[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"postoperative-pain\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:postoperative-pain":27},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,298,0,25,[9,42,69,93,118,146,176,201,239,264,285,316,339,367,387,414,439,462,484,511,533,551,574,597,616],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":16,"eligibilityCriteria":17,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100053994","sex-hormones-postoperative-pain-and-opioid-use-100053994",false,"NCT06023225","Sex Hormones, Postoperative Pain and Opioid Use","Relationship Between Sex Hormones, Postoperative Pain and Opioid Use: the Role of Immune Factors","SPO","Inclusion Criteria:\n\nPediatric female patients between the ages 11-16 undergoing an orthopedic (trauma and non-trauma) surgical procedure involving a long bone or joint, or the spine, English speaking\n\nExclusion Criteria:\n\nPregnancy; Diagnosis of chronic pain, Psychiatric, developmental or neurological disorders, Disorders that are associated with pubertal maturation (e.g., precocious puberty).","FEMALE","11 Years","16 Years",{"count":22,"type":23},210,"ESTIMATED","OBSERVATIONAL","Aim 1- To identify relationships between sex hormone levels and postoperative pain and opioid use.\n\nAim 2: To determine whether the effects of testosterone on postoperative pain and opioid use are mediated by immune factors",[27,28],"Postoperative Pain","Opioid Use","RECRUITING","2026-07-10",{"date":32,"type":33},"2026-07-13","ACTUAL",{"date":35,"type":33},"2023-09-01",{"date":37,"type":23},"2029-07-01",{"name":39,"class":40},"Washington University School of Medicine","OTHER",1,{"id":43,"slug":44,"hasResults":12,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":4,"eligibilityCriteria":48,"healthyVolunteers":12,"sex":49,"minAge":50,"maxAge":51,"enrollmentInfo":52,"targetDuration":4,"studyType":54,"phases":55,"briefSummary":58,"conditions":59,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":62,"completionDateStruct":64,"leadSponsor":66,"locationsCount":41},"100053591","phase-2-evaluate-the-safety-and-efficacy-of-hl-1186-tablet-for-postoperative-analgesia-in-orthopedic-surgery-100053591","NCT07699601","Evaluate the Safety and Efficacy of HL-1186 Tablet for Postoperative Analgesia in Orthopedic Surgery","A Multicenter, Randomized, Double-Blind, Placebo- and Active-Controlled Parallel-Group Phase II\u002FIII Clinical Trial to Evaluate the Efficacy and Safety of HL-1186 Tablets for Postoperative Analgesia in Orthopedic Surgery","Inclusion Criteria:\n\n1. 18 years old ≤ age ≤ 75 years old, gender is not limited.\n2. 18 kg\u002Fm2 ≤ Body Mass Index (BMI) ≤ 30kg\u002Fm2.\n3. Scheduled to undergo orthopedic surgery under general anesthesia, with expected moderate-to-severe postoperative pain intensity.\n4. Able to understand the research process and the use of pain scales, and communicate effectively with researchers.\n5. After surgery completion, the participant is judged by the investigator to be awake and has a resting NRS score ≥ 4.\n\nExclusion Criteria:\n\n1. Previous surgery on the same site that may affect pain perception at the surgical site.\n2. Paresthesia or other pain that may affect postoperative pain evaluation or scale assessment.\n3. Neuropsychological disorders that may affect postoperative pain evaluation or scale assessment.\n4. Unstable angina, myocardial infarction, severe arrhythmia, NYHA cardiac function class ≥ III, or recurrent asthma attacks, etc., deemed unsuitable for inclusion by the investigator.\n5. Poorly controlled hypertension.\n6. Sleep apnea syndrome, or the presence of a difficult airway as assessed by the investigator.\n7. Known allergy to any component of the investigational drug(s), to perioperative (from induction of anesthesia to completion of surgery) anesthetic\u002Fanalgesic\u002Fantiemetic drugs, or a history of allergy to ≥ 3 substances.\n8. Positive for human immunodeficiency virus (HIV) antibody; positive for Treponema pallidum antibody and positive toluidine red unheated serum test (TRUST); positive for hepatitis B surface antigen (HBsAg) with detectable HBV-DNA; or positive for hepatitis C virus (HCV) antibody.\n9. Women who are pregnant or breastfeeding (within 1 year after delivery).\n10. Participation in another drug or medical device trial within 1 month before screening, or currently participating in another clinical trial receiving investigational intervention.\n11. Any other condition considered unsuitable for participation by the investigator.","ALL","18 Years","75 Years",{"count":53,"type":23},330,"INTERVENTIONAL",[56,57],"PHASE2","PHASE3","This clinical trial is a multiple-center, randomized, double-blind, placebo- and active-controlled parallel-group Phase II\u002FIII clinical trial, to evaluate the efficacy and safety of HL-1186 Tablets for Postoperative Analgesia in Orthopedic Surgery.",[27],"2026-07-08",{"date":32,"type":33},{"date":63,"type":33},"2026-05-09",{"date":65,"type":23},"2026-12",{"name":67,"class":68},"Shanghai Huilun Pharmaceutical Co., Ltd.","INDUSTRY",{"id":70,"slug":71,"hasResults":12,"nctId":72,"briefTitle":73,"officialTitle":74,"acronym":75,"eligibilityCriteria":76,"healthyVolunteers":12,"sex":49,"minAge":50,"maxAge":4,"enrollmentInfo":77,"targetDuration":4,"studyType":54,"phases":79,"briefSummary":81,"conditions":82,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":41},"100534892","pain-control-after-aortic-endoaneurysmectomy-popeye-100534892","NCT06244732","Pain Control After Aortic EndoaneurYsmEctomy (POPEYE)","Post-Operative Pain Control After Aortic EndoaneurYsmEctomy","POPEYE","Inclusion Criteria:\n\n* adult patients (age \\> 18 years)\n* patients who have given their consent to participate in the study\n* patients undergoing elective \"open\" surgical treatment of an abdominal aortic aneurysm with a midline xipho-pubic incision.\n\nExclusion Criteria:\n\n* Pregnant women\n* Patients being treated for chronic pain\n* Known allergy to drugs included in analgesia protocols\n* Contraindications to the use of one of the two methods provided:\n\n  * refusal by the patient\n  * infection at the puncture site\n  * coagulopathy:\n\n    1. PTT \\> 40 s and\u002For INR \\> 1.4\n    2. platelet count \\\u003C 50,000\u002FµL\n    3. taking antiplatelet or anticoagulant drugs that have not been discontinued in good time, according to international guidelines\n* Emergent intervention\n* Lack of consent to participate in the study",{"count":78,"type":23},60,[80],"NA","Open abdominal aortic aneurysm repair (OR-AAA) is an operation associated with high morbidity, and has 30-day mortality rates of between 4 and 14%. Post-operative pain management represents a primary anesthetic focus.\n\nA better analgesia, in addition to being desirable for the patient, can potentially reduce complications associated with postoperative pain and ensure faster functional recovery.\n\nThe modern concept of multimodal analgesia involves the association of multiple drugs and\u002For analgesic techniques to maximize the quality of analgesia and reduce the side effects of the individual methods. In this context, the addition of epidural analgesia (EA) to the intravenous administration of \"traditional\" analgesic drugs has assumed the role of gold standard in many surgeries, including OR-AAA.\n\nOver time, EA has proven to be a better analgesic technique than the use of intravenous opioids alone, however there is much uncertainty regarding its ability to reduce complications, morbidity and mortality of patients.\n\nFor some time, efforts to research effective, less invasive and safe anesthetic alternatives, have been directed towards the development of multimodal analgesia protocols with the aim of reducing complications and ensuring faster recovery. New approaches to post-operative pain management are emerging, including rectus sheat block (RSB).\n\nCurrently there is no evidence regarding the effectiveness of RSB in pain control after OR-AAA.