[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"postoperative-recovery\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:postoperative-recovery":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,24,0,[8,51,82,118,151,174,202,232,262,288,313,334,359,391,418,448,480,507,531,551,581,605,633,656],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":41,"startDateStruct":44,"completionDateStruct":46,"leadSponsor":48,"locationsCount":4},"100645168","recovery-with-virtual-reality-for-stress-and-pain-100645168",false,"NCT07679022","Recovery With Virtual Reality for Stress and Pain","Recovery With Virtual Reality for Stress & Pain (ReVRS)","ReVRS","Inclusion Criteria:\n\n* Adults aged 18 years or older.\n* Scheduled to undergo elective gynecological surgery according to the study protocol at a participating center where virtual reality can be provided.\n* Able and willing to provide informed consent for study participation, 1:1 randomization, and use of virtual reality.\n\nExclusion Criteria:\n\n* Increased risk of adverse effects related to virtual reality, including pronounced motion sickness, claustrophobia, or photosensitive epilepsy.\n* Active substance use disorder or active misuse of alcohol or illicit drugs.\n* Severe chronic pain and\u002For regular preoperative opioid treatment, as defined in the study protocol.","ALL","18 Years",{"count":20,"type":21},140,"ESTIMATED","INTERVENTIONAL",[24],"NA","This randomized controlled trial will evaluate whether a brief preoperative virtual reality intervention reduces anxiety and improves early recovery in adults undergoing elective gynecological surgery. Approximately 140 participants will be randomly assigned in a 1:1 ratio to either virtual reality in addition to usual care or usual care alone. The virtual reality intervention will consist of approximately 10-20 minutes of an immersive relaxation experience before surgery. The primary outcome is the change in preoperative anxiety measured before and after the intervention. Secondary outcomes include postoperative quality of recovery, pain, opioid consumption, postoperative nausea and vomiting, and early recovery-related healthcare outcomes.",[27,28,29],"Preoperative Anxiety","Postoperative Pain","Postoperative Recovery",[31,32,33,34,35,27,28,36,37,38],"Virtual Reality","Perioperative Care","Gynecologic Surgery","Quality of Recovery","QoR-15","Opioid Consumption","Postoperative Nausea and Vomiting","Nonpharmacologic Intervention","NOT_YET_RECRUITING","2026-06-25",{"date":42,"type":43},"2026-07-01","ACTUAL",{"date":45,"type":21},"2026-09-30",{"date":47,"type":21},"2029-02-28",{"name":49,"class":50},"Region Skane","OTHER",{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":57,"eligibilityCriteria":58,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":59,"enrollmentInfo":60,"targetDuration":4,"studyType":22,"phases":62,"briefSummary":63,"conditions":64,"keywords":68,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":76,"completionDateStruct":77,"leadSponsor":79,"locationsCount":81},"100644228","quality-of-recovery-15-after-opioid-free-versus-opioid-based-general-anesthesia-in-major-urological-surgery-100644228","NCT07665463","Quality of Recovery-15 After Opioid-free Versus Opioid-based General Anesthesia in Major Urological Surgery","Uality of Recovery-15 After Opioid-free Versus Opioid-based General Anesthesia in Patients Undergoing Elective Major Urological Surgery: A Randomized Controlled Trial","QoR-OFA-URO","Inclusion Criteria:\n\n* Adults aged 18 to 75 years.\n* Scheduled for elective major urological surgery under general anesthesia, including laparoscopic or robotic nephrectomy, laparoscopic or robotic prostatectomy, or laparoscopic or robotic cystectomy.\n* Ability to operate a patient-controlled analgesia pump postoperatively.\n* Ability to understand and use the Numeric Rating Scale for pain assessment.\n* Ability to understand and complete the Quality of Recovery-15 questionnaire.\n* Written informed consent.\n\nExclusion Criteria:\n\n* Patient refusal to participate.\n* Inability to operate the patient-controlled analgesia pump.\n* Inability to understand the Numeric Rating Scale for pain assessment.\n* Inability to understand or complete the Quality of Recovery-15 questionnaire.\n* Known hypersensitivity to any of the study drugs, including anesthetics, ketamine, dexmedetomidine, lidocaine, ropivacaine, oxycodone, metamizole, paracetamol, or ibuprofen.\n* Second- or third-degree atrioventricular block.\n* Symptomatic bradycardia.\n* Chronic opioid use.\n* Contraindication to the planned regional anesthesia technique, including coagulopathy, therapeutic anticoagulation, or infection at the puncture site.","75 Years",{"count":61,"type":21},200,[24],"This randomized controlled trial evaluates postoperative quality of recovery assessed with the Quality of Recovery-15 questionnaire in adult patients undergoing elective major urological surgery under opioid-free versus opioid-based general anesthesia.\n\nOpioid-free anesthesia is a multimodal anesthetic technique that avoids intraoperative opioids by combining non-opioid analgesic and sympatholytic agents such as dexmedetomidine, ketamine, lidocaine, non-steroidal anti-inflammatory drugs, and regional analgesia. Opioid-based general anesthesia in this trial includes intraoperative remifentanil infusion.\n\nParticipants will undergo elective urological surgery, including laparoscopic nephrectomy, robotic nephrectomy, laparoscopic prostatectomy, robotic prostatectomy, laparoscopic cystectomy, or robotic cystectomy.\n\nThe primary objective is to compare patient-reported quality of recovery between the opioid-free anesthesia group and the remifentanil-based anesthesia group using the Quality of Recovery-15 questionnaire. QoR-15 will be assessed before surgery and on postoperative day 7.\n\nSecondary objectives include total postoperative oxycodone dose administered via patient-controlled analgesia during the first 24 hours after surgery, postoperative pain intensity measured using the Numeric Rating Scale at 1, 2, 6, 12, and 24 hours after surgery, incidence of postoperative nausea and vomiting, change in serum creatinine from baseline to postoperative day 1, change in white blood cell count from baseline to postoperative day 1, and the ratio of demanded to delivered PCA boluses.\n\nPre-specified subgroup analyses will compare outcomes according to surgical procedure type: laparoscopic nephrectomy, robotic nephrectomy, laparoscopic prostatectomy, robotic prostatectomy, laparoscopic cystectomy, and robotic cystectomy. Subgroup-by-treatment interaction tests will be performed.\n\nPlanned enrollment is approximately 600 patients, with 300 patients per treatment arm. The primary patient-reported recovery endpoint will be assessed on postoperative day 7, while analgesic, pain, and early postoperative safety outcomes will be assessed during the first 24 hours after surgery.",[29,65,66,67],"Anesthesia, General","Analgesics, Opioid","Urologic Surgical Procedure",[69,35,70,71,72],"Quality of Recovery-15","Opioid-free anesthesia","Remifentanil","Urological surgery","2026-06-18",{"date":75,"type":43},"2026-06-24",{"date":42,"type":21},{"date":78,"type":21},"2027-12-31",{"name":80,"class":50},"Jagiellonian University",1,{"id":83,"slug":84,"hasResults":11,"nctId":85,"briefTitle":86,"officialTitle":87,"acronym":88,"eligibilityCriteria":89,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":90,"enrollmentInfo":91,"targetDuration":93,"studyType":94,"phases":4,"briefSummary":95,"conditions":96,"keywords":101,"overallStatus":108,"whyStopped":4,"lastUpdateSubmitDate":109,"lastUpdatePostDateStruct":110,"startDateStruct":112,"completionDateStruct":114,"leadSponsor":116,"locationsCount":81},"100615091","target-controlled-infusion-tci-vs-inhalational-anesthesia-in-video-assisted-thoracoscopic-surgery-vats-100615091","NCT07288099","Target-Controlled Infusion (TCI) vs Inhalational Anesthesia in Video-Assisted Thoracoscopic Surgery (VATS)","Prospective Observational Cohort Study Comparing Recovery Profiles After Target-Controlled Infusion Versus Inhalational Anesthesia in Video-Assisted Thoracoscopic Surgery","TCI-INHALE","Inclusion Criteria:\n\n* Adults aged 18 to 65 years\n\nPatients scheduled for elective video-assisted thoracoscopic surgery (VATS)\n\nASA physical status I-III\n\nAble to provide informed consent\n\nPlanned postoperative recovery in PACU and surgical ward\n\nExclusion Criteria:\n\n* ASA IV or higher\n\nHemodynamic or respiratory instability before surgery\n\nKnown allergy or contraindication to commonly used anesthetic agents\n\nNeurological or psychiatric conditions that may interfere with recovery assessment\n\nEmergency surgeries\n\nPatients who decline participation","80 Years",{"count":92,"type":21},100,"1 Day","OBSERVATIONAL","This study is designed as a prospective observational cohort to evaluate recovery after video-assisted thoracoscopic surgery (VATS). In our clinic, anesthesia for VATS is commonly provided either with target-controlled infusion (TCI) or with inhalational agents, depending on the routine practice of the anesthesiologist. No randomization or additional intervention will be performed.