plane block (IPB), is very similar and has also shown good results in hip arthroscopy. However, these two techniques have never been directly compared in patients undergoing hip replacement surgery using the posterior approach.\n\nGoal:\n\nThis study aims to see if the IPB is just as effective as the PENG block for controlling pain and helping patients recover well after hip replacement surgery.\n\nMethod:\n\n118 adult patients scheduled for hip replacement under spinal anesthesia will be randomly assigned to receive either: IPB: 7 ml of Ropivacaine 7.5 mg\u002Fml PENG: 14 ml of Ropivacaine 3.75 mg\u002Fml Both injections are given under ultrasound guidance 30 minutes before spinal anesthesia. Neither the patient, the surgeon, nor the data collector will know which technique was used.\n\nPost-Surgery Care:\n\nAll patients will receive standard pain relief, including:\n\nParacetamol every 6 hours Etoricoxib once a day Morphine via a patient-controlled pump for 48 hours\n\nMain Outcome Measured:\n\nThe primary goal is to compare pain during movement 6 hours after surgery, using a pain scale from 0 (no pain) to 10 (worst pain). The study will consider the two blocks equivalent if the difference in average pain scores is less than 1 point.\n\nOther Outcomes:\n\nTotal morphine used in 48 hours Pain scores at rest and during movement at various time points Walking ability (2- and 6-minute walk tests, and timed-up-and-go test) Quality of recovery (using the QoR-15 questionnaire) Side effects of morphine Patient satisfaction Length of hospital stay\n\nSafety:\n\nBoth techniques are safe and already used in clinical practice. Ultrasound guidance minimizes risks like nerve injury, bleeding, or infection.\n\nConclusion:\n\nIf the IPB is shown to be as effective as the PENG block, both can be considered reliable options for pain control and early recovery after hip replacement surgery.",[276,28,277,278,279],"Total Hip Arthroplasty (THA)","Peripheral Nerve Blocks","PENG Block","Iliopsoas Nerve Block","2026-04-29",{"date":282,"type":37},"2026-05-06",{"date":284,"type":37},"2025-10-01",{"date":286,"type":22},"2026-10-10",{"name":288,"class":44},"University of Liege",{"id":290,"slug":291,"hasResults":12,"nctId":292,"briefTitle":293,"officialTitle":294,"acronym":295,"eligibilityCriteria":296,"healthyVolunteers":12,"sex":17,"minAge":19,"maxAge":4,"enrollmentInfo":297,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":299,"conditions":300,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":303,"lastUpdatePostDateStruct":304,"startDateStruct":306,"completionDateStruct":307,"leadSponsor":309,"locationsCount":45},"100623298","can-ultrasound-guided-fascial-plane-blocks-reduce-postoperative-pulmonary-complications-after-major-abdominal-surgery-100623298","NCT07394816","Can Ultrasound-Guided Fascial Plane Blocks Reduce Postoperative Pulmonary Complications After Major Abdominal Surgery?","The Effect of Ultrasound-Guided Fascial Plane Blocks on Postoperative Pulmonary Complications in Patients Undergoing Major Abdominal Surgery: A Prospective Observational Study","FPB-PPC","Inclusion Criteria:\n\n* Age 65 years or older\n* Scheduled for elective major abdominal surgery (e.g., colorectal, hepatobiliary, pancreatic, or gastric surgery)\n* ASA physical status II-III\n* Ability to provide written informed consent\n* Planned use of general anesthesia with or without adjunct regional techniques\n\nExclusion Criteria:\n\n* Refusal or inability to provide informed consent\n* Known allergy or contraindication to local anesthetics\n* Coagulopathy or ongoing anticoagulant therapy contraindicating regional anesthesia\n* Infection at the site of planned block\n* Pre-existing chronic opioid use or chronic pain syndrome\n* Severe hepatic, renal, or cardiac failure (e.g., Child-Pugh C, end-stage renal disease, EF \\\u003C30%)\n* Cognitive impairment or severe dementia preventing adequate pain assessment\n* Emergency surgery\n* Body mass index (BMI \\> 40 kg\u002Fm²)",{"count":298,"type":22},500,"This prospective observational study aims to evaluate whether the use of ultrasound-guided fascial plane blocks is associated with a lower incidence of postoperative pulmonary complications in adult patients undergoing elective major abdominal surgery under general anesthesia.\n\nPatients will be observed in two groups based on routine clinical practice: those who receive an ultrasound-guided fascial plane block for postoperative analgesia and those managed with other standard analgesic methods. The choice of analgesic technique will be determined by the responsible anesthesia team and not influenced by the study.\n\nPostoperative pulmonary complications occurring within the first 7 days after surgery will be recorded using reopening the European Perioperative Clinical Outcome (EPCO) criteria. Secondary outcomes will include unplanned intensive care unit admission, length of hospital stay, and 30-day mortality. No additional procedures or interventions will be performed for research purposes.",[301,302,28],"Postoperative Pulmonary Complications (PPCs)","Abdominal Surgeries","2026-04-25",{"date":305,"type":37},"2026-04-30",{"date":259,"type":37},{"date":308,"type":22},"2026-08-15",{"name":310,"class":44},"Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital",{"id":312,"slug":313,"hasResults":12,"nctId":314,"briefTitle":315,"officialTitle":316,"acronym":317,"eligibilityCriteria":318,"healthyVolunteers":12,"sex":17,"minAge":319,"maxAge":177,"enrollmentInfo":320,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":322,"conditions":323,"keywords":328,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":333,"lastUpdatePostDateStruct":334,"startDateStruct":336,"completionDateStruct":338,"leadSponsor":340,"locationsCount":45},"100584253","pain-education-after-rotator-cuff-surgery-100584253","NCT06886932","Pain Education After Rotator Cuff Surgery","The Effect of Pain Neuroscience Education on Patients Undergoing Surgical Repair of Moderate-Sized Rotator Cuff Tears","PNE-RCS","Eligibility Criteria\n\nInclusion Criteria:\n\nDiagnosis of a medium-sized rotator cuff tear (1-3 cm) confirmed by Magnetic Resonance Imaging (MRI) and scheduled for surgical repair Age between 40 and 75 years Sufficient Turkish language proficiency to understand and complete the informed consent form and assessment scales Mini-Mental State Examination (MMSE) score ≥ 24, indicating adequate cognitive function for study participation\n\nExclusion Criteria:\n\nCorticosteroid injection received within the last 6 weeks Adhesive capsulitis, defined as loss of passive external rotation greater than 50% or 30° History of previous cervical, thoracic, or shoulder surgery Presence of cervical radiculopathy, characterized by pain and tingling radiating to the arm due to nerve root involvement Acromioclavicular joint pathology or shoulder instability causing shoulder pain Full-thickness rotator cuff tear Calcific tendinitis Systemic diseases (e.g., inflammatory arthritis, malignancy) or neurological disorders (e.g., fibromyalgia, other neurological deficits) Fracture, labral lesion, or biceps tendon injury in the affected shoulder Prior participation in a chronic pain psychological management program or presence of generalized body pain","40 Years",{"count":321,"type":22},45,"Study Title: The Effect of Pain Neuroscience Education Combined with Conventional Rehabilitation on Pain Management and Functional Outcomes in Patients Undergoing Mini-Open Rotator Cuff Repair\n\nPurpose: This study aims to investigate whether adding Pain Neuroscience Education (PNE) to a conventional rehabilitation program improves pain management, physical function, and psychosocial outcomes in patients who have undergone mini-open surgery for rotator cuff tears (RCT). The study will also compare the effects of PNE when delivered before versus after surgery.