[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"postoperative-pulmonary-complications-ppcs\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:postoperative-pulmonary-complications-ppcs":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,20,0,[8,49,77,114,144,169,182,217,242,265,293,322,351,375,405,430,456,480,507,532],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100053808","pro-stress-trial-proactive-low-dose-norepinephrine-to-reduce-intraoperative-fluid-administration-in-patients-at-high-risk-for-postoperative-pulmonary-complications-undergoing-laparoscopic-abdominal-surgery-100053808",false,"NCT07627360","PRO STRESS Trial: Proactive Low-Dose Norepinephrine to Reduce Intraoperative Fluid Administration in Patients at High-Risk for Postoperative Pulmonary Complications Undergoing Laparoscopic Abdominal Surgery","Proactive Low-Dose Norepinephrine to Reduce Intraoperative Fluid Administration in Patients at High-Risk for Postoperative Pulmonary Complications Undergoing Laparoscopic Abdominal Surgery: A Randomized Controlled Trial","PRO STRESS","Inclusion Criteria:\n\n* Adult patients aged 18 years or older.\n* American Society of Anesthesiologists (ASA) physical status I-III.\n* Scheduled for elective laparoscopic major abdominal surgery under general anesthesia with an expected duration greater than 2 hours.\n* Patients with ARISCAT score ≥ 45 indicating high risk for postoperative pulmonary complications.\n\nExclusion Criteria:\n\n* Known hypersensitivity to norepinephrine.\n* Severe left ventricular dysfunction with ejection fraction \\\u003C 35%.\n* Significant cardiac arrhythmia.\n* Uncontrolled hypertension defined as systolic blood pressure ≥ 180 mmHg or diastolic blood pressure ≥ 110 mmHg.\n* End-stage renal disease.\n* Requirement for vasopressor support before induction of anesthesia.\n* Emergency surgery.","ALL","18 Years",{"count":20,"type":21},130,"ESTIMATED","INTERVENTIONAL",[24],"NA","Intraoperative hypotension is commonly treated with fluid administration; however, excessive fluid therapy may contribute to postoperative pulmonary complications. This randomized double-blind controlled trial evaluates whether proactive administration of fixed low-dose norepinephrine reduces intraoperative crystalloid administration while maintaining hemodynamic stability in high-risk patients undergoing laparoscopic abdominal surgery. One hundred and thirty patients will be randomized to receive either norepinephrine infusion (0.03 µg\u002Fkg\u002Fmin) or placebo from induction until skin closure within a protocolized hemodynamic strategy guided by mean arterial pressure and pulse pressure variation.",[27,28,29],"Intraoperative Hypotension","Postoperative Pulmonary Complications (PPCs)","Fluid Over-load",[31,32,33,34,35],"Norepinephrine","Fluid Therapy","Pulmonary Complications","Abdominal Surgery","Vasopressor","NOT_YET_RECRUITING","2026-07-10",{"date":39,"type":40},"2026-07-13","ACTUAL",{"date":42,"type":21},"2026-07-15",{"date":44,"type":21},"2026-11",{"name":46,"class":47},"Suez Canal University","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":55,"eligibilityCriteria":56,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":57,"targetDuration":4,"studyType":22,"phases":59,"briefSummary":60,"conditions":61,"keywords":63,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":48},"100643157","flow-controlled-ventilation-to-improve-postoperative-pulmonary-outcome-after-thoracic-surgery-100643157","NCT07623395","Flow-Controlled Ventilation to Improve Postoperative Pulmonary Outcome After Thoracic Surgery","PROtective Ventilation With FLOW-Controlled Ventilation to Improve Postoperative Pulmonary Outcome After THORACic Surgery - an International Multicenter Pilot Randomized Clinical Trial","PROFLOW-THORAC","Inclusion Criteria:\n\n* aged ≥ 18 years; and\n* scheduled for elective open, video- or robot-assisted thoracic surgery with one-lung ventilation using a double-lumen tube (DLT); and\n* able to give written informed consent.\n\nExclusion Criteria:\n\n* body weight \\\u003C 40 kg;\n* ASA score IV - VI;\n* lung separation with other method than DLT (e.g. difficult airway, tracheostomy);\n* previous lung surgery;\n* COPD GOLD grades III and IV, lung fibrosis, documented bullae, severe emphysema, pneumothorax;\n* uncontrolled asthma;\n* Heart failure NYHA Grade 3 and 4, Coronary Heart Disease CCS Grade 3 and 4;\n* documented pulmonary arterial hypertension \\>25 mmHg mPAP at rest or \\>40mmHg syst. (estimated by ultrasound) or \\>20 mmHg mPAP measured by right heart catheterization, or pulmonary vascular resistance \\> 2.0 Wood units;\n* documented or suspected neuromuscular disease (thymoma, myasthenia, myopathies, muscular dystrophies, others);\n* planned mechanical ventilation after surgery;\n* bilateral procedures;\n* surgery in prone position;\n* persistent hemodynamic instability, intractable shock;\n* intracranial injury or tumor;\n* esophagectomy, pleural surgery only, sympathectomy surgery only, chest wall surgery only, mediastinal surgery only, lung transplantation;\n* presence before induction of anesthesia of one of the adverse events, listed as postoperative pulmonary complications (aspiration, moderate respiratory failure, infiltrates, pulmonary infection, atelectasis, cardiopulmonary oedema, pleural effusion, pneumothorax, pulmonary embolism, purulent pleuritis, lung hemorrhage);\n* documented preoperative hypercapnia \\> 45mmHg (6kPa)\n* previous enrolment in the current study;\n* being the study investigator of this study, his\u002Fher family members, employees and other dependent persons;\n* if female and of childbearing potential, known pregnancy or a positive urine pregnancy test (confirmed by a positive serum pregnancy test), or lactating; or\n* no written informed consent.",{"count":58,"type":21},140,[24],"In an international multicenter randomized clinical pilot trial, intraoperative flow-controlled ventilation (FCV) will be compared with volume-controlled ventilation (VCV) in patients scheduled for (open, video- or robot-assisted) thoracic surgery with one-lung ventilation (OLV). This pilot trial is designed to test the feasibility and safety of FCV during all phases of intraoperative ventilation, and in particular during OLV, and to inform the design of a future trial testing the efficacy of FCV with regard to postoperative outcomes, including postoperative pulmonary complications (PPC).