\n\nDuring the study period, patients who receive either method as part of standard care will be followed, and perioperative and postoperative data will be recorded. Awakening time, extubation time, Aldrete score progression, pain levels, and early postoperative complications will be compared between the two groups. The aim is to better understand how these widely used anesthesia techniques may influence recovery in VATS patients and to support future clinical decision-making.",[97,98,29,99,100],"Video-assisted Thoracoscopic Surgery (VATS)","Thoracic Surgery, Video Assisted","General Anesthesia","Anesthesia Techniques",[102,103,104,105,106,29,107],"Video-Assisted Thoracoscopic Surgery","VATS","Thoracic Surgery","Target-Controlled Infusion","Inhalational Anesthesia","Extubation Time","RECRUITING","2026-06-12",{"date":111,"type":43},"2026-06-15",{"date":113,"type":43},"2026-01-12",{"date":115,"type":21},"2026-07",{"name":117,"class":50},"Istanbul University - Cerrahpasa",{"id":119,"slug":120,"hasResults":11,"nctId":121,"briefTitle":122,"officialTitle":123,"acronym":124,"eligibilityCriteria":125,"healthyVolunteers":11,"sex":17,"minAge":126,"maxAge":127,"enrollmentInfo":128,"targetDuration":4,"studyType":22,"phases":130,"briefSummary":131,"conditions":132,"keywords":135,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":142,"lastUpdatePostDateStruct":143,"startDateStruct":145,"completionDateStruct":147,"leadSponsor":149,"locationsCount":81},"100643719","pre-emptive-local-anesthesia-and-emergence-behavior-after-pediatric-dental-general-anesthesia-100643719","NCT07604337","Pre-emptive Local Anesthesia and Emergence Behavior After Pediatric Dental General Anesthesia","Effects of Pre-emptive Local Anesthesia on Emergence Behavior and Early Recovery Quality After Ambulatory Pediatric Dental General Anesthesia: A Parallel-Group Randomized Controlled Trial","PEDLA-QOR","Inclusion Criteria:\n\n* Children aged 7 to 12 years\n* ASA physical status I or II\n* Scheduled for ambulatory dental treatment under general anesthesia\n* Ability to understand and respond to age-appropriate pain and recovery assessment tools\n* Written informed consent obtained from a parent or legal guardian\n* Child assent obtained when appropriate\n\nExclusion Criteria:\n\n* Known allergy or contraindication to local anesthetic agents\n* Developmental delay or cognitive impairment preventing assessment\n* Autism spectrum disorder or severe behavioral disorder\n* Neurological disease affecting behavior or consciousness\n* Chronic analgesic or sedative medication use\n* Severe hepatic, renal, cardiac, or respiratory disease\n* Emergency dental procedure\n* Need for postoperative hospital admission\n* Inability to complete postoperative assessment tools","7 Years","12 Years",{"count":129,"type":21},80,[24],"This study will evaluate whether pre-emptive local anesthesia improves early recovery after ambulatory pediatric dental general anesthesia. Children aged 7-12 years scheduled for dental treatment under general anesthesia will be randomly assigned to receive either pre-emptive local anesthesia or no local anesthesia. Emergence delirium, pain, sedation level, and recovery quality will be assessed during the early postoperative period. The primary outcome will be the longitudinal Pediatric Anesthesia Emergence Delirium Scale score during the first 30 minutes in the post-anesthesia care unit.",[133,134,29],"Emergence Delirium","Pediatric Dental General Anesthesia",[136,137,138,139,140,141],"Pre-emptive local anesthesia","Pediatric anesthesia","Dental anesthesia","Emergence behavior","QoR-15 Pictorial","Ambulatory surgery","2026-06-05",{"date":144,"type":43},"2026-06-09",{"date":146,"type":21},"2026-06",{"date":148,"type":21},"2026-12",{"name":150,"class":50},"seher orbay yasli",{"id":152,"slug":153,"hasResults":11,"nctId":154,"briefTitle":155,"officialTitle":156,"acronym":157,"eligibilityCriteria":158,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":159,"targetDuration":4,"studyType":94,"phases":4,"briefSummary":161,"conditions":162,"keywords":4,"overallStatus":108,"whyStopped":4,"lastUpdateSubmitDate":164,"lastUpdatePostDateStruct":165,"startDateStruct":167,"completionDateStruct":169,"leadSponsor":171,"locationsCount":81},"100643620","qor-15t-in-cardiac-surgery-100643620","NCT07593794","QoR-15T in Cardiac Surgery","Validity and Reliability of the Turkish Quality of Recovery-15 (QoR-15T) Scale in Cardiac Surgery Patients: A Prospective Observational Cohort Study","QoR15T-CARDİAC","Inclusion Criteria:\n\n* Adult patients aged 18 years and older.\n* Patients scheduled for elective cardiac surgery (CABG, valve replacement, or aortic surgery).\n* Patients capable of understanding and answering the Turkish version of the QoR-15 questionnaire.\n* Patients who provide written informed consent.\n\nExclusion Criteria:\n\n* Emergency surgeries or revision surgeries\n* Patients with severe cognitive impairment or psychiatric disorders that prevent completion of the scale\n* Patients who refuse to participate at any stage.",{"count":160,"type":21},150,"The objective of this prospective observational cohort study is to evaluate the validity, reliability, and responsiveness of the Turkish version of the Quality of Recovery-15 (QoR-15T) scale in adult patients undergoing elective cardiac surgery. While the QoR-15T has been validated for general surgery in Turkey, its performance remains to be established in high-risk cardiac surgery populations involving cardiopulmonary bypass and intensive care stays.Approximately 150 patients at Kocaeli City Hospital will be enrolled. The study will compare the patients' QoR-15T scores-recorded preoperatively and on the 7th postoperative day-with the Global Recovery Visual Analog Scale (VAS) to determine construct validity.",[29,163],"Patient Reported Outcome Measures","2026-06-04",{"date":166,"type":43},"2026-06-08",{"date":168,"type":43},"2026-05-18",{"date":170,"type":21},"2026-10-15",{"name":172,"class":173},"Kocaeli City Hospital","OTHER_GOV",{"id":175,"slug":176,"hasResults":11,"nctId":177,"briefTitle":178,"officialTitle":179,"acronym":180,"eligibilityCriteria":181,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":182,"targetDuration":4,"studyType":22,"phases":184,"briefSummary":185,"conditions":186,"keywords":191,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":194,"lastUpdatePostDateStruct":195,"startDateStruct":197,"completionDateStruct":198,"leadSponsor":200,"locationsCount":4},"100637194","impact-of-topical-aromatherapy-on-postoperative-quality-of-recovery-after-lung-resection-100637194","NCT07622602","Impact of Topical Aromatherapy on Postoperative Quality of Recovery After Lung Resection","Evaluation of the Impact of Aromatherapy Applied to the Skin as a Complementary Treatment on the Quality of Recovery (QoR) Following Lung Resection","AromaQoR","Inclusion Criteria:\n\n* Adults aged 18 years or older,\n* undergoing scheduled lung resection for diagnostic or therapeutic purposes\n* able to give free, informed, signed consent (no later than the day of inclusion and before any examination required by the research)\n* person affiliated with or beneficiary of a social security system.\n\nExclusion Criteria:\n\n* Patients with chronic pain prior to surgery\n* patients undergoing daily pain relief treatment prior to surgery\n* patients using essential oils applied to the skin for pain relief.