[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"postoperative-pulmonary-atelectasis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:postoperative-pulmonary-atelectasis":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,52,86,113,137],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":31,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":41,"startDateStruct":44,"completionDateStruct":46,"leadSponsor":48,"locationsCount":51},"100615588","evaluation-of-the-effect-of-perioperative-recruitment-maneuver-practice-on-lung-ultrasound-score-and-mechanical-power-in-pediatric-patients-100615588",false,"NCT07294560","Evaluation of the Effect of Perioperative Recruitment Maneuver Practice on Lung Ultrasound Score and Mechanical Power in Pediatric Patients","Evaluation of the Effect of Perioperative Recruitment Maneuver Practice on Lung Ultrasound Score and Mechanical Power in Pediatric Patients; A Prospective Randomized Study","LUS RM PEEP","Inclusion Criteria:\n\n* Patients aged 1-14 years with\n* ASA score of 1-3\n* who had surgery in the operating rooms of Cerrahpaşa Medical Faculty during the study period\n* surgical duration was at least 2 hours\n\nExclusion Criteria:\n\n* ASA score of 4\n* defined lung disease (patients using medication due to asthma and having 2 emergency visits within 1 year)\n* prematurity (\\\u003C 36 weeks gestational age \u002F bronchopulmonary dysplasia)\n* cystic fibrosis\n* diagnosed syndromic disease\n* congenital cardiac disease\n* abnormal chest X-ray\n* chest wall deformity\n* or history of previous chest surgery","ALL","1 Year","14 Years",{"count":21,"type":22},78,"ESTIMATED","INTERVENTIONAL",[25],"NA","Pulmonary atelectasis is common during general anesthesia and increases the risk of hypoxemia, especially in pediatric patients. PEEP and recruitment maneuvers (RM) are effective in preventing atelectasis. Lung ultrasound is practical for diagnosis. Mechanical power refers to the amount of energy delivered to the lung by the ventilator; excessive mechanical power can cause lung injury. Limiting mechanical power may reduce postoperative complications. This study aimed to determine the effectiveness of recruitment maneuvers in preventing atelectasis using lung ultrasound during the intraoperative period, to examine the relationship between lung ultrasound scores and mechanical power, and to demonstrate the effect of recruitment maneuvers on postoperative pulmonary complications. This study is based on the hypothesis that \"The recruitment maneuver reduces perioperative atelectasis and the development of related complications, and lung ultrasound can be used to detect this. The lung ultrasound score also decreases in patients with reduced mechanical force.\" It will be prospectively applied to pediatric patients aged 1-14 years who will undergo surgery in the operating rooms of Cerrahpaşa Medical Faculty.\n\nPatients included in the study will be prospectively randomized into 3 groups. The randomization performed using the sealed opaque envelope method.All patients will be ventilated in VG-Pressure guaranteed mode. Tidal volume will be calculated as 6-8 ml\u002Fkg of ideal body weight.\n\nGROUP 1: Fixed PEEP: 5 cmH2O, GROUP 2: PEEP: 5 cmH2O, 5 cycles, recruitment maneuver with plateau P\\\u003C35 cm H2O and vital capacity x2. GROUP 3: PEEP: 5 cmH2O, 5 cycles of recruitment maneuvers will be performed in the right and left lateral decubitus position before extubation with P\\\u003C35 cmH2O and vital capacity x2.\n\nLung ultrasound will be performed before induction (1), 5 minutes after intubation (2), before extubation (3), and finally 5 minutes after extubation(4). Each hemithorax will be divided into 6 regions, and lung scores will be recorded. At 5 minutes after intubation and every hour there after, PeakP, PlateauP, DeltaP, Compliance, Driving Pressures, and Mechanical Work calculations will be recorded before and after the maneuver in the group undergoing the recruitment maneuver.",[28,29,30],"Postoperative Pulmonary Complications","Postoperative Pulmonary Atelectasis","Pediatric Surgery",[32,33,34,35,36,37,38],"recruitment maneuver","pediatric