\n\nThe ventilation modes are conducted with CE-marked medical devices (anesthesia ventilators or medical ventilators), however these medical devices themselves are not under investigation. All CE-marked standard medical devices from varied manufacturers in use at the participating study centers will be used in full accordance with their instructions for use. FCV has shown safety and feasibility in various surgical settings, including thoracic surgery with OLV, however its feasibility in a multicenter trial has not been investigated yet.",[62,28],"Mechanical Ventilation",[64,65,66,67],"Flow-Controlled Ventilation","Thoracic Surgery","One-Lung Ventilation","Mechanical Power","2026-06-28",{"date":70,"type":40},"2026-07-01",{"date":72,"type":21},"2026-09-01",{"date":74,"type":21},"2027-12-01",{"name":76,"class":47},"Cantonal Hospital of St. Gallen",{"id":78,"slug":79,"hasResults":11,"nctId":80,"briefTitle":81,"officialTitle":82,"acronym":83,"eligibilityCriteria":84,"healthyVolunteers":11,"sex":85,"minAge":18,"maxAge":4,"enrollmentInfo":86,"targetDuration":4,"studyType":22,"phases":88,"briefSummary":89,"conditions":90,"keywords":95,"overallStatus":104,"whyStopped":4,"lastUpdateSubmitDate":105,"lastUpdatePostDateStruct":106,"startDateStruct":108,"completionDateStruct":110,"leadSponsor":112,"locationsCount":48},"100644334","timing-of-recruitment-maneuver-in-robotic-prostate-surgery-100644334","NCT07662642","Timing of Recruitment Maneuver in Robotic Prostate Surgery","Comparison of the Effects of Recruitment Maneuver Timing on Postoperative Pulmonary Complications in Patients Undergoing Robotic Prostate Surgery","ROBPROREC1","Inclusion Criteria:\n\n* Patients scheduled for elective robotic prostate surgery\n* Age 18 years or older\n* Body mass index between 18 and 35 kg\u002Fm²\n* No cognitive impairment\n* Ability to provide written informed consent\n\nExclusion Criteria:\n\n* Age younger than 18 years\n* Emergency surgery\n* Preoperative oxygen requirement\n* Cognitive impairment\n* Refusal to participate in the study","MALE",{"count":87,"type":21},86,[24],"Robotic prostate surgery is commonly performed under general anesthesia with carbon dioxide pneumoperitoneum and steep Trendelenburg positioning. These conditions may reduce lung volumes, impair respiratory mechanics, and increase the risk of atelectasis and postoperative pulmonary complications. Recruitment maneuvers combined with individualized positive end-expiratory pressure may improve intraoperative oxygenation and lung compliance; however, the optimal timing of recruitment maneuver application in robotic prostate surgery remains unclear.\n\nThis prospective randomized study aims to compare the effects of recruitment maneuver timing on postoperative pulmonary complications in adult patients undergoing elective robotic prostate surgery. Participants will be randomized into two groups. In the Supine Recruitment Group, the recruitment maneuver will be performed before carbon dioxide insufflation while the patient is in the supine position, followed by individualized PEEP determination. In the Trendelenburg Recruitment Group, the recruitment maneuver will be performed after pneumoperitoneum and Trendelenburg positioning, followed by individualized PEEP determination. Patients will be evaluated for postoperative pulmonary complications up to postoperative 72 hours or until discharge, whichever occurs first.",[91,92,28,93,94],"Robotic Surgery","Urologic Surgical Procedures","Pulmonary Atelectasis","Postoperative Complications",[96,97,98,99,100,101,102,103],"Robotic prostate surgery","Recruitment maneuver","Pneumoperitoneum","Trendelenburg position","Positive end-expiratory pressure","Atelectasis","Postoperative pulmonary complications","General anesthesia","RECRUITING","2026-06-16",{"date":107,"type":40},"2026-06-23",{"date":109,"type":40},"2026-05-09",{"date":111,"type":21},"2026-07-20",{"name":113,"class":47},"Ankara University",{"id":115,"slug":116,"hasResults":11,"nctId":117,"briefTitle":118,"officialTitle":119,"acronym":4,"eligibilityCriteria":120,"healthyVolunteers":11,"sex":85,"minAge":18,"maxAge":121,"enrollmentInfo":122,"targetDuration":4,"studyType":124,"phases":4,"briefSummary":125,"conditions":126,"keywords":130,"overallStatus":104,"whyStopped":4,"lastUpdateSubmitDate":134,"lastUpdatePostDateStruct":135,"startDateStruct":137,"completionDateStruct":139,"leadSponsor":141,"locationsCount":48},"100643495","intraoperative-driving-pressure-and-postoperative-lung-ultrasound-score-in-robot-assisted-radical-prostatectomy-100643495","NCT07610824","Intraoperative Driving Pressure and Postoperative Lung Ultrasound Score in Robot-Assisted Radical Prostatectomy","Evaluation of the Relationship Between Intraoperative Driving Pressure and Postoperative Lung Ultrasound Score in Patients Undergoing Robot-Assisted Laparoscopic Radical Prostatectomy","Inclusion Criteria:\n\n* Male patients aged between 18 and 80 years.\n\nScheduled for elective robot-assisted laparoscopic radical prostatectomy.\n\nAmerican Society of Anesthesiologists (ASA) physical status I, II, or III.\n\nWillingness to provide written informed consent.\n\nExclusion Criteria:\n\n* Patient refusal to participate.\n\nSevere obstructive or restrictive pulmonary disease (e.g., severe COPD, uncontrolled asthma).\n\nBody Mass Index (BMI) \\> 35 kg\u002Fm\\^2.\n\nPre-existing severe lung pathology or active pulmonary infection.\n\nHemodynamic instability or severe cardiovascular disease (e.g., severe heart failure, recent myocardial infarction).\n\nRequirement for postoperative mechanical ventilation.\n\nEmergency surgery.","80 Years",{"count":123,"type":21},76,"OBSERVATIONAL","The primary objective of this study is to evaluate the relationship between intraoperative driving pressure and postoperative lung ultrasound scores in patients undergoing robot-assisted laparoscopic radical prostatectomy. During this specific surgery, factors such as pneumoperitoneum and patient positioning can significantly affect respiratory mechanics. Postoperative lung condition will be objectively assessed using the lung ultrasound score (LUS). The findings may provide valuable insights for optimizing intraoperative mechanical ventilation strategies.",[62,28,127,128,129],"Prostatic Neoplams","Driving Pressure","Lung Ultrasonography Score",[131,132,133],"driving pressure","lung ultrasonography score","postoperative pulmonary comlications","2026-06-09",{"date":136,"type":40},"2026-06-11",{"date":138,"type":21},"2026-05-30",{"date":140,"type":21},"2026-09-15",{"name":142,"class":143},"Ankara Etlik City Hospital","OTHER_GOV",{"id":145,"slug":146,"hasResults":11,"nctId":147,"briefTitle":148,"officialTitle":149,"acronym":4,"eligibilityCriteria":150,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":121,"enrollmentInfo":151,"targetDuration":4,"studyType":22,"phases":153,"briefSummary":154,"conditions":155,"keywords":157,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":161,"lastUpdatePostDateStruct":162,"startDateStruct":164,"completionDateStruct":166,"leadSponsor":167,"locationsCount":48},"100637429","individualized-peep-and-pulmonary-complications-in-on-pump-cabg-100637429","NCT07623109","Individualized PEEP and Pulmonary Complications in On-Pump CABG","Effect of Individualized PEEP Guided by Driving Pressure and Mechanical Power on Postoperative Pulmonary Complications in On-Pump CABG: A Randomized Controlled Trial","Patients with ASA physical status II-III who are scheduled to undergo elective open-heart surgery via on-pump median sternotomy will be included in the study.\n\nPatients scheduled for emergency surgery, those planned to undergo off-pump cardiac surgery, patients with a history of myocardial infarction within the last 3 months, patients with advanced COPD, patients with an ARISCAT score of 44 or higher, patients with a BMI of 35 kg\u002Fm² or higher, patients with NYHA class IV status, patients receiving preoperative immunotherapy, and patients with severe hepatic or renal failure will be excluded from the study.",{"count":152,"type":21},80,[24],"Postoperative pulmonary complications (PPCs) are an important cause of morbidity and mortality after major surgery and are frequently observed in cardiac surgery patients undergoing cardiopulmonary bypass (CPB). These complications are associated with prolonged mechanical ventilation, longer intensive care unit and hospital stays, increased healthcare costs, and higher mortality (1,2).