\n* In relation to aromatherapy:\n* history of allergy to essential oils\n* atopic skin\n* known allergies\n* asthma\n* pregnant or breastfeeding women\n* nut allergies (in relation to sweet almond oil)\n* individuals who are vulnerable or deprived of their liberty by judicial or administrative decision\n* patients participating in other interventional studies on pain.",{"count":183,"type":21},124,[24],"The key to early surgery recovery lies in optimal and immediate control of postoperative pain. Despite standard pain management protocols, lung resection is often associated with acute, neuropathic, or chronic pain, compounded by the side effects of morphine-based treatments. In this context, aromatherapy can provide complementary support, both to alleviate pain and to improve the quality of recovery after surgery.",[187,29,188,189,190],"Thoracic Surgical Procedures","Pain","Complementary Therapies","Aromatherapy",[34,190,192,193],"Essential Oil","Thoracic surgery","2026-05-27",{"date":196,"type":43},"2026-06-03",{"date":146,"type":21},{"date":199,"type":21},"2028-06",{"name":201,"class":50},"University Hospital, Toulouse",{"id":203,"slug":204,"hasResults":11,"nctId":205,"briefTitle":206,"officialTitle":207,"acronym":208,"eligibilityCriteria":209,"healthyVolunteers":11,"sex":17,"minAge":210,"maxAge":4,"enrollmentInfo":211,"targetDuration":4,"studyType":22,"phases":213,"briefSummary":214,"conditions":215,"keywords":217,"overallStatus":108,"whyStopped":4,"lastUpdateSubmitDate":223,"lastUpdatePostDateStruct":224,"startDateStruct":226,"completionDateStruct":228,"leadSponsor":230,"locationsCount":81},"100588221","eras-protocols-in-breast-conserving-surgery-100588221","NCT06938581","ERAS Protocols in Breast Conserving Surgery","The Utility of Enhanced Recovery After Surgery (ERAS) Protocols in Breast Conserving Surgery: A Randomized Control Trial","ERAS","Inclusion Criteria:\n\n* Males or females 19 years of age or older\n* Able to provide study-specific informed consent\n* Histologic confirmation of breast cancer on core needle biopsy\n* Clinical or radiographic cT1-T3 N0 disease\n* Undergoing breast conserving surgery with lumpectomy \\& sentinel lymph node biopsy\n* No prior definitive treatment or intervention\n* Able to swallow and retain oral carbohydrate drinks and medication\n\nExclusion Criteria:\n\n* Pregnant\n* Contraindications to ERAS protocol components\n* Undergoing lumpectomy without sentinel lymph node biopsy, mastectomy, or other specified procedures\n* Diagnosed with cT4 or N1-3 disease\n* Metastatic disease at presentation\n* Taking opioid pain medications for other indications\n* History of substance use disorder\n* Any condition where ERAS could compromise safety","19 Years",{"count":212,"type":21},260,[24],"Enhanced Recovery After Surgery (ERAS) protocols have been of increasing interest in the surgical community for decades. The emphasis has been development of protocols to maximize pain control post-operatively without the use of opioids. While this approach has been studied extensively in the oncology surgery literature, little data exists on the utility of ERAS protocols in the setting of breast conserving surgery (BCS), which is a type of surgery to remove breast cancer while saving as much of the breast as possible. The purpose of this study is to determine the utility of implementing ERAS protocols in breast cancer patients undergoing breast conserving surgery. Study participants will be randomized to either ERAS protocol or standard peri-operative care without ERAS. The study will assess the how many opioid prescriptions are given in the first week after surgery and how much pain participants report right after surgery. Investigators will also look at how long participants stay in the recovery room and if medicine for nausea is needed.",[216,29],"Breast Cancer",[218,219,220,221,222,32],"Eras","Opioid Use","Pain Management","Breast Conserving Surgery","Sentinel Lymph Node Biopsy","2026-05-15",{"date":225,"type":43},"2026-05-19",{"date":227,"type":43},"2025-07-11",{"date":229,"type":21},"2029-02",{"name":231,"class":50},"University of Nebraska",{"id":233,"slug":234,"hasResults":11,"nctId":235,"briefTitle":236,"officialTitle":237,"acronym":238,"eligibilityCriteria":239,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":240,"enrollmentInfo":241,"targetDuration":4,"studyType":22,"phases":243,"briefSummary":244,"conditions":245,"keywords":248,"overallStatus":108,"whyStopped":4,"lastUpdateSubmitDate":253,"lastUpdatePostDateStruct":254,"startDateStruct":256,"completionDateStruct":258,"leadSponsor":260,"locationsCount":81},"100630886","virtual-reality-for-postoperative-recovery-after-major-abdominal-surgery-100630886","NCT07493499","Virtual Reality for Postoperative Recovery After Major Abdominal Surgery","Effect of Virtual Reality on Quality of Recovery and Hospital Stay After Major Abdominal Surgery","VR-RECOVER","Inclusion Criteria:\n\n* Adult patients aged 18 to 60 years.\n* Scheduled for elective major abdominal surgery (e.g., colorectal, gastric, or hepatobiliary procedures).\n* Physical and cognitive ability to provide informed consent.\n* Ability to use and interact with Virtual Reality (VR) equipment (head-mounted display).\n* Followed the standardized Enhanced Recovery After Surgery (ERAS) protocol at the hospital.\n\nExclusion Criteria:\n\n\\- Patients with a history of epilepsy or photosensitive seizures.\n\n* Significant cognitive impairment or diagnosed psychiatric disorders that may interfere with study participation.\n* Severe visual or auditory impairments that prevent effective interaction with VR content.\n* Patients with pre-existing motion sickness or severe vertigo.\n* Presence of open wounds or infections in the head or face area that prevent wearing the VR headset.","60 Years",{"count":242,"type":21},60,[24],"Major abdominal surgery often leads to significant postoperative pain, anxiety, and prolonged hospital stays, which can delay overall recovery. This study aims to evaluate the effectiveness of immersive Virtual Reality (VR) as a non-pharmacological intervention to enhance the quality of recovery and reduce the length of hospital stay. Patients in the intervention group will engage in standardized VR sessions featuring guided relaxation and mindfulness-based stress reduction, starting from the evening before surgery through the third postoperative day. The study compares this VR-enhanced protocol against standard perioperative care within an Enhanced Recovery After Surgery (ERAS) framework. The findings are expected to determine if VR can serve as a feasible and effective tool to improve clinical outcomes and patient well-being in surgical wards.",[246,29,28,247],"Abdominal Surgery","Length of Hospital Stay",[31,249,250,251,32,252],"VR Therapy","Distraction Therapy","ERAS (Enhanced Recovery After Surgery)","Non-pharmacological Pain Management","2026-04-19",{"date":255,"type":43},"2026-04-23",{"date":257,"type":43},"2026-03-28",{"date":259,"type":21},"2026-05",{"name":261,"class":50},"Alexandria University",{"id":263,"slug":264,"hasResults":11,"nctId":265,"briefTitle":266,"officialTitle":266,"acronym":4,"eligibilityCriteria":267,"healthyVolunteers":268,"sex":269,"minAge":18,"maxAge":270,"enrollmentInfo":271,"targetDuration":4,"studyType":22,"phases":273,"briefSummary":275,"conditions":276,"keywords":4,"overallStatus":108,"whyStopped":4,"lastUpdateSubmitDate":278,"lastUpdatePostDateStruct":279,"startDateStruct":281,"completionDateStruct":283,"leadSponsor":285,"locationsCount":287},"100542815","phase-1-the-effect-of-oral-gan-shuangbi-during-the-perinatal-period-on-the-recovery-of-intestinal-function-after-cesarean-section-in-pregnant-women--a-multicenter-double-blind-randomized-controlled-clinical-trial-100542815","NCT06347770","The Effect of Oral Gan Shuangbi During the Perinatal Period on the Recovery of Intestinal Function After Cesarean Section in Pregnant Women- A Multicenter, Double-blind, Randomized Controlled Clinical Trial","Inclusion Criteria:\n\n* Chinese woman who is pregnant with a single fetus\n* Pregnant women who planned to perform lower section of uterus due to social factors, relative head basin asymmetry, macrosomia, cicatricial uterus and other reasons.