recruitment maneuver","PEEP","mechanical power","mechanical work","compliance","atelectasis","NOT_YET_RECRUITING","2026-02-09",{"date":42,"type":43},"2026-02-11","ACTUAL",{"date":45,"type":22},"2026-02-15",{"date":47,"type":22},"2026-07-15",{"name":49,"class":50},"Istanbul University - Cerrahpasa","OTHER",1,{"id":53,"slug":54,"hasResults":11,"nctId":55,"briefTitle":56,"officialTitle":56,"acronym":4,"eligibilityCriteria":57,"healthyVolunteers":58,"sex":17,"minAge":59,"maxAge":4,"enrollmentInfo":60,"targetDuration":4,"studyType":23,"phases":62,"briefSummary":63,"conditions":64,"keywords":73,"overallStatus":77,"whyStopped":4,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":51},"100607313","driving-pressure-during-surgeries-with-high-risk-for-postoperative-pulmonary-complications-100607313","NCT07186933","Driving Pressure During Surgeries With High Risk for Postoperative Pulmonary Complications","Inclusion Criteria\n\n* \\>17 years old\n* Surgery with general anesthesia \\& invasive mechanical ventilation\n* Preoperative ARISCAT score estimation \\>25\n\nExclusion Criteria:\n\n* \\\u003C18 years old\n* Preoperative ARISCAT score estimation \\\u003C26\n* Women during pregnancy or just given birth\n* Other type of anesthesia (Not general)\n* Contraindication of administration of neuromuscular blockade agents.\n* Contraindication of cease of spontaneous ventilation.\n* Mechanical ventilation without endotracheal intubation.\n* Severe heart failure \u002F Severe cardiac arrhythmia.\n* Severe emphysematous lung disease.\n* Patient denial of participation in the trial.",true,"18 Years",{"count":61,"type":22},200,[25],"The goal of this clinical trial is to compare two different types of perioperative mechanical ventilation (MV), specifically Protective Mechanical Ventilation (PMV) and MV with the lowest possible Driving Pressure (ΔP), in relation to the appearance of postoperative pulmonary complications (PPCs) in adult patients who are operated and have higher risk of PPCs.\n\nThe main questions it aims to answer are:\n\n* Is MV with lower ΔP better than conventional PMV in preventing PPCs in patients with higher risk for PPCs?\n* Does MV with lower ΔP decrease hospital stay, Intensive Care Unit (ICU) need and mortality?\n* Does MV with lower ΔP suit better than PMV to lung characteristics and needs intraoperatively?\n\nResearchers will compare MV with the lowest possible Driving Pressure (ΔP) to Protective Mechanical Ventilation (PMV) to see if any of this is more protective than the other concerning PPCs.\n\nAll participants will receive perioperative MV.\n\nHalf of them will receive conventional Protective Mechanical Ventilation (PMV). This will include well known generally protective settings for mechanical ventilation of patients, concerning volumes, pressures, respiratory rate, inspiratory gases and ventilation maneuvers.\n\nThe rest of participants will be ventilated with the lowest possible Driving Pressure (ΔP). This will be similar to PMV in the chosen volumes, respiratory rate, inspiratory gases and ventilation maneuvers. However, the pressure inside lung at the end of expiration, eg Positive End Expiratory Pressure (PEEP), will be not be preset for every patient. Initially, the investigators will perform a maneuver that will quantify each individual's lung characteristics and mechanics. According to this, the investigators will find the exact PEEP that seems to suit each patients lungs most, and use this perioperatively, trying to provide lungs the best conditions every time.\n\nAfter the completion of the operation, all the patients will be screened for PPCs, via arterial blood testing and chest X ray, and the results will be statistically analyzed trying to find if any of the forementioned strategies of mechanical ventilation surpasses the other concerning PPCs appearance. PPCs include atelectasis, respiratory failure, bronchospasm, pleural effusion, pneumonia, aspiration and pneumothorax.