[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"postoperative-sleep-disturbance\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:postoperative-sleep-disturbance":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,48,74],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100642017","effect-of-asmr-and-white-noise-on-sleep-quality-in-patients-undergoing-elective-lower-extremity-surgery-100642017",false,"NCT07651228","Effect of ASMR and White Noise on Sleep Quality in Patients Undergoing Elective Lower Extremity Surgery","Effect of ASMR and White Noise on Sleep Quality in Patients Undergoing Elective Lower Extremity Surgery: A Randomized Controlled Trial","SLEEP-ASMR","Inclusion Criteria:\n\n* Age 18 years and older\n* Undergoing elective lower extremity surgery\n* Conscious and able to communicate\n* No hearing impairment or hearing aid use\n* Numeric Rating Scale (NRS) pain score of 5 or lower\n* No use of medications affecting sleep\n* Willing to participate in the study\n* Able to provide written informed consent\n\nExclusion Criteria:\n\n* Participation in another clinical study\n* Surgery due to trauma\n* Transfer to the intensive care unit during the postoperative period\n* Development of serious postoperative complications\n* Withdrawal from the study at any stage\n* Failure to comply with study procedures","ALL","18 Years",{"count":20,"type":21},90,"ESTIMATED","INTERVENTIONAL",[24],"NA","This randomized controlled trial aims to evaluate the effects of Autonomous Sensory Meridian Response (ASMR) and white noise on postoperative sleep quality in patients undergoing elective lower extremity surgery. Postoperative sleep disturbances are common after orthopedic surgery and may negatively affect pain perception, recovery, and overall patient outcomes. Participants will be randomly assigned to one of three groups: ASMR intervention, white noise intervention, or control group. Patients in the intervention groups will listen to standardized 30-minute audio recordings before sleep during the postoperative period, while the control group will receive routine care with headphones only. Sleep quality will be assessed using the Richards-Campbell Sleep Questionnaire (RCSQ). The study aims to determine which non-pharmacological intervention is more effective in improving postoperative sleep quality.",[27,28,29],"Postoperative Sleep Disturbance","Orthopedic Surgery Patients","Sleep Quality",[31,32,29,33,34],"ASMR","White Noise","Orthopedic Surgery","Lower Extremity Surgery","NOT_YET_RECRUITING","2026-06-15",{"date":38,"type":39},"2026-06-16","ACTUAL",{"date":41,"type":21},"2026-09-05",{"date":43,"type":21},"2027-01-05",{"name":45,"class":46},"muzeyyen ataseven","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":55,"enrollmentInfo":56,"targetDuration":4,"studyType":22,"phases":58,"briefSummary":59,"conditions":60,"keywords":61,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":47},"100641827","transcutaneous-electrical-acupoint-stimulation-for-perioperative-sleep-disturbances-in-cancer-patients-100641827","NCT07654075","Transcutaneous Electrical Acupoint Stimulation for Perioperative Sleep Disturbances in Cancer Patients","Clinical Study on Transcutaneous Electrical Acupoint Stimulation (TEAS) for the Prevention and Treatment of Perioperative Sleep Disturbances in Cancer Patients","Inclusion Criteria:\n\n* Patients aged between 18 and 75 years old, regardless of gender.\n* Diagnosed with malignant tumors requiring elective surgery under general anesthesia.\n* ASA physical status I-III.\n* Able to understand and complete study-related questionnaires (PSQI, AIS, NRS, etc.).\n* Voluntarily sign the informed consent form.\n\nExclusion Criteria:\n\n* Severe cardiac, hepatic, renal or respiratory dysfunction that affects the implementation of TEAS.\n* History of psychiatric disorders or use of psychotropic drugs.\n* History of drug or alcohol abuse.\n* Presence of infection, skin lesions or contraindications at TEAS acupoints.\n* Preoperative use of strong opioids (e.g., morphine, oxycodone) for more than 1 week.\n* Pregnant or lactating women.\n* Participation in other clinical trials within 3 months prior to enrollment.\n* Inability to cooperate with the study due to cognitive impairment or language barriers.","75 Years",{"count":57,"type":21},176,[24],"Postoperative sleep disturbance (POSD) is highly prevalent among cancer patients after tumor resection, affecting 43%-80% of perioperative individuals. Poor sleep aggravates postoperative pain, anxiety and adverse cardiovascular events, hindering postoperative recovery. Conventional hypnotic medicines carry potential risks of drug dependence and respiratory depression.\n\nTranscutaneous Electrical Acupoint Stimulation (TEAS) is a non-invasive physical therapy derived from traditional acupuncture, which delivers low-frequency electrical stimulation on acupoints. Previous small-scale researches suggest TEAS may improve perioperative sleep, but high-quality randomized controlled trial evidence for cancer surgical patients is insufficient.