\n\nExclusion Criteria:\n\n* Gastrointestinal disease or family history\n* Antibiotic usage during pregnancy\n* Habit of eating foods with high probiotic content such as yogurt and cheese during pregnancy\n* Take other probiotics or probiotic drinks during pregnancy regularly\n* Hypertension, Diabetes Mellitus, Hyperthyroidism, Hypothyroidism, Autoimmune Disease, or Other Endocrine and Metabolic Disease\n* Transfusion History, Organ Transplantation History or Immunotherapy\n* Gestational hypertension, gestational diabetes, gestational thyroid dysfunction and other endocrine and metabolic diseases occurred during this pregnancy.",true,"FEMALE","45 Years",{"count":272,"type":21},404,[274],"PHASE1","This study aims to evaluate the effect of probiotics 7 days before cesarean section (CS) on postoperative recovery and the change of gut microbiota in pregnant women. Samples were obtained from a total of 202 pregnant individuals, divided into control group and probiotics group. Anal exhaust time and first defecating time were set as the primary outcome of recovery of CS.",[277,29],"Microbiota","2026-04-12",{"date":280,"type":43},"2026-04-15",{"date":282,"type":43},"2024-01-08",{"date":284,"type":21},"2028-03-31",{"name":286,"class":50},"Zhe Li",2,{"id":289,"slug":290,"hasResults":11,"nctId":291,"briefTitle":292,"officialTitle":292,"acronym":4,"eligibilityCriteria":293,"healthyVolunteers":268,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":294,"targetDuration":4,"studyType":94,"phases":4,"briefSummary":295,"conditions":296,"keywords":300,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":304,"lastUpdatePostDateStruct":305,"startDateStruct":307,"completionDateStruct":309,"leadSponsor":311,"locationsCount":4},"100632182","intercultural-adaptation-and-validation-of-the-ukrainian-quality-of-recovery-15-questionnaire-100632182","NCT07510360","Intercultural Adaptation and Validation of the Ukrainian Quality of Recovery-15 Questionnaire","Inclusion criteria\n\n1. Age 18 or older\n2. Patient scheduled for elective or emergency surgery under general or regional anaesthesia\n3. Able to read and understand Ukrainian\n\nExclusion criteria\n\n1. Patient unable or unwilling to provide informed consent\n2. Any severe preexisting medical condition or cognitive impairment that limits objective assessment after operation\n3. Known substance use disorder associated with cognitive impairment\n\nWithdrawal criteria\n\n1\\. Presence of life-threatening post-operative complications",{"count":61,"type":21},"The Quality of Recovery 15-questionnaire (QoR-15) is used to assess postoperative quality of recovery after surgery and anesthesia from the patient's perspective. It evaluates five dimensions including pain, physical comfort, physical independence, psychological support, and emotional state. The aim of this study is to validate a Ukrainian version of the QoR-15 scale (QoR-15Ukr) to measure postoperative recovery in Ukrainian-speaking patients.",[29,297,298,299],"General Anaesthesia","Validation","Questionnaire",[301,302,303,35],"postoperative recovery","validation","Ukrainian","2026-03-30",{"date":306,"type":43},"2026-04-03",{"date":308,"type":21},"2026-05-01",{"date":310,"type":21},"2026-11-30",{"name":312,"class":173},"Rostyslav Voloshchuk",{"id":314,"slug":315,"hasResults":11,"nctId":316,"briefTitle":317,"officialTitle":318,"acronym":4,"eligibilityCriteria":319,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":320,"enrollmentInfo":321,"targetDuration":4,"studyType":22,"phases":322,"briefSummary":323,"conditions":324,"keywords":4,"overallStatus":108,"whyStopped":4,"lastUpdateSubmitDate":257,"lastUpdatePostDateStruct":326,"startDateStruct":328,"completionDateStruct":330,"leadSponsor":332,"locationsCount":81},"100631908","impact-of-combined-intravenous-inhalational-vs-inhalational-anesthesia-on-qor-15-recovery-scores-in-gynecologic-surgery-100631908","NCT07506798","Impact of Combined Intravenous-Inhalational vs Inhalational Anesthesia on QoR-15 Recovery Scores in Gynecologic Surgery","Effects of Combined Intravenous-Inhalational Anesthesia Versus Inhalational Anesthesia on Postoperative Recovery in Gynecological Operations: A Comparison Based on QoR-15 Scores","Inclusion Criteria:\n\n1. Patients aged 18-65 years\n2. Scheduled for elective gynecologic surgery at Sakarya University Faculty of Medicine Training and Research Hospital\n3. Classified as ASA I-III\n4. Able to understand and complete the QoR-15 questionnaire\n5. Provided written informed consent\n\nExclusion Criteria:\n\n1. Severe comorbidities (beyond ASA III)\n2. Patients with advanced neurological disease or cognitive impairment\n3. Known allergy to anesthetic drugs used in the study\n4. Classified as ASA IV-V\n5. Refusal to participate in the study\n6. Emergency or urgent surgery","65 Years",{"count":92,"type":21},[24],"This study aims to compare the effects of combined intravenous-inhalational anesthesia versus inhalational anesthesia alone on postoperative recovery in patients undergoing elective gynecologic surgery.\n\nA total of 100 patients, aged 18-65 years and classified as ASA I-III, scheduled for elective gynecologic procedures at Sakarya University Faculty of Medicine Training and Research Hospital, will be included. The sample size was calculated based on the primary outcome, the Quality of Recovery-15 (QoR-15) score.\n\nPatients will complete the QoR-15 questionnaire preoperatively, before knowing which anesthesia method will be applied. Postoperative QoR-15 scores will be collected on postoperative days 1 and 2, and intraoperative data will be obtained from anesthesia records.\n\nThe study evaluates postoperative recovery using QoR-15 scores, covering physical comfort, emotional state, psychological support, pain, and ability to perform daily activities. Higher scores indicate better recovery, whereas lower scores indicate impaired postoperative recovery.",[33,29,325],"Anesthesia",{"date":327,"type":43},"2026-04-02",{"date":329,"type":43},"2025-10-01",{"date":331,"type":21},"2027-04",{"name":333,"class":50},"Sakarya University",{"id":335,"slug":336,"hasResults":11,"nctId":337,"briefTitle":338,"officialTitle":339,"acronym":4,"eligibilityCriteria":340,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":320,"enrollmentInfo":341,"targetDuration":4,"studyType":22,"phases":343,"briefSummary":344,"conditions":345,"keywords":347,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":351,"lastUpdatePostDateStruct":352,"startDateStruct":354,"completionDateStruct":355,"leadSponsor":357,"locationsCount":81},"100629029","comparison-of-the-effects-of-moderate--and-high-dose-glucocorticoids-on-postoperative-recovery-100629029","NCT07469332","Comparison of the Effects of Moderate- and High-Dose Glucocorticoids on Postoperative Recovery","Comparison of the Effects of Moderate- and High-Dose Glucocorticoid Administration on Postoperative Recovery: A Prospective Randomized Controlled Trial","Inclusion Criteria:\n\n* Age between 18 and 65 years\n* ASA physical status I-II\n* Scheduled for elective laparoscopic cholecystectomy\n* Undergoing general anesthesia\n* Ability to provide written informed consent\n\nExclusion Criteria:\n\n* Patients younger than 18 years or older than 65 years\n* Known allergy to dexamethasone\n* ASA physical status III or higher\n* Surgical procedures lasting longer than 120 minutes\n* Emergency surgeries\n* Pregnant or breastfeeding patients\n* Patients with coagulopathy or receiving anticoagulant therapy\n* Known allergy to local anesthetics\n* Localized infection at the injection site\n* Inflammatory bowel disease\n* Autoimmune diseses\n* Chronic pain conditions\n* Ocular herpes simplex infection\n* Cushing's disease\n* Myasthenia gravis\n* Anticipated poor compliance with the study protocol\n* Vaccination within the last 14 days\n* Use of systemic glucocorticoids or immunosuppressive drugs\n* İmpaired renal function (GFR \\\u003C 30 mL\u002Fmin)\n* Liver cirrhosis\n* Congestive heart failure\n* Peripheral nerve disorders\n* Elective laparoscopic cholecystectomy due to malignancy\n* Conversion to open surgery during the operation\n* Epilepsy\n* Body mass index (BMI) \\> 30 kg\u002Fm²",{"count":342,"type":21},135,[24],"Laparoscopic cholecystectomy is a commonly performed minimally invasive surgical procedure; however, postoperative pain, nausea, and delayed recovery remain clinically relevant problems. Glucocorticoids such as dexamethasone are widely used in perioperative care for the prevention of postoperative nausea and vomiting and as part of multimodal analgesia strategies.