\n\nFurthermore hospital stay, ICU need and mortality will be noted. Finally, measurements of perioperative lung pressures, volumes and derived variables will be noted and compared statistically as well.",[29,28,65,66,67,68,69,70,71,72],"Postoperative Respiratory Failure","Postoperative Bronchospasm","Postoperative Pleural Effusion","Postoperative Pneumothorax","Postoperative Pneumonia","Postoperative Aspiration Pneumonitis","Mechanical Power","Driving Pressure",[72,71,74,75,28,65,76],"Atelectasis","Pulmonary Complications","Elastic Power","RECRUITING","2026-02-08",{"date":42,"type":43},{"date":81,"type":43},"2025-11-03",{"date":83,"type":22},"2027-11-30",{"name":85,"class":50},"University General Hospital of Patras",{"id":87,"slug":88,"hasResults":11,"nctId":89,"briefTitle":90,"officialTitle":91,"acronym":4,"eligibilityCriteria":92,"healthyVolunteers":11,"sex":17,"minAge":59,"maxAge":93,"enrollmentInfo":94,"targetDuration":4,"studyType":96,"phases":4,"briefSummary":97,"conditions":98,"keywords":101,"overallStatus":77,"whyStopped":4,"lastUpdateSubmitDate":104,"lastUpdatePostDateStruct":105,"startDateStruct":107,"completionDateStruct":109,"leadSponsor":111,"locationsCount":51},"100600697","the-effect-of-single-lung-ventilation-duration-on-postoperative-pulmonary-complications-in-thoracic-surgery-100600697","NCT07100860","The Effect of Single Lung Ventilation Duration on Postoperative Pulmonary Complications in Thoracic Surgery","Does Duration Matter? A Study on Single-Lung Ventilation Time and Pulmonary Complications in Thoracic Procedures","Inclusion Criteria:\n\nAge ≥18 years Undergoing thoracic surgery OLV planned during the procedure\n\nExclusion Criteria:\n\nPediatric patients Patients not requiring OLV Previous thoracic surgery","85 Years",{"count":95,"type":22},134,"OBSERVATIONAL","This observational study investigates the relationship between the duration of single-lung ventilation (SLV) and the incidence of postoperative pulmonary complications (PPCs) such as pneumonia, pneumothorax, hemothorax, acute lung injury, and acute respiratory distress syndrome (ARDS) in adult patients undergoing thoracic surgery. A total of 134 patients aged 18-85 years, scheduled for thoracic surgery requiring SLV, will be monitored. Data including SLV duration, perioperative parameters, and postoperative pulmonary outcomes will be analyzed.",[28,99,100,29],"One Lung Ventilation","Ards",[102,103],"postoperative pulmonary complications","one lung ventilation","2025-12-10",{"date":106,"type":43},"2025-12-18",{"date":108,"type":43},"2025-01-01",{"date":110,"type":22},"2026-01-01",{"name":112,"class":50},"Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital",{"id":114,"slug":115,"hasResults":11,"nctId":116,"briefTitle":117,"officialTitle":118,"acronym":4,"eligibilityCriteria":119,"healthyVolunteers":11,"sex":17,"minAge":59,"maxAge":4,"enrollmentInfo":120,"targetDuration":4,"studyType":23,"phases":122,"briefSummary":123,"conditions":124,"keywords":125,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":128,"lastUpdatePostDateStruct":129,"startDateStruct":131,"completionDateStruct":133,"leadSponsor":135,"locationsCount":4},"100585427","effectiveness-of-oscillation-on-postoperative-pulmonary-complications-after-elective-postcardiac-surgery-100585427","NCT06902220","Effectiveness of Oscillation on Postoperative Pulmonary Complications After Elective Postcardiac Surgery","Effectiveness of Oscillation on Postoperative Pulmonary Complications After Elective Postcardiac Surgery: a Study Protocol for a Multicenter Randomized Controlled Trial","Inclusion Criteria:\n\n* Adult patients (18 years or older) undergoing elective cardiac surgery will be included. Participants must provide informed consent upon ICU admission and have at least one risk factor for PPCs, including age ≥ 75 years, American Society of Anesthesiologists (ASA) score ≥ 2, history of chronic obstructive pulmonary disease (COPD) stage ≥ 2 or asthma (moderate to severe), current heavy smoking or heavy smoking history within the past 6 months, obstructive sleep apnea, frailty index \\> 0.21 or body max index (BMI) ≥ 30 kg\u002Fm².