\n\nWho Can Participate: Adults aged 40-75 who have been diagnosed with a medium-sized rotator cuff tear and are scheduled for mini-open surgical repair. Participants must meet specific health criteria and be willing to participate in the rehabilitation program.\n\nStudy Details:\n\nParticipants will be randomly assigned to one of three groups:\n\nGroup 1: Conventional rehabilitation only. Group 2: Conventional rehabilitation + PNE before surgery. Group 3: Conventional rehabilitation + PNE after surgery. PNE involves educational sessions that explain the biology of pain, how the nervous system processes pain, and strategies to reduce fear and catastrophizing related to pain.\n\nThe study will last approximately 12 weeks, with regular assessments of pain levels, physical function, and psychosocial factors (e.g., fear of movement, depression, sleep quality).\n\nPotential Benefits:\n\nParticipants may experience reduced pain, improved shoulder function, and better overall recovery.\n\nThe study may provide valuable insights into how PNE can enhance rehabilitation outcomes for patients with rotator cuff tears.\n\nPotential Risks:\n\nSome participants may find the educational sessions time-consuming or mentally challenging.\n\nThere is a small risk of discomfort during physical assessments or rehabilitation exercises.\n\nWhy is this study important?:\n\nRotator cuff tears are a common cause of shoulder pain and disability, especially in older adults. Post-surgical pain and fear of movement can slow recovery and reduce quality of life. This study will help determine whether PNE, when combined with conventional rehabilitation, can improve recovery outcomes and provide a better understanding of how timing (before or after surgery) affects its effectiveness.",[324,28,325,326,327],"Rotator Cuff Tears","Shoulder Dysfunction","Kinesiophobia (Fear of Movement)","Postoperative Rehabilitation",[329,327,330,331,332,28],"Pain Neuroscience Education","Rotator Cuff Tear","Kinesiophobia","Shoulder Surgery Outcomes","2026-04-18",{"date":335,"type":37},"2026-04-22",{"date":337,"type":37},"2025-04-01",{"date":339,"type":22},"2026-09-30",{"name":341,"class":44},"Elif Dilara Durmaz",{"id":343,"slug":344,"hasResults":12,"nctId":345,"briefTitle":346,"officialTitle":346,"acronym":4,"eligibilityCriteria":347,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":348,"targetDuration":4,"studyType":57,"phases":350,"briefSummary":352,"conditions":353,"keywords":355,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":362,"lastUpdatePostDateStruct":363,"startDateStruct":365,"completionDateStruct":366,"leadSponsor":368,"locationsCount":4},"100608471","phase-2-intraoperative-placement-of-vancomycin-impregnated-calcium-sulfate-beads-conjugated-with-analgesics-to-improve-spine-surgery-outcomes-100608471","NCT07201987","Intraoperative Placement of Vancomycin-impregnated Calcium Sulfate Beads Conjugated With Analgesics to Improve Spine Surgery Outcomes","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Able to understand and provide consent in English\n* Undergoing elective lumbar spinal decompression and fusion surgery at one or two levels\n\nExclusion Criteria:\n\n* History of allergy or hypersensitivity to morphine, bupivacaine, or calcium sulfate.\n* Active systemic or localized infection at the surgical site.\n* History of chronic opioid dependence or opioid use disorder (as it may confound pain assessment).\n* Patients with severe renal or hepatic impairment (due to altered metabolism of analgesics and risk of complications from analgesic side effects).\n* Pregnant or breastfeeding individuals.\n* Filling of defects that are intrinsic to the stability of the bony structure\n* Severe vascular or neurological disease\n* Uncontrolled diabetes\n* Severe degenerative bone disease\n* Hypercalcemia",{"count":349,"type":22},100,[351],"PHASE2","The goal of this clinical trial is to learn if using calcium sulfate beads that contain vancomycin (an antibiotic) and pain-relieving medicines during spine surgery can improve recovery compared to standard care with intravenous (IV) morphine and local pain medicines.\n\nResearchers want to know if the sustained release formulation of morphine from these calcium sulfate beads affect:\n\n* Postoperative length of stay\n* Postoperative pain scores\n* Postoperative narcotic analgesic requirements\n\nAll participants in this study will already be scheduled to have spine surgery as part of their regular medical care. During surgery, participants will be assigned to receive either intraoperative placement of calcium sulfate beads with vancomycin alone or vancomycin with morphine and bupivacaine. All patients will still have access to standard of care with IV and PO pain regimens. Participants will then be followed after surgery to measure their pain, recovery, and medication use.\n\nParticipation is voluntary, and choosing not to join will not affect a person's medical care.",[354,28],"Spine Surgery",[356,357,358,359,360,361],"Spine surgery","Postoperative pain management","Calcium sulfate beads","Vancomycin","Analgesics","Hospital length of stay","2026-04-14",{"date":364,"type":37},"2026-04-16",{"date":74,"type":22},{"date":367,"type":22},"2028-01-01",{"name":369,"class":44},"Ganesh M. Shankar",{"id":371,"slug":372,"hasResults":12,"nctId":373,"briefTitle":374,"officialTitle":375,"acronym":4,"eligibilityCriteria":376,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":147,"enrollmentInfo":377,"targetDuration":4,"studyType":57,"phases":379,"briefSummary":380,"conditions":381,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":384,"lastUpdatePostDateStruct":385,"startDateStruct":387,"completionDateStruct":389,"leadSponsor":391,"locationsCount":393},"100613631","phase-4-efficacy-and-safety-of-anrikefon-for-postoperative-analgesia-in-ophthalmic-surgery-100613631","NCT07269106","Efficacy and Safety of Anrikefon for Postoperative Analgesia in Ophthalmic Surgery","Efficacy and Safety of Anrikefon for Postoperative Analgesia in Ophthalmic Surgery: A Multicenter, Randomized, Parallel-Control, Non-Inferiority Trial","Inclusion Criteria:\n\n* Scheduled for ophthalmic surgery under general anesthesia.\n* Aged 18 to 70 years.\n* With American Society of Anesthesiologists (ASA) physical status I to III.\n* Body mass index (BMI) between 18 and 30 kg\u002Fm²\n* Agree to participate in the trial and provide written informed consent.\n\nExclusion Criteria:\n\n* History of cardiovascular or cerebrovascular events within the past 6 months, including unstable angina, ischemic myocardial infarction, or heart failure; or current presence of uncontrolled hypertension (\\>180\u002F110 mmHg), aneurysm, or severe cardiac arrhythmia.