\n\nIn this context, the study aims to compare two different post-operative pain management protocols, with the aim of verifying whether the use of RSB can guarantee a non-inferior level of analgesia with reduction of complications compared to AE.",[27,83],"Abdominal Aortic Aneurysm","2026-07-01",{"date":86,"type":33},"2026-07-02",{"date":88,"type":33},"2024-02-19",{"date":90,"type":23},"2027-03",{"name":92,"class":40},"IRCCS Policlinico S. Donato",{"id":94,"slug":95,"hasResults":12,"nctId":96,"briefTitle":97,"officialTitle":98,"acronym":99,"eligibilityCriteria":100,"healthyVolunteers":12,"sex":49,"minAge":50,"maxAge":101,"enrollmentInfo":102,"targetDuration":4,"studyType":54,"phases":103,"briefSummary":104,"conditions":105,"keywords":107,"overallStatus":110,"whyStopped":4,"lastUpdateSubmitDate":111,"lastUpdatePostDateStruct":112,"startDateStruct":113,"completionDateStruct":114,"leadSponsor":116,"locationsCount":41},"100644830","rectointercostal-plane-block-ricpb-for-laparoscopic-cholecystectomy-100644830","NCT07676552","Rectointercostal Plane Block (RICPB) for Laparoscopic Cholecystectomy","Rectointercostal Plane Block (RICPB) for Postoperative Analgesia After Laparoscopic Cholecystectomy: A Randomized Controlled Trial","RICPB","Inclusion Criteria:\n\n* Age between 18 and 65 years\n* American Society of Anesthesiologists (ASA) physical status I-III\n* Scheduled for elective laparoscopic cholecystectomy\n* Body mass index (BMI) between 18 and 35 kg\u002Fm²\n* Ability to understand the study procedures and provide written informed consent\n\nExclusion Criteria:\n\n* Refusal to participate or inability to provide informed consent\n* Known allergy or hypersensitivity to local anesthetics, opioids, or study medications\n* Chronic opioid use or chronic pain syndrome\n* Coagulation disorders or ongoing anticoagulant therapy\n* Infection at the planned injection site\n* Pregnancy or breastfeeding\n* Cognitive impairment or inability to communicate pain scores\n* Severe hepatic, renal, cardiac, or respiratory disease judged by the investigator to interfere with study participation\n* Conversion from laparoscopic to open surgery\n* Previous upper abdominal surgery that may interfere with the block technique or pain assessment","65 Years",{"count":78,"type":23},[80],"This prospective randomized controlled trial is designed to evaluate the analgesic efficacy of ultrasound-guided rectointercostal plane block (RICPB) in patients undergoing elective laparoscopic cholecystectomy. Patients will be randomized to receive unilateral right-sided RICPB at the end of surgery. Postoperative opioid consumption, Numeric Rating Scale (NRS) pain scores, and postoperative complications will be assessed to determine the effectiveness of RICPB in postoperative pain management.",[106,27],"Cholelithiasis",[108,109,99],"Laparoscopic Cholecystectomy","Rectointercostal Plane Block","NOT_YET_RECRUITING","2026-06-30",{"date":86,"type":33},{"date":84,"type":23},{"date":115,"type":23},"2027-02-01",{"name":117,"class":40},"Koç University",{"id":119,"slug":120,"hasResults":12,"nctId":121,"briefTitle":122,"officialTitle":123,"acronym":4,"eligibilityCriteria":124,"healthyVolunteers":12,"sex":49,"minAge":50,"maxAge":101,"enrollmentInfo":125,"targetDuration":4,"studyType":54,"phases":127,"briefSummary":128,"conditions":129,"keywords":133,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":111,"lastUpdatePostDateStruct":139,"startDateStruct":140,"completionDateStruct":142,"leadSponsor":144,"locationsCount":41},"100611543","external-oblique-intercostal-block-eoicb-for-laparoscopic-cholecystectomy-100611543","NCT07241949","External Oblique Intercostal Block (EOICB) for Laparoscopic Cholecystectomy","Paravertebral Block or External Oblique Intercostal Block? A Comparative Analysis of Pain and Opioid Consumption After Laparoscopic Cholecystectomy: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Age between 18 and 65 years\n* Scheduled for elective laparoscopic cholecystectomy under general anesthesia\n* ASA physical status I-III\n* Able to understand the study procedure and provide informed consent\n\nExclusion Criteria:\n\nPatient refusal or inability to provide informed consent\n\nAllergy or contraindication to local anesthetics, tramadol, or study medications\n\nCoagulopathy or current anticoagulant therapy\n\nLocal infection at the planned block injection site\n\nSevere hepatic or renal impairment\n\nChronic opioid use or opioid dependence\n\nNeurological or psychiatric disorders affecting pain perception or communication\n\nPregnancy or breastfeeding\n\nBody mass index (BMI) \\> 35 kg\u002Fm²\n\nConversion to open cholecystectomy during surgery",{"count":126,"type":23},147,[80],"This single-center, prospective, randomized controlled trial aims to compare the effects of paravertebral block (PVB), external oblique intercostal (EOI) block, and intravenous patient-controlled analgesia (PCA) with tramadol on postoperative pain and opioid consumption in patients undergoing elective laparoscopic cholecystectomy. The primary endpoint is total tramadol consumption within 24 hours postoperatively. Secondary outcomes include pain scores, additional analgesic use, incidence of nausea\u002Fvomiting, mobilization time, and length of hospital stay.",[27,108,130,131,132],"Paravertebral Block","External Oblique Intercostal Plane Block","Patient Controlled Analgesia",[134,135,136,137,138],"Cholecystectomy","Pain","Analgesia","Tramadol","Nerve Block",{"date":86,"type":33},{"date":141,"type":33},"2025-12-01",{"date":143,"type":23},"2026-12-05",{"name":145,"class":40},"Cukurova University",{"id":147,"slug":148,"hasResults":12,"nctId":149,"briefTitle":150,"officialTitle":151,"acronym":4,"eligibilityCriteria":152,"healthyVolunteers":12,"sex":49,"minAge":50,"maxAge":101,"enrollmentInfo":153,"targetDuration":4,"studyType":54,"phases":155,"briefSummary":156,"conditions":157,"keywords":160,"overallStatus":110,"whyStopped":4,"lastUpdateSubmitDate":168,"lastUpdatePostDateStruct":169,"startDateStruct":170,"completionDateStruct":172,"leadSponsor":174,"locationsCount":4},"100644621","interscalene-block-versus-infraspinatus-teres-minor-interfascial-plane-block-for-shoulder-arthroscopy-100644621","NCT07670780","Interscalene Block Versus Infraspinatus-Teres Minor Interfascial Plane Block for Shoulder Arthroscopy","Comparison of the Effects of Interscalene Block and Infraspinatus-Teres Minor Interfascial Plane Block on Postoperative Analgesia and Diaphragmatic Function in Patients Undergoing Shoulder Arthroscopy.","Inclusion Criteria:\n\n* Age between 18 and 65 years\n* ASA physical status I-II\n* Scheduled for elective shoulder arthroscopy\n* No known allergy to study medications\n* No psychiatric disorder\n* No opioid dependence\n* Ability to use patient-controlled analgesia (PCA) and complete VAS assessments\n* No contraindication to peripheral nerve blocks\n* Written informed consent obtained\n\nExclusion Criteria:\n\n* Refusal to participate\n* Uncontrolled hypertension\n* Chronic pain or ongoing analgesic treatment\n* Significant cardiac disease (coronary artery disease, arrhythmia, heart failure)\n* Diabetes mellitus",{"count":154,"type":23},120,[80],"This prospective randomized controlled study aims to compare the effects of interscalene block, infraspinatus-teres minor interfascial plane block, and a control group on postoperative analgesia and diaphragmatic function in patients undergoing shoulder arthroscopy. A total of 120 patients will be enrolled and allocated into three groups. Postoperative pain scores, opioid consumption, rescue analgesic requirements, and diaphragmatic function will be evaluated and compared among the groups. The study seeks to determine whether the infraspinatus-teres minor interfascial plane block can provide effective postoperative analgesia with less impact on diaphragmatic function compared with interscalene block.",[27,158,159],"Shoulder Arthroscopic Surgeries","Diaphragmatic Dysfunction",[161,162,163,164,165,166,167],"ınterscalene block","Shoulder Arthroscopy","Regional Anesthesia","Postoperative Analgesia","Diaphragmatic Function","Ultrasound-Guided Block","Infraspinatus-Teres Minor Interfascial Plane Block","2026-06-29",{"date":84,"type":33},{"date":171,"type":23},"2026-06-22",{"date":173,"type":23},"2028-08-28",{"name":175,"class":40},"TC Erciyes University",{"id":177,"slug":178,"hasResults":12,"nctId":179,"briefTitle":180,"officialTitle":181,"acronym":182,"eligibilityCriteria":183,"healthyVolunteers":12,"sex":49,"minAge":50,"maxAge":101,"enrollmentInfo":184,"targetDuration":4,"studyType":54,"phases":186,"briefSummary":187,"conditions":188,"keywords":189,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":168,"lastUpdatePostDateStruct":194,"startDateStruct":195,"completionDateStruct":197,"leadSponsor":199,"locationsCount":41},"100636513","preventive-analgesia-with-anrikefon-in-laparoscopic-cholecystectomy-100636513","NCT07566663","Preventive Analgesia With Anrikefon in Laparoscopic Cholecystectomy","Effect of Preventive Analgesia With Anrikefon on Postoperative Acute Pain and Rehabilitation Process in Adult Patients Undergoing Laparoscopic Cholecystectomy","ANIPAP","Inclusion Criteria:\n\n1. ASA physical status classification I-III;\n2. Age 18-65 years;\n3. Scheduled for elective laparoscopic cholecystectomy;\n4. Voluntary signed informed consent;\n5. BMI between 18-28 kg\u002Fm²;\n6. No history of general anesthesia surgery within the past 3 months.