\n\nIntraoperative lung-protective ventilation strategies have traditionally focused on individual parameters such as low tidal volume, positive end-expiratory pressure (PEEP), plateau pressure, and driving pressure. However, the effects of these parameters on postoperative pulmonary outcomes in cardiac surgery patients remain unclear. In particular, PEEP- and driving pressure-guided approaches are controversial in terms of feasibility and safety in patients undergoing CPB, who may be hemodynamically vulnerable.\n\nMechanical power is a comprehensive parameter that reflects the total energy delivered to the respiratory system per unit of time by integrating ventilatory variables such as tidal volume, airway pressures, respiratory rate, and flow. Therefore, mechanical power may provide a more comprehensive assessment of the mechanical load applied to the lungs compared with individual ventilatory parameters. Previous studies have reported that higher mechanical power values may be associated with lung injury, postoperative pulmonary complications, and mortality (3).\n\nThe aim of this study is to evaluate the effect of monitoring mechanical power during perioperative mechanical ventilation on postoperative pulmonary complications in patients undergoing cardiac surgery with cardiopulmonary bypass. The study hypothesis is that a mechanical power-based ventilation approach may reduce the incidence of PPCs compared with strategies based on conventional ventilation parameters.",[156,67,28],"Cardiac Surgery",[158,159,160],"cardica surgery","mechanical power","postoperative pulmonary complications","2026-06-01",{"date":163,"type":40},"2026-06-03",{"date":165,"type":21},"2026-05-15",{"date":42,"type":21},{"name":168,"class":143},"Bursa City Hospital",{"id":170,"slug":4,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":171,"targetDuration":4,"studyType":22,"phases":172,"briefSummary":25,"conditions":173,"keywords":174,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":175,"lastUpdatePostDateStruct":176,"startDateStruct":178,"completionDateStruct":180,"leadSponsor":181,"locationsCount":48},"100639434",{"count":20,"type":21},[24],[27,28,29],[31,32,33,34,35],"2026-05-31",{"date":177,"type":40},"2026-06-04",{"date":179,"type":21},"2026-05-23",{"date":44,"type":21},{"name":46,"class":47},{"id":183,"slug":184,"hasResults":11,"nctId":185,"briefTitle":186,"officialTitle":187,"acronym":188,"eligibilityCriteria":189,"healthyVolunteers":11,"sex":17,"minAge":190,"maxAge":191,"enrollmentInfo":192,"targetDuration":4,"studyType":22,"phases":194,"briefSummary":195,"conditions":196,"keywords":199,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":208,"lastUpdatePostDateStruct":209,"startDateStruct":211,"completionDateStruct":213,"leadSponsor":215,"locationsCount":48},"100638373","effect-of-positioning-and-acbt-on-pulmonary-complications-after-cardiac-surgery-100638373","NCT07612033","Effect of Positioning and ACBT on Pulmonary Complications After Cardiac Surgery","Effect of Positioning Combined With Active Cycle of Breathing Techniques on Pulmonary Complications After Cardiac Surgeries","P-ACBT","Inclusion Criteria:\n\n* Adult patients (aged from 20 years to 65 years old).\n* Undergoing elective cardiac surgery (Coronary Artery bypass Grafting (CABG) or valves surgeries) via median sternotomy.\n* Hemodynamically stable postoperatively (no high-dose vasopressor support).\n* Fully conscious and capable of following complex verbal instructions.\n\nExclusion Criteria:\n\n* • Patients undergoing emergency cardiac surgery.\n\n  * History of chronic respiratory diseases such as chronic obstructive pulmonary disease (COPD), bronchial asthma, or bronchiectasis\n  * Pre-existing pulmonary complications (e.g., pneumonia, atelectasis, pleural effusion) prior to surgery\n  * Neuromuscular disorders affecting respiratory muscles\n  * Severe obesity (e.g., BMI ≥35 kg\u002Fm²)\n  * Cognitive impairment or inability to follow instructions\n  * Any contraindication to physiotherapy techniques (e.g., unstable sternum, severe pain not controlled)","20 Years","65 Years",{"count":193,"type":21},124,[24],"The goal of this quasi-experimental clinical trial is to learn if position management combined with the Active Cycle of Breathing Techniques (ACBT) works to reduce postoperative pulmonary complications in adult patients undergoing elective cardiac surgery. It will also evaluate the individual effects of each technique compared to routine care.\n\nThe main questions it aims to answer are:\n\nDoes the combination of positioning and ACBT significantly lower the incidence and severity of postoperative pulmonary complications (like atelectasis, pneumonia, and respiratory failure) within the first 7 days after surgery? Does the combination of these techniques reduce the length of hospital stay compared to using each technique alone or routine care? Does the application of ACBT alone lower the rate of respiratory infections? Does position management alone improve oxygenation parameters (such as SpO\\_{2} and PaO\\_{2})?\n\nResearchers will compare four groups of patients to determine the most effective nursing approach:\n\nGroup 1 (Control Group): Participants will receive routine postoperative hospital care only.\n\nGroup 2 (ACBT Group): Participants will perform the Active Cycle of Breathing Techniques (breathing control, thoracic expansion, and huffing) three times daily for 10-15 minutes over 5 postoperative days.\n\nGroup 3 (Positioning Group): Participants will receive structured position management exclusively, shifting from head elevation (30-45) early after surgery to a semi-recumbent position (approx60) during waking hours, alongside other positions like lateral or forward-leaning as tolerated.\n\nGroup 4 (Combined Group): Participants will receive both structured position management and perform the ACBT sessions according to the same schedules.\n\nAll participants will undergo daily respiratory assessments using a standardized scoring system for 7 days post-surgery or until hospital discharge.",[28,197,101,198],"Cardiac Surgery With Sternotomy","Postoperative Pneumonia",[200,201,202,203,204,205,206,207],"Position management","Active Cycle of Breathing Techniques ACBT","Postoperative pulmonary complications (PPCs)","Cardiac surgery (Open heart surgery)","Median sternotomy","Respiratory rehabilitation","Atelectasis prevention","Nursing-driven intervention","2026-05-21",{"date":210,"type":40},"2026-05-28",{"date":212,"type":21},"2026-06-15",{"date":214,"type":21},"2027-01-01",{"name":216,"class":47},"Assiut University",{"id":218,"slug":219,"hasResults":11,"nctId":220,"briefTitle":221,"officialTitle":221,"acronym":222,"eligibilityCriteria":223,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":224,"targetDuration":4,"studyType":22,"phases":226,"briefSummary":227,"conditions":228,"keywords":229,"overallStatus":104,"whyStopped":4,"lastUpdateSubmitDate":233,"lastUpdatePostDateStruct":234,"startDateStruct":236,"completionDateStruct":238,"leadSponsor":240,"locationsCount":48},"100628675","postoperative-high-flow-nasal-oxygenation-after-high-risk-surgery-in-the-frail-adult-100628675","NCT07464730","Postoperative High-flow Nasal Oxygenation After High-risk Surgery in the Frail Adult","Hi-POP","Inclusion Criteria:\n\nAdults (≥18 years old) scheduled for elective abdominal (laparotomy or laparoscopy), open abdominal vascular or non-cardiac thoracic surgery under general anaesthesia with an estimated duration over 3 hours.