\n* Severe respiratory diseases such as pulmonary fibrosis, severe pulmonary abscess, cor pulmonale, or advanced chronic obstructive pulmonary disease (COPD).\n* Significant neurological disorders such as brain injury or seizures, as well as severe psychiatric illnesses.\n* Known allergy to kappa opioid receptor agonists or to general anesthetic agents used in this study.\n* Current peptic ulcer disease, gastrointestinal bleeding, or known hypersensitivity to nonsteroidal anti-inflammatory drugs (NSAIDs), such as flurbiprofen axetil or paracetamol.\n* Prior use of opioid or non-opioid analgesics, with the last administration occurring within five half-life periods of the drug.\n* Continuous use of opioid analgesics for more than 10 days within the 3 months prior to screening.\n* Use of drugs with unknown half-life periods that may affect analgesic efficacy within 14 days before randomization.\n* History of major surgery within the past 3 months that may interfere with postoperative pain assessment.",{"count":378,"type":22},204,[151],"The goal of this clinical trial is to learn if Anrikefon works as well as nalbuphine to control postoperative pain in adults undergoing ophthalmic surgery under general anesthesia. It will also learn about the safety and recovery outcomes of using Anrikefon.\n\nThe main questions it aims to answer are:\n\n* Does Anrikefon provide pain relief that is not inferior to nalbuphine after ophthalmic surgery?\n* Does Anrikefon cause fewer central side effects, such as sedation or dizziness, compared with nalbuphine?\n* Does Anrikefon help patients recover and get discharged faster after day-surgery procedures? Researchers will compare Anrikefon to nalbuphine to see if Anrikefon can offer effective and safer perioperative analgesia for ophthalmic day-surgery patients.\n\nParticipants will:\n\n* Receive either an intravenous dose of Anrikefon or nalbuphine during surgery.\n* Be monitored for pain scores, side effects, and recovery parameters after surgery.\n* Complete follow-up assessments.",[382,28,383],"Ophthalmic Surgery","Opioid Analgesia","2026-03-31",{"date":386,"type":37},"2026-04-01",{"date":388,"type":37},"2026-01-22",{"date":390,"type":22},"2027-12-31",{"name":392,"class":44},"Zhongshan Ophthalmic Center, Sun Yat-sen University",3,{"id":395,"slug":396,"hasResults":12,"nctId":397,"briefTitle":398,"officialTitle":399,"acronym":4,"eligibilityCriteria":400,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":401,"targetDuration":4,"studyType":57,"phases":403,"briefSummary":404,"conditions":405,"keywords":406,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":410,"lastUpdatePostDateStruct":411,"startDateStruct":413,"completionDateStruct":415,"leadSponsor":417,"locationsCount":45},"100629869","mtlip-vs-qipb-for-postoperative-analgesia-in-lumbar-microdiscectomy-surgery-100629869","NCT07480278","mTLIP vs QIPB for Postoperative Analgesia in Lumbar Microdiscectomy Surgery","Comparison of Ultrasound-Guided Modified Thoracolumbar Interfascial Plane Block Versus Quadro-Iliac Plane Block for Postoperative Analgesia in Patients Undergoing Lumbar Microdiscectomy","Inclusion Criteria:\n\n* Age between 18 and 65 years\n* Classified as American Society of Anesthesiologists physical status I-III\n* Scheduled for elective lumbar microdiscectomy surgery under general anesthesia\n* Provision of written informed consent\n\nExclusion Criteria:\n\n* Use of anticoagulant medications or presence of bleeding diathesis\n* Known allergy or hypersensitivity to local anesthetics or opioid drugs\n* Infection at the planned block site\n* Alcohol or drug dependence\n* Cognitive impairment preventing reliable pain assessment\n* Pregnancy or lactation\n* History of previous lumbar spine surgery\n* Diabetes mellitus\n* Renal or hepatic insufficiency",{"count":402,"type":22},80,[59],"The aim of this prospective randomized clinical study is to compare the analgesic efficacy and side effects of modified thoracolumbar interfascial plane block and quadroiliac plane block applied preoperatively in patients undergoing lumbar microdiscectomy surgery.The study will include a total of 80 patients aged 18-65 years with ASA I-III, with 40 patients in each group( Group mTLIP and Group QIPB) undergoing lumbar microdiscectomy surgery.\n\nThe primary objective of the study is to compare groups in terms of PCA opioid consumption during the 48-hour postoperative period. Secondary objectives are to compare groups in terms of QoR-15 recovery score, dynamic and static numerical rating scale scores, total rescue analgesic use, time to first request for rescue analgesia, length of hospital stay, block and opioid-related side effects and complications, and perioperative remifentanil infusion dose.",[28],[100,407,408,409],"Quadro-iliac plane block","Lumbar Microdiscectomy","Modified thoracolumbar interfascial plane block","2026-03-26",{"date":412,"type":37},"2026-03-27",{"date":414,"type":37},"2026-03-25",{"date":416,"type":22},"2026-09-01",{"name":231,"class":232},{"id":419,"slug":420,"hasResults":12,"nctId":421,"briefTitle":422,"officialTitle":423,"acronym":4,"eligibilityCriteria":424,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":54,"enrollmentInfo":425,"targetDuration":4,"studyType":57,"phases":427,"briefSummary":428,"conditions":429,"keywords":430,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":433,"lastUpdatePostDateStruct":434,"startDateStruct":435,"completionDateStruct":437,"leadSponsor":439,"locationsCount":45},"100617249","phase-4-suprainguinal-fascia-iliaca-block-with-vs-without-dexmedetomidine-100617249","NCT07316166","Suprainguinal Fascia Iliaca Block With vs Without Dexmedetomidine","Comparison of Suprainguinal Fascia Iliac Block With and Without Dexmedetomidine as an Adjunct to Ropivacaine for Postoperative Analgesia Following Hip Surgery: a Randomized, Double-blinded Study.","Inclusion Criteria:\n\n* Patients undergoing elective total hip arthroplasty\n* 18-80 years old\n* ASA 1-3 classifications\n\nExclusion Criteria:\n\n* ASA classification of 4 or greater\n* Infection at the site of nerve blockade\n* Coagulopathy\n* Known allergy to study medications\n* Chronic opioid consumption (\\>3 months)\n* Currently using lidocaine patches\n* Pre-existing neuropathy\n* A history of CVA\n* High grade atrioventricular block (cardiac conduction system impairment)\n* Organ dysfunction (cardiac failure, respiratory failure, end stage renal disease, hepatic dysfunction, hypoalbuminemia)\n* Morbid obesity (≥40 kg\u002Fm2)\n* Prior surgery in supra and\u002For infrainguinal region\n* Non-English-speaking participants",{"count":426,"type":22},120,[151],"The investigators are evaluating postoperative outcomes in patients undergoing hip replacement surgery performed with either spinal or general anesthesia, who also receive a suprainguinal fascia iliaca block using either perineural ropivacaine alone or ropivacaine combined with dexmedetomidine.",[28],[431,432],"Hip Surgery","Nerve block","2026-03-24",{"date":414,"type":37},{"date":436,"type":37},"2026-01-20",{"date":438,"type":22},"2027-06",{"name":440,"class":44},"Rhode Island Hospital",{"id":442,"slug":443,"hasResults":12,"nctId":444,"briefTitle":445,"officialTitle":446,"acronym":4,"eligibilityCriteria":447,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":177,"enrollmentInfo":448,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":449,"conditions":450,"keywords":452,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":460,"lastUpdatePostDateStruct":461,"startDateStruct":463,"completionDateStruct":465,"leadSponsor":467,"locationsCount":45},"100627224","sensory-analysis-and-cutaneous-mapping-of-different-regional-anesthesia-techniques-100627224","NCT07445854","Sensory Analysis and Cutaneous Mapping of Different Regional Anesthesia Techniques","Sensory Analysis and Cutaneous Mapping of Different Regional Anesthesia Techniques in Laparoscopic Cholecystectomy Surgery: A Prospective Observational Study","Inclusion Criteria:\n\n* Patients scheduled for elective laparoscopic cholecystectomy surgery and who have received a regional anesthesia technique for this purpose.