\n\nExclusion Criteria:\n\n1. Severe cardiovascular disease, respiratory disease, or psychiatric disorders;\n2. Severe renal insufficiency;\n3. Recent use of diuretics or compound medications containing diuretics;\n4. Continuous use of opioid analgesics for more than 10 days within the past 3 months;\n5. Use of medications with unknown half-life affecting analgesic efficacy within 14 days prior to randomization;\n6. Pregnant women, lactating women, or those planning pregnancy in the near future;\n7. History of hypersensitivity to study medications.",{"count":185,"type":23},274,[80],"This study will determine the optimal timing for Anrikefon administration. It will also assess the quality of patient recovery. Laparoscopic cholecystectomy (LC) is a routine surgical procedure. However, the incidence of acute visceral and incision pain is high, reaching 50% to 70%. This pain significantly impairs patient recovery.\n\nAnrikefon is novel peripherally restricted κ-opioid receptor agonist. It has very low brain penetration. This property reduces central nervous system side effects and respiratory depression. Preventive analgesia blocks the transmission of nociceptive stimuli to the central nervous system. It reduces postoperative pain sensitization and intensity. Currently, research on Anrikefon for preventive analgesia in LC patients is limited. It impacts on the recovery process is not yet fully understood. This study will compare drug administration before anesthesia induction with intra-operative administration.\n\nParticipants will be assigned to one of two groups with equal probability using computer-generated random numbers. Patients in the Preventive Analgesia group will receive Anrikefon injection 15 minutes before anesthesia induction. Bridging Analgesia group is the control group. Patients in this group will receive Anrikefon immediately after the gallbladder is detached from the liver. Both groups will receive the identical drug dosage of 1 μg\u002Fkg.\n\nBoth treatment groups will receive identical care beyond the time of Anrikefon administration. All patients will undergo standardized anesthesia management. Parecoxib sodium 40 mg will be injected for rescue analgesia if NRS score \\> 4. We will analyze the primary, secondary, and exploratory outcome measures after surgery, aiming to explore the optimal timing of Anrikefon and its impact on the patient's recovery process.",[27],[190,108,191,192,193],"Preventive Analgesia","Postoperative Acute Pain","Visceral Pain","Anrikefon",{"date":84,"type":33},{"date":196,"type":33},"2026-06-02",{"date":198,"type":23},"2028-06-30",{"name":200,"class":40},"Xuanwu Hospital, Beijing",{"id":202,"slug":203,"hasResults":12,"nctId":204,"briefTitle":205,"officialTitle":206,"acronym":207,"eligibilityCriteria":208,"healthyVolunteers":12,"sex":49,"minAge":50,"maxAge":101,"enrollmentInfo":209,"targetDuration":4,"studyType":54,"phases":211,"briefSummary":213,"conditions":214,"keywords":217,"overallStatus":110,"whyStopped":4,"lastUpdateSubmitDate":231,"lastUpdatePostDateStruct":232,"startDateStruct":233,"completionDateStruct":235,"leadSponsor":237,"locationsCount":41},"100642443","phase-4-oral-nifedipine-versus-placebo-for-pain-and-healing-after-hemorrhoidectomy-100642443","NCT07659665","Oral Nifedipine Versus Placebo for Pain and Healing After Hemorrhoidectomy","The Effect of Oral Nifedipine Versus Placebo on Postoperative Pain and Healing Following Hemorrhoidectomy in Adult Patients: A Randomized Controlled Trial in Sana'a, Yemen","NIFEDIPINE-HD","Inclusion Criteria:\n\n* Adult patients aged 18-65 years\n* Scheduled for elective hemorrhoidectomy for grade III or IV hemorrhoids\n* Ability to provide written informed consent\n* Ability to understand and complete study questionnaires\n* Willingness to comply with the study protocol and follow-up visits\n\nExclusion Criteria:\n\n* Known hypersensitivity to nifedipine\n* Severe cardiovascular disease (unstable angina, recent myocardial infarction, severe heart failure)\n* Hypotension (systolic blood pressure \\\u003C 90 mmHg)\n* Severe hepatic or renal impairment\n* Pregnancy or breastfeeding\n* Current use of calcium channel blockers or nitrates\n* Emergency hemorrhoidectomy\n* Concurrent inflammatory bowel disease\n* History of anorectal surgery within the past 6 months",{"count":210,"type":23},100,[212],"PHASE4","The goal of this clinical trial is to evaluate whether oral nifedipine reduces postoperative pain and improves wound healing after hemorrhoidectomy in adult patients aged 18-65 years undergoing elective surgery for grade III or IV hemorrhoids in Sana'a, Yemen.\n\nThe main questions it aims to answer are:\n\n* Does oral nifedipine 20 mg twice daily for 14 days reduce postoperative pain compared with placebo?\n* Does oral nifedipine improve wound healing progression and shorten time to complete healing compared with placebo?\n\nResearchers will compare the nifedipine group to the placebo group to see if there is a significant reduction in pain scores, faster wound healing, lower analgesic consumption, and fewer complications.\n\nParticipants will:\n\n* Take either oral nifedipine 20 mg or an identical-looking placebo capsule twice daily for 14 consecutive days, starting 6 hours after surgery.\n* Report pain intensity using a standard 0-10 Visual Analogue Scale at multiple time points during the first 28 days.\n* Attend follow-up visits on postoperative days 7, 14, and 28 for wound healing assessment and safety monitoring.\n* Use rescue analgesia (paracetamol and\u002For diclofenac) as needed for breakthrough pain.",[215,27,216,136],"Hemorrhoids","Wound Healing",[218,219,220,221,222,223,224,225,226,227,228,229,230],"Hemorrhoidectomy","Post-hemorrhoidectomy pain","Internal anal sphincter","Anal sphincter spasm","Nifedipine","Calcium channel blocker","Randomized controlled trial","Yemen","Placebo","Visual Analogue Scale","Pain management","Wound healing","Ecchymosis Discharge Approximation score","2026-06-27",{"date":84,"type":33},{"date":234,"type":23},"2026-08-01",{"date":236,"type":23},"2026-12-30",{"name":238,"class":40},"Sana'a University",{"id":240,"slug":241,"hasResults":12,"nctId":242,"briefTitle":243,"officialTitle":244,"acronym":245,"eligibilityCriteria":246,"healthyVolunteers":12,"sex":49,"minAge":50,"maxAge":51,"enrollmentInfo":247,"targetDuration":4,"studyType":54,"phases":249,"briefSummary":250,"conditions":251,"keywords":252,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":256,"lastUpdatePostDateStruct":257,"startDateStruct":258,"completionDateStruct":259,"leadSponsor":261,"locationsCount":41},"100644008","interscalene-brachial-plexus-block-versus-serratus-posterior-superior-intercostal-plane-block-for-arthroscopic-shoulder-surgery-100644008","NCT07668648","Interscalene Brachial Plexus Block Versus Serratus Posterior Superior Intercostal Plane Block for Arthroscopic Shoulder Surgery","Comparison of Interscalene Brachial Plexus Block and Serratus Posterior Superior Intercostal Plane Block for Postoperative Analgesia After Arthroscopic Shoulder Surgery: A Prospective, Randomized, Double-Blind Controlled Trial","SISA","Inclusion Criteria:\n\n* Age between 18 and 75 years\n* ASA physical status I, II, or III\n* Scheduled for elective arthroscopic shoulder surgery under general anesthesia\n* Provision of written informed consent\n\nExclusion Criteria:\n\n* Refusal to participate in the study\n* Coagulopathy\n* Current anticoagulant therapy\n* Infection at the block site\n* Previous surgery involving the planned block site\n* Known allergy or history of toxicity to local anesthetics\n* Hepatic failure\n* Renal failure\n* Uncontrolled diabetes mellitus\n* Cognitive impairment or mental disability preventing reliable assessment\n* Chronic opioid use or ongoing chronic pain treatment\n* Pregnancy, suspected pregnancy, or breastfeeding\n* Chronic pulmonary disease (e.g., COPD or asthma)\n* Failed block",{"count":248,"type":23},80,[80],"Arthroscopic shoulder surgery is associated with moderate to severe postoperative pain that may delay recovery and rehabilitation. Interscalene brachial plexus block (ISB) is widely used for postoperative analgesia in shoulder surgery; however, it may be associated with complications such as phrenic nerve paralysis. The serratus posterior superior intercostal plane (SPSIP) block is a recently described fascial plane block that may provide effective analgesia while avoiding some of the limitations of ISB.