\n\nAND\n\nMeeting at least two of the following criteria:\n\n* Age \\> 65 years\n* BMI \\>30\n* Preoperative SpO2 \\\u003C95 %\n* Scheduled for lobectomy or pulmonary segment resection\n* Respiratory tract infection the last month\n* Preoperative anaemia (Hb \\\u003C100) or severe hypoalbuminemia (\\\u003C20 g\u002FL)\n* Current smoker or previous smoker with \\>30 packyears\n* Pulmonary disease or OSAS\n* Heart failure\n* Clinical frailty (CFS 4)\n\nExclusion Criteria:\n\n* Not suitable for postoperative HFNO, as decided by a study member or the anaesthetist in charge (such as total nasal obstruction, skull fracture, facial injuries)\n* Pregnancy\n* Not able to understand the study information or sign an informed consent.\n* Not able to participate with the treatment postoperatively\n* Planned for delayed extubation in the intensive care\n* Preoperative non-invasive ventilation due to respiratory failure or a higher level of care than a regular ward",{"count":225,"type":21},200,[24],"High flow nasal oxygen (HFNO) in the immediate postoperative period has been demonstrated to reduce the risk of postoperative pulmonary complications (PPC) after cardiothoracic surgery. In specific groups of patients such as the obese and after upper abdominal surgery the results are contradictive. However, there is lack of evidence if HFNO in the general high-risk patient after abdominal and non-cardiac thoracic surgery can reduce the prevalence of PPC, hypoxaemia and escalation of therapy. Therefore, the investigators aim to compare the use of HFNO with conventional oxygen therapy (COT) in high-risk patients after abdominal and non-cardiac thoracic surgery regarding postoperative pulmonary complications.",[28],[230,231,232],"HFNO","High flow nasal oxygen","Postoperative pulmonary complication","2026-05-11",{"date":235,"type":40},"2026-05-14",{"date":237,"type":40},"2026-04-20",{"date":239,"type":21},"2029-03-09",{"name":241,"class":143},"Region Stockholm",{"id":243,"slug":244,"hasResults":11,"nctId":245,"briefTitle":246,"officialTitle":247,"acronym":248,"eligibilityCriteria":249,"healthyVolunteers":11,"sex":17,"minAge":191,"maxAge":4,"enrollmentInfo":250,"targetDuration":4,"studyType":124,"phases":4,"briefSummary":252,"conditions":253,"keywords":4,"overallStatus":104,"whyStopped":4,"lastUpdateSubmitDate":256,"lastUpdatePostDateStruct":257,"startDateStruct":259,"completionDateStruct":261,"leadSponsor":263,"locationsCount":48},"100623298","can-ultrasound-guided-fascial-plane-blocks-reduce-postoperative-pulmonary-complications-after-major-abdominal-surgery-100623298","NCT07394816","Can Ultrasound-Guided Fascial Plane Blocks Reduce Postoperative Pulmonary Complications After Major Abdominal Surgery?","The Effect of Ultrasound-Guided Fascial Plane Blocks on Postoperative Pulmonary Complications in Patients Undergoing Major Abdominal Surgery: A Prospective Observational Study","FPB-PPC","Inclusion Criteria:\n\n* Age 65 years or older\n* Scheduled for elective major abdominal surgery (e.g., colorectal, hepatobiliary, pancreatic, or gastric surgery)\n* ASA physical status II-III\n* Ability to provide written informed consent\n* Planned use of general anesthesia with or without adjunct regional techniques\n\nExclusion Criteria:\n\n* Refusal or inability to provide informed consent\n* Known allergy or contraindication to local anesthetics\n* Coagulopathy or ongoing anticoagulant therapy contraindicating regional anesthesia\n* Infection at the site of planned block\n* Pre-existing chronic opioid use or chronic pain syndrome\n* Severe hepatic, renal, or cardiac failure (e.g., Child-Pugh C, end-stage renal disease, EF \\\u003C30%)\n* Cognitive impairment or severe dementia preventing adequate pain assessment\n* Emergency surgery\n* Body mass index (BMI \\> 40 kg\u002Fm²)",{"count":251,"type":21},500,"This prospective observational study aims to evaluate whether the use of ultrasound-guided fascial plane blocks is associated with a lower incidence of postoperative pulmonary complications in adult patients undergoing elective major abdominal surgery under general anesthesia.\n\nPatients will be observed in two groups based on routine clinical practice: those who receive an ultrasound-guided fascial plane block for postoperative analgesia and those managed with other standard analgesic methods. The choice of analgesic technique will be determined by the responsible anesthesia team and not influenced by the study.\n\nPostoperative pulmonary complications occurring within the first 7 days after surgery will be recorded using reopening the European Perioperative Clinical Outcome (EPCO) criteria. Secondary outcomes will include unplanned intensive care unit admission, length of hospital stay, and 30-day mortality. No additional procedures or interventions will be performed for research purposes.",[28,254,255],"Abdominal Surgeries","Postoperative Pain Management","2026-04-25",{"date":258,"type":40},"2026-04-30",{"date":260,"type":40},"2026-03-01",{"date":262,"type":21},"2026-08-15",{"name":264,"class":47},"Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital",{"id":266,"slug":267,"hasResults":11,"nctId":268,"briefTitle":269,"officialTitle":270,"acronym":271,"eligibilityCriteria":272,"healthyVolunteers":273,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":274,"targetDuration":4,"studyType":22,"phases":276,"briefSummary":277,"conditions":278,"keywords":281,"overallStatus":104,"whyStopped":4,"lastUpdateSubmitDate":285,"lastUpdatePostDateStruct":286,"startDateStruct":288,"completionDateStruct":290,"leadSponsor":291,"locationsCount":292},"100570174","protective-ventilation-with-flow-controlled-ventilation-100570174","NCT06703814","PROtective Ventilation With FLOW-Controlled Ventilation","PROtective Ventilation With FLOW-Controlled Ventilation to Improve Postoperative Pulmonary Outcome After ROBOT-Assisted Laparoscopic Surgery - an International Multicenter Pilot Randomized Clinical Trial.","PROFLOW","Inclusion Criteria:\n\n* undergoing elective robot-assisted laparoscopic surgery in supine or Trendelenburg position (either abdominal, urologic or gynecologic surgery);\n* AND increased risk of PPCs according to the ARISCAT risk score (≥ 26 points);\n* OR the combination of age \\> 40 years, scheduled surgery lasting \\> 2 hours and planned to receive an intra-arterial catheter for blood pressure monitoring during the surgery;\n* aged ≥ 18 years; and\n* able to give written informed consent to participate in the study and agree to comply with the study protocol prior to initiation of any study-mandated procedure and study intervention.