\n\nThis prospective randomized controlled trial aims to compare the effects of moderate- and high-dose intravenous dexamethasone administered intraoperatively on postoperative recovery in patients undergoing elective laparoscopic cholecystectomy. The primary outcomes include postoperative nausea and vomiting, inflammatory markers (CRP and WBC), and Quality of Recovery-15 (QoR-15) scores. Secondary outcomes include postoperative pain scores, intraoperative remifentanil consumption, postoperative opioid consumption, and adverse events.",[29,346],"PONV",[29,28,348,37,349,350],"dexamethasone","high dose","moderate dose","2026-03-09",{"date":353,"type":43},"2026-03-13",{"date":304,"type":21},{"date":356,"type":21},"2026-07-30",{"name":358,"class":50},"Ankara City Hospital Bilkent",{"id":360,"slug":361,"hasResults":11,"nctId":362,"briefTitle":363,"officialTitle":364,"acronym":4,"eligibilityCriteria":365,"healthyVolunteers":11,"sex":17,"minAge":240,"maxAge":4,"enrollmentInfo":366,"targetDuration":4,"studyType":22,"phases":368,"briefSummary":369,"conditions":370,"keywords":375,"overallStatus":108,"whyStopped":4,"lastUpdateSubmitDate":383,"lastUpdatePostDateStruct":384,"startDateStruct":386,"completionDateStruct":388,"leadSponsor":389,"locationsCount":81},"100623756","hope-theory-based-nursing-intervention-after-hip-fracture-surgery-100623756","NCT07400770","Hope Theory-Based Nursing Intervention After Hip Fracture Surgery","Effect of a Snyder Hope Theory-Based Nursing Intervention on Psychological Status, Pain, and Functional Recovery in Elderly Patients After Hip Fracture Surgery: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Age ≥ 60 years.\n* Patients with hip fracture requiring surgical intervention.\n* Patients who have undergone hip fracture surgery within the past 2 weeks.\n* Patients who are able to communicate and provide informed consent.\n* Patients and\u002For their family members who are willing to participate in the study.\n\nExclusion Criteria:\n\n* Patients with other lower limb fractures or history of lower limb thrombosis.\n* Patients with multiple fractures.\n* Patients with severe damage to major organs (heart, lungs, brain) or malignant tumors.\n* Patients who have undergone hip replacement surgery in the past.\n* Patients with infectious diseases or immune system disorders.\n* Patients with chronic diseases or neurological disorders.",{"count":367,"type":21},112,[24],"This is a randomized controlled trial to evaluate the effectiveness of a Snyder Hope Theory-based nursing intervention on elderly patients following hip fracture surgery. The study aims to improve the patient's psychological well-being, reduce pain, and enhance their functional recovery. Participants will be randomly assigned to either the intervention group or the control group. The intervention involves individualized counseling, goal setting, and rehabilitation training based on the Snyder Hope Theory. The trial will assess changes in hope levels, anxiety, pain, hip joint function, and quality of life before and after the intervention.",[371,372,29,373,374],"Hip Fracture","Elderly Patients","Nursing Interventions","Snyder Hope Theory",[376,377,378,379,380,381,382],"Hope Theory","Elderly Hip Fracture Surgery","Postoperative Nursing","Psychological Counseling","Rehabilitation Training","Pain Management, Anxiety","Quality of Life","2026-02-03",{"date":385,"type":43},"2026-02-10",{"date":387,"type":43},"2024-05-01",{"date":310,"type":21},{"name":390,"class":173},"Institute of Orthopaedic Surgery, Taizhou No.3 People's Hospital",{"id":392,"slug":393,"hasResults":11,"nctId":394,"briefTitle":395,"officialTitle":396,"acronym":4,"eligibilityCriteria":397,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":398,"targetDuration":4,"studyType":22,"phases":399,"briefSummary":400,"conditions":401,"keywords":405,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":409,"lastUpdatePostDateStruct":410,"startDateStruct":412,"completionDateStruct":414,"leadSponsor":416,"locationsCount":81},"100621727","nurse-led-early-mobilization-after-colorectal-surgery-100621727","NCT07374380","Nurse-Led Early Mobilization After Colorectal Surgery","Effect of a Nurse-Led Early Mobilization Protocol on Colorectal Surgery Patients: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Adults aged 18 years and older\n* Scheduled for elective colorectal surgery (e.g., procedures related to\n* colorectal cancer, diverticulitis, or inflammatory bowel disease \\[IBD\\])\n* Able to ambulate independently preoperatively\n* Medically and cognitively able to participate in a mobilization protocol\n* Able to provide written informed consent\n\nExclusion Criteria:\n\n* Undergoing emergency colorectal surgery\n* Patients requiring postoperative intensive care unit (ICU) admission\n* Severe cognitive impairment or psychiatric disorders that may affect participation\n* Musculoskeletal or neurological conditions that impair mobility\n* Inability to understand study instructions due to language or communication barriers",{"count":129,"type":21},[24],"This study was designed to evaluate the effectiveness of a nurse-led early mobilization protocol on postoperative recovery outcomes in patients undergoing elective colorectal surgery. The outcomes assessed include walking distance, mobility levels, gastrointestinal function (time to first flatus and first defecation), nausea, vomiting, comfort, fatigue, time to initiation of oral intake, patient satisfaction, incidence of postoperative complications, and length of hospital stay.\n\nResearch Question:\n\nIn patients undergoing colorectal surgery (P), does a nurse-led early mobilization protocol (I), compared with standard mobilization practices (C), improve postoperative recovery outcomes (O), including walking distance, mobility levels, gastrointestinal function (time to first flatus and first defecation), nausea, vomiting, comfort, fatigue, time to initiation of oral intake, patient satisfaction, postoperative complication rates, and length of hospital stay?",[402,403,404,29],"Colorectal Surgery","Early Mobilization","Postoperative Care",[406,407,408],"colorectal surgery","early mobilization","Nurse-Led Intervention","2026-01-25",{"date":411,"type":43},"2026-01-28",{"date":413,"type":21},"2026-01-05",{"date":415,"type":21},"2026-12-29",{"name":417,"class":50},"Ege University",{"id":419,"slug":420,"hasResults":11,"nctId":421,"briefTitle":422,"officialTitle":423,"acronym":4,"eligibilityCriteria":424,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":425,"targetDuration":4,"studyType":22,"phases":427,"briefSummary":428,"conditions":429,"keywords":432,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":439,"lastUpdatePostDateStruct":440,"startDateStruct":442,"completionDateStruct":444,"leadSponsor":446,"locationsCount":81},"100602646","hot-water-foot-bath-for-pain-and-gas-relief-after-laparoscopic-cholecystectomy-100602646","NCT07126223","Hot Water Foot Bath for Pain and Gas Relief After Laparoscopic Cholecystectomy","The Effect of Hot Water Foot Bath on Pain and Gas Release After Laparoscopic Cholecystectomy: A Randomised Controlled Trial","Inclusion Criteria:\n\n* Age 18 years or older\n* Undergoing elective laparoscopic cholecystectomy\n* Received the same preoperative gastrointestinal preparation protocol\n* Received the same postoperative analgesia protocol\n* Numeric Rating Scale (NRS) pain score of 3 or higher at the 3rd postoperative hour\n* Voluntarily agreed to participate and signed the informed consent form\n* Classified as ASA I or ASA II according to the American Society of Anesthesiologists (ASA)\n\nExclusion Criteria:\n\n* Undergoing emergency cholecystectomy or open surgery (laparotomy)\n* Presence of open wounds, infections, circulatory disorders, or lesions in the feet (hot foot bath area)\n* Use of patient-controlled analgesia (PCA) in the early postoperative period\n* Any condition that impairs verbal communication\n* History of inflammatory bowel disease (due to potential influence on bowel motility)\n* Use of medications or probiotic agents affecting bowel motility in the pre- or postoperative period",{"count":426,"type":21},62,[24],"This study investigates the effects of a hot foot bath on postoperative pain and time to first gas release in patients undergoing laparoscopic cholecystectomy. The intervention is a non-pharmacological supportive method applied during the early postoperative period. Participants will be randomly assigned to either intervention or control groups. No FDA-regulated drug or device is involved.",[430,28,431,29,373],"Laparoscopic Cholecystectomy","Gastrointestinal Motility",[433,434,435,436,437,438],"foot bath","gas release","pain management","complementary therapy","nursing","cholesistectomy","2025-12-04",{"date":441,"type":43},"2025-12-05",{"date":443,"type":21},"2025-12-20",{"date":445,"type":21},"2026-06-30",{"name":447,"class":50},"Cansu Mert",{"id":449,"slug":450,"hasResults":11,"nctId":451,"briefTitle":452,"officialTitle":453,"acronym":454,"eligibilityCriteria":455,"healthyVolunteers":11,"sex":269,"minAge":18,"maxAge":320,"enrollmentInfo":456,"targetDuration":4,"studyType":22,"phases":458,"briefSummary":459,"conditions":460,"keywords":463,"overallStatus":108,"whyStopped":4,"lastUpdateSubmitDate":471,"lastUpdatePostDateStruct":472,"startDateStruct":474,"completionDateStruct":476,"leadSponsor":478,"locationsCount":81},"100610786","intrathecal-morphine-versus-trocar-site-and-intraperitoneal-bupivacaine-for-quality-of-recovery-after-laparoscopic-hysterectomy-100610786","NCT07232108","Intrathecal Morphine Versus Trocar-Site and Intraperitoneal Bupivacaine for Quality of Recovery After Laparoscopic Hysterectomy","Effects of Intrathecal Morphine Compared With Trocar-Site Infiltration and Intraperitoneal Bupivacaine on Postoperative Quality of Recovery and Inflammatory Markers After Laparoscopic Hysterectomy: A Prospective, Randomized, Double-Blind Controlled Trial","ITM-LH-QoR","Inclusion Criteria:\n\n* Female patients aged 18-65 years.