\n\nThis prospective, randomized, double-blind controlled trial aims to compare the analgesic efficacy of ISB and SPSIP block in patients undergoing elective arthroscopic shoulder surgery under general anesthesia. The primary outcome is total postoperative opioid consumption during the first 24 hours after surgery. Secondary outcomes include postoperative pain scores, quality of recovery, time to first rescue analgesia, rescue analgesic requirements, intraoperative opioid consumption, sensory block distribution, motor block characteristics, and block-related complications.",[27,162],[253,254,163,255],"Interscalene Brachial Plexus Block","Serratus Posterior Superior Intercostal Plane Block","Ultrasound-Guided Nerve Block","2026-06-25",{"date":168,"type":33},{"date":256,"type":33},{"date":260,"type":23},"2026-12-15",{"name":262,"class":263},"Ferit Yetik","OTHER_GOV",{"id":265,"slug":266,"hasResults":12,"nctId":267,"briefTitle":268,"officialTitle":269,"acronym":270,"eligibilityCriteria":271,"healthyVolunteers":12,"sex":18,"minAge":50,"maxAge":101,"enrollmentInfo":272,"targetDuration":4,"studyType":54,"phases":274,"briefSummary":275,"conditions":276,"keywords":277,"overallStatus":110,"whyStopped":4,"lastUpdateSubmitDate":256,"lastUpdatePostDateStruct":279,"startDateStruct":280,"completionDateStruct":281,"leadSponsor":283,"locationsCount":41},"100644956","spsip-block-versus-esp-block-for-chronic-pain-after-unilateral-breast-surgery-100644956","NCT07674836","SPSIP Block Versus ESP Block for Chronic Pain After Unilateral Breast Surgery","Comparison of Serratus Posterior Superior Intercostal Plane Block and Erector Spinae Plane Block for the Prevention of Chronic Postoperative Pain After Unilateral Breast Surgery: A Prospective, Randomized, Assessor-Blinded Trial","SPES-CPSP","Inclusion Criteria:\n\n* Female patients aged 18-65 years\n* ASA physical status I-III\n* Body mass index (BMI) between 18 and 35 kg\u002Fm²\n* Scheduled for elective unilateral breast surgery (mastectomy with or without sentinel lymph node biopsy)\n* Ability to understand and provide written informed consent\n\nExclusion Criteria:\n\n* Infection at the site of block application\n* Known allergy to local anesthetics\n* Coagulopathy or anticoagulant therapy\n* Chronic opioid use\n* Pregnancy\n* Inability to communicate or cooperate\n* Refusal to participate\n* Failed block\n* Requirement of additional intraoperative analgesia outside the study protocol\n* Development of serious intraoperative complications",{"count":273,"type":23},90,[80],"This prospective, randomized, assessor-blinded study will compare serratus posterior superior intercostal plane block and erector spinae plane block in adult female patients undergoing unilateral breast surgery. The primary outcome is chronic postoperative pain at 3 months, assessed using the Brief Pain Inventory-Short Form.",[27,28],[278,28],"Post Operative Pain",{"date":111,"type":33},{"date":84,"type":23},{"date":282,"type":23},"2026-12-01",{"name":284,"class":263},"Engin Çetin",{"id":286,"slug":287,"hasResults":12,"nctId":288,"briefTitle":289,"officialTitle":290,"acronym":291,"eligibilityCriteria":292,"healthyVolunteers":12,"sex":49,"minAge":50,"maxAge":4,"enrollmentInfo":293,"targetDuration":4,"studyType":54,"phases":295,"briefSummary":296,"conditions":297,"keywords":300,"overallStatus":110,"whyStopped":4,"lastUpdateSubmitDate":256,"lastUpdatePostDateStruct":309,"startDateStruct":310,"completionDateStruct":312,"leadSponsor":314,"locationsCount":4},"100645168","recovery-with-virtual-reality-for-stress-and-pain-100645168","NCT07679022","Recovery With Virtual Reality for Stress and Pain","Recovery With Virtual Reality for Stress & Pain (ReVRS)","ReVRS","Inclusion Criteria:\n\n* Adults aged 18 years or older.\n* Scheduled to undergo elective gynecological surgery according to the study protocol at a participating center where virtual reality can be provided.\n* Able and willing to provide informed consent for study participation, 1:1 randomization, and use of virtual reality.\n\nExclusion Criteria:\n\n* Increased risk of adverse effects related to virtual reality, including pronounced motion sickness, claustrophobia, or photosensitive epilepsy.\n* Active substance use disorder or active misuse of alcohol or illicit drugs.\n* Severe chronic pain and\u002For regular preoperative opioid treatment, as defined in the study protocol.",{"count":294,"type":23},140,[80],"This randomized controlled trial will evaluate whether a brief preoperative virtual reality intervention reduces anxiety and improves early recovery in adults undergoing elective gynecological surgery. Approximately 140 participants will be randomly assigned in a 1:1 ratio to either virtual reality in addition to usual care or usual care alone. The virtual reality intervention will consist of approximately 10-20 minutes of an immersive relaxation experience before surgery. The primary outcome is the change in preoperative anxiety measured before and after the intervention. Secondary outcomes include postoperative quality of recovery, pain, opioid consumption, postoperative nausea and vomiting, and early recovery-related healthcare outcomes.",[298,27,299],"Preoperative Anxiety","Postoperative Recovery",[301,302,303,304,305,298,27,306,307,308],"Virtual Reality","Perioperative Care","Gynecologic Surgery","Quality of Recovery","QoR-15","Opioid Consumption","Postoperative Nausea and Vomiting","Nonpharmacologic Intervention",{"date":84,"type":33},{"date":311,"type":23},"2026-09-30",{"date":313,"type":23},"2029-02-28",{"name":315,"class":40},"Region Skane",{"id":317,"slug":318,"hasResults":12,"nctId":319,"briefTitle":320,"officialTitle":321,"acronym":4,"eligibilityCriteria":322,"healthyVolunteers":323,"sex":49,"minAge":324,"maxAge":325,"enrollmentInfo":326,"targetDuration":4,"studyType":54,"phases":328,"briefSummary":329,"conditions":330,"keywords":4,"overallStatus":110,"whyStopped":4,"lastUpdateSubmitDate":331,"lastUpdatePostDateStruct":332,"startDateStruct":334,"completionDateStruct":335,"leadSponsor":337,"locationsCount":4},"100644484","phase-4-intraperitoneal-ketamine-versus-fentanyl-as-adjuvants-to-bupivacaine-in-laparoscopic-cholecystectomy-100644484","NCT07670052","Intraperitoneal Ketamine Versus Fentanyl as Adjuvants to Bupivacaine in Laparoscopic Cholecystectomy","Intraperitoneal Instillation of Ketamine Versus Fentanyl as Adjuvants to Bupivacaine for Postoperative Pain Control in Laparoscopic Cholecystectomy _a Double-blinded Randomized Trial.","Inclusion Criteria:\n\n* Patients of age 20-50 years\n* Patients of either gender\n* Patients planned to undergo elective LC.\n* Patients have I-II of the American Society of Anaesthesiologists (ASA)\n\nExclusion Criteria:\n\n* Patient's refusal.\n* body mass index (BMI) ≥40 kg\u002Fm2.\n* History of hypersensitivity to the drugs being evaluated\n* Inability to comprehend postoperatively the pain assessment scale\u002Fneuropsychiatric disorders.\n* chronic use of opioids and opioid addiction\n* Patients with acute cholecystitis or converted to open surgery.\n* Carcinoma of gall bladder\n* Pregnant female\n* Bleeding disorders",true,"20 Years","50 Years",{"count":327,"type":23},84,[212],"Laparoscopic cholecystectomy is the standard surgical treatment for gallbladder stones; however, the origin of pain after LC is multifactorial and complex in nature. Pain arising from incision sites is parietal pain, whereas pain from the gall bladder bed is mainly visceral in nature, and shoulder pain is mainly referred owing to the residual carbon dioxide irritating the diaphragm. Intraperitoneal administration of local anesthetics has been shown to improve postoperative pain control and reduce the need for systemic analgesics. The addition of adjuvant agents such as fentanyl or ketamine may further enhance analgesic efficacy. This randomized double-blind study aims to compare the effectiveness of intraperitoneal ketamine versus fentanyl as adjuvants to bupivacaine in reducing postoperative pain and analgesic requirements following laparoscopic cholecystectomy.",[27],"2026-06-23",{"date":333,"type":33},"2026-06-26",{"date":234,"type":23},{"date":336,"type":23},"2027-09-01",{"name":338,"class":40},"Assiut University",{"id":340,"slug":341,"hasResults":12,"nctId":342,"briefTitle":343,"officialTitle":343,"acronym":4,"eligibilityCriteria":344,"healthyVolunteers":12,"sex":49,"minAge":50,"maxAge":345,"enrollmentInfo":346,"targetDuration":4,"studyType":54,"phases":348,"briefSummary":349,"conditions":350,"keywords":354,"overallStatus":110,"whyStopped":4,"lastUpdateSubmitDate":171,"lastUpdatePostDateStruct":361,"startDateStruct":362,"completionDateStruct":363,"leadSponsor":365,"locationsCount":4},"100644517","phase-4-comparative-evaluation-of-diaphragmatic-function-following-interscalene-anterior-suprascapular-and-costoclavicular-nerve-blocks-in-shoulder-surgery-100644517","NCT07671352","Comparative Evaluation of Diaphragmatic Function Following Interscalene, Anterior Suprascapular, and Costoclavicular Nerve Blocks in Shoulder Surgery","Inclusion Criteria:\n\nAdults of both sexes, aged 18 to 70 years American Society of Anesthesiologists (ASA) physical status I-II Scheduled for elective shoulder surgery\n\nExclusion Criteria:\n\nPulmonary disease or baseline diaphragmatic dysfunction Refusal to provide informed consent Pre-existing neuropathy in the operated limb Allergy to local anesthetics Infection at the injection site Coagulopathy Pregnancy","80 Years",{"count":347,"type":23},75,[212],"Shoulder surgery causes significant postoperative pain, and ultrasound-guided regional anesthesia is central to its management. The interscalene block (ISB) is the gold standard but frequently causes phrenic nerve paralysis and hemi-diaphragmatic paresis, limiting its use in patients with reduced pulmonary reserve. The suprascapular (SSNB) and costoclavicular (CCB) blocks are proposed diaphragm-sparing alternatives, but data directly comparing all three are limited.