\n\nExclusion Criteria:\n\n* ideal body weight \\\u003C 40 kg;\n* ASA Physical Status Classification System score IV - VI;\n* previous enrolment into the current study;\n* being the study investigator, his\u002Fher family members, employees and other dependent persons;\n* if female and of childbearing potential, known pregnancy or a positive urine pregnancy test (confirmed by a positive serum pregnancy test), or lactating; or\n* No informed consent",true,{"count":275,"type":21},100,[24],"The investigators want to investigate in patients undergoing robot-assisted laparoscopic surgery (a minimally invasive procedure) how applicable flow-controlled ventilation is, and whether it might also be safer than the current ventilation techniques, as well as its impact on potentially reducing the risk of lung-specific complications.\n\nFlow-controlled ventilation has already been tested in several studies on animals and humans and has proven to be a safe form of ventilation for patients undergoing surgery under general anesthesia.\n\nWhen patients undergo major surgery, general anesthesia is required and, as a result, mechanical ventilation of the lungs. Especially in long and complex surgeries, ventilation can become more difficult or lead to complications postoperatively. These patients may then experience shortness of breath, coughing, or require medication to improve lung function. In some cases, reintubation or additional mechanical ventilation may be necessary for support.\n\nPrevious human studies have shown that flow-controlled ventilation is less stressful and, therefore, potentially safer for the lungs compared to traditional ventilation techniques, and that less supplemental oxygen is required. This effect and the safety of flow-controlled ventilation have been demonstrated in several studies.\n\nTherefore, in this study, the investigators aim to explore whether flow-controlled ventilation is potentially safer and easier to apply than traditional ventilation techniques and whether it can reduce the risk of lung-specific complications following robot-assisted surgeries, thereby improving the recovery process postoperatively.",[28,279,280],"Feasibility Studies","Pilot Study",[282,160,283,284],"flow-controlled ventilation","mechanical ventilation","intraoperative ventilation","2026-04-16",{"date":287,"type":40},"2026-04-21",{"date":289,"type":40},"2025-08-02",{"date":175,"type":21},{"name":76,"class":47},3,{"id":294,"slug":295,"hasResults":11,"nctId":296,"briefTitle":297,"officialTitle":298,"acronym":299,"eligibilityCriteria":300,"healthyVolunteers":11,"sex":301,"minAge":18,"maxAge":4,"enrollmentInfo":302,"targetDuration":4,"studyType":22,"phases":303,"briefSummary":304,"conditions":305,"keywords":307,"overallStatus":104,"whyStopped":4,"lastUpdateSubmitDate":313,"lastUpdatePostDateStruct":314,"startDateStruct":316,"completionDateStruct":318,"leadSponsor":320,"locationsCount":292},"100606051","eit-vs-dynamic-compliance-guided-peep-titration-during-laparoscopic-gynecological-surgery-100606051","NCT07170514","EIT vs Dynamic Compliance Guided PEEP Titration During Laparoscopic Gynecological Surgery","Electrical Impedance Tomography vs Dynamic Compliance Guided Positive End-expiratory Pressure Titration During Laparoscopic Gynecological Surgery: A Multi-center, Prospective Randomized Trial - TITRANT","TITRANT","Inclusion criteria:\n\n* Patient scheduled for elective laparoscopic gynaecological surgery\n* Age \\> 18 years\n* Signed consent to participate in the trial\n\nExclusion criteria:\n\n* Age \\\u003C 18 years\n* American Society of Anesthesiologists (ASA) physical status IV\n* History of severe restrictive or chronic obstructive pulmonary disease (COPD, Global Initiative for Chronic Obstructive Lung Disease grades III or IV)\n* Uncontrolled bronchial asthma\n* Pulmonary metastases\n* History of any thoracic surgery\n* Need for thoracic drainage before surgery\n* Congestive heart failure (NYHA grades III or IV)\n* Extreme obesity (BMI\\>35 kg m-2)\n* Lack of patient's consent","FEMALE",{"count":225,"type":21},[24],"The goal of this randomized controlled clinical trial is to compare the pulmonary protective effects of two different positive end-expiratory pressure (PEEP) titrating methods in patients with non-injured lungs undergoing laparoscopic gynecological surgery.\n\nDespite dynamic pulmonary compliance (Cdyn) guided lung protective ventilation has several proven advantages, the investigators hypothesize that optimizing intraoperative mechanical ventilation using electrical impedance tomography (EIT) may further improve patient outcomes, enhance postoperative recovery, shorten in-hospital stay and reduce healthcare related costs.\n\nThe main questions aim to answer are:\n\n* May EIT-guided PEEP titration reduce the mechanical power of ventilation and improve oxygenation more significantly than the Cdyn-guided method?\n* What effect might a decrease in mechanical power of ventilation have on postoperative pulmonary complications?\n\nParticipants will:\n\n* Receive an EIT-guided or a Cdyn-guided PEEP titration procedure during laparoscopic gynecological surgery.\n* Be assessed for mechanical power of ventilation, oxygenation, atelectasis and postoperative pulmonary complications during and 2 days after surgery.\n* Be followed-up for mortality until the 28th postoperative day.",[67,28,306],"Oxygenation",[308,309,310,159,311,312,160],"electrical impedance tomography","dynamic pulmonary compliance","positive end-expiratory pressure","pulmonary protective ventilation","Pao\u002FFiO2","2026-04-09",{"date":315,"type":40},"2026-04-14",{"date":317,"type":40},"2025-11-10",{"date":319,"type":21},"2027-10-30",{"name":321,"class":47},"Pest County Flór Ferenc Hospital",{"id":323,"slug":324,"hasResults":11,"nctId":325,"briefTitle":326,"officialTitle":327,"acronym":328,"eligibilityCriteria":329,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":191,"enrollmentInfo":330,"targetDuration":4,"studyType":124,"phases":4,"briefSummary":332,"conditions":333,"keywords":335,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":342,"lastUpdatePostDateStruct":343,"startDateStruct":345,"completionDateStruct":347,"leadSponsor":349,"locationsCount":4},"100632539","lung-ultrasound-score-and-postoperative-pulmonary-complications-in-major-non-thoracic-surgery-100632539","NCT07515001","Lung Ultrasound Score and Postoperative Pulmonary Complications in Major Non-Thoracic Surgery","Predictive Value of Perioperative Lung Ultrasound Score for Early Postoperative Oxygen Requirement and Pulmonary Complications in Patients Undergoing Major Non-Thoracic Surgery","LUS-POSTOP","Inclusion Criteria:\n\n* Aged 18 to 65 years\n* Scheduled for elective major non-thoracic surgery\n* Undergoing surgery under general anesthesia\n* Expected surgical duration of 3 hours or longer\n* ASA physical status I-III\n* Willing to participate in the study\n* Provides written informed consent\n\nExclusion Criteria:\n\n* Patients undergoing thoracic or cardiac surgery\n* Advanced chronic lung disease (e.g., severe COPD or pulmonary fibrosis)\n* History of previous lung resection\n* Preoperative pneumonia or active pulmonary infection\n* Body mass index greater than or equal to 40 kg\u002Fm2\n* Pregnancy\n* Emergency surgery\n* Planned postoperative mechanical ventilation or intensive care unit admission\n* Refusal to participate in the study",{"count":331,"type":21},97,"This prospective observational cohort study aims to evaluate the predictive value of perioperative lung ultrasound (LUS) score in determining early