\n* Elective laparoscopic hysterectomy planned for benign gynecological conditions.\n* American Society of Anesthesiologists (ASA) physical status I-III.\n* Ability to provide written informed consent.\n\nExclusion Criteria:\n\n* Coagulopathy or bleeding disorders.\n* Opioid dependence or chronic opioid use.\n* Allergy or contraindication to local anesthetics or morphine.\n* Contraindication to neuraxial (spinal) anesthesia.\n* History of chronic pain syndromes.\n* Severe renal or hepatic dysfunction.\n* Pregnancy or breastfeeding.",{"count":457,"type":21},64,[24],"This study aims to compare the effects of intrathecal morphine with trocar-site infiltration and intraperitoneal bupivacaine on postoperative pain control, quality of recovery, and inflammatory response in patients undergoing elective laparoscopic hysterectomy. Laparoscopic hysterectomy is widely used for benign gynecologic conditions, but postoperative pain may result from trocar-site trauma, peritoneal irritation, and carbon dioxide insufflation. Effective postoperative analgesia can improve patient comfort, reduce opioid use, and enhance early recovery.\n\nIntrathecal morphine is known to provide potent early postoperative analgesia but may cause side effects such as nausea, vomiting, pruritus, and respiratory depression. Local anesthetic techniques, including trocar-site infiltration and intraperitoneal bupivacaine, have also been shown to reduce postoperative pain after minimally invasive gynecologic surgery.\n\nIn this prospective, randomized, double-blind study, patients will be assigned to one of two groups:\n\nIntrathecal morphine (ITM) administered before induction of anesthesia;\n\nLocal anesthesia group (LA) receiving trocar-site infiltration and intraperitoneal bupivacaine at the end of surgery.\n\nThe primary outcome is the Quality of Recovery-15 (QoR-15) score at 24 hours. Secondary outcomes include pain scores, opioid consumption, time to first rescue analgesia, postoperative nausea and vomiting, pruritus, respiratory depression, early mobilization, bowel function recovery, and perioperative inflammatory markers such as neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), and systemic immune-inflammation index (SII).\n\nThe results of this trial are expected to guide clinicians in selecting optimal analgesic strategies for laparoscopic hysterectomy and to contribute to improved patient recovery and postoperative satisfaction.",[461,462,29],"Postoperative Pain Management","Laparoscopic Hysterectomy",[464,465,466,462,467,28,36,468,469,470],"Intrathecal Morphine","Trocar-Site Infiltration","Intraperitoneal Bupivacaine","Quality of Recovery (QoR-15)","Inflammatory Markers","Neutrophil-to-Lymphocyte Ratio (NLR)","Systemic Immune-Inflammation Index (SII)","2025-12-02",{"date":473,"type":43},"2025-12-08",{"date":475,"type":43},"2025-12-01",{"date":477,"type":21},"2026-06-02",{"name":479,"class":50},"Ataturk University",{"id":481,"slug":482,"hasResults":11,"nctId":483,"briefTitle":484,"officialTitle":484,"acronym":4,"eligibilityCriteria":485,"healthyVolunteers":268,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":486,"targetDuration":4,"studyType":22,"phases":488,"briefSummary":490,"conditions":491,"keywords":494,"overallStatus":108,"whyStopped":4,"lastUpdateSubmitDate":499,"lastUpdatePostDateStruct":500,"startDateStruct":502,"completionDateStruct":504,"leadSponsor":506,"locationsCount":81},"100602466","phase-4-effect-of-combined-intravenous-inhalational-anesthesia-civia-on-postoperative-recovery-patterns-100602466","NCT07123870","Effect of Combined Intravenous-Inhalational Anesthesia (CIVIA) on Postoperative Recovery Patterns.","Inclusion Criteria:\n\n* Scheduled for spine surgery\n* Expected surgery duration longer than 3 hours\n* Use of intraoperative neuromonitoring\n* BIS-guided anesthesia administered\n* TIVA (with TCI) as the primary anesthetic technique\n* Age \\>18 years\n\nExclusion Criteria:\n\n* Emergency surgeries\n* Patients receiving sole inhaled anesthesia (no TIVA)\n* Perioperative dural injury\n* Intraoperative severe hypotension requiring inotropic support\n* Hypothermia (based on temperature measured before recovery)",{"count":487,"type":21},210,[489],"PHASE4","This study was planned as a single-center, prospective, randomized trial. Adult patients undergoing elective spinal surgery lasting longer than three hours, performed in a neurosurgery operating room, will be evaluated. Patients managed with three different anesthesia methods currently used will be examined for recovery patterns:\n\n1. Total intravenous anesthesia (TIVA),\n2. TIVA Combined anesthesia with sevoflurane and intravenous agents (sevoflurane-CIVIA),\n3. TIVA Combined anesthesia with desflurane and intravenous agents (desflurane-CIVIA).\n\nRecovery patterns include; extubation time, eye opening time, emergence agitation, postoperative nausia and vomiting and postoperative recovery unit discharge time.",[29,492,493],"Inhalation Anesthesia","Total Intravenous Anesthesia",[495,496,497,498,301],"CIVIA","TIVA","sevoflurane","desflurane","2025-08-08",{"date":501,"type":43},"2025-08-14",{"date":503,"type":43},"2025-07-23",{"date":505,"type":21},"2025-11-15",{"name":172,"class":173},{"id":508,"slug":509,"hasResults":11,"nctId":510,"briefTitle":511,"officialTitle":512,"acronym":4,"eligibilityCriteria":513,"healthyVolunteers":11,"sex":17,"minAge":514,"maxAge":127,"enrollmentInfo":515,"targetDuration":4,"studyType":22,"phases":517,"briefSummary":518,"conditions":519,"keywords":4,"overallStatus":108,"whyStopped":4,"lastUpdateSubmitDate":522,"lastUpdatePostDateStruct":523,"startDateStruct":525,"completionDateStruct":527,"leadSponsor":529,"locationsCount":81},"100590458","perfusion-index-in-pediatric-low-flow-anesthesia-100590458","NCT06967675","Perfusion Index in Pediatric Low-Flow Anesthesia","Changes in Perfusion Index Under Low-Flow Anesthesia and Its Effects on Postoperative Emergence in Pediatric Patients","Inclusion Criteria:\n\n* ASA I-II pediatric patients\n* Age 2 to 12 years\n* Undergoing elective surgery lasting between 1-6 hours\n* Informed consent obtained from parents\u002Fguardians\n\nExclusion Criteria:\n\n* Cardiovascular, respiratory, neurological, metabolic, or endocrine disorders\n* Premature birth with corrected age \\\u003C 2 years\n* Obesity or severe malnutrition (BMI \\\u003C5th or \\>95th percentile)\n* Psychiatric or neurodevelopmental disorders (e.g., autism)\n* Malignant hyperthermia or hypersensitivity to anesthetics\n* Emergency surgeries\n* Lack of IV access requiring inhalational induction\n* Contraindications to low-flow anesthesia including:\n* Severe pulmonary disease\n* Congenital heart disease with shunt physiology\n* Anticipated high oxygen demand\n* Airway obstruction risk\n* Surgeries requiring high gas flow or \\>6 hours duration","2 Years",{"count":516,"type":21},90,[24],"This study aims to evaluate changes in perfusion index (PI) in pediatric patients undergoing elective surgery under low-flow anesthesia. PI will be monitored at multiple intraoperative and postoperative time points to assess its relationship with hemodynamic stability and depth of anesthesia. The study will