\n\nThis randomised, double-blinded trial will compare the incidence of hemi-diaphragmatic paresis among ultrasound-guided ISB, SSNB, and CCB in elective shoulder surgery. Seventy-five ASA I-II patients aged 18-70 will be allocated 1:1:1 to one block. The primary outcome is the incidence of hemi-diaphragmatic paresis, measured by ultrasound diaphragmatic excursion before induction and after recovery in the PACU. Secondary outcomes include postoperative pain, analgesic consumption, and patient satisfaction. The investigators hypothesise that SSNB and CCB will cause less hemidiaphragmatic paresis than ISB while providing comparable analgesia.",[351,27,352,353],"Hemidiaphragmatic Paralysis","Shoulder Surgery","Brachial Plexus Block",[355,356,357,358,359,360],"Interscalene block","Suprascapular nerve block","Costoclavicular block","Diaphragmatic excursion","Ultrasound-guided regional anesthesia","Phrenic nerve palsy",{"date":333,"type":33},{"date":256,"type":23},{"date":364,"type":23},"2027-01-01",{"name":366,"class":40},"Menoufia University",{"id":368,"slug":369,"hasResults":12,"nctId":370,"briefTitle":371,"officialTitle":372,"acronym":4,"eligibilityCriteria":373,"healthyVolunteers":12,"sex":49,"minAge":50,"maxAge":345,"enrollmentInfo":374,"targetDuration":4,"studyType":54,"phases":376,"briefSummary":377,"conditions":378,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":171,"lastUpdatePostDateStruct":380,"startDateStruct":381,"completionDateStruct":383,"leadSponsor":385,"locationsCount":41},"100641931","effect-of-liposomal-bupivacaine-tapb-combined-with-oxycodone-pcia-on-postoperative-gastrointestinal-recovery-in-patients-undergoing-major-abdominal-surgery-100641931","NCT07651722","Effect of Liposomal Bupivacaine TAPB Combined With Oxycodone PCIA on Postoperative Gastrointestinal Recovery in Patients Undergoing Major Abdominal Surgery","Effect of Liposomal Bupivacaine TAPB Combined With Oxycodone PCIA on Postoperative Gastrointestinal Function in Patients Undergoing Major Abdominal Surgery: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Patients scheduled to undergo elective major abdominal surgery, specifically small bowel or colorectal resections.\n* Aged between 18 and 80 years (inclusive).\n* American Society of Anesthesiologists (ASA) physical status I, II, or III.\n* Capable of understanding the study procedures, cooperating with postoperative pain\u002Frecovery assessments (e.g., VAS, QoR-15, I-FEED), and providing written informed consent prior to surgery.\n\nExclusion Criteria:\n\n* History of significant neuropsychiatric disorders, including schizophrenia, epilepsy, Parkinson's disease, or myasthenia gravis, that may interfere with pain perception or cognitive evaluation.\n* History of alcohol abuse or chronic opioid\u002Fanalgesic dependence.\n* Severe, uncontrolled hypertension (defined as systolic blood pressure ≥ 180 mmHg or diastolic blood pressure ≥ 110 mmHg).\n* Severe cardiac, hepatic, renal, or pulmonary dysfunction that poses a high surgical\u002Fanesthetic risk or alters drug metabolism.\n* Pregnant or lactating women.\n* Known allergy, hypersensitivity, or contraindications to any of the study medications, including local anesthetics (ropivacaine, bupivacaine) or opioids (sufentanil, oxycodone).",{"count":375,"type":23},132,[80],"Rationale and Objective:\n\nThe purpose of this study is to evaluate the clinical efficacy and safety of a novel multimodal analgesia regimen, combining transversus abdominis plane block (TAPB) with patient-controlled intravenous analgesia (PCIA), in improving postoperative gastrointestinal function recovery in patients undergoing major abdominal surgery.\n\nStudy Design and Interventions:\n\nThis is a prospective, single-center, randomized, double-blind, parallel-controlled trial. A total of 132 eligible patients (aged 18-80 years, ASA I-III, scheduled for elective small bowel or colorectal surgery) will be randomly allocated to one of three groups (n = 44 per group) to receive distinct postoperative analgesia regimens:\n\nGroup R-S: 0.375% Ropivacaine TAPB + Sufentanil PCIA; Group LB-S: 266 mg Liposomal Bupivacaine TAPB + Sufentanil PCIA; Group LB-O: 266 mg Liposomal Bupivacaine TAPB + Oxycodone PCIA.\n\nPrimary Outcome:\n\nThe primary outcome is the area under the curve (AUC) of the I-FEED scoring system within the first 7 postoperative days, which comprehensively reflects the overall trajectory of gastrointestinal function recovery.\n\nHypothesis:\n\nThe investigators hypothesize that the combination of long-acting Liposomal Bupivacaine TAPB (for prolonged somatic pain relief) and Oxycodone PCIA (for precise visceral pain control via dual u and k receptor agonism) will synergistically attenuate the perioperative stress-inflammatory response. Consequently, this regimen is expected to significantly mitigate postoperative ileus (POI) and accelerate the recovery of gastrointestinal motility",[27,379],"Postoperative Ileus",{"date":256,"type":33},{"date":382,"type":33},"2026-06-16",{"date":384,"type":23},"2026-09",{"name":386,"class":40},"Tianjin First Central Hospital",{"id":388,"slug":389,"hasResults":12,"nctId":390,"briefTitle":391,"officialTitle":392,"acronym":4,"eligibilityCriteria":393,"healthyVolunteers":12,"sex":394,"minAge":395,"maxAge":396,"enrollmentInfo":397,"targetDuration":4,"studyType":54,"phases":398,"briefSummary":399,"conditions":400,"keywords":402,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":407,"lastUpdatePostDateStruct":408,"startDateStruct":409,"completionDateStruct":411,"leadSponsor":413,"locationsCount":41},"100639100","comparison-of-sacral-esp-block-and-caudal-block-in-pediatric-hypospadias-surgery-100639100","NCT07619651","Comparison of Sacral ESP Block and Caudal Block in Pediatric Hypospadias Surgery","Prospective Comparison of Sacral Erector Spinae Plane Block and Caudal Epidural Block for Postoperative Analgesia in Pediatric Hypospadias Surgery","Inclusion Criteria:\n\n1. Male patients aged between 6 months to 7 years\n2. Scheduled for hypospadias repair surgery\n3. ASA physical status I-II\n4. No known allergy to local anesthetic agents\n5. No contraindications to peripheral nerve blocks\n6. Written informed consent obtained from parents or legal guardians\n\nExclusion Criteria:\n\n1. Known congenital coagulopathy\n2. Known allergy to local anesthetic agents\n3. Severe systemic disease (ASA III-IV)\n4. Severe organ failure\n5. Neurological disorders","MALE","6 Months","7 Years",{"count":78,"type":23},[80],"Hypospadias surgery in pediatric patients requires effective postoperative analgesia to ensure patient comfort and reduce perioperative stress. Caudal epidural block is widely used for analgesia in pediatric urological procedures; however, alternative regional techniques such as the sacral erector spinae plane (ESP) block have recently gained attention.\n\nThis prospective comparative study aims to compare the analgesic efficacy of sacral ESP block and caudal epidural block in pediatric patients undergoing hypospadias surgery. Participants will be allocated to receive either sacral ESP block or caudal epidural block according to the study protocol.