[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"postoperative-respiratory-complication\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:postoperative-respiratory-complication":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,42,72],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100592029","management-of-post-operative-respiratory-failure-by-using-niv-and-high-velocity-nasal-insufflation-hvni-100592029",false,"NCT06988111","Management of Post-operative Respiratory Failure by Using NIV and High Velocity Nasal Insufflation (HVNI)","A Prospective, Randomized Controlled Trial Comparing Noninvasive Ventilation (NIV) Versus High-Velocity Nasal Cannula (HVNC) in the Management of Acute Post-Operative Respiratory Failure","Inclusion criteria:\n\n* Age above 18 years\n* within 48 hours after major surgery\n* PAO2\u002FFIO2 less than 200\n* Signs of respiratory distress and respiratory rate (RR) more than 25 cycles\u002Fminute\n\nExclusion Criteria:\n\n* Age below 18 years\n* Pregnant ladies\n* Orofacial trauma or burns\n* Active Gastrointestinal bleeding","ALL","18 Years",{"count":19,"type":20},180,"ESTIMATED","INTERVENTIONAL",[23],"NA","Postoperative respiratory failure (PORF) remains a critical driver of morbidity, mortality, and incremental care costs in surgical populations. Traditional escalation often involves invasive mechanical ventilation, which is associated with ventilator-associated pneumonia (VAP), prolonged intensive care unit (ICU) stays, and increased resource burden.",[26,27,28],"Respiratory Failure Without Hypercapnia","Respiratory Failure With Hypercapnia","Postoperative Respiratory Complication","RECRUITING","2026-04-26",{"date":32,"type":33},"2026-04-30","ACTUAL",{"date":35,"type":33},"2025-07-01",{"date":37,"type":20},"2026-12-01",{"name":39,"class":40},"Assiut University","OTHER",1,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":4,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":16,"minAge":49,"maxAge":50,"enrollmentInfo":51,"targetDuration":4,"studyType":21,"phases":53,"briefSummary":54,"conditions":55,"keywords":56,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":4},"100613538","nebulized-lidocaine-vs-3-sodium-chloride-in-pediatric-adenoidtonsil-surgery-100613538","NCT07267897","Nebulized Lidocaine vs 3% Sodium Chloride in Pediatric Adenoid\u002FTonsil Surgery","The Effect of Preoperative Nebulized Lidocaine and Nebulized 3% NaCl Premedication on Postoperative Respiratory Complications in Pediatric Patients Undergoing Adenoidectomy and\u002For Adenotonsillectomy Surgery","Inclusion Criteria:\n\n* Patients who agree to participate in the study\n* Patients undergoing adenoidectomy or adenotonsillectomy\n* Patients with ASA physical status 1-2\n* Children aged 18 months to 16 years\n\nExclusion Criteria:\n\n* Patients who do not agree to participate in the study\n* Patients with allergy to lidocaine or 3% NaCl\n* Patients with ASA physical status 3-4\n* Patients whose surgery duration exceeds 1 hour","18 Months","16 Years",{"count":52,"type":20},90,[23],"This prospective, randomized clinical trial aims to evaluate the effect of preoperative nebulized lidocaine and nebulized 3% hypertonic sodium chloride (NaCl) on the incidence of postoperative respiratory complications in pediatric patients undergoing adenoidectomy and\u002For adenotonsillectomy. Lidocaine, a versatile sodium channel blocker, has shown antitussive, bronchodilatory, and anti-inflammatory benefits when nebulized, and has been safely used in children for respiratory procedures. Hypertonic 3% NaCl is known to improve mucociliary clearance, reduce airway edema, and enhance secretion mobilization, particularly in pediatric respiratory conditions. Both agents have demonstrated individual safety and efficacy in respiratory management, yet their preoperative nebulized use for preventing postoperative respiratory adverse events (PRAEs) in pediatric airway surgery has not been previously studied. This trial seeks to determine