\n* Aged between 18-75 years.\n* Belonging to ASA I-III group.\n* Having provided written informed consent.\n\nExclusion Criteria:\n\n* Patients who refuse to participate.\n* Patients who did not receive a block.\n* Patients classified as ASA IV.\n* History of previous abdominal surgery (affecting the laparoscopic approach).\n* Patients with cognitive dysfunction or inability to cooperate.\n* Patients diagnosed with psychiatric disorders (schizophrenia, mania, depression, etc.).\n* Patients who have been using antipsychotic medication for more than 4 weeks.",{"count":120,"type":22},"This prospective observational study aims to evaluate and compare the sensory block distribution and regression patterns of two regional anesthesia techniques - External Oblique Plane Block (EOPB) and Serratus Intercostal Plane Block (SIPB) - in patients undergoing laparoscopic cholecystectomy.\n\nThirty adult patients (ASA I-III, BMI ≤ 35 kg\u002Fm², ≥50 kg) scheduled for elective laparoscopic cholecystectomy procedures will be included, with 20 in each block group. Sensory block areas will be assessed using pinprick test, and dermatomal mapping will visualize the spread. The findings are expected to improve understanding of block behavior and guide multimodal analgesia strategies in laparoscopic cholecystectomy.",[451,28,190],"Laparoscopic Cholecystectomy",[453,454,455,456,457,458,459],"regional anesthesia","Pain Management","Sensory Mapping","serratus intercostal plane block","external oblique plane block","eopb","sipb","2026-02-25",{"date":462,"type":37},"2026-03-03",{"date":464,"type":37},"2025-11-15",{"date":466,"type":22},"2026-06-01",{"name":468,"class":44},"Samsun University",{"id":470,"slug":471,"hasResults":12,"nctId":472,"briefTitle":473,"officialTitle":473,"acronym":474,"eligibilityCriteria":475,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":476,"targetDuration":4,"studyType":57,"phases":478,"briefSummary":479,"conditions":480,"keywords":492,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":500,"lastUpdatePostDateStruct":501,"startDateStruct":503,"completionDateStruct":505,"leadSponsor":506,"locationsCount":45},"100609711","trans-auricular-stimulation-for-postoperative-inflammation-in-spine-surgery-100609711","NCT07218133","Trans-Auricular Stimulation for Postoperative Inflammation in Spine Surgery","TAPIS","Inclusion Criteria:\n\n* Long-segment spinal fusions (defined as constructs spanning at least L2-pelvis for thoracolumbar fusions or C2-T2 for cervical fusions)\n* Ability to undergo a reliable neurologic examination and pain assessments\n\nExclusion Criteria:\n\n* Patients \\\u003C18 years of age\n* Shorter-segment spinal fusions than those described above\n* Undergoing current active cancer therapy\n* Undergoing treatment with immunosuppressive drugs\n* Additional spinal surgery within past 6 months\n* Sustained bradycardia or presence of pacemaker\n* History of substance abuse",{"count":477,"type":22},50,[59],"This study is a randomized controlled trial that will evaluate the effect of non-invasive auricular vagal nerve stimulation on inflammatory markers, glycemic control, postoperative pain, and inflammation-related clinical outcomes after long-segment spinal fusion surgeries when compared to current accepted management.",[481,482,28,483,484,485,486,487,488,489,490,491],"Spinal Fusion","Hyperglycemia","Postoperative Care","Spine Disease","Neurologic Deficits","Neurological Disorder","Inflammation","Spine Condition","Spinal (Fusion) Surgery","Cytokine Levels","Spine Fusion",[493,129,494,495,496,497,498,499],"spinal fusion","glycemic control","inflammation","vagal nerve stimulation","postoperative complications","cytokine","spine surgery","2026-02-17",{"date":502,"type":37},"2026-02-20",{"date":504,"type":37},"2025-10-08",{"date":136,"type":22},{"name":507,"class":44},"Alexander T. Yahanda",{"id":509,"slug":510,"hasResults":12,"nctId":511,"briefTitle":512,"officialTitle":513,"acronym":4,"eligibilityCriteria":514,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":515,"enrollmentInfo":516,"targetDuration":4,"studyType":57,"phases":518,"briefSummary":520,"conditions":521,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":522,"lastUpdatePostDateStruct":523,"startDateStruct":525,"completionDateStruct":527,"leadSponsor":528,"locationsCount":139},"100607274","phase-3-a-clinical-trial-evaluating-the-efficacy-and-safety-of-hsk21542-in-patients-for-postoperative-pain-treatment-in-orthopedic-surgery-100607274","NCT07186426","A Clinical Trial Evaluating the Efficacy and Safety of HSK21542 in Patients for Postoperative Pain Treatment in Orthopedic Surgery","A Multi-Center, Randomized, Double-Blind, Placebo\u002FActive-Controlled Phase III Clinical Study to Evaluate the Efficacy and Safety of HSK21542 Injection for Postoperative Pain Treatment in Orthopedic Surgery","Inclusion Criteria:\n\n* 18 years old ≤ age ≤74 years old, regardless of gender;\n* 18 kg\u002Fm2≤BMI≤32 kg\u002Fm2，meet the weight range specified in the protocol；\n* American Society of Anesthesiologists (ASA) grade ⅰ-ⅲ;\n* Accept hip replacement under general anesthesia;\n* Within 4 hours after the end of surgery, NRS≥4 in the resting state at any time;\n* Fully understand and voluntarily participate this trial, and sign the informed consent form;\n\nExclusion Criteria:\n\n* Patients with allergy to opioids or any component of the trial drug；\n* Patients with a history of severe cardiovascular and cerebrovascular diseases, ,and psychiatric disorders;\n* Last use of opioid or non-opioid analgesics less than 5 half-lives or the duration of drug efficacy prior to randomization; use of drugs with unclear half-lives that may affect analgesic efficacy within 7 days prior to randomization, or last use of drugs affecting analgesic efficacy less than 5 half-lives prior to randomization, as well as Chinese herbal medicines or proprietary Chinese medicines deemed by the investigator as potentially impacting the evaluation of efficacy and safety；\n* Continuous use of opioid analgesics for more than 7 days for any reason within 30 days prior to screening;\n* Laboratory test results during the screening period meeting any of the following criteria: 1) Significantly abnormal hematology results; 2) Significantly abnormal prothrombin time test results; 3) Significantly abnormal liver or kidney function; 4) Significantly abnormal fasting blood glucose;\n* Positive test results during the screening period for hepatitis B surface antigen (HBsAg), hepatitis C antibody (HCVAb), syphilis antibody, or human immunodeficiency virus (HIV) antibody;\n* A history of drug, drug, and\u002For alcohol abuse；\n* Participate in any clinical trail within 30 days;\n* Pregnant or lactating female subjects；\n* Subjects of childbearing potential who are unwilling to use contraception throughout the study period or plan to become pregnant within 3 months after the study.