also investigate whether low-flow anesthesia affects the incidence of emergence agitation (EA). Patients will be assigned to either low-flow or normal-flow anesthesia groups based on routine clinical practice. No intervention will be applied beyond standard care. The findings are expected to provide insight into the predictive value of PI in postoperative recovery and support safer anesthesia practices in pediatric populations.",[520,521,29],"Perfusion Index","Low-Flow Anesthesia","2025-07-08",{"date":524,"type":43},"2025-07-10",{"date":526,"type":43},"2025-06-15",{"date":528,"type":21},"2025-08-10",{"name":530,"class":50},"Istinye University",{"id":532,"slug":533,"hasResults":11,"nctId":534,"briefTitle":535,"officialTitle":536,"acronym":4,"eligibilityCriteria":537,"healthyVolunteers":11,"sex":269,"minAge":18,"maxAge":4,"enrollmentInfo":538,"targetDuration":4,"studyType":94,"phases":4,"briefSummary":540,"conditions":541,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":543,"lastUpdatePostDateStruct":544,"startDateStruct":546,"completionDateStruct":548,"leadSponsor":550,"locationsCount":4},"100596896","sleep-during-recovery-effect-of-preoperative-regional-block-on-postoperative-sleep-quality-in-mastectomy-patients-100596896","NCT07051434","Sleep During Recovery: Effect of Preoperative Regional Block on Postoperative Sleep Quality in Mastectomy Patients","Sleep During Recovery: Does Preoperative Regional Block Affect Postoperative Sleep Quality in Mastectomy Patients? A Prospective Evaluation Using Two Validated Sleep Quality Scales","Inclusion Criteria:\n\n* Female patients aged 18 years or older\n* Undergoing elective mastectomy surgery\n* ASA physical status I to III\n* Willing and able to provide written informed consent\n* Expected to remain hospitalized for at least 24 hours postoperatively\n\nExclusion Criteria:\n\n* History of major psychiatric or neurological disorders\n* Regular use of antidepressants, anxiolytics, or hypnotics\n* Difficult airway management during anesthesia (e.g., intubation or ventilation complications)\n* Reoperation within the first 24 hours after surgery\n* Inability to complete questionnaires due to deep sedation or visual\u002Fauditory impairment",{"count":539,"type":21},66,"This prospective observational study investigates the impact of preoperative regional anesthesia on postoperative sleep quality in patients undergoing mastectomy. Sleep quality will be assessed using two validated tools: the Richards-Campbell Sleep Questionnaire (RCSQ) for all participants, and the Pittsburgh Sleep Quality Index (PSQI) in a subgroup. The study also examines the relationship between sleep quality and postoperative pain, patient satisfaction, and psychological status measured by the Hospital Anxiety and Depression Scale (HADS). Patients will be grouped based on anesthesia technique-general anesthesia alone or general anesthesia combined with regional block-and sleep outcomes will be compared. The study aims to provide evidence on how anesthetic technique and psychological factors affect recovery and sleep quality after breast cancer surgery.",[542,29,100],"Sleep Quality","2025-06-26",{"date":545,"type":43},"2025-07-04",{"date":547,"type":21},"2025-07-01",{"date":549,"type":21},"2026-02-01",{"name":530,"class":50},{"id":552,"slug":553,"hasResults":11,"nctId":554,"briefTitle":555,"officialTitle":556,"acronym":557,"eligibilityCriteria":558,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":559,"targetDuration":4,"studyType":22,"phases":560,"briefSummary":562,"conditions":563,"keywords":565,"overallStatus":108,"whyStopped":4,"lastUpdateSubmitDate":572,"lastUpdatePostDateStruct":573,"startDateStruct":575,"completionDateStruct":577,"leadSponsor":579,"locationsCount":81},"100590483","phase-1-double-blind-pilot-study-on-the-effect-of-anionic-exposome-enrichment-biow-on-recovery-and-sleep-quality-in-postoperative-patients-100590483","NCT06968000","Double-blind Pilot Study on the Effect of Anionic Exposome Enrichment (Biow) on Recovery and Sleep Quality in Postoperative Patients","Pilot, Controlled, Double-blind Study to Evaluate the Effect of the Exposome Anionic Enrichment System (Biow) on Hospital Recovery Quality, Clinical Response, and Sleep Quality in Postoperative Patients","EOX","Inclusion Criteria:\n\n* Adults aged ≥18 years, regardless of sex.\n* Undergoing elective general surgery, preferably hepatobiliary procedures.\n* Hospitalized for at least 4 days postoperatively in Unit 69 (HUFJD).\n* Able to provide written informed consent.\n* Considered to have medium or high risk of oxidative stress or mitochondrial dysfunction.\n\nExclusion Criteria:\n\n* Surgery within the previous 6 months, either outpatient or inpatient.\n* Diagnosed psychiatric or neurological disorders, including epilepsy.\n* Active progressive cancer or chronic inflammatory disease.\n* Cognitive impairment or inability to comply with study procedures.\n* BMI ≥30 kg\u002Fm² (obesity class I or higher).",{"count":160,"type":21},[274,561],"PHASE2","Airborne nanoparticle exposure is increasingly recognized as a significant contributor to oxidative stress, mitochondrial dysfunction, and low-grade systemic inflammation-factors that impair postoperative recovery. The World Health Organization and European initiatives such as the Human Exposome Project have highlighted the clinical importance of the exposome, defined as the totality of environmental exposures influencing health throughout life.\n\nEOX is a CE-certified air regeneration system designed to modify the indoor exposome through a dual mechanism: advanced filtration and controlled emission of bioavailable anions using cold atmospheric plasma (CAP). Its multistage filter removes particulate matter, pathogens, and volatile organic compounds, while the anionic plasma phase modulates cellular oxidative balance and metabolic function.\n\nExperimental and clinical data indicate that exposure to EOX improves mitochondrial efficiency, increases ATP production, and reduces oxidative protein damage. EOX has also been shown to influence molecular pathways involved in stress adaptation and repair, such as the HIF-1α-VEGF-EPO axis and protein synthesis signaling (e.g., mTOR-p70S6K). These mechanisms may collectively enhance tissue recovery, vascularization, and metabolic resilience in the postoperative setting.\n\nThe present study investigates the effects of EOX in hospitalized postoperative patients, evaluating both subjective (sleep quality, well-being) and objective (vital signs, metabolomics, microbiota composition) endpoints. The central hypothesis is that EOX induces a beneficial hormetic response-an adaptive reaction to mild environmental stressors-reflected by improved clinical recovery and biomarker modulation (e.g., succinate reduction, increased ATPase activity). The goal is to assess whether EOX can serve as an effective environmental intervention to support physiological healing and improve the quality of inpatient recovery.",[564,29],"Inflammatory Response After Surgery",[566,567,568,569,570,571],"Exposome","Bioavailable anions","Postoperative recovery","Mitochondrial function","Oxidative stress","Surgical inflammation","2025-05-05",{"date":574,"type":43},"2025-05-13",{"date":576,"type":43},"2025-03-01",{"date":578,"type":21},"2027-03-01",{"name":580,"class":50},"Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz",{"id":582,"slug":583,"hasResults":11,"nctId":584,"briefTitle":585,"officialTitle":586,"acronym":587,"eligibilityCriteria":588,"healthyVolunteers":11,"sex":17,"minAge":589,"maxAge":4,"enrollmentInfo":590,"targetDuration":4,"studyType":94,"phases":4,"briefSummary":592,"conditions":593,"keywords":594,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":597,"lastUpdatePostDateStruct":598,"startDateStruct":600,"completionDateStruct":602,"leadSponsor":603,"locationsCount":81},"100573159","rapid-move-following-outpatient-surgery-safety-and-patient-characteristics-100573159","NCT06742658","Rapid Move Following Outpatient Surgery: Safety and Patient Characteristics","A Retrospective Study on the Safety of the Rapid Move Following Outpatient Surgery and the Characteristics of Patients in the Rapid Move","OUTSIDE","Inclusion Criteria:\n\n* Patients aged 15 years or older;\n* Patients who went to the Rapid Move after their outpatient procedure. Eligible procedures are: gastroscopy, coloscopy, vasectomy, scrotal surgery, circumcision or other minor penile surgery, intravesical Botox, insertion or removal of eardrum tubes in adults, sinus irrigation in adults, sleep endoscopy, bronchoscopy, removal of osteosynthetic material in the lower leg and foot, and tooth extraction (including wisdom teeth) and upper-forearm orthopedic surgery (excluding prosthetic surgery).