postoperative oxygen requirement and pulmonary complications in patients undergoing major non-thoracic surgery. Postoperative pulmonary complications remain a significant cause of morbidity and mortality in surgical patients. Lung ultrasound is a non-invasive, bedside imaging modality that allows real-time assessment of lung aeration and pathology. This study will investigate the association between perioperative LUS score and early postoperative respiratory outcomes, including oxygen requirement and pulmonary complications.",[28,334],"Hypoxemia",[336,337,338,94,339,340,341],"lung ultrasound","Lus Score","Perioperative Ultrasound","Oxygen Requirement","Non-Thoracic Surgery","Anesthesia","2026-03-31",{"date":344,"type":40},"2026-04-07",{"date":346,"type":21},"2026-04",{"date":348,"type":21},"2027-01",{"name":350,"class":47},"Dicle University",{"id":352,"slug":353,"hasResults":11,"nctId":354,"briefTitle":355,"officialTitle":355,"acronym":4,"eligibilityCriteria":356,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":357,"enrollmentInfo":358,"targetDuration":4,"studyType":22,"phases":360,"briefSummary":361,"conditions":362,"keywords":363,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":366,"lastUpdatePostDateStruct":367,"startDateStruct":369,"completionDateStruct":371,"leadSponsor":373,"locationsCount":4},"100628411","perioperative-prophylactic-positive-pressure-ventilation-reduces-postoperative-pulmonary-complications-100628411","NCT07461285","Perioperative Prophylactic Positive Pressure Ventilation Reduces Postoperative Pulmonary Complications.","Inclusion Criteria:\n\n* Patients who have signed the informed consent form and are willing to comply with the study protocol;\n* Age ≥ 18 years and ≤ 90 years;\n* ASA physical status classification I to III;\n* Scheduled for major elective abdominal surgery;\n* Undergoing general anesthesia with endotracheal intubation;\n* ARISCAT (Assessement of Respiratory Risk in Surgical Patients in Catalonia) score ≥ 45;\n* Anticipated surgery duration ≥ 2 hours.\n\nExclusion Criteria:\n\n* Untreated ischemic heart disease; severe cardiovascular or cerebrovascular disease;\n* Severe asthma, pulmonary bullae\u002Fbullous lung disease, pneumothorax, bronchopleural fistula, etc.;\n* Severe underlying hepatic or renal disease;\n* Age \\\u003C 18 years or \\> 90 years;\n* Refusal to participate in the clinical study.","90 Years",{"count":359,"type":21},206,[24],"The incidence of postoperative pulmonary complications (PPCs) ranges from 5% to 33%. PPCs significantly prolong hospital stay, increase the economic burden, and are associated with postoperative mortality at 30 days and 1 year. The occurrence of PPCs is associated with multiple perioperative factors. A multimodal approach may provide better prevention against PPCs. We hypothesize that perioperative prophylactic positive pressure ventilation can reduce the incidence of PPCs in patients undergoing high-risk abdominal surgery.",[28],[102,364,365],"positive pressure ventilation","abdominal surgery","2026-03-07",{"date":368,"type":40},"2026-03-10",{"date":370,"type":21},"2026-03-20",{"date":372,"type":21},"2026-09-30",{"name":374,"class":47},"Jun Zhang",{"id":376,"slug":377,"hasResults":11,"nctId":378,"briefTitle":379,"officialTitle":380,"acronym":4,"eligibilityCriteria":381,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":382,"enrollmentInfo":383,"targetDuration":4,"studyType":22,"phases":385,"briefSummary":386,"conditions":387,"keywords":390,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":396,"lastUpdatePostDateStruct":397,"startDateStruct":399,"completionDateStruct":401,"leadSponsor":403,"locationsCount":48},"100622761","individualized-open-lung-ventilation-and-postoperative-pulmonary-complications-in-thoracic-surgery-100622761","NCT07387822","Individualized Open Lung Ventilation and Postoperative Pulmonary Complications in Thoracic Surgery","Effect of Individualized Versus Standardized Open-Lung Ventilation on Postoperative Pulmonary Complications in Thoracic Surgery: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Age 18 to 75 years.\n* American Society of Anesthesiologists (ASA) physical status I-III.\n* Body mass index between 18 and 30 kg\u002Fm².\n* Scheduled for elective video-assisted thoracoscopic surgery (VATS).\n* Expected duration of one-lung ventilation longer than 1 hour.\n* Able to understand the study procedures and provide written informed consent.\n\nExclusion Criteria:\n\n* Pregnancy or breastfeeding.\n* Emergency surgery or reoperation.\n* History of severe pulmonary disease, including chronic obstructive pulmonary disease, pulmonary fibrosis, severe emphysema, pulmonary bullae, pneumothorax, or uncontrolled asthma.\n* History of heart failure or coronary artery disease.\n* Previous thoracic surgery or mechanical ventilation within 1 month before surgery.\n* Planned postoperative mechanical ventilation.\n* Bilateral thoracic surgery.\n* Participation in another interventional clinical trial.\n* Conversion to open thoracotomy during surgery.","75 Years",{"count":384,"type":21},352,[24],"This prospective, single-center, randomized controlled trial aims to evaluate the efficacy of an intraoperative \"Individualized Open Lung Ventilation\" strategy compared to a standard lung-protective ventilation strategy in patients undergoing thoracic surgery.\n\nOne-lung ventilation (OLV) is essential for thoracic surgery but can cause lung injury. While standard care often uses fixed ventilation parameters, this study investigates whether personalizing Positive End-Expiratory Pressure (PEEP) to achieve the lowest driving pressure can reduce the incidence of postoperative pulmonary complications (PPCs) within 7 days after surgery.",[28,388,389],"One-lung Ventilation (OLV)","Thoracic Surgery, Video Assisted",[391,128,392,393,394,395],"Individualized Open Lung Ventilation","PEEP Titration","Lung Recruitment Maneuver","Lung Protective Ventilation","Video-Assisted Thoracic Surgery","2026-01-30",{"date":398,"type":40},"2026-02-04",{"date":400,"type":21},"2026-02-10",{"date":402,"type":21},"2026-05-10",{"name":404,"class":47},"Aerospace Center Hospital",{"id":406,"slug":407,"hasResults":11,"nctId":408,"briefTitle":409,"officialTitle":410,"acronym":4,"eligibilityCriteria":411,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":121,"enrollmentInfo":412,"targetDuration":4,"studyType":22,"phases":414,"briefSummary":415,"conditions":416,"keywords":417,"overallStatus":104,"whyStopped":4,"lastUpdateSubmitDate":421,"lastUpdatePostDateStruct":422,"startDateStruct":424,"completionDateStruct":426,"leadSponsor":428,"locationsCount":48},"100619835","automated-intraoperative-lung-recruitment-maneuvers-in-major-laparoscopic-surgery-100619835","NCT07349784","Automated Intraoperative Lung Recruitment Maneuvers in Major Laparoscopic Surgery","Effect of Automated Intraoperative Lung Recruitment Maneuvers on Atelectasis in Patients Undergoing Major Laparoscopic Surgery: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Age between 18 and 80 years\n* Scheduled for elective laparoscopic colorectal cancer surgery\n* American Society of Anesthesiologists (ASA) physical status I-III\n\nExclusion Criteria:\n\n* ASA physical status IV or higher\n* Pregnancy\n* Body mass index (BMI) \\> 40 kg\u002Fm²\n* Severe chronic