；\n* Subjects with any other factor considered by the investigator to be ineligible for participation in the trial.","74 Years",{"count":517,"type":22},405,[519],"PHASE3","This is a multi-center, randomized, double-blind, placebo\u002Factive-controlled study. 405 subjects undergoing orthopedic surgery under general anesthesia are planned to be enrolled and randomized into the HSK21542 group, morphine group, and placebo group.",[28],"2026-02-11",{"date":524,"type":37},"2026-02-13",{"date":526,"type":37},"2025-07-28",{"date":259,"type":22},{"name":529,"class":530},"Haisco Pharmaceutical Group Co., Ltd.","INDUSTRY",{"id":532,"slug":533,"hasResults":12,"nctId":534,"briefTitle":535,"officialTitle":536,"acronym":537,"eligibilityCriteria":538,"healthyVolunteers":539,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":540,"targetDuration":4,"studyType":57,"phases":542,"briefSummary":543,"conditions":544,"keywords":547,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":555,"lastUpdatePostDateStruct":556,"startDateStruct":557,"completionDateStruct":558,"leadSponsor":560,"locationsCount":45},"100624014","effects-of-ankle-block-on-postoperative-analgesia-in-diabetic-and-non-diabetic-patients-100624014","NCT07404124","Effects of Ankle Block on Postoperative Analgesia in Diabetic and Non-Diabetic Patients","Comparison of Sensory and Motor Block Characteristics and Postoperative Analgesic Consumption After Ultrasound-Guided Ankle Block in Diabetic and Non-Diabetic Patients Undergoing Lower Extremity Surgery","ANKLE-DM","Inclusion Criteria:\n\n* Adults aged 18 years and older.\n* Patients scheduled for lower extremity surgery under ultrasound-guided ankle block as part of routine clinical care.\n* Patients able to provide written informed consent.\n* Availability of complete perioperative data including blood glucose levels, -HbA1c values, pain scores, and postoperative analgesic consumption.\n\nExclusion Criteria:\n\n* Refusal or inability to provide informed consent.\n* Failure of ankle block requiring conversion to another anesthesia technique.\n* Known coagulation disorders contraindicating peripheral nerve block.\n* Active infection at the site of block application.\n* Chronic opioid or analgesic use, chronic alcohol use, or substance abuse.\n* History of diabetic ketoacidosis or hyperosmolar hyperglycemic state.\n* Severe renal or hepatic insufficiency.\n* Known allergy to local anesthetics such as lidocaine or bupivacaine.\n* Inability to perform perioperative blood glucose monitoring.\n* Cognitive impairment or psychiatric conditions interfering with study participation or data collection.",true,{"count":541,"type":22},46,[59],"This prospective observational study aims to evaluate the effects of ultrasound-guided ankle block on sensory and motor block characteristics and postoperative analgesic outcomes in patients undergoing lower extremity surgery. The study will compare diabetic and non-diabetic patients and will also assess the impact of glycemic control on block onset time and postoperative analgesic consumption.\n\nAnkle block is commonly used in patients undergoing foot and ankle surgery, particularly in those with diabetes, peripheral neuropathy, or vascular disease, when general or neuraxial anesthesia may not be suitable. Previous studies suggest that diabetic neuropathy and impaired glycemic control may influence the onset and duration of peripheral nerve blocks.\n\nAdult patients scheduled for lower extremity surgery under ankle block will be included. All procedures will be performed as part of routine clinical care, and no additional interventions will be applied for research purposes. Sensory and motor block onset times, postoperative pain scores, opioid consumption within the first 24 hours, and patient and surgeon satisfaction will be recorded.\n\nThe results of this study are expected to provide clinically relevant information regarding the effects of diabetes and glycemic control on ankle block characteristics and postoperative analgesia.",[545,546,28],"Diabetes Mellitus","Diabetic Neuropathy",[548,549,550,545,546,551,191,552,553,554],"Ankle Block","Ultrasound-Guided Regional Anesthesia","Peripheral Nerve Block","Glycemic Control","HBA1C","Lower Extremity Surgery","Opioid Consumption","2026-02-09",{"date":522,"type":37},{"date":259,"type":22},{"date":559,"type":22},"2026-11-01",{"name":561,"class":44},"Fatih Sultan Mehmet Training and Research Hospital",{"id":563,"slug":564,"hasResults":12,"nctId":565,"briefTitle":566,"officialTitle":566,"acronym":4,"eligibilityCriteria":567,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":147,"enrollmentInfo":568,"targetDuration":4,"studyType":57,"phases":570,"briefSummary":571,"conditions":572,"keywords":576,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":583,"lastUpdatePostDateStruct":584,"startDateStruct":586,"completionDateStruct":588,"leadSponsor":589,"locationsCount":45},"100623823","effect-of-dezocine-versus-nalbuphine-combined-with-sufentanil-on-postoperative-analgesia-complications-and-free-flap-survival-in-patients-undergoing-oral-cancer-radical-surgery-a-randomized-controlled-clinical-trial-100623823","NCT07401641","Effect of Dezocine Versus Nalbuphine Combined With Sufentanil on Postoperative Analgesia, Complications, and Free Flap Survival in Patients Undergoing Oral Cancer Radical Surgery: A Randomized Controlled Clinical Trial.","Inclusion Criteria:\n\n1. Diagnosed with oral malignant tumor.\n2. Scheduled for oral cancer radical surgery with free flap reconstruction at Sun Yat-sen Memorial Hospital.\n3. Age between 18 and 70 years.\n4. Sign informed consent.\n\nExclusion Criteria:\n\n1. Use of analgesic medications within two weeks prior to surgery.\n2. History of diabetes, arteriosclerosis, or peripheral vascular disease.\n3. Use of hormones, chemotherapy, or immunosuppressants.\n4. Severe cardiac, pulmonary, hematological, hepatic, or renal diseases.\n5. Known allergy to the study drugs.",{"count":569,"type":22},60,[59],"Background: Oral cancer radical surgery often requires free flap reconstruction. Postoperative pain is severe, and traditional opioids like sufentanil have side effects and may adversely affect tumor biology. Dezocine and nalbuphine are opioid agonist-antagonists with potentially better safety profiles. Their comparative effects on analgesia, complications, and flap survival in oral cancer surgery are unknown.\n\nObjective: To compare the efficacy of dezocine versus nalbuphine, both combined with sufentanil, for postoperative analgesia, and to evaluate their impact on postoperative complications and free flap survival\u002Ffunction in patients undergoing oral cancer radical surgery with flap reconstruction.