\n\nThe primary outcome will be postoperative pain scores within the first 24 hours after surgery. Secondary outcomes will include total analgesic consumption, time to first rescue analgesia, and block-related complications.",[401,27],"Hypospadias",[403,404,405,164,406],"Sacral Erector Spinae Plane Block","Caudal Epidural Block","Hypospadias Surgery","Pediatric Urology","2026-06-21",{"date":256,"type":33},{"date":410,"type":33},"2026-01-05",{"date":412,"type":23},"2026-11-01",{"name":175,"class":40},{"id":415,"slug":416,"hasResults":12,"nctId":417,"briefTitle":418,"officialTitle":419,"acronym":4,"eligibilityCriteria":420,"healthyVolunteers":12,"sex":49,"minAge":50,"maxAge":421,"enrollmentInfo":422,"targetDuration":4,"studyType":54,"phases":424,"briefSummary":425,"conditions":426,"keywords":428,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":407,"lastUpdatePostDateStruct":432,"startDateStruct":433,"completionDateStruct":435,"leadSponsor":437,"locationsCount":41},"100618424","external-oblique-intercostal-plane-block-for-postoperative-analgesia-after-major-upper-abdominal-surgery-100618424","NCT07331441","External Oblique Intercostal Plane Block for Postoperative Analgesia After Major Upper Abdominal Surgery","External Oblique Intercostal Plane Block for Postoperative Analgesia After Major Upper Abdominal Surgery: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Obtain written informed consent from participants or their legal representatives\n* Age between 18 and 85 years\n* American Society of Anesthesiologists (ASA) physical status classification I-III\n* Scheduled for elective laparoscopic major upper abdominal surgery (e.g., gastric, hepatic, gallbladder, pancreatic surgery)\n* Expected surgical duration ≥ 2 hours\n* Ability to use the intravenous patient-controlled analgesia (IV PCA) system\n\nExclusion Criteria:\n\n* Hepatic disease (liver enzyme levels ≥ 2× the upper limit of normal)\n* Renal disease (serum creatinine levels ≥ 2× the upper limit of normal)\n* Allergy to local anesthetics or known study-related drugs\n* Pregnancy or lactation\n* Low surgical incision site (not involving the upper abdominal wall innervated by T6-T10 nerves)\n* Coagulopathy or current use of anticoagulant medications\n* Opioid use for more than 2 weeks in the past 6 months","85 Years",{"count":423,"type":23},78,[80],"Postoperative pain after laparoscopic major upper abdominal surgery (e.g., gastric, hepatic, gallbladder, pancreatic surgery) is often severe, and inadequate analgesia may lead to increased opioid use, opioid dependence, and poor functional recovery. Current analgesic techniques such as neuraxial block have safety concerns (e.g., hypotension, neurological injury), while transversus abdominis plane (TAP) block is ineffective for blocking the lateral cutaneous branches of intercostal nerves in the upper abdomen. The External Oblique Intercostal Plane Block (EOIB) is a novel regional block technique that has shown promise in reducing postoperative opioids and pain in small-scale studies, but evidence for its use in major upper abdominal surgery is limited. This randomized controlled trial (RCT) aims to evaluate the analgesic efficacy and safety of bilateral EOIB combined with standard multimodal analgesia versus standard multimodal analgesia alone in patients undergoing elective laparoscopic major upper abdominal surgery. The primary outcome is the total postoperative opioid consumption (measured as Morphine Milligram Equivalents, MME) within 24 hours. Secondary and additional outcomes include pain scores (Verbal Rating Scale, VRS), recovery quality (QoR-15 scale), incidence of adverse events, and hospital stay.",[427,27],"Abdominal Surgery",[131,27,429,430,431],"Laparoscopic Surgery","Pain Management","Randomized Controlled Trial",{"date":256,"type":33},{"date":434,"type":33},"2026-02-01",{"date":436,"type":23},"2026-08-31",{"name":438,"class":40},"Jun Zhang",{"id":440,"slug":441,"hasResults":12,"nctId":442,"briefTitle":443,"officialTitle":444,"acronym":445,"eligibilityCriteria":446,"healthyVolunteers":12,"sex":18,"minAge":50,"maxAge":51,"enrollmentInfo":447,"targetDuration":4,"studyType":54,"phases":448,"briefSummary":449,"conditions":450,"keywords":452,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":455,"lastUpdatePostDateStruct":456,"startDateStruct":458,"completionDateStruct":459,"leadSponsor":461,"locationsCount":41},"100642239","riss-versus-spsip-block-in-modified-radical-mastectomy-100642239","NCT07659990","RISS Versus SPSIP Block in Modified Radical Mastectomy","Comparison of Rhomboid Intercostal-Subserratus Plane Block and Serratus Posterior Superior Intercostal Plane Block for Postoperative Analgesia and Dermatomal Spread After Modified Radical Mastectomy: A Randomized Double-Blind Trial","RSMRM","Inclusion Criteria:\n\n* Female patients aged 18-75 years\n* ASA physical status I-III\n* Scheduled for elective unilateral modified radical mastectomy with axillary dissection under general anesthesia\n* Provision of written informed consent\n\nExclusion Criteria:\n\n* Anticoagulant therapy\n* Bleeding diathesis\n* Known allergy to local anesthetics or opioids\n* Infection at the block application site or previous surgery in the block area\n* Cognitive impairment preventing NRS assessment\n* Pregnancy or lactation\n* Chronic opioid use\n* Severe hepatic or renal failure\n* Refusal to participate in the study\n* Technical inability to perform the block or failed block",{"count":248,"type":23},[80],"This prospective randomized double-blind controlled trial aims to compare the postoperative analgesic efficacy and dermatomal spread of rhomboid intercostal-subserratus plane (RISS) block and serratus posterior superior intercostal plane (SPSIP) block in patients undergoing modified radical mastectomy. Postoperative pain scores, opioid consumption, rescue analgesic requirements, block-related complications, and quality of recovery outcomes will be evaluated.",[27,451],"Breast Cancer",[453,27,454],"Breast Neoplasms","Anesthesia, Conduction","2026-06-19",{"date":457,"type":33},"2026-06-24",{"date":455,"type":33},{"date":460,"type":23},"2026-11",{"name":262,"class":263},{"id":463,"slug":464,"hasResults":12,"nctId":465,"briefTitle":466,"officialTitle":467,"acronym":4,"eligibilityCriteria":468,"healthyVolunteers":12,"sex":49,"minAge":50,"maxAge":101,"enrollmentInfo":469,"targetDuration":4,"studyType":54,"phases":470,"briefSummary":471,"conditions":472,"keywords":474,"overallStatus":110,"whyStopped":4,"lastUpdateSubmitDate":478,"lastUpdatePostDateStruct":479,"startDateStruct":480,"completionDateStruct":481,"leadSponsor":482,"locationsCount":4},"100644260","the-effect-of-pericapsular-nerve-group-block-with-different-local-anesthetic-volumes-100644260","NCT07666737","The Effect of Pericapsular Nerve Group Block With Different Local Anesthetic Volumes","The Effect of Pericapsular Nerve Group Block With Different Local Anesthetic Volumes on Postoperative Pain in Arthroscopic Shoulder Surgery","Inclusion Criteria:\n\n* elective arthroscopic shoulder surgery planned\n* ASA I-III physical status\n\nExclusion Criteria: Patients with\n\n* coagulopathy,\n* neuropathy,\n* anticoagulant use\n* history of chronic pain,\n* pre-existing psychiatric illness\n* body mass index greater than 35 kg\u002Fm2\n* allergy or sensitivity to local anesthetics and opiods\n* infection at the injection site\n* who cannot understand pain scoring\n* whose follow-up and treatment are continuing in the intensive care unit\n* who will undergo open shoulder surgery.",{"count":78,"type":23},[80],"Early postoperative pain following shoulder surgery is a significant clinical problem for both patients and orthopedic surgeons. Effective pain control is crucial for improving postoperative comfort and optimizing rehabilitation. Pericapsular nerve group block (PENG) is a regional anesthesia method that has recently gained attention due to its lack of motor block and absence of pulmonary complications. The aim of this study is to evaluate the effect of PENG block, applied at two different volumes, on postoperative pain and opioid consumption in patients undergoing arthroscopic shoulder surgery.",[473,27],"Pericapsuler Nerve Group Block",[475,476,477],"arthroscopic shoulder surgery","postoperative pain","pericapsular nerve group block","2026-06-18",{"date":457,"type":33},{"date":84,"type":23},{"date":115,"type":23},{"name":483,"class":40},"Selcuk University",{"id":485,"slug":486,"hasResults":12,"nctId":487,"briefTitle":488,"officialTitle":489,"acronym":4,"eligibilityCriteria":490,"healthyVolunteers":12,"sex":18,"minAge":50,"maxAge":4,"enrollmentInfo":491,"targetDuration":4,"studyType":54,"phases":492,"briefSummary":493,"conditions":494,"keywords":498,"overallStatus":110,"whyStopped":4,"lastUpdateSubmitDate":478,"lastUpdatePostDateStruct":504,"startDateStruct":505,"completionDateStruct":507,"leadSponsor":509,"locationsCount":41},"100641523","timing-of-serratus-anterior-plane-block-in-mastectomy-surgery-100641523","NCT07661212","Timing of Serratus Anterior Plane Block in Mastectomy Surgery","The Effect of Serratus Anterior Plane Block Timing on Postoperative Quality of Recovery, Postoperative Pain, and Inflammatory Response in Elective Unilateral Mastectomy Surgery: A Prospective Randomized Controlled Clinical Trial","Inclusion Criteria:\n\n* Female patients aged 18 years or older\n* Scheduled for elective unilateral mastectomy surgery\n* Planned to undergo surgery under general anesthesia\n* American Society of Anesthesiologists physical status I-III\n* Willing and able to participate in the study\n* Provision of written informed consent\n\nExclusion Criteria:\n\n* Refusal to participate in the study\n* Known allergy to local anesthetics planned for use in the study\n* Chronic opioid use\n* Current steroid or immunosuppressive therapy\n* Presence of chronic inflammatory disease\n* Surgical duration shorter than 30 minutes\n* Active infection\n* Coagulopathy\n* Infection at the planned block site\n* Pregnancy or lactation\n* Advanced hepatic failure or advanced renal failure\n* Reoperation due to recurrent disease\n* Inability to communicate adequately or to provide reliable pain scores\n* Psychiatric or neurological condition limiting reliable completion of the QoR-15 questionnaire or Numeric Rating Scale assessments",{"count":248,"type":23},[80],"Postoperative pain following mastectomy may adversely affect early mobilization, patient comfort, and overall quality of recovery. Serratus anterior plane block is an ultrasound-guided regional anesthesia technique that provides analgesia to the anterolateral thoracic wall and is increasingly used as part of multimodal analgesia for breast surgery. Although the analgesic efficacy of serratus anterior plane block has been investigated in breast surgery, the clinical impact of the timing of block administration remains insufficiently defined.