\n\nThis single-center randomized sham-controlled trial aims to verify whether perioperative TEAS at Shenmen (HT7), Neiguan (PC6) and Hegu (LI4) can improve postoperative sleep quality, relieve surgical pain and regulate stress hormone level. A total of 176 eligible patients aged 18-75 years undergoing elective gastrointestinal or gynecologic cancer resection under general anesthesia will be enrolled and randomly divided into 1:1 intervention group and sham control group. The TEAS group receives acupoint electrical stimulation from pre-anesthesia to the end of surgery, while control group uses identical electrodes without actual electrical output. All subjects receive standardized anesthesia and routine postoperative analgesia. Researchers evaluate primary outcomes including PSQI and AIS sleep scales, alongside secondary indicators such as VAS pain score, QoR-15 and serum cortisol at postoperative Day1, Day3, Day7 and postoperative 30-day follow-up.",[27],[62,63,64,65],"postoperative sleep disturbance","transcutaneous electrical acupoint stimulation","cortisol","Shenmen (HT7), Neiguan (PC6), Hegu (LI4)",{"date":67,"type":39},"2026-06-17",{"date":69,"type":21},"2026-06-13",{"date":71,"type":21},"2026-07-20",{"name":73,"class":46},"Second Hospital of Shanxi Medical University",{"id":75,"slug":76,"hasResults":11,"nctId":77,"briefTitle":78,"officialTitle":78,"acronym":4,"eligibilityCriteria":79,"healthyVolunteers":11,"sex":80,"minAge":81,"maxAge":4,"enrollmentInfo":82,"targetDuration":4,"studyType":22,"phases":84,"briefSummary":85,"conditions":86,"keywords":88,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":101},"100617165","effect-of-esketamine-on-postoperative-sleep-in-postmenopausal-women-100617165","NCT07315074","Effect of Esketamine on Postoperative Sleep in Postmenopausal Women","Inclusion Criteria:\n\n1. American Society of Anesthesiologists (ASA) physical status I-III.\n2. Aged ≥ 45 years.\n3. Women with natural menopause (aged ≥ 45 years and postmenopause for more than 12 months without surgical or medical intervention) .\n4. Scheduled to undergo elective lower-limb fracture surgery with an expected duration of more than 60 min under general anesthesia.\n5. Body Mass Index (BMI) between 18 and 28 kg\u002Fm².\n\nExclusion Criteria:\n\n1. Presence of preoperative sleep-related disorders, such as obstructive sleep apnea or restless legs syndrome.\n2. History of drug or alcohol abuse or dependence.\n3. Known contraindications or allergies to esketamine or other anesthetic agents.\n4. Use of psychotropic medications or sex hormones within the past 3 months.\n5. Shift work or taking medications affecting melatonin.\n6. Severe comorbid conditions, including but not limited to uncontrolled hypertension, coronary artery disease, cardiac insufficiency, pulmonary hypertension, intracranial hypertension or elevated intraocular pressure, hyperthyroidism, severe hepatic or renal dysfunction.\n7. History of cerebral infarction, intracerebral hemorrhage, or residual central nervous system deficits.\n8. Impairments of language, hearing, vision, or cognitive function that would prevent completion of questionnaires or cooperation with sleep monitoring.\n9. Active oral pathologies.\n10. Transfer to ICU postoperatively.","FEMALE","45 Years",{"count":83,"type":21},164,[24],"The prevalence of sleep disturbance among postmenopausal women has been reported to reach 51.6%. Epidemiological studies consistently show that the incidence of sleep disorders increases with age and menopausal transition. Compared with premenopausal women, postmenopausal women demonstrate reduced circadian rhythm stability and a higher prevalence of sleep disturbance. In this population, levels of melatonin, total sleep time, sleep latency, N3 stage sleep, and the circadian amplitude of alertness are all diminished. Sleep disturbance can adversely affect both the mental and physical health of women and significantly impair their social functioning. Poor sleep is associated with decreased cognitive performance and heightened emotional distress, contributing to diminished quality of life.\n\nCircadian rhythms are endogenous physiological and behavioral cycles that oscillate over approximately 24 hours, governing critical processes such as sleep-wake cycles, hormonal fluctuations (e.g., cortisol and melatonin). These rhythms are regulated by the suprachiasmatic nucleus (SCN). Disruptions in circadian rhythms have been associated with sleep disturbances.\n\nEsketamine is the S (+) enantiomer of ketamine and has a higher affinity for the NMDA receptor than the R-enantiomer. Previous studies have demonstrated that intraoperative administration of esketamine can improve postoperative sleep quality and reduce the incidence of postoperative sleep disturbances, through its antidepressant efficacy, anti-inflammatory properties, analgesic efficacy, neurocognitive and anxiolytic effects. However, few studies have investigated whether esketamine can regulate perioperative circadian rhythms and subsequently affect sleep, especially in postmenopausal women.\n\nThe objective of this multi-center, prospective, randomized controlled clinical trial is to investigate the effects of esketamine on postoperative sleep in postmenopausal women.",[87,27],"Circadian Rhythm",[89,87,90,27,91],"Esketamine","Melatonin","Postmenopause","2026-03-13",{"date":94,"type":39},"2026-03-17",{"date":96,"type":21},"2026-03-01",{"date":98,"type":21},"2026-12-31",{"name":100,"class":46},"Zhuan Zhang",2]