whether preoperative nebulization with these agents can reduce postoperative respiratory complications, improve recovery, and enhance perioperative safety in this high-risk population.",[28],[28,57,58,59,60,61],"Lidocaine","%3 Sodium Chloride","Pediatric","Adenoidectomy","Adenotonsillectomy","NOT_YET_RECRUITING","2025-11-25",{"date":65,"type":33},"2025-12-05",{"date":67,"type":20},"2026-03-15",{"date":69,"type":20},"2026-10-15",{"name":71,"class":40},"Sakarya University",{"id":73,"slug":74,"hasResults":11,"nctId":75,"briefTitle":76,"officialTitle":77,"acronym":78,"eligibilityCriteria":79,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":80,"targetDuration":4,"studyType":21,"phases":82,"briefSummary":83,"conditions":84,"keywords":87,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":102},"100568995","postoperative-extubation-in-hypoxemic-patients-100568995","NCT06688487","Postoperative Extubation in Hypoxemic Patients","Early Postoperative Extubation in Hypoxemic ICU Patients: a Multicenter, Randomized Controlled Trial","EPHYRE","Inclusion Criteria:\n\n* Francophone patient affiliated to a health insurance plan;\n* Patient having granted free, informed and written consent to participate in the study;\n* Patient with hypoxemia defined as SpO2 ≤ 90% under 6 L\u002Fmin or FiO2 40% during spontaneous breathing trial.\n\nExclusion Criteria:\n\n* Presence of hypercapnia at the end of SBT (PaCO2 above 50 mmHg);\n* Presence of severe hypoxemia during SBT defined by SpO2 below 86% under 9 L\u002Fmin or FiO2 = 50%;\n* Presence of poor clinical tolerance of SBT defined by polypnoea above 30\u002Fmin, agitation, sweating, hypertension (PAS above 180 mmHg), tachycardia (HR above 140 bpm) or arrhythmia;\n* Presence of an ineffective cough or major bronchial congestion;\n* Patient already included in a type 1 interventional research protocol (RIPH1), modifying the procedure for ventilatory weaning and\u002For ventilatory support after extubation;\n* Anatomical factors precluding the use of NIV or high-flow oxygen therapy, notably facial or cervico-facial malformations;\n* Tracheostomized patient;\n* History of obstructive ventilatory disorders with indication for NIV post-extubation, chronic obstructive pulmonary disease (COPD) GOLD score III\u002FIV;\n* History of obstructive sleep apnea syndrome with equipment;\n* cardiogenic pulmonary edema;\n* Patient on extracorporeal membrane oxygenation (ECMO) at the time of inclusion;\n* Patient under guardianship or curatorship;\n* Minor patients;\n* Patient deprived of liberty or under court protection;\n* Pregnant or breast-feeding women;\n* Patient in therapeutic limitation with decision not to re-intubate.",{"count":81,"type":20},152,[23],"The objective of this clinical trial is to assess whether early extubation of patients with hypoxemia during the spontaneous breathing trial (SBT) shortens the duration of ventilatory support. The trial will also evaluate the safety of this approach. The key research questions include:\n\nDoes early extubation of hypoxemic patients reduce the total duration of ventilatory support (both invasive and non-invasive) by 36 hours? Does early extubation of hypoxemic patients increase the number of ventilator-free days by day 28? Can the safety of early extubation in hypoxemic patients be ensured by confirming no significant differences in rates of reintubation, tracheostomy, or mortality? The trial will compare ventilatory outcomes between two groups: hypoxemic patients who undergo early extubation (hypoxemic extubation group) and those who remain on invasive ventilation until hypoxemia resolves (conventional extubation group).",[85,86,28],"Hypoxemia","Extubation",[88,89,90,91,92],"extubation","hypoxemia","postoperative respiratory complication","weaning","facilitative non invasive strategy","2024-11-12",{"date":95,"type":33},"2024-11-14",{"date":97,"type":20},"2024-11-18",{"date":99,"type":20},"2027-01-31",{"name":101,"class":40},"Fondation Hôpital Saint-Joseph",12]