\n\nThis prospective, randomized, controlled, patient and assessor blinded clinical trial will compare two different timings of ultrasound-guided serratus anterior plane block in adult female patients undergoing elective unilateral mastectomy under general anesthesia. Participants will be randomized to receive serratus anterior plane block either after induction of general anesthesia and before surgical incision, or after completion of surgery and before extubation. In both groups, the block will be performed under ultrasound guidance using 25 mL of 0.25% bupivacaine.\n\nThe primary outcome is postoperative quality of recovery at 24 hours, assessed using the Quality of Recovery-15 questionnaire. Secondary outcomes include postoperative pain scores at predefined time points during the first 24 postoperative hours, intraoperative remifentanil consumption, postoperative opioid and non-opioid analgesic requirements, time to first analgesic requirement, postoperative nausea and vomiting, length of hospital stay, complications, inflammatory response markers including CRP and neutrophil-to-lymphocyte ratio, and intraoperative hemodynamic variables.\n\nThe study is planned to enroll 80 participants at a single tertiary training and research hospital. The findings are expected to clarify whether preincisional administration of serratus anterior plane block provides superior postoperative recovery, analgesic efficacy, and modulation of inflammatory response compared with administration at the end of surgery.",[495,496,27,497],"Quality of Recovery After Mastectomy","Serratus Anterior Plane Block","Mastectomy",[496,27,497,163,430,499,304,500,501,502,503],"Bupivacaine","CRP","Neutrophil-Lymphocyte Ratio","Inflammation","Breast Surgery",{"date":171,"type":33},{"date":506,"type":23},"2026-09-01",{"date":508,"type":23},"2027-10-01",{"name":510,"class":263},"Bakirkoy Dr. Sadi Konuk Research and Training Hospital",{"id":512,"slug":513,"hasResults":12,"nctId":514,"briefTitle":515,"officialTitle":516,"acronym":4,"eligibilityCriteria":517,"healthyVolunteers":12,"sex":49,"minAge":50,"maxAge":101,"enrollmentInfo":518,"targetDuration":4,"studyType":54,"phases":520,"briefSummary":521,"conditions":522,"keywords":523,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":478,"lastUpdatePostDateStruct":527,"startDateStruct":528,"completionDateStruct":529,"leadSponsor":531,"locationsCount":41},"100641919","erector-spinae-plane-block-and-low-flow-anaesthesia-in-laparoscopic-cholecystectomy-100641919","NCT07653490","Erector Spinae Plane Block and Low-Flow Anaesthesia in Laparoscopic Cholecystectomy","Evaluation of the Effects of Preoperative Erector Spinae Plane Block Combined With Low-Flow Anaesthesia on Postoperative Quality of Recovery and Opioid Consumption: A Prospective, Randomized, Controlled Study","Inclusion Criteria:\n\n* Patients aged 18-65 years\n* ASA physical status I-II\n* Body mass index (BMI) \\\u003C35 kg\u002Fm²\n* Scheduled for elective laparoscopic cholecystectomy\n* Ability to provide written informed consent\n\nExclusion Criteria:\n\n* Coagulopathy or bleeding disorders\n* Allergy to local anaesthetic agents\n* Infection at the block application site\n* Neurological or psychiatric disorders\n* Communication difficulties\n* Chronic opioid or analgesic use\n* Reoperation cases\n* Acute cholecystitis\n* Conversion to open surgery\n* Inadequate dermatomal block after ESPB\n* Severe intraoperative hemodynamic instability\n* Intraoperative blood loss ≥250 mL\n* Development of allergic reactions or major complications during follow-up",{"count":519,"type":23},72,[80],"This prospective randomized controlled study aims to evaluate the effects of preoperative ultrasound-guided erector spinae plane (ESP) block combined with low-flow anaesthesia on postoperative quality of recovery and opioid consumption in patients undergoing elective laparoscopic cholecystectomy. The study will compare postoperative recovery quality, pain scores, analgesic requirements, and perioperative outcomes between patients receiving ESP block with low-flow anaesthesia and those receiving standard anaesthetic management.",[27,108],[524,525,306,526,108],"Erector Spinae Plane Block","Low-Flow Anaesthesia","Enhanced Recovery",{"date":331,"type":33},{"date":478,"type":33},{"date":530,"type":23},"2027-06-18",{"name":532,"class":263},"Taksim Egitim ve Arastirma Hastanesi",{"id":534,"slug":535,"hasResults":12,"nctId":536,"briefTitle":537,"officialTitle":538,"acronym":539,"eligibilityCriteria":540,"healthyVolunteers":12,"sex":49,"minAge":50,"maxAge":51,"enrollmentInfo":541,"targetDuration":4,"studyType":54,"phases":542,"briefSummary":543,"conditions":544,"keywords":545,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":478,"lastUpdatePostDateStruct":547,"startDateStruct":548,"completionDateStruct":549,"leadSponsor":550,"locationsCount":41},"100641788","riss-versus-esp-block-in-laparoscopic-cholecystectomy-100641788","NCT07655323","RISS Versus ESP Block in Laparoscopic Cholecystectomy","Comparison of the Analgesic Efficacy and Effects on Diaphragmatic Function of Bilateral Erector Spinae Plane Block and Bilateral Rhomboid Intercostal-Subserratus Plane Block in Laparoscopic Cholecystectomy: A Prospective Randomized Controlled Trial","RISS-ESP-LC","Inclusion Criteria:-\n\n* Age between 18 and 75 years\n* ASA physical status I-III\n* Scheduled for elective laparoscopic cholecystectomy under general anesthesia\n* Provision of written informed consent\n\nExclusion Criteria:\n\n* Coagulation disorders or anticoagulant therapy\n* Known allergy to local anesthetics\n* Infection at the block application site\n* Pregnancy or lactation\n* Chronic opioid use\n* Cognitive impairment\n* Refusal to participate in the study\n* Technical inability to perform the block\n* Failed block",{"count":248,"type":23},[80],"This prospective randomized controlled trial aims to compare the analgesic efficacy and effects on diaphragmatic function of bilateral erector spinae plane (ESP) block and bilateral rhomboid intercostal-subserratus plane (RISS) block in patients undergoing elective laparoscopic cholecystectomy. Postoperative pain scores, opioid consumption, diaphragmatic excursion, pulmonary function, and recovery outcomes will be evaluated.",[27],[108,524,546,163,165,164],"Rhomboid Intercostal Subserratus Plane Block",{"date":171,"type":33},{"date":478,"type":33},{"date":65,"type":23},{"name":262,"class":263},{"id":552,"slug":553,"hasResults":12,"nctId":554,"briefTitle":555,"officialTitle":556,"acronym":557,"eligibilityCriteria":558,"healthyVolunteers":12,"sex":49,"minAge":50,"maxAge":51,"enrollmentInfo":559,"targetDuration":4,"studyType":54,"phases":560,"briefSummary":561,"conditions":562,"keywords":564,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":478,"lastUpdatePostDateStruct":570,"startDateStruct":571,"completionDateStruct":572,"leadSponsor":573,"locationsCount":41},"100641532","spsip-versus-riss-block-in-volume-preserving-vats-100641532","NCT07655336","SPSIP Versus RISS Block in Volume-Preserving VATS","Comparison of Serratus Posterior Superior Intercostal Plane Block and Rhomboid Intercostal-Subserratus Plane Block on Postoperative Analgesia and Respiratory Functions in Volume-Preserving Video-Assisted Thoracoscopic Surgery: A Prospective Randomized Controlled Trial","SRVATS","Inclusion Criteria:\n\n* Patients scheduled for elective biportal video-assisted thoracoscopic surgery (VATS) with lung parenchyma-preserving thoracic procedures under general anesthesia\n* American Society of Anesthesiologists (ASA) physical status I-III\n* Age between 18 and 75 years\n* Provision of written informed consent\n\nExclusion Criteria:\n\n* Use of anticoagulant or antiplatelet therapy\n* Bleeding diathesis\n* Known allergy to local anesthetics\n* Infection at the planned block site\n* Severe chronic pulmonary disease or advanced respiratory failure (e.g., severe COPD or restrictive lung disease)\n* Cognitive impairment preventing reliable NRS assessment\n* Pregnancy or lactation\n* Chronic opioid use (regular use for ≥3 months)\n* Severe hepatic or renal