[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"postoperative-respiratory-complications\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:postoperative-respiratory-complications":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,7,0,[8,52,78,104,131,160,190],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":29,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":41,"lastUpdatePostDateStruct":42,"startDateStruct":45,"completionDateStruct":47,"leadSponsor":49,"locationsCount":4},"100639198","combined-rsbi-tof-and-bis-for-prediction-of-extubation-success-100639198",false,"NCT07577453","Combined RSBI, TOF, and BIS for Prediction of Extubation Success","Predictive Value of Combined RSBI, TOF, and BIS Monitoring for Extubation Success After General Anesthesia","Inclusion Criteria:\n\n* Age between 18 and 80 years\n* ASA physical status I-III\n* Patients scheduled for elective surgery under general anesthesia\n* Patients undergoing endotracheal intubation during general anesthesia\n* Patients receiving neuromuscular blocking agents during anesthesia\n* Patients planned for extubation in the operating room\n* Availability of pre-extubation RSBI, TOF ratio, and BIS measurements\n* Written informed consent obtained from the patient\n\nExclusion Criteria:\n\n* Emergency surgery\n* Age \\\u003C18 years or \\>80 years\n* ASA physical status IV or higher\n* Known or anticipated difficult airway\n* Anticipated difficult extubation\n* Preoperative mechanical ventilation\n* Planned postoperative mechanical ventilation or transfer to the intensive care unit while intubated\n* Known neuromuscular disease\n* Severe chronic respiratory failure\n* Severe chronic obstructive pulmonary disease associated with respiratory failure\n* Significant neurological disease affecting respiratory drive or level of consciousness\n* Conditions or medications that may interfere with reliable neuromuscular monitoring\n* Inability to obtain reliable RSBI, TOF ratio, or BIS measurements\n* Refusal to participate\n* Incomplete perioperative or post-extubation outcome data",true,"ALL","18 Years","80 Years",{"count":21,"type":22},150,"ESTIMATED","OBSERVATIONAL","This prospective observational study aims to evaluate the predictive value of the combined use of the rapid shallow breathing index, train-of-four ratio, and bispectral index for extubation success after general anesthesia. Adult patients undergoing elective surgery under general anesthesia and planned for extubation in the operating room will be included.\n\nBefore extubation, RSBI, TOF ratio, BIS value, respiratory parameters, and relevant perioperative data will be recorded. The decision to extubate will be made by the attending anesthesiologist according to routine clinical practice and will not be altered by the study protocol. Patients will be followed for 30 minutes after extubation to assess extubation success or the development of complications such as desaturation, laryngospasm, need for airway intervention, mask ventilation, or reintubation.\n\nThe primary aim is to determine whether the combined RSBI, TOF, and BIS model predicts extubation success more accurately than each parameter alone.",[26,27,28],"Extubation Success","Extubation Failure","Postoperative Respiratory Complications",[30,31,32,33,34,35,36,37,38,39],"Extubation","Extubation Succcess","Extubation failure","General anesthesia","Rapid shallow breathing index","TOF ratio","Bispectral index","Neuromuscular monitoring","Postoperative respiratory complications","Prediction model","NOT_YET_RECRUITING","2026-05-09",{"date":43,"type":44},"2026-05-13","ACTUAL",{"date":46,"type":22},"2026-06-15",{"date":48,"type":22},"2026-08-15",{"name":50,"class":51},"Gaziantep City Hospital","OTHER",{"id":53,"slug":54,"hasResults":11,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":4,"eligibilityCriteria":58,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":59,"targetDuration":4,"studyType":61,"phases":62,"briefSummary":64,"conditions":65,"keywords":4,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":77},"100628641","effect-of-neuromuscular-block-depth-on-driving-pressure-and-postoperative-respiratory-events-in-abdominal-surgeries-100628641","NCT07464288","Effect of Neuromuscular Block Depth on Driving Pressure and Postoperative Respiratory Events in Abdominal Surgeries","The Effect of Different Depths of Neuromuscular Blockade, Assessed by Train of Four (TOF) Monitoring, On Driving Pressure and the Development of Postoperative Critical Respiratory Events