\n\nExclusion Criteria:\n\n* Patients will be excluded if they have contraindications for oscillation treatment (e.g., untreated tension pneumothorax); have pneumothorax or air leak syndrome at entry; require more than 2 μg\u002Fkg\u002Fmin of norepinephrine; have been diagnosed with pneumonia within 2 weeks prior to surgery; have refractory arrhythmia at entry; have a left ventricular ejection fraction \\\u003C 35%; have mean pulmonary artery pressure (mPAP) \\> 35 mmHg; are postoperative from spinal surgery within the past 2 weeks; require a ventricular assist device; have renal failure requiring continuous renal replacement therapy (CRRT) at entry; are planned for re-operation within 48 hours or have undergone organ transplantation.",{"count":121,"type":22},470,[25],"Our study aims to evaluate the effectiveness of continuous high-frequency oscillation therapy in reducing PPCs in patients following elective cardiac surgery. Through a prospective, multicenter, randomized controlled trial, we seek to establish evidence that could lead to improved postoperative pulmonary care and outcomes for cardiac surgery patients.",[29],[126,127,102],"postcardiac surgery","oscillation","2025-03-24",{"date":130,"type":43},"2025-03-30",{"date":132,"type":22},"2025-09-01",{"date":134,"type":22},"2027-01-31",{"name":136,"class":50},"Southeast University, China",{"id":138,"slug":139,"hasResults":11,"nctId":140,"briefTitle":141,"officialTitle":142,"acronym":4,"eligibilityCriteria":143,"healthyVolunteers":11,"sex":17,"minAge":59,"maxAge":93,"enrollmentInfo":144,"targetDuration":4,"studyType":23,"phases":146,"briefSummary":147,"conditions":148,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":150,"lastUpdatePostDateStruct":151,"startDateStruct":153,"completionDateStruct":155,"leadSponsor":157,"locationsCount":4},"100526691","intravenous-lidocaine-infusion-reduce-postoperative-pulmonary-complications-in-patients-undergoing-minimally-invasive-esophagectomy-100526691","NCT06138041","Intravenous Lidocaine Infusion Reduce Postoperative Pulmonary Complications in Patients Undergoing Minimally Invasive Esophagectomy","Effect of Intravenous Lidocaine Infusion on Postoperative Pulmonary Complications in Patients Undergoing Minimally Invasive Esophagectomy: a Double-center, Double-blind, Randomized Controlled Trial","Inclusion Criteria:\n\nPatients between 18 and 85 years of age with a recent schedule for MIE are screened for this study. Patients who show clear consciousness and ASA status I - III will be included as eligible participants.\n\nExclusion Criteria:\n\nThe exclusion criteria are as follows: patients with severe psychiatric disorders, such as schizophrenia, depression, dementia, etc.; severe hepatic insufficiency (concentration of glutamic oxaloacetic transaminase, glutamic pyruvic transaminase or bilirubin ≥2.5 times the upper limit of normal); renal impairment (creatinine clearance \\\u003C60 mL\u002Fmin); allergy to amide local anesthetics; history of seizures; presence of II\u002FIII atrioventricular block; patients with severe sinus bradycardia or sick sinus syndrome; patients with Adams-Stokes syndrome or pre-excitation syndrome; intracardiac block (e.g. complete bundle branch block, atrioventricular block); serum potassium ion concentration below 2.5 or above 5.0 mmol\u002FL; PH\\>7.55 or PH\\\u003C7.2. Patients will be discontinued if any of the following situations occur: the patient has an allergic reaction, severe cardiovascular events that cannot be managed with symptomatic treatment, and the patient is unwilling to continue the study.",{"count":145,"type":22},770,[25],"The goal of this double-center, double-blind, randomized controlled clinical trial is to compare the effect of intravenous lidocaine infusion on postoperative pulmonary complications in patients undergoing minimally invasive esophagectomy. The main question it aims to answer are whether intravenous lidocaine reduce postoperative pulmonary complications in patients undergoing minimally invasive esophagectomy. Participants will be given intravenous lidocaine infusion in lidocaine group or placebo in control group.",[69,29,149],"Postoperative Pulmonary Edema","2024-10-20",{"date":152,"type":43},"2024-10-22",{"date":154,"type":22},"2025-02-01",{"date":156,"type":22},"2025-08-30",{"name":158,"class":50},"Sichuan Cancer Hospital and Research Institute"]