\n\nMethods: This is a prospective, randomized, double-blind, controlled trial. Sixty eligible patients (aged 18-70, ASA I-III) will be randomly assigned (1:1) to receive postoperative patient-controlled intravenous analgesia (PCIA) with either Sufentanil + Dezocine or Sufentanil + Nalbuphine. The primary outcome is pain intensity assessed by the Visual Analogue Scale (VAS) at 2, 24, and 48 hours postoperatively. Secondary outcomes include flap survival status, sensory function recovery, incidence of adverse events (e.g., nausea, vomiting), and hospitalization duration.\n\nPotential Impact: This study may identify a superior postoperative analgesic regimen that provides effective pain relief while potentially improving flap outcomes and minimizing side effects for oral cancer patients.",[573,28,574,575],"Oral Cancer","Free Tissue Flaps","Mouth Neoplasms",[577,578,579,580,191,581,582],"Dezocine","Nalbuphine","Oral Cancer Surgery","Free Flap Reconstruction","Randomized Controlled Trial","Flap Survival","2026-02-03",{"date":585,"type":37},"2026-02-10",{"date":587,"type":37},"2025-06-01",{"date":466,"type":22},{"name":590,"class":44},"Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University",{"id":592,"slug":593,"hasResults":12,"nctId":594,"briefTitle":595,"officialTitle":596,"acronym":4,"eligibilityCriteria":597,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":598,"targetDuration":4,"studyType":57,"phases":600,"briefSummary":601,"conditions":602,"keywords":603,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":609,"lastUpdatePostDateStruct":610,"startDateStruct":612,"completionDateStruct":614,"leadSponsor":616,"locationsCount":4},"100620249","phase-4-suzetrigine-versus-usual-care-opioids-for-postop-pain-in-sports-100620249","NCT07355166","Suzetrigine Versus Usual-care Opioids for Postop Pain in Sports","Suzetrigine Versus Usual-care Opioids for Postoperative Pain After Common Ambulatory Orthopaedic Sports Procedures - A Randomized Control Trial","Inclusion Criteria:\n\n* Patients undergoing reconstruction of primary ACL tear\n\nExclusion Criteria:\n\n* Concurrent ligamentous injuries requiring surgical intervention\n* Full thickness cartilage injury requiring discrete surgical intervention\n* Chronic opioid use\n* Significant hepatic disease (Child\u002FPugh C)\n* Women who are pregnant or breastfeeding\n* Women of childbearing age using hormonal contraceptives containing progestins other than levonorgestrel and norethindrone\n* Allergies or intolerance to any study medications\n* Inability to complete ePROs (due to literacy or infirmity)",{"count":599,"type":22},140,[151],"The goal of this clinical trial is to learn if a Suzetrigine-based multimodal pain regimen can reduce the volume of opioid consumption while maintaining non-inferior pain control compared to an opioid-based multimodal pain regimen after common ambulatory orthopaedic sports procedures. The main questions it aims to answer are:\n\n1. Does including Suzetrigine in the multimodal pain regimen lower the volume of opioids consumed by participants while maintaining non-inferior pain control?\n2. How does the side-effect profile of a Suzetrigine-based multimodal postop pain regimen compare to that of an opioid-based multimodal postoperative pain regimen?\n\nEligible participants will be assigned to receive one of the postop pain regimens and report their opioid use, their pain level, and the side effects they faced every day for 7 days.",[28],[604,605,606,607,608,28],"Suzetrigine","Journavx","Opioid Use","ACL Reconstruction","Rotator Cuff Repair","2026-01-19",{"date":611,"type":37},"2026-01-21",{"date":613,"type":22},"2026-02",{"date":615,"type":22},"2026-07",{"name":617,"class":44},"University of California, Los Angeles",{"id":619,"slug":620,"hasResults":12,"nctId":621,"briefTitle":622,"officialTitle":623,"acronym":624,"eligibilityCriteria":625,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":54,"enrollmentInfo":626,"targetDuration":4,"studyType":57,"phases":627,"briefSummary":628,"conditions":629,"keywords":632,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":635,"startDateStruct":637,"completionDateStruct":639,"leadSponsor":641,"locationsCount":45},"100620859","single--versus-two-level-esp-block-for-analgesia-after-lumbar-stabilization-surgery-100620859","NCT07363096","Single- Versus Two-Level ESP Block for Analgesia After Lumbar Stabilization Surgery","Comparison Of Single- Versus Two-Level Erector Spinae Plane Block For Postoperative Analgesia In Patients Undergoing Lumbar Stabilization Surgery","ESP-Lumbar","Inclusion Criteria:\n\n* ASA I-II-III,\n* BMI:18-40,\n* Patients undergoing lumbar stabilization surgery involving 2 to 4 vertebral levels\n* Patients who personally provide written informed consent to participate in the study\n\nExclusion Criteria:\n\n* Patients with chronic pain conditions\n* Patients with a history of chronic opioid use\n* Patients undergoing emergency lumbar stabilization surgery",{"count":569,"type":22},[59],"Lumbar stabilization surgery is commonly associated with moderate to severe postoperative pain. Effective pain control is important to improve patient comfort, early mobilization, and recovery. The erector spinae plane (ESP) block is a regional anesthesia technique that has been increasingly used for postoperative pain management in spine surgery.\n\nThis study aims to compare the effectiveness of single-level versus two-level ultrasound-guided ESP block for postoperative pain control in patients undergoing lumbar stabilization surgery. Patients will be randomly assigned to receive either a single-level ESP block or a two-level ESP block in addition to standard analgesic treatment.\n\nPostoperative pain scores, opioid consumption, and the incidence of side effects will be evaluated during the postoperative period. The results of this study may help determine the most effective ESP block technique for pain management after lumbar stabilization surgery.",[28,630,631],"Lumbar Spinal Fusion Surgery","Erector Spina Plan Block",[633,634,28],"Erector Spina Plane Block","Acute Pain",{"date":636,"type":37},"2026-01-23",{"date":638,"type":22},"2026-02-01",{"date":640,"type":22},"2027-01-03",{"name":642,"class":232},"Ankara Etlik City Hospital",{"id":644,"slug":645,"hasResults":12,"nctId":646,"briefTitle":647,"officialTitle":648,"acronym":4,"eligibilityCriteria":649,"healthyVolunteers":12,"sex":17,"minAge":19,"maxAge":4,"enrollmentInfo":650,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":651,"conditions":652,"keywords":657,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":663,"lastUpdatePostDateStruct":664,"startDateStruct":665,"completionDateStruct":666,"leadSponsor":668,"locationsCount":45},"100619015","the-effect-of-single-lung-ventilation-duration-and-intraoperative-brain-oxygenation-on-cognitive-function-and-postoperative-pain-in-geriatric-patients-100619015","NCT07339124","The Effect of Single Lung Ventilation Duration and Intraoperative Brain Oxygenation on Cognitive Function and Postoperative Pain in Geriatric Patients","The Effect of Single Lung Ventilation Duration and Intraoperative Brain Oxygenation on Cognitive Function and Postoperative Pain in Geriatric Patients Undergoing Single Lung Ventilation; Prospective Observational Study","Inclusion Criteria:\n\n* Patients aged 65 and over with a high school diploma or higher education\n* Patients undergoing lung resection via thoracotomy (wedge resection, lingulectomy, segmentectomy, lobectomy, pneumonectomy)\n* American Society of Anesthesiologists (ASA) score I-II-III,\n* Body mass index (BMI) between 18-40 kg\u002Fm2,\n* Patients undergoing surgery under general anesthesia will be included in the study.