in Abdominal Surgeries","Inclusion Criteria:\n\n* Elective abdominal surgery under general anesthesia that is expected to last longer than one hour\n* ASA I-II-III\n* Age ≥18 years\n* Written informed consent\n\nExclusion Criteria:\n\n* Refusal to participate in the study\n* ASA ≥ IV\n* Age \\\u003C18\n* Obesity (BMI\\>30) and cachexia (BMI \\\u003C18)\n* Laparoscopic surgery\n* Emergency procedure\n* Allergy to drugs used during induction and maintenance of general anesthesia\n* Presence of psychiatric\u002Fneurologic\u002Fneuromuscular disease\n* Risk of malignant hyperthermia or having any relative with history of malignant hyperthermia\n* Use of medications that may affect neuromuscular function (anticonvulsants, aminoglycosides, magnesium salts, etc.)\n* Pregnancy\n* Presence of advanced chronic lung disease (asthma, COPD, etc.)\n* Presence of advanced liver and renal disease (creatinine\\>1.6, liver function tests above twice the normal range)",{"count":60,"type":22},128,"INTERVENTIONAL",[63],"NA","This randomized controlled study aims to evaluate the effects of deep versus moderate neuromuscular blockade on intraoperative driving pressure and the development of postoperative critical respiratory events in patients undergoing abdominal surgery under general anesthesia.",[66,67,28],"Driving Pressure","Neuromuscular Blockade Monitoring","2026-03-15",{"date":70,"type":44},"2026-03-17",{"date":72,"type":22},"2026-03-23",{"date":74,"type":22},"2026-04-24",{"name":76,"class":51},"Ankara City Hospital Bilkent",1,{"id":79,"slug":80,"hasResults":11,"nctId":81,"briefTitle":82,"officialTitle":83,"acronym":84,"eligibilityCriteria":85,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":86,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":88,"conditions":89,"keywords":92,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":77},"100585202","prevention-of-postoperative-respiratory-complications-100585202","NCT06899295","Prevention of Postoperative Respiratory Complications","Data From Advanced Respiratory Monitoring During Alveolar Recruitment Maneuvers (ARM). A Prospective Observational Study","RAMAGE","Inclusion Criteria:\n\n1. Patients ≥ 18 years of age\n2. undergoing :\n\n   * scheduled surgery at Hospital Lariboisière.\n   * scheduled to last more than 2 hours under general anesthesia for abdominal surgery under laparoscopy or surgery in the prone position, or for obese patients with a BMI \\>35.\n   * And for whom the ventilator used includes advanced monitoring\n   * for whom placement of a gastric tube is indicated either because of the duration of the procedure or because it is necessary for the surgery.\n3. Patient informed and expressing non-opposition to participation in this study\n\nExclusion Criteria:\n\n* \\- Patients under 18 years of age.\n* Contraindications to esophageal tube placement\n* Contraindications to ARMs\n* Patient opposed to protocol participation\n* Pregnant, parturient or breast-feeding women\n* Patient under legal protection",{"count":87,"type":22},34,"Given the huge number of patients mechanically ventilated during general anaesthesia, optimizing alveolar recruitment by limiting pulmonary and systemic aggression is a key objective for further progress in perioperative patient management.\n\nDuring general anaesthesia, ventilation disorders with atelectasis, derecruitment of posteroinferior zones and reduced functional residual capacity (FRC) occur in relation to the operative position, the effect of neuromuscular block and general anaesthesia. These conditions of poor pulmonary aeration favor postoperative respiratory complications and are responsible for excess mortality in the perioperative period.\n\nAlveolar recruitment maneuvers (ARMs) are ventilatory strategies used during general anesthesia that aim to restore lung aeration with Positive End Expiratory Pressure (PEEP) sufficient to keep the lungs open afterwards. This pulmonary hyperinflation not only has a major impact on hemodynamics but also presents a risk of barotrauma. ARM is currently performed without precise measurement of the pressures prevailing in the lung.\n\nAdvanced monitoring is now available and integrated into the latest-generation ventilators and includes the combination of Transpulmonary pressure (TPP) and Electro-Impedance Tomography \" (EIT) measurements.