obstructive pulmonary disease (COPD), GOLD stage III-IV\n* Advanced heart failure with left ventricular ejection fraction \\\u003C35%\n* Previous thoracic surgery\n* Preoperative requirement for supplemental oxygen therapy\n* Refusal or inability to provide informed consent\n* Intraoperative conversion to open surgery\n* Development of significant hemodynamic instability during lung recruitment maneuvers",{"count":413,"type":21},56,[24],"Laparoscopic colorectal surgery is associated with an increased risk of intraoperative atelectasis due to pneumoperitoneum, Trendelenburg positioning, and prolonged anesthesia duration. Atelectasis developing during surgery may persist into the postoperative period and contribute to postoperative pulmonary complications. Automated lung recruitment maneuvers delivered by modern anesthesia ventilators may offer a standardized method to improve lung aeration and reduce atelectasis. This prospective, randomized, single-center controlled trial aims to evaluate the effect of automated intraoperative lung recruitment maneuvers on atelectasis detected by lung ultrasonography in patients undergoing elective major laparoscopic colorectal cancer surgery. Adult patients will be randomized to receive either automated lung recruitment maneuvers or standard mechanical ventilation without recruitment. Lung ultrasonography will be used to assess atelectasis at predefined perioperative time points. The primary outcome is the incidence of atelectasis detected by lung ultrasound, and secondary outcomes include postoperative pulmonary complications, length of intensive care unit stay, length of hospital stay, and perioperative hemodynamic instability.",[101,28],[418,419,420],"Lung Ultrasound Score (LUS)","Automated Lung Recruitment Maneuvers","Laparoscopic Colorectal Surgery","2026-01-19",{"date":423,"type":40},"2026-01-21",{"date":425,"type":40},"2025-12-13",{"date":427,"type":21},"2026-12",{"name":429,"class":143},"Bakirkoy Dr. Sadi Konuk Research and Training Hospital",{"id":431,"slug":432,"hasResults":11,"nctId":433,"briefTitle":434,"officialTitle":434,"acronym":435,"eligibilityCriteria":436,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":437,"targetDuration":4,"studyType":22,"phases":439,"briefSummary":440,"conditions":441,"keywords":442,"overallStatus":104,"whyStopped":4,"lastUpdateSubmitDate":447,"lastUpdatePostDateStruct":448,"startDateStruct":450,"completionDateStruct":452,"leadSponsor":454,"locationsCount":48},"100582571","perioperative-inhaled-therapy-in-carcinological-thoracic-surgery-in-patients-at-high-risk-of-postoperative-pulmonary-complications-100582571","NCT06865040","Perioperative Inhaled Therapy in Carcinological Thoracic Surgery in Patients at High Risk of Postoperative Pulmonary Complications","TICTAC","Inclusion Criteria:\n\n* Adult (\\>18 years)\n* Lung cancer eligible for surgical management by lung resection (non-small cell lung carcinoma = NSCLC) by any route\n* Naïve to long-term inhaled bronchodilator therapy\n* High risk of post-operative pulmonary complications (Pre-operative FEV1 \\\u003C 80%)\n\nExclusion Criteria:\n\n* Patient refusal\n* Pregnancy\n* Emergency surgery\n* Patient with a physiological status of WHO IV or ASA ≥ IV\n* Asthma\n* Patients treated with long-acting bronchodilators\n* Severe heart failure (NYHA IV), unstable ischaemic heart disease (angina or recent infarction \\\u003C 3 months), obstructive hypertrophic cardiomyopathy, subvalvular aortic stenosis, severe uncontrolled hypertension Recent stroke \\\u003C 3 months\n* High-grade unresponsive conductive disorders or unstable arrhythmia\n* Thyrotoxicosis, pheochromocytoma\n* Unbalanced diabetes\n* Hypersensitivity to ß-2 mimetics or lactose\n* Current participation in a trial of another drug therapy",{"count":438,"type":21},266,[24],"The objective of the study is to evaluate, in a clinical trial, the efficacy of peri operative administration of long-acting inhaled ß-2 mimetics on the occurrence of postoperative pulmonary complications",[65,28],[443,160,444,445,446],"Thoracic surgery","Inhaled therapy","bronchodilators","B2 mimetics","2026-01-15",{"date":449,"type":40},"2026-01-16",{"date":451,"type":40},"2025-07-31",{"date":453,"type":21},"2028-09",{"name":455,"class":47},"Centre Hospitalier Universitaire, Amiens",{"id":457,"slug":458,"hasResults":11,"nctId":459,"briefTitle":460,"officialTitle":461,"acronym":462,"eligibilityCriteria":463,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":464,"enrollmentInfo":465,"targetDuration":466,"studyType":124,"phases":4,"briefSummary":467,"conditions":468,"keywords":469,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":472,"lastUpdatePostDateStruct":473,"startDateStruct":475,"completionDateStruct":476,"leadSponsor":478,"locationsCount":48},"100620612","prediction-of-postoperative-pulmonary-complications-in-thoracic-surgery-100620612","NCT07359885","Prediction of Postoperative Pulmonary Complications in Thoracic Surgery","Prediction of Postoperative Pulmonary Complications in Thoracic Surgery: an Immuno-inflammatory Approach","PREDICT-PPC","Inclusion Criteria:\n\n* Age ≥ 18 years\n* ASA score ≤ 3\n* Patients undergoing scheduled video-assisted or robot-assisted lobectomy, bilobectomy, or segmentectomy.\n* Patients who have read and understood the information letter and do not object to the research.\n* For women of childbearing age (non-sterile): effective contraception\n* Menopausal (non-medically induced amenorrhea for at least 12 months)\n* Patients covered by a social security scheme\n\nExclusion Criteria:\n\n* Minor patients\n* Surgery scheduled for a Friday\n* Patients undergoing a pneumonectomy\n* Pregnant or breastfeeding women\n* Patients deprived of their liberty by an administrative or judicial decision, as well as those under legal protection, guardianship, or curatorship","99 Years",{"count":275,"type":21},"3 Months","Lung cancer is a common disease, and its treatment is lobectomy or pulmonary segmentectomy. In France, approximately 8,000 patients undergo this procedure each year, but it remains associated with significant Postoperative Pulmonary Complications (PPC). This surgical trauma triggers a multicellular and orchestrated immune response, necessary for defense against pathogens, as well as for inflammatory resolution and wound healing. Preoperative single-cell analysis of the patient's immune system is therefore a promising strategy for identifying biomarkers of postoperative pulmonary complications (PPC). Brice Gaudilliere's laboratory at Stanford University, in collaboration with the Paris-based startup Surge, has developed and patented a multivariate model integrating mass cytometry data, proteomic analyses, and clinical data collected before surgery to accurately predict surgical site complications after major abdominal surgery. However, no study has yet explored the identification of inflammatory biomarkers predictive of PPC after thoracic surgery.",[28],[470,471],"lung cancer","immuno-inflammatory approach","2026-01-14",{"date":474,"type":40},"2026-01-22",{"date":161,"type":21},{"date":477,"type":21},"2029-03-01",{"name":479,"class":47},"University Hospital, Rouen",{"id":481,"slug":482,"hasResults":11,"nctId":483,"briefTitle":484,"officialTitle":484,"acronym":485,"eligibilityCriteria":486,"healthyVolunteers":273,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":487,"targetDuration":4,"studyType":22,"phases":489,"briefSummary":490,"conditions":491,"keywords":496,"overallStatus":104,"whyStopped":4,"lastUpdateSubmitDate":498,"lastUpdatePostDateStruct":499,"startDateStruct":501,"completionDateStruct":503,"leadSponsor":505,"locationsCount":48},"100612845","effect-of-vexus-ultrasound-protocol-venous-excess-ultrasound-on-perioperative-fluid-management-on-the-incidence-of-postoperative-pulmonary-complications-and-postoperative-acute-kidney-injury-in-patients-undergoing-thoracic-surgery-100612845","NCT07258875","Effect of VExUS Ultrasound Protocol (Venous Excess Ultrasound) on Perioperative Fluid Management, on the Incidence of Postoperative Pulmonary Complications and Postoperative Acute Kidney Injury in Patients Undergoing Thoracic Surgery","VEXUS","Inclusion Criteria:\n\n* Adults \\>18 years undergoing video assisted thoracic surgery\u002F lobectomy requiring one-lung ventilation.