\n\nExclusion Criteria:\n\n* Patients under 65 years of age, patients over 65 who are illiterate,\n* Who have completed primary or secondary school,\n* Patients with pre-existing cognitive impairment confirmed by preoperative Mini Mental State Examination (MMSE),\n* Patients with a history of previously diagnosed mental illness, cerebrovascular disease, senile dementia, stroke,\n* Patients using continuous anti-inflammatory\u002Fanalgesic medications,\n* Patients with preoperative chronic pain,\n* Severe cardiovascular disease,\n* Diagnosed neurological and psychiatric diseases,\n* Patients allergic to the anesthetic and analgesic drugs to be administered,\n* Patients with severe renal failure, gastrointestinal ulceration or severe asthma that prevents the administration of standard analgesia protocols,\n* Patients undergoing surgery other than lung resection,\n* Patients undergoing surgery with TIVA (total intravenous anesthesia) will be excluded from the study.",{"count":21,"type":22},"One lung ventilation (OLV) is commonly used in thoracic surgery. Although the lack of ventilation of the lung in the surgical area (independent lung) during OLV redirects pulmonary blood flow to the dependent lung, shunt development is inevitable, and consequently, hypoxia is a frequently encountered condition. Therefore, one of the most important aspects that clinicians pay attention to during OLV is cerebral oxygen saturation in addition to peripheral oxygenation monitoring.\n\nStudies have shown a correlation between decreased cerebral oxygen saturation and postoperative cognitive dysfunction (POCD). Patients undergoing OLV are also at risk of cerebral desaturation due to this non-physiological ventilation.\n\nPatients undergoing OLV are at risk of cerebral oxygen desaturation. Therefore, in these patients, both cognitive dysfunction and changes in brain oxygenation can negatively affect pain-related centers, altering pain perception. Geriatric patients are particularly more affected by these negative effects. It is generally accepted by healthcare professionals specializing in pain management that the application of pain management should differ for elderly patients compared to younger patients. Analgesic dose adjustment should be done more carefully in geriatric patients. Increased sensitivity to opioids due to hypoxia can cause respiratory depression and increased analgesic effects. To avoid these, opioid dose adjustment is necessary in these patients. In conclusion, cerebral oxygen saturation measurement can be an effective method to detect cerebral oxygen desaturation, especially in the geriatric patient group. In this way, the effect of hypoxia caused by OLV on cerebral oxygen saturation can be detected early, and POCD can be limited. We believe that this situation can also contribute to effective postoperative pain management. This study aimed to investigate the effect of intraoperative brain oxygenation on cognitive function and postoperative pain in geriatric patients who underwent OLV.\n\nMATERİAL AND METHODS This study will be conducted in accordance with the Helsinki Declaration and will take place at Health Sciences University Ankara Atatürk Sanatorium Training and Research Hospital . The study will be planned for geriatric patients over 65 years of age with a high school diploma or higher education level who have given informed consent and are scheduled for OLV with standard anesthesia monitoring. These patients, undergoing thoracic surgery via thoracotomy and who agree to participate in this study and sign an informed consent form, will be prospectively enrolled. A total of 30 patients will be included in our study. Preoperatively, patients will undergo standard monitoring including non-invasive arterial blood pressure, electrocardiography, and peripheral oxygen saturation (SpO2). Cerebral oxygenation of patients who have signed an informed consent form the day before will be recorded throughout the surgical procedure using probes placed on the forehead before the induction of anesthetic drugs.\n\nThe standard anesthesia and analgesia protocol that we routinely apply to patients will be applied throughout the surgery. Routine preoperative blood tests, age, height, weight, Body Mass Index (BMI), gender, diagnosis, preoperative comorbidities (hypertension, diabetes, coronary artery disease, chronic obstructive pulmonary disease, etc.), previous surgeries (any surgical procedure performed under general anesthesia before this study), American Society of Anesthesiologists ( ASA) score, and duration of surgery will be recorded for each patient. Hemodynamic data (systolic arterial pressure (SAP), diastolic arterial pressure (DAP), mean arterial pressure (MAP), pulse, SpO2, and cerebral oxygen saturation will be recorded before anesthesia induction, after induction, and at 5, 10, 20, 30, and 60 minutes after the start of OLV. These hemodynamic data will also be recorded at the end OLV and at the end of the operation. OLV duration, anesthesia duration, surgery duration, amount of fluid administered, urine output, and whether blood replacement was performed will be recorded. Visual Analog Scale (VAS) scores will be recorded at 1, 2, 4, 8, 16, and 24 hours postoperatively. Analgesic medications administered during the 24-hour postoperative period will also be recorded. VAS evaluation will be performed on a 100 mm scale, where 0: no pain and 100: maximum pain, indicating the patient's pain level. During this process, any possible side effects that may develop due to analgesic treatment will be recorded.\n\nThe Mini Mental Test (MMT) form will be completed by patients one day before surgery, 48 hours postoperatively, on the 7th day postoperatively. MMT consists of eleven items grouped under five main headings: Orientation, recording memory, attention and calculation, recall, and language, and is evaluated out of a total score of 30.",[653,654,655,656,28],"Thoracic Anesthesia","Geriatric Anesthesia","One Lung Ventillation (OLV)","POCD - Postoperative Cognitive Dysfunction",[658,659,660,661,662,129],"thoracic anesthesia","geriatric patients","cognitive function","one lung ventilation","cerebral oxygenation","2026-01-14",{"date":39,"type":37},{"date":39,"type":22},{"date":667,"type":22},"2026-10-30",{"name":669,"class":232},"Ankara Ataturk Sanatorium Training and Research Hospital",{"id":671,"slug":672,"hasResults":12,"nctId":673,"briefTitle":674,"officialTitle":675,"acronym":4,"eligibilityCriteria":676,"healthyVolunteers":12,"sex":17,"minAge":677,"maxAge":18,"enrollmentInfo":678,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":679,"conditions":680,"keywords":682,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":686,"lastUpdatePostDateStruct":687,"startDateStruct":689,"completionDateStruct":690,"leadSponsor":692,"locationsCount":45},"100619700","anatomical-measurements-of-pudendal-nerve-block-in-children-100619700","NCT07348029","Anatomical Measurements of Pudendal Nerve Block in Children","Investigation of the Distance of the Needle Entry Point From the Anus and the Depth to Reach the Pudendal Nerve in