[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"postoperative-respiratory-failure\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:postoperative-respiratory-failure":23},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,45,79,112],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":4,"briefSummary":21,"conditions":22,"keywords":28,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100644604","assessment-of-reintubation-risk-using-multiple-parameters-in-postoperative-intensive-care-unit-patients-100644604",false,"NCT07672106","Assessment of Reintubation Risk Using Multiple Parameters in Postoperative Intensive Care Unit Patients","Inclusion Criteria:\n\nAdult patients aged 18 years and older\n\nPatients requiring postoperative intensive care follow-up after major surgery, including abdominal, vascular, orthopedic, or ear, nose, throat, head and neck surgery\n\nPatients extubated in the operating room and admitted to the intensive care unit with spontaneous breathing\n\nPatients without any clinical condition preventing the planned measurements within the first 0-2 hours after ICU admission (T0 and T1)\n\nPatients for whom written informed consent can be obtained from the patient or legally authorized representative\n\nPatients admitted to the intensive care unit within the specified study period after ethics committee approval and enrolled consecutively\n\nExclusion Criteria:\n\nPatients younger than 18 years of age\n\nPatients who leave the operating room intubated or are admitted to the intensive care unit while intubated\n\nPatients with a tracheostomy\n\nPatients with a history of diaphragmatic paralysis\n\nPatients with a significant neuromuscular disease, such as ALS, myasthenia gravis, or similar conditions\n\nPatients with conditions that significantly prevent ultrasound measurements, including marked subcutaneous emphysema, large dressings or bandages covering the measurement area, inability to access the measurement site due to drains or the surgical field, or inability to obtain technically adequate images\n\nPatients in whom the planned measurements cannot be performed due to clinical instability requiring emergency intubation immediately after ICU admission\n\nPatients from whom informed consent cannot be obtained, or patients or legally authorized representatives who refuse participation","ALL","18 Years",{"count":18,"type":19},600,"ESTIMATED","OBSERVATIONAL","This prospective, non-interventional observational study will evaluate the risk of reintubation in adult postoperative patients admitted to the intensive care unit after major surgery. Reintubation after extubation is an important clinical problem because it may increase complications, prolong mechanical ventilation, and extend intensive care and hospital stay.\n\nThe study will include adult patients who are extubated in the operating room and admitted to the intensive care unit with spontaneous breathing. Within the first hours after ICU admission, bedside ultrasound measurements of diaphragm thickness, parasternal intercostal muscle thickness, and lung ultrasound score will be performed. The ROX index will also be calculated using oxygen saturation, inspired oxygen concentration, and respiratory rate. Perioperative fluid balance will be recorded from anesthesia and patient files.\n\nPatients will be followed for 48 to 72 hours after ICU admission to determine whether reintubation is required. The study aims to assess whether respiratory muscle ultrasound findings, lung ultrasound score, ROX index, and perioperative fluid balance can help predict reintubation risk in postoperative ICU patients. No additional treatment or intervention will be applied as part of the study, and all clinical decisions will be made by the responsible intensive care team according to routine clinical practice.",[23,24,25,26,27],"Postoperative Respiratory Failure","Extubation Failure","Lung Ultrasonography Score","Diaphragm Thickness","Parasternal Intercostal Muscle Thickness",[29,30,31,23],"lung ultrasonography score","Diaphragm thickness","parasternal intercostal muscle thickness","RECRUITING","2026-06-22",{"date":35,"type":36},"2026-06-26","ACTUAL",{"date":38,"type":36},"2026-04-28",{"date":40,"type":19},"2026-10-28",{"name":42,"class":43},"Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":53,"targetDuration":4,"studyType":55,"phases":56,"briefSummary":58,"conditions":59,"keywords":63,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":4},"100638342","mechanical-power-for-ventilatory-settings-in-operating-room-100638342","NCT07620132","Mechanical Power for Ventilatory Settings in Operating Room","Mechanical Power for Ventilatory Settings in Operating Room: a Multicenter Randomized Controlled Trial","IMPROVEIII","Inclusion Criteria:\n\n* Adult (≥ 18 years)\n* Laparoscopic or non-laparoscopic abdominal surgery\n* With an expected