\n\nThe aim of this observational study is to measure and record advanced respiratory monitoring data in a minimally invasive way, during alveolar recruitment tests routinely performed for the target population (obese, prone, laparoscopic surgery). Describe and a posteriori analyze the recorded data and establish a relationship between the PEEP values set by conventional ARM and those determined by advanced monitoring combining EIT and PTP for the same patient.",[90,91,28],"General Anesthesia","Ventilator-Induced Lung Injuries",[93,94],"Ventilator optimization","Ventilator induced lung injury","2026-02-17",{"date":97,"type":44},"2026-02-18",{"date":99,"type":22},"2026-05",{"date":101,"type":22},"2028-05",{"name":103,"class":51},"Assistance Publique - Hôpitaux de Paris",{"id":105,"slug":106,"hasResults":11,"nctId":107,"briefTitle":108,"officialTitle":109,"acronym":4,"eligibilityCriteria":110,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":111,"enrollmentInfo":112,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":114,"conditions":115,"keywords":117,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":121,"lastUpdatePostDateStruct":122,"startDateStruct":124,"completionDateStruct":126,"leadSponsor":128,"locationsCount":77},"100623288","ultrasonographic-subglottic-airway-measurements-and-postoperative-respiratory-events-in-young-children-100623288","NCT07394686","Ultrasonographic Subglottic Airway Measurements and Postoperative Respiratory Events in Young Children","Association Between Ultrasonographic Subglottic Airway Measurements and Postoperative Respiratory Adverse Events in Children Under Three Years of Age","Inclusion Criteria:\n\n* Children aged 0 to 35 months\n* Scheduled for elective surgery under general anesthesia\n* Planned airway management with a laryngeal mask airway\n* Ability to perform intraoperative ultrasonographic subglottic airway measurements\n* Written informed consent obtained from a parent or legal guardian\n\nExclusion Criteria:\n\n* Known congenital or acquired airway anomalies\n* Craniofacial anomalies\n* Emergency surgical procedures\n* Planned tracheal intubation instead of laryngeal mask airway\n* Inability to obtain adequate ultrasonographic subglottic airway measurements","3 Years",{"count":113,"type":22},350,"This study aims to better understand postoperative respiratory adverse events that may occur in some children under three years of age undergoing airway management during surgery. As part of the study, ultrasonographic measurements of a portion of the upper airway will be performed during surgery using a non-invasive ultrasound device. These measurements will be evaluated in relation to perioperative respiratory outcomes. The results of this study may contribute to improved understanding of airway-related factors associated with postoperative respiratory safety in young children.",[116,28],"Perioperative Respiratory Adverse Events",[28,118,119,120],"Pediatric airway","Pediatric airway evaluation","Subglottic airway measurements","2026-02-05",{"date":123,"type":44},"2026-02-06",{"date":125,"type":22},"2026-02-01",{"date":127,"type":22},"2027-02-01",{"name":129,"class":130},"Bursa Sevket Yilmaz Training and Research Hospital","OTHER_GOV",{"id":132,"slug":133,"hasResults":11,"nctId":134,"briefTitle":135,"officialTitle":135,"acronym":136,"eligibilityCriteria":137,"healthyVolunteers":11,"sex":17,"minAge":138,"maxAge":18,"enrollmentInfo":139,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":141,"conditions":142,"keywords":4,"overallStatus":149,"whyStopped":4,"lastUpdateSubmitDate":150,"lastUpdatePostDateStruct":151,"startDateStruct":153,"completionDateStruct":155,"leadSponsor":157,"locationsCount":159},"100616404","a-multicenter-retrospective-analysis-of-postoperative-respiratory-complications-in-children-with-obstructive-sleepapnea-100616404","NCT07305168","A Multicenter Retrospective Analysis of Postoperative Respiratory Complications in Children With Obstructive Sleepapnea","MRA PORC","Inclusion Criteria:\n\n* scheduled for (adeno)tonsillectomy as treatment for OSAS\n\nExclusion Criteria:\n\n* other surgery than (adeno)tonsillectomy performed as treatment for OSAS\n* Polysomnography not available within 1 year before surgery","1 Year",{"count":140,"type":22},200,"This retrospective observational study aims to evaluate postoperative respiratory complications (PORC) after (adeno)tonsillectomy in children with OSA.