Pudendal Nerve Block Application in Children","Inclusion Criteria:\n\n* Children aged 1-18 years\n* Scheduled for penile surgery (e.g., hypospadias, phimosis)\n* Planned to receive neurostimulation-guided pudendal nerve block\n* Patient and parents\u002Flegal guardians willing to participate under general anesthesia\n\nExclusion Criteria:\n\n* Patients with incomplete measurement data\n* Cases where successful nerve block cannot be performed or nerve stimulation is not detectable at currents ≥1.5 mA\n* Patients or parents\u002Flegal guardians who refuse pudendal nerve block\n* Patients with pelvic deformities or neuromuscular disorders","1 Year",{"count":477,"type":22},"This prospective observational study aims to investigate the relationship between anatomical parameters-specifically the distance from the anus to the needle insertion point and the depth required to reach the pudendal nerve-during neurostimulation-guided pudendal nerve block and patients' age, height, and weight in children undergoing penile surgery.",[28,681],"Penile Surgery-Related Pain",[683,684,685],"Pudendal Nerve Block","Pediatric Regional Anesthesia","Neurostimulation","2026-01-09",{"date":688,"type":37},"2026-01-16",{"date":436,"type":22},{"date":691,"type":22},"2026-06-10",{"name":693,"class":44},"Istanbul University - Cerrahpasa",{"id":695,"slug":696,"hasResults":12,"nctId":697,"briefTitle":698,"officialTitle":699,"acronym":4,"eligibilityCriteria":700,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":701,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":703,"conditions":704,"keywords":708,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":686,"lastUpdatePostDateStruct":712,"startDateStruct":714,"completionDateStruct":716,"leadSponsor":718,"locationsCount":45},"100618302","opioid-consumption-after-thoracotomy-and-factors-affecting-postoperative-acute-pain-100618302","NCT07329855","Opioid Consumption After Thoracotomy and Factors Affecting Postoperative Acute Pain","Analysis of Opioid Consumption After Thoracotomy and Factors Affecting Postoperative Acute Pain","Inclusion Criteria:\n\n* Patients aged over 18 years\n* Patients scheduled for thoracotomy\n* Patients with an American Society of Anesthesiologists (ASA) physical status classification of I-III\n* Patients who have provided informed consent\n* Patients with a body mass index (BMI) between 18-40 kg\u002Fm²\n\nExclusion Criteria:\n\n* Patients with ASA class IV or higher\n* Patients younger than 18 years old\n* Patients with systemic inflammatory disease\n* Patients receiving continuous anti-inflammatory and\u002For analgesic medication\n* Patients with chronic preoperative pain\n* Pregnant patients\n* Outpatients who received anesthesia outside the operating room\n* Emergency cases\n* Patients who underwent VATS, sternotomy, mediastinoscopy, or tracheal resection\n* Patients with a history of previous thoracic surgery\n* Patients who had a thoracic epidural catheter inserted for postoperative pain management\n* Patients with a BMI \\\u003C18 or \\>40 kg\u002Fm²",{"count":702,"type":22},35,"Thoracic surgery operations constitute a significant portion of surgical procedures performed in hospitals. In the United States, more than 50,000 thoracic surgical procedures are performed annually, and more than 80% of these patients experience moderate to severe postoperative pain requiring opioid administration, which increases the risk of complications . It has also been reported that chronic pain develops in approximately 50% of patients after thoracic surgery .\n\nThoracic surgery is commonly associated with severe, multifactorial pain during the postoperative period and is among the surgical branches with a high risk of developing chronic pain Despite advances in understanding postoperative pain mechanisms and improvements in pain management, inadequate postoperative pain control remains an unresolved healthcare problem. Higher acute pain scores are associated with less effective ventilation and coughing, increased incidence of lower respiratory tract infections, and prolonged ICU and hospital stays .\n\nIn the management of acute postoperative pain after thoracic surgery, clinicians have sought alternatives to thoracic epidural analgesia to avoid its potential adverse effects. Truncal blocks such as thoracic paravertebral block, erector spinae plane block, and serratus anterior block have been used to reduce postoperative pain . Additionally, various other analgesic techniques such as patient-controlled analgesia (PCA) and multimodal analgesia have been employed. Historically, the cornerstone of acute postoperative pain control has been systemic opioids administered via oral, intravenous, or thoracic epidural routes . Although opioids provide excellent pain relief, they are associated with significant side effects that can adversely affect recovery .\n\nWith the increasing use of ultrasonography (USG), truncal blocks have become more widespread. Alongside the development of Enhanced Recovery After Thoracic Surgery (ERATS) protocols, efforts have been made to reduce opioid use, leading to differing opinions regarding the management of acute pain after thoracic surgery. To prevent opioid use disorder and potential side effects, opioid-free or opioid-sparing approaches are now being encouraged in perioperative pain management . Conversely, some studies suggest that intraoperative opioid administration may have favorable effects on postoperative acute and chronic pain. Previous research has reported that the average daily opioid consumption after thoracic surgery is approximately 30 morphine milligram equivalents (MME) .\n\nAlthough video-assisted thoracoscopic surgery (VATS) has become more common, thoracotomy cases still constitute a large proportion of thoracic surgery procedures. Moreover, severe postoperative pain after thoracic surgery is most commonly associated with the thoracotomy incision itself. While some studies have suggested that new truncal block techniques may provide effective analgesia and reduce opioid consumption after thoracotomy, further studies are needed to determine which blocks are most commonly preferred and how opioid consumption patterns have changed with the adoption of these newer regional techniques.\n\nA review of the current literature reveals that the factors influencing acute pain after thoracotomy have not been sufficiently evaluated. Therefore, a re-evaluation of the factors affecting acute pain following thoracotomy, considering recent developments in pain management, is necessary. Furthermore, examining the relationship between perioperative opioid consumption, postoperative complications, and hospital length of stay in this patient population will provide valuable contributions to the literature.\n\nThe aim of this study is to evaluate the amount of opioid consumption following thoracotomy and to investigate whether perioperative opioid use affects acute pain, postoperative complications, and the length of hospital stay.",[653,705,706,28,707],"Thoracotomy","Opioid","Length of Hospital Stay",[705,709,710,497,711],"opioid consumption","postoperative acute pain","length of hospital stay",{"date":713,"type":37},"2026-01-12",{"date":715,"type":22},"2026-01-05",{"date":717,"type":22},"2026-05-05",{"name":669,"class":232}]