duration of at least 2 hours\n\nExclusion Criteria:\n\n* Patients already receiving mechanical ventilation \\> 12 hours before surgery;\n* Chronic respiratory disease requiring oxygen therapy or mechanical ventilation at home;\n* Undrained pneumothorax or subcutaneous emphysema;\n* Intracranial hypertension;\n* Patients for which death is deemed imminent and inevitable or patients with an underlying disease process with a life expectancy of less than 3 months;\n* Patients already enrolled in the IMPROVE III trial;\n* Pregnancy in progress or planned during the study period or breastfeeding women (Art. L1121-5 of the French Public Health Code);\n* Patients protected by law (Art. L1121-6 to L1121-8 of the French Public Health Code): Individuals deprived of their liberty by judicial or administrative decision, vulnerable persons, minors, adults under guardianship or curatorship;\n* Patients not covered by a French social security scheme and not benefiting from such a scheme;\n* Absence of free and informed oral consent from the patient before inclusion (except in emergency situation where the patient is unable to provide consent), or absence of written informed consent from his\u002Fher proxy if present in an emergency situation (except in life-threatening emergency, where inclusion without consent from the patient or his\u002Fher proxy is permitted), in which case consent will be obtained as soon as possible after inclusion.",{"count":54,"type":19},490,"INTERVENTIONAL",[57],"NA","Postoperative respiratory failure (PRF) is a dreaded complication that imposes a significant burden through unplanned admission to the ICU, post discharge disability and mortality. Despite widespread implementation of intraoperative lung-protective ventilation strategies over the past decade, results remain inconsistent. Interventions targeting individual parameters like tidal volume or positive end-expiratory pressure (PEEP) have shown equivocal results. The use of high PEEP and recruitment maneuvers raises safety concerns by possible negative hemodynamic effects. Recent studies suggest that individualizing ventilation strategies based on mechanical power-a composite parameter integrating tidal volume, plateau pressure, PEEP, and ventilator frequency-may better predict and help prevent PRF, independently of patients' baseline respiratory system compliance. These studies identified this parameter as interventional targets to reduce lung injury during mechanical ventilation. However, no multicenter randomized controlled trial has been performed in the field of ventilatory settings titration during invasive mechanical ventilation in operating room.\n\nThe investigators hypothesize that a ventilation strategy aimed at decreasing mechanical power will reduce the incidence of PRF and mortality in patients undergoing abdominal surgery, compared with a standard strategy using fixed tidal volume and PEEP",[23,60,61,62],"Abdominal Surgery","Postoperative Pulmonary Complications","Morality",[64,65,66,67,68],"Mechanical ventilation","Intubation","Mechanical power-guided ventilation","Laparoscopic or non-laparoscopic abdominal surgery","Intensive care unit","NOT_YET_RECRUITING","2026-05-26",{"date":72,"type":36},"2026-06-02",{"date":74,"type":19},"2026-06-01",{"date":76,"type":19},"2029-01-01",{"name":78,"class":43},"University Hospital, Montpellier",{"id":80,"slug":81,"hasResults":11,"nctId":82,"briefTitle":83,"officialTitle":83,"acronym":4,"eligibilityCriteria":84,"healthyVolunteers":85,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":86,"targetDuration":4,"studyType":55,"phases":88,"briefSummary":89,"conditions":90,"keywords":99,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":103,"lastUpdatePostDateStruct":104,"startDateStruct":106,"completionDateStruct":108,"leadSponsor":110,"locationsCount":44},"100607313","driving-pressure-during-surgeries-with-high-risk-for-postoperative-pulmonary-complications-100607313","NCT07186933","Driving Pressure During Surgeries With High Risk for Postoperative Pulmonary Complications","Inclusion Criteria\n\n* \\>17 years old\n* Surgery with general anesthesia \\& invasive mechanical ventilation\n* Preoperative ARISCAT score estimation \\>25\n\nExclusion Criteria:\n\n* \\\u003C18 years old\n* Preoperative ARISCAT score estimation \\\u003C26\n* Women during pregnancy or just given birth\n* Other type of anesthesia (Not general)\n* Contraindication of administration of neuromuscular blockade agents.\n* Contraindication of cease of spontaneous ventilation.\n* Mechanical ventilation without endotracheal intubation.\n* Severe heart failure \u002F Severe cardiac arrhythmia.\n* Severe emphysematous lung disease.