\n\nIn order to increase the number of patients available for analysis, we will merge data collected at UZA with data collected at the the Department of Sleep Laboratory and Sleep Surgery at the Heim Pal National Pediatric Institute, Hungary. These colleagues performed an identical prospective data collection.",[143,28,144,145,146,147,148],"Obstructive Sleep Apnea","Adenotonsillectomy","Child Obesity","Craniofacial Abnormalities","Children With Down Syndrome","Neurologic Disorder","RECRUITING","2025-12-11",{"date":152,"type":44},"2025-12-26",{"date":154,"type":44},"2022-05-02",{"date":156,"type":22},"2027-03-01",{"name":158,"class":51},"University Hospital, Antwerp",2,{"id":161,"slug":162,"hasResults":11,"nctId":163,"briefTitle":164,"officialTitle":165,"acronym":4,"eligibilityCriteria":166,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":167,"enrollmentInfo":168,"targetDuration":170,"studyType":23,"phases":4,"briefSummary":171,"conditions":172,"keywords":175,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":181,"lastUpdatePostDateStruct":182,"startDateStruct":184,"completionDateStruct":186,"leadSponsor":188,"locationsCount":77},"100610423","timing-of-opioid-administration-and-postoperative-respiratory-depression-100610423","NCT07227389","Timing of Opioid Administration and Postoperative Respiratory Depression.","The Relationship Between Timing of Opioid Administration and Postoperative Respiratory Depression.","Inclusion Criteria:\n\n* Written informed consent\n* Adults ≥18 years of age and ≤85 years of age\n* Patients planned for general anesthesia with an expected anesthetic time of at least 2 hours\n* Patients expected to receive postoperative opioid analgesia\n\nExclusion Criteria:\n\n* Non-operative procedure (imaging)\n* Patients not admitted to the PACU postoperatively\n* Use of patient-controlled analgesia systems\n* Female patients who are pregnant or breastfeeding\n* Patients with asymmetric lung disease\n* American Society of Anesthesiologists (ASA) classification V\n* Emergency surgery (ASA E Modifier)","85 Years",{"count":169,"type":22},52,"1 Day","The goal of this study is to determine if a relationship can be detected between the administration of an opioid and quantitative respiratory depression in spontaneously breathing non-intubated patients who have undergone general anesthesia and have received perioperative opioids.\n\nThe primary aim is to determine the temporal effect of opioid administration on respiratory depression as assessed by minute ventilation with a reduction of at least 20% in the percent of predicted minute ventilation.\n\nA secondary aim is to determine a dose response of opioid administration and its effect on minute ventilation.\n\nThe investigators aim to determine the influence of opioid administration on minute ventilation on spontaneously breathing patients during post-anesthesia care unit (PACU) stay.",[173,174,28],"Respiratory Complications","Opioid Induced Respiratory Depression",[176,177,178,179,180],"opioids","bio-impedance","hypoxia","hypercapnia","minute ventilation","2025-11-13",{"date":183,"type":44},"2025-11-14",{"date":185,"type":22},"2025-12",{"date":187,"type":22},"2029-01-01",{"name":189,"class":51},"Wayne State University",{"id":191,"slug":192,"hasResults":11,"nctId":193,"briefTitle":194,"officialTitle":195,"acronym":196,"eligibilityCriteria":197,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":198,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":200,"conditions":201,"keywords":202,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":207,"lastUpdatePostDateStruct":208,"startDateStruct":210,"completionDateStruct":212,"leadSponsor":214,"locationsCount":4},"100577483","perioperative-respiratory-support-and-postoperative-outcomes-100577483","NCT06798883","Perioperative Respiratory Support and Postoperative Outcomes","Perioperative Respiratory Support and Postoperative Outcomes: Russian National Epidemiological Study \"RuVent-A\"","RuVent-A","Inclusion Criteria:\n\n* Patients aged ≥18 years undergoing surgical procedures with general anesthesia and respiratory support.\n\nExclusion Criteria:\n\n* No",{"count":199,"type":22},1000,"This study aims to evaluate the methodology and parameters of perioperative respiratory support (RS) and the frequency of postoperative pulmonary complications (PPCs) in the Russian Federation. The study will analyze respiratory support strategies, equipment availability, and their correlation with PPC outcomes in surgical patients.",[28],[203,204,205,206],"anesthesia","respiratory support","complications","mechanical ventilation","2025-01-27",{"date":209,"type":44},"2025-01-29",{"date":211,"type":22},"2025-04-07",{"date":213,"type":22},"2025-05-11",{"name":215,"class":51},"Russian Federation of Anesthesiologists and Reanimatologists"]