failure\n* Refusal to participate\n* Technical failure or unsuccessful regional block\n* Conversion to open thoracotomy during surgery",{"count":327,"type":23},[80],"This prospective randomized controlled study aims to compare the effects of Serratus Posterior Superior Intercostal Plane (SPSIP) block and Rhomboid Intercostal and Subserratus (RISS) block on postoperative pain, respiratory function, and recovery quality in patients undergoing volume-preserving video-assisted thoracoscopic surgery (VATS). Eighty-four patients will be randomized in a 1:1 ratio to receive either SPSIP block or RISS block. The primary outcome is the incidence of somatic pain at the chest drain insertion site at postoperative 2 hours. Secondary outcomes include pain scores, opioid consumption, quality of recovery, diaphragmatic function, pulmonary function, rescue analgesic requirements, postoperative nausea and vomiting, and block-related complications.",[27,563],"Thoracic Surgery",[565,566,254,567,568,569],"Video-Assisted Thoracic Surgery","VATS","Rhomboid Intercostal and Subserratus Block","Diaphragmatic Excursion","Peak Expiratory Flow",{"date":171,"type":33},{"date":478,"type":33},{"date":65,"type":23},{"name":262,"class":263},{"id":575,"slug":576,"hasResults":12,"nctId":577,"briefTitle":578,"officialTitle":579,"acronym":4,"eligibilityCriteria":580,"healthyVolunteers":12,"sex":49,"minAge":50,"maxAge":51,"enrollmentInfo":581,"targetDuration":4,"studyType":54,"phases":582,"briefSummary":583,"conditions":584,"keywords":585,"overallStatus":110,"whyStopped":4,"lastUpdateSubmitDate":589,"lastUpdatePostDateStruct":590,"startDateStruct":591,"completionDateStruct":593,"leadSponsor":595,"locationsCount":41},"100610473","phase-4-esp-blocks-for-posterior-spinal-fusion-100610473","NCT07228039","ESP Blocks for Posterior Spinal Fusion","A Double-Blind Prospective RCT Assessment of ESP Blocks for Analgesia Following Posterior Spinal Fusion","Inclusion Criteria\n\n* English speaking\n* Age 18-75\n* ASA physical status 1-3\n* Undergoing elective cervical or lumbar posterior spinal fusion (≤3 levels)\n\nExclusion Criteria\n\n* Age \\\u003C18 or \\>75\n* ASA IV or V\n* Non-English speaking\n* BMI \\>40\n* Opioid dependence\n* Chronic pain\n* Anticoagulation or coagulopathy\n* Injection site infection\n* Hepatic or renal insufficiency\n* Allergy to study drugs\n* Pregnancy\n* Inability to communicate with investigators",{"count":347,"type":23},[212],"This prospective randomized double-blind study evaluates the efficacy of erector spinae plane (ESP) blocks on postoperative pain in patients undergoing cervical or lumbar posterior spinal fusion. Patients will receive either 0.5% bupivacaine plus liposomal bupivacaine or 0.5% plain bupivacaine. Outcomes include opioid consumption over 72 hours, pain scores, length of stay, and time to ambulation.",[27],[586,587,588],"ESP Block","Spinal Fusion","Multimodal Analgesia","2026-06-17",{"date":171,"type":33},{"date":592,"type":23},"2026-07",{"date":594,"type":23},"2028-01",{"name":596,"class":40},"Duke University",{"id":598,"slug":599,"hasResults":12,"nctId":600,"briefTitle":601,"officialTitle":602,"acronym":4,"eligibilityCriteria":603,"healthyVolunteers":12,"sex":49,"minAge":50,"maxAge":604,"enrollmentInfo":605,"targetDuration":4,"studyType":54,"phases":607,"briefSummary":608,"conditions":609,"keywords":4,"overallStatus":110,"whyStopped":4,"lastUpdateSubmitDate":382,"lastUpdatePostDateStruct":610,"startDateStruct":611,"completionDateStruct":612,"leadSponsor":614,"locationsCount":4},"100641119","investigating-the-analgesic-efficacy-and-ease-of-perfomance-of-modified-throracoabdominal-plane-block-and-comparing-it-with-erector-spinea-plane-block-in-laparacopic-sleeve-gasterctomy-surgeries-100641119","NCT07654556","Investigating the Analgesic Efficacy and Ease of Perfomance of Modified Throracoabdominal Plane Block and Comparing it With Erector Spinea Plane Block in Laparacopic Sleeve Gasterctomy Surgeries","Evaluating Analgesic Efficacy and Feasibility of Modified Thoracoabdominal Plane Block Compared With Erector Spinae Plane Block in Laparoscopic Sleeve Gastrectomy: A Randomized Controlled Study","Inclusion Criteria:\n\n* Patients from both sexes.\n* 18 to 60 years old.\n* ASA physical status II-III scheduled for laparoscopic sleeve gastrectomy.\n* Patients with BMI (40-50) kg\u002F m2\n\nExclusion Criteria:\n\n* Patient Refusal\n* Lack of patient cooperation.\n* Patients with any contraindication to regional nerve blocks as coagulopathy or infection at site of injection\n* Patients with anatomical abnormalities at site of injection\n* Patients with known hypersensitivity to bupivacaine, or any of the used drugs.\n* Patients with pre-existing neurological disorder\n* Patients with chronic pain syndromes including fibromyalgia, complex regional pain syndrome (CRPS), or chronic pain requiring long-term opioid or neuropathic pain medications.\n* Patients with history of long-acting opioids, steroids, anticonvulsants perioperatively.","60 Years",{"count":606,"type":23},64,[80],"Interest in surgical weight loss interventions continues to rise in the face of what has been dubbed the obesity epidemic. The most popular of these weight loss interventions is laparoscopic sleeve gastrectomy, which has proven to reduce morbidity and mortality of morbidly obese patients. The aim of effective perioperative pain management extends beyond increased patient comfort and includes reduced recumbency period, enhanced recovery, reduced hospital stay, and lowers postoperative complication rates.\n\nEffective postoperative pain management has traditionally relied on multimodal strategies that combine systemic opioids, non-opioid medications, and regional anesthesia. Despite their efficacy, opioids are associated with a range of undesirable effects, such as nausea, vomiting, sedation, pruritus, and respiratory depression, which may impede early mobilization and recovery. These concerns have accelerated the adoption of ultrasound-guided regional anesthesia techniques as part of Enhanced Recovery After Surgery (ERAS) protocols, delivering superior pain control with fewer systemic adverse effects.",[27],{"date":478,"type":33},{"date":84,"type":23},{"date":613,"type":23},"2027-03-30",{"name":615,"class":40},"Cairo University",{"id":617,"slug":618,"hasResults":12,"nctId":619,"briefTitle":620,"officialTitle":621,"acronym":4,"eligibilityCriteria":622,"healthyVolunteers":12,"sex":49,"minAge":50,"maxAge":101,"enrollmentInfo":623,"targetDuration":4,"studyType":54,"phases":624,"briefSummary":625,"conditions":626,"keywords":630,"overallStatus":110,"whyStopped":4,"lastUpdateSubmitDate":633,"lastUpdatePostDateStruct":634,"startDateStruct":635,"completionDateStruct":637,"leadSponsor":639,"locationsCount":4},"100641947","intertransverse-process-block-versus-m-tapa-block-after-laparoscopic-cholecystectomy-100641947","NCT07589491","Intertransverse Process Block Versus M-TAPA Block After Laparoscopic Cholecystectomy","Intertransverse Process Block Versus M-TAPA Block After Laparoscopic Cholecystectomy: A Prospective Randomized Controlled Trial","Inclusion Criteria:\n\n* Patients aged 18-65 years\n* ASA physical status I-III\n* Scheduled for elective laparoscopic sleeve gastrectomy\n* Body mass index (BMI) 18-35 kg\u002Fm²\n* Ability to understand and use the patient-controlled analgesia (PCA) device\n* Ability to provide written informed consent\n\nExclusion Criteria:\n\n* Refusal to participate\n* Allergy to local anesthetics\n* Infection at the injection site\n* Coagulopathy or ongoing anticoagulant therapy\n* Chronic opioid use or opioid dependence\n* Severe hepatic or renal insufficiency\n* Pregnancy or breastfeeding\n* Cognitive impairment or inability to communicate pain scores\n* Body mass index (BMI) \\>35 kg\u002Fm²",{"count":78,"type":23},[80],"This randomized clinical trial aims to evaluate and compare the analgesic efficacy of the Intertransverse Process Block (ITPB) and the Modified Thoracoabdominal Nerve Block through Perichondrial Approach (M-TAPA) in patients undergoing laparoscopic cholecystectomy. The primary outcome is the Visual Analog Scale (VAS) score within the first 24 hours after surgery. Secondary outcomes include total opioid consumption, requirement for rescue analgesia, block- related complications and adverse effects (hematoma, pneumothorax, local anesthetic systemic complications, vascular puncture, and infection), patient satisfaction assessed using a Likert scale, quality of recovery assessed using the QoR-15 questionnaire, and incidence of postoperative nausea and vomiting.",[627,628,108,27,629],"Intertransverse Process Block","Mtapa Block","Regional Anaesthesia",[631,632],"M-TAPA","ITP","2026-06-15",{"date":382,"type":33},{"date":636,"type":23},"2026-11-15",{"date":638,"type":23},"2027-10-30",{"name":640,"class":40},"Antalya City Hospital"]