\n* Patient denial of participation in the trial.",true,{"count":87,"type":19},200,[57],"The goal of this clinical trial is to compare two different types of perioperative mechanical ventilation (MV), specifically Protective Mechanical Ventilation (PMV) and MV with the lowest possible Driving Pressure (ΔP), in relation to the appearance of postoperative pulmonary complications (PPCs) in adult patients who are operated and have higher risk of PPCs.\n\nThe main questions it aims to answer are:\n\n* Is MV with lower ΔP better than conventional PMV in preventing PPCs in patients with higher risk for PPCs?\n* Does MV with lower ΔP decrease hospital stay, Intensive Care Unit (ICU) need and mortality?\n* Does MV with lower ΔP suit better than PMV to lung characteristics and needs intraoperatively?\n\nResearchers will compare MV with the lowest possible Driving Pressure (ΔP) to Protective Mechanical Ventilation (PMV) to see if any of this is more protective than the other concerning PPCs.\n\nAll participants will receive perioperative MV.\n\nHalf of them will receive conventional Protective Mechanical Ventilation (PMV). This will include well known generally protective settings for mechanical ventilation of patients, concerning volumes, pressures, respiratory rate, inspiratory gases and ventilation maneuvers.\n\nThe rest of participants will be ventilated with the lowest possible Driving Pressure (ΔP). This will be similar to PMV in the chosen volumes, respiratory rate, inspiratory gases and ventilation maneuvers. However, the pressure inside lung at the end of expiration, eg Positive End Expiratory Pressure (PEEP), will be not be preset for every patient. Initially, the investigators will perform a maneuver that will quantify each individual's lung characteristics and mechanics. According to this, the investigators will find the exact PEEP that seems to suit each patients lungs most, and use this perioperatively, trying to provide lungs the best conditions every time.\n\nAfter the completion of the operation, all the patients will be screened for PPCs, via arterial blood testing and chest X ray, and the results will be statistically analyzed trying to find if any of the forementioned strategies of mechanical ventilation surpasses the other concerning PPCs appearance. PPCs include atelectasis, respiratory failure, bronchospasm, pleural effusion, pneumonia, aspiration and pneumothorax.\n\nFurthermore hospital stay, ICU need and mortality will be noted. Finally, measurements of perioperative lung pressures, volumes and derived variables will be noted and compared statistically as well.",[91,61,23,92,93,94,95,96,97,98],"Postoperative Pulmonary Atelectasis","Postoperative Bronchospasm","Postoperative Pleural Effusion","Postoperative Pneumothorax","Postoperative Pneumonia","Postoperative Aspiration Pneumonitis","Mechanical Power","Driving Pressure",[98,97,100,101,61,23,102],"Atelectasis","Pulmonary Complications","Elastic Power","2026-02-08",{"date":105,"type":36},"2026-02-11",{"date":107,"type":36},"2025-11-03",{"date":109,"type":19},"2027-11-30",{"name":111,"class":43},"University General Hospital of Patras",{"id":113,"slug":114,"hasResults":11,"nctId":115,"briefTitle":116,"officialTitle":117,"acronym":4,"eligibilityCriteria":118,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":119,"enrollmentInfo":120,"targetDuration":4,"studyType":55,"phases":122,"briefSummary":123,"conditions":124,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":126,"lastUpdatePostDateStruct":127,"startDateStruct":129,"completionDateStruct":131,"leadSponsor":133,"locationsCount":44},"100468430","the-effect-of-hyperoxia-on-ventilation-during-recovery-from-general-anesthesia-100468430","NCT05379673","The Effect of Hyperoxia on Ventilation During Recovery From General Anesthesia","Recovery of Ventilation After General Anesthesia for Robotic-Assisted Laparoscopic Nephrectomy or Prostatectomy: The Effect of Oxygen Supplementation","Inclusion Criteria:\n\n* American Society of Anesthesiologists (ASA) physical status I-III\n* Body mass index (BMI) less than 40 kg\u002Fm2\n* Scheduled to undergo robotic-assisted radical laparoscopic nephrectomy or prostatectomy.\n\nExclusion Criteria:\n\n* Patients with a diagnosis of chronic obstructive pulmonary disorder (COPD), severe neurological, cardiopulmonary, psychiatric, or untreated thyroid disorder\n* Chronic pain condition that is being treated with opioids\n* Patients with a hematocrit lower than 30% at the end of surgery, or those with an excessive blood loss, requiring transfusion of blood products during surgery.","70 Years",{"count":121,"type":19},60,[57],"In this randomized-controlled trial the investigators will examine the effect of oxygen supplementation on the recovery of breathing for 90 minutes in the immediate post-anesthesia period starting from extubation of the trachea.",[125,23],"Ventilatory Depression","2025-05-13",{"date":128,"type":36},"2025-05-16",{"date":130,"type":36},"2022-10-04",{"date":132,"type":19},"2026-12",{"name":134,"class":43},"Stanford University"]