\n\nExclusion Criteria:\n\n* Refusal to participate.\n* Pneumonectomy.\n* Young athletes (risk of physiologically large IVC \\>2 cm).\n* Moderate-severe tricuspid regurgitation, moderate to severe pulmonary hypertension\n* Heart failure with reduced ejection fraction, EF\\\u003C35%\n* Portal hypertension, portal vein thrombosis, or liver cirrhosis.\n* Stage 4 or end-stage chronic kidney disease (eGFR \\\u003C30 mL\u002Fmin\u002F1.73 m² or dialysis).\n* Transfusion with more than 2 packed red blood cells unit perioperatively (intraoperatively, in the PACU, in the ward)",{"count":488,"type":21},230,[24],"This study aims to investigate the effect of a VExUS ultrasound guided protocol of perioperative fluid management within a goal-directed therapy framework, on postoperative respiratory complications, and the occurrence of acute kidney injury (AKI) in patients undergoing thoracic surgery.",[492,493,494,495,28],"Thoracic Surgery With One-lung Ventilation","VExUS","Fluid Management","Acute Kidney Injury",[497],"VExUS, fluid management, pulmonary complications, acute kidney injury, thoracic surgery, one lung ventilation","2025-11-20",{"date":500,"type":40},"2025-12-02",{"date":502,"type":40},"2024-11-27",{"date":504,"type":21},"2029-11-01",{"name":506,"class":47},"University of Crete",{"id":508,"slug":509,"hasResults":11,"nctId":510,"briefTitle":511,"officialTitle":512,"acronym":4,"eligibilityCriteria":513,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":514,"targetDuration":4,"studyType":22,"phases":516,"briefSummary":517,"conditions":518,"keywords":520,"overallStatus":104,"whyStopped":4,"lastUpdateSubmitDate":523,"lastUpdatePostDateStruct":524,"startDateStruct":526,"completionDateStruct":528,"leadSponsor":530,"locationsCount":48},"100594820","sigh-ventilation-in-cardiac-surgery-100594820","NCT07024420","Sigh Ventilation in Cardiac Surgery","Effect of Sigh Ventilation on Postoperative Pulmonary Complications in Cardiac Surgery: A Multicenter, Randomized Controlled Trial","Inclusion Criteria:\n\n* 18 years of age or older;\n* Elective cardiac surgery with cardiopulmonary bypass, aortic clamp and cardioplegia;\n* Written informed consent is obtained from patients and\u002For their legal representatives.\n\nExclusion Criteria:\n\n* Emergence surgery;\n* Left ventricular assist device implantation;\n* Planned thoracotomy with one lung ventilation;\n* Undergo concurrent surgical procedures outside cardiology;\n* Neuromuscular illness;\n* Mechanical ventilation within the last 2 weeks before surgery, include CPAP and NIV;\n* Preoperative shock;\n* Preoperative Hypoxemia (PaO2\\\u003C60mmHg OR SpO2\\\u003C90% on ambient air);\n* Preoperative left ventricular ejection fraction \\\u003C 40%;\n* Systolic pulmonary artery pressure \\> 50 mmHg.",{"count":515,"type":21},686,[24],"The purpose of this trial is to investigate whether sigh ventilation strategy, combining sigh breaths, low tidal volume, and moderate PEEP levels, protects against major pulmonary complications within the first 7 postoperative days after cardiac surgery, as compared with conventional ventilation strategy with low tidal volume, and moderate PEEP levels.",[28,519],"Cardiac Surgery in Adult Patient",[521,156,522],"Sigh Ventilation","Postoperative Pulmonary Complications","2025-11-14",{"date":525,"type":40},"2025-11-18",{"date":527,"type":40},"2025-10-09",{"date":529,"type":21},"2027-12-31",{"name":531,"class":47},"Zhongda Hospital",{"id":533,"slug":534,"hasResults":11,"nctId":535,"briefTitle":536,"officialTitle":537,"acronym":538,"eligibilityCriteria":539,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":191,"enrollmentInfo":540,"targetDuration":4,"studyType":22,"phases":542,"briefSummary":543,"conditions":544,"keywords":549,"overallStatus":104,"whyStopped":4,"lastUpdateSubmitDate":554,"lastUpdatePostDateStruct":555,"startDateStruct":557,"completionDateStruct":559,"leadSponsor":560,"locationsCount":48},"100608916","eit-guided-peep-titration-versus-standard-ventilation-in-bariatric-surgery-100608916","NCT07207772","EIT-guided PEEP Titration Versus Standard Ventilation in Bariatric Surgery","Prevention of Postoperative Pulmonary Complications in Patients Undergoing Laparoscopic Gastric Sleeve Resection by PEEP Titration Based on EIT: A Randomized Controlled Study","EIT","Inclusion Criteria:\n\n1. Age between 18 and 65 years;\n2. Plan to receive laparoscopic bariatric surgery under general anesthesia;\n3. American Society of Anaesthesiologists (ASA) physical status I-III;\n4. BMI between 30 and 55 kg\u002Fm2;\n5. Voluntary participation in this study and signing of an informed consent form.\n\nExclusion Criteria:\n\n1. History of smoking or previous thoracic surgery;\n2. Invasive mechanical ventilation within 30 days;\n3. Pregnancy;\n4. Allergy to EIT electrodes;\n5. Persistent hemodynamic instability or refractory shock;\n6. Severe cardiopulmonary disease (e.g., severe COPD (Chronic obstructive pulmonary disease), NYHA (New York Heart Association) Class III or IV, acute coronary syndrome, or sustained ventricular tachycardia);\n7. Severe pulmonary hypertension (systolic pulmonary artery pressure \\>40 mmHg);\n8. Increased intracranial pressure, intracranial injury\u002Ftumor, or neuromuscular disorders;\n9. Conversion to laparotomy;\n10. Planned transfer to intensive care unit after surgery.",{"count":541,"type":21},118,[24],"This study is a prospective, single-center, single-blind, randomized controlled clinical trial. Patients scheduled for laparoscopic bariatric surgery will be selected and randomly assigned to either the EIT-guided individualized PEEP group (Group P-eit) or the control group (Group P-8). Group P will be ventilated using the PEEP value determined by EIT, while Group C will be ventilated with a fixed PEEP value of 8 cmH2O.The primary outcome is the incidence of postoperative pulmonary complications (PPCs) within 72 hours after surgery.",[545,28,546,547,548],"Electrical Impedance Tomography (EIT)","Recruitment","Mechanical Ventilation Complication","Obesity",[545,28,550,551,552,553],"Lung protective ventilation strategy","Recruitment manoeuvre(RM)","Conventional lung-protective ventilation","bariatric","2025-09-27",{"date":556,"type":40},"2025-10-06",{"date":558,"type":40},"2025-07-28",{"date":529,"type":21},{"name":561,"class":47},"Jianbo Wu"]