\n\nExclusion Criteria:\n\n* Inpatients defined as a patient who is formally admitted (or \"hospitalized\") to an institution for treatment and\u002For care and stays for a minimum of one night in the hospital or other institution providing inpatient care;\n* Patients undergoing emergency procedures.","15 Years",{"count":591,"type":21},1500,"A descriptive, retrospective cohort study will be conducted to gain insight in the safety of the Rapid Move. The trial will include a group of Rapid Move patients, who were transferred to the Rapid Move after their outpatient surgery and subsequently discharged home. The Rapid Move is a short-stay PACU where patients recover from anaesthesia, are continuously monitored, and prepared for discharge within an hour after surgery.",[29],[568,595,596],"PACU","Rapid Move","2024-12-18",{"date":599,"type":43},"2024-12-19",{"date":601,"type":21},"2025-12",{"date":601,"type":21},{"name":604,"class":50},"Algemeen Ziekenhuis Maria Middelares",{"id":606,"slug":607,"hasResults":11,"nctId":608,"briefTitle":609,"officialTitle":610,"acronym":611,"eligibilityCriteria":612,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":613,"targetDuration":4,"studyType":94,"phases":4,"briefSummary":614,"conditions":615,"keywords":620,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":624,"lastUpdatePostDateStruct":625,"startDateStruct":627,"completionDateStruct":629,"leadSponsor":631,"locationsCount":81},"100569867","validation-of-the-greek-postoperative-quality-of-recovery-score-15-100569867","NCT06699823","Validation of the Greek Postoperative Quality of Recovery Score 15","Cultural Adaptation and Validation of the Greek Version of the Postoperative Quality of Recovery Score 15 (QoR-15Gr)","(QoR-15Gr)","Inclusion Criteria:\n\n* Age\\>18 years old\n* Scheduled elective general surgery under general anesthesia\n\nExclusion Criteria:\n\n* Emergency surgery\n* Poor Greek comprehension\n* Inability to give consent\n* A psychiatric or neurological condition that precludes cooperation\n* Known history of alcohol or drug dependence\n* Life-threatening postoperative complications\n* Postoperative admission to ITU",{"count":160,"type":21},"The goal of this observational study is to translate a patient questionnaire about recovery after an operation into Greek and assess how accurate, reliable, acceptable, and feasible this Greek version is.",[29,616,617,618,619],"Quality of Recovery From Anaesthesia","PROMs","Validation Study","Cultural Adaptation",[621,622,35,302,623],"quality of recovery","patient reported outcomes","cultural adaptation","2024-11-22",{"date":626,"type":43},"2024-11-26",{"date":628,"type":21},"2024-12-01",{"date":630,"type":21},"2025-02-28",{"name":632,"class":50},"IASO Thessalias",{"id":634,"slug":635,"hasResults":11,"nctId":636,"briefTitle":637,"officialTitle":638,"acronym":639,"eligibilityCriteria":640,"healthyVolunteers":11,"sex":17,"minAge":320,"maxAge":4,"enrollmentInfo":641,"targetDuration":4,"studyType":94,"phases":4,"briefSummary":643,"conditions":644,"keywords":4,"overallStatus":108,"whyStopped":4,"lastUpdateSubmitDate":647,"lastUpdatePostDateStruct":648,"startDateStruct":650,"completionDateStruct":652,"leadSponsor":654,"locationsCount":81},"100552163","older-peoples-neurocognitive-recovery-after-cardiac-surgery-100552163","NCT06469515","Older People's Neurocognitive Recovery After Cardiac Surgery","Enhanced Continuity of Postoperative Care for Older People in Their Neurocognitive Recovery After Cardiac Surgery","ECPON","Inclusion Criteria:\n\n* Scheduled for elective or urgent open-heart surgery or minimally invasive cardiac surgery\n* Resident in the area\u002Fregion for the current thoracic clinic\n* Able to read and understand Swedish\n\nExclusion Criteria:\n\n* Physical, mental, and cognitive difficulties that prevent the individual from completing the cognitive tests\n* Undergone surgery within the last 6 months",{"count":642,"type":21},220,"Society is aging and advantages in anesthesia and surgery allow more complex interventions in older persons. Old age is a significant risk factor for the development of postoperative neurocognitive decline characterized by a gradual decrease in performance in several cognitive domains such as memory, attention, information processing, and executive functions, leading to problems with performing daily activities and maintaining independence and postoperative complications. The purpose of this study is to measure older persons' postoperative neurocognitive function, to detect neurocognitive decline, and to identify risk factors and difficulties in daily living as well as explore close relatives' experiences of it. We will include 220 participants ≥65 years of age undergoing planned cardiac surgery. Cognitive symptoms and signs and neurocognitive function will be assessed up to 6 months after surgery. Risk\u002Faffected factors such as delirium, functional status, recovery, depression, and healthcare-related quality of life, as well as close relative's experiences and burden, will be measured. The results will have immediate relevance for a substantial number of older persons undergoing surgery, and their close relatives, by enhancing knowledge about postoperative cognitive decline and recovery, and subsequently identifying what support needs to be implemented.",[645,29,646],"Postoperative Cognitive Dysfunction","Cardiac Surgery","2024-11-06",{"date":649,"type":43},"2024-11-07",{"date":651,"type":43},"2024-11-01",{"date":653,"type":21},"2027-12",{"name":655,"class":50},"Karolinska Institutet",{"id":657,"slug":658,"hasResults":11,"nctId":659,"briefTitle":660,"officialTitle":660,"acronym":4,"eligibilityCriteria":661,"healthyVolunteers":11,"sex":17,"minAge":662,"maxAge":59,"enrollmentInfo":663,"targetDuration":4,"studyType":22,"phases":665,"briefSummary":666,"conditions":667,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":669,"lastUpdatePostDateStruct":670,"startDateStruct":672,"completionDateStruct":674,"leadSponsor":676,"locationsCount":4},"100453460","a-single-center-study-on-the-effect-of-systemicselective-lymph-node-dissection-on-the-prognosis-of-ground-glass-nodules-smaller-than-3cm-and-with-components-with-consolidationtumor-ratio-between-05-1-100453460","NCT05184829","A Single-center Study on the Effect of Systemic\u002FSelective Lymph Node Dissection on the Prognosis of Ground Glass Nodules Smaller Than 3cm and With Components With Consolidation\u002FTumor Ratio Between 0.5-1","Inclusion Criteria:\n\nPatients enrolled in the study must meet all of the following conditions:\n\n* 1.Aged between 25 and 75 years;\n* 2\\. GGO is diagnosed by thin-section lung CT (thickness \\\u003C1.5mm) within one month before surgery;\n* 3\\. The maximum diameter of the GGO is smaller than 3cm;\n* 4\\. The solid component in GGO between 50%-100%;\n* 5\\. Preoperative examination showed that the patient could tolerate lobectomy;\n* 6\\. The patient is able to understand and comply with the study and has provided written informed consent.\n\nExclusion Criteria:\n\nPatients meeting any of the following criteria are not eligible for this trial:\n\n* 1\\. Patients with a history of lung surgery;\n* 2\\. Postoperative pathology showed non-primary lung cancer;\n* 3\\. The scope of surgical resection is larger than one lung lobe;\n* 4\\. Patients with a history of other tumors;\n* 5\\. Patients with severe complications (coronary heart disease, valvular heart disease, end-stage renal disease, severe liver cirrhosis);\n* 6\\. Unable to cooperate with the researchers because of dementia or cognitive decline\n* 7\\. Other situations that are not in conformity with the standards and requirements of this trial.","25 Years",{"count":664,"type":21},500,[24],"A single-center study on the effect of systemic\u002Fselective lymph node dissection on the prognosis of ground glass nodules smaller than 3cm and with components with consolidation\u002Ftumor ratio between 0.5-1",[668,29],"Progression","2021-12-28",{"date":671,"type":43},"2022-01-11",{"date":673,"type":21},"2022-01-01",{"date":675,"type":21},"2029-12-31",{"name":677,"class":50},"Shanghai Zhongshan Hospital"]