[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"postoperative-sleep-disturbances\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:postoperative-sleep-disturbances":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,43,78],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100644382","effectiveness-of-perioperative-percutaneous-acupuncture-on-postoperative-sleep-disturbances-and-chronic-pain-in-patients-undergoing-video-assisted-thoracoscopic-lung-cancer-resection-a-prospective-randomized-single-blind-superiority-controlled-trial-100644382",false,"NCT07662733","Effectiveness of Perioperative Percutaneous Acupuncture on Postoperative Sleep Disturbances and Chronic Pain in Patients Undergoing Video-Assisted Thoracoscopic Lung Cancer Resection: A Prospective, Randomized, Single-Blind, Superiority Controlled Trial","Effectiveness of Perioperative Percutaneous Acupoint Acupuncture on Postoperative Sleep Disturbances in Patients Undergoing Video-Assisted Thoracoscopic Lung Cancer Resection: A Prospective, Randomized, Single-Blind, Superiority Controlled Trial","PASA-VATS","Inclusion Criteria：\n\n1. Patients aged 18-75 years scheduled for elective video-assisted thoracoscopic surgery (VATS) for lung cancer resection.\n2. American Society of Anesthesiologists (ASA) physical status classification I-II.\n3. Body Mass Index (BMI) between 18.5 and 28 kg\u002Fm².\n4. Clinical tumor stage according to the 8th edition of the AJCC\u002FUICC TNM Classification: cTis-3N0-1M0.\n5. Mentally competent, able to understand and correctly use the Numeric Rating Scale (NRS) for pain assessment.\n6. Willing and able to provide written informed consent prior to study participation.\n\nExclusion Criteria：\n\n1. Critical preoperative condition or inability to cooperate.\n2. History of sleep apnea or moderate to severe snoring.\n3. Pittsburgh Sleep Quality Index (PSQI) ≥7 or Athens Insomnia Scale (AIS) score ≥6.\n4. Implanted cardiac pacemaker, preoperative sinus bradycardia (heart rate ≤50 bpm), sinoatrial node disease, or second-\u002Fthird-degree atrioventricular block.\n5. Long-term use of anticonvulsants, antidepressants, or other psychotropic medications.\n6. Known hypersensitivity or allergy to the study materials (needles\u002Fdevices) or related medications.\n7. Severe cardiac, hepatic, or renal dysfunction.\n8. Participation in another clinical trial within the past 3 months.\n9. Hearing and\u002For language communication impairment.\n10. Pregnancy or breastfeeding.\n11. Fever (body temperature ≥38.5°C) or clinical evidence of infection (hematological, radiological, and\u002For microbiological) prior to surgery.\n12. Planned reoperation, or anticipated postoperative recurrence, severe complications, or critical illness requiring exclusion from follow-up.","ALL","18 Years","75 Years",{"count":21,"type":22},316,"ESTIMATED","INTERVENTIONAL",[25],"NA","This study evaluates whether acupuncture at specific body points before and after surgery can improve sleep quality and reduce long-term postoperative pain in patients undergoing video-assisted thoracoscopic lung cancer resection. Eligible adult patients will be randomly assigned to receive either true acupuncture or sham (placebo) acupuncture in addition to standard care. Chronic pain will be assessed during hospital stay and up to 6 months after surgery.",[28,29],"Postoperative Sleep Disturbances","Chronic Post-surgical Pain","RECRUITING","2026-06-17",{"date":33,"type":34},"2026-06-23","ACTUAL",{"date":36,"type":34},"2025-06-13",{"date":38,"type":22},"2027-11-29",{"name":40,"class":41},"Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine","OTHER",2,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":47,"acronym":48,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":17,"minAge":50,"maxAge":4,"enrollmentInfo":51,"targetDuration":4,"studyType":23,"phases":53,"briefSummary":55,"conditions":56,"keywords":59,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":77},"100553011","phase-4-the-effect-of-nocturnal-dexmedetomidine-on-postoperative-sleep-quality-and-fatigue-after-major-surgery-in-elderly-patients-dexsleep-study-100553011","NCT06480539","The Effect of Nocturnal Dexmedetomidine on Postoperative Sleep Quality and Fatigue After Major Surgery in Elderly Patients: DEXSLEEP Study","DEXSLEEP","Inclusion Criteria:\n\n* aged 60 years or older;\n* scheduled for thoracoscopic lung surgery.\n\nExclusion Criteria:\n\n* lack of informed consent or inability to give informed consent;\n* ≥ 2nd-degree atrioventricular block without pacemaker;\n* uncontrolled hypotension (blood pressure \\< 90\u002F60 mmHg);\n* known hypersensitivity to dexmedetomidine or to any of the excipients;\n* acute cerebrovascular conditions;\n* urgent, not elective surgery.","60 Years",{"count":52,"type":22},102,[54],"PHASE4","In the aftermath of major surgery, many patients suffer from pain, fatigue, reduced general well-being, and cognitive dysfunction. Another common concern after major surgery is sleep impairment and there is little known about its effect on postoperative morbidity, especially postoperative fatigue and muscle function.\n\nDexmedetomidine has been shown to possibly improve postoperative sleep quality in critically ill patients. However, whether the administration of dexmedetomidine translates into reduced postoperative fatigue and\u002For weakness and improved enhanced recovery after surgery by improving sleep, is currently unknown.\n\nThe DEXSLEEP study will evaluate the effect of nocturnal administration of dexmedetomidine, as compared to placebo (i.e. no dexmedetomidine), on postoperative quality of recovery, postoperative fatigue and muscle weakness.",[57,28,58],"Postoperative Fatigue","Surgical Stress Response",[60,61,62,63,64,65,66,67],"Major surgery","Enhanced Recovery After Surgery (ERAS)","Elderly patients","Quality of recovery","Postoperative fatigue","Postoperative muscle weakness","Postoperative sleep disturbances","Dexmedetomidine","2026-04-07",{"date":70,"type":34},"2026-04-08",{"date":72,"type":34},"2024-06-06",{"date":74,"type":22},"2026-04",{"name":76,"class":41},"Ziekenhuis Oost-Limburg",1,{"id":79,"slug":80,"hasResults":11,"nctId":81,"briefTitle":82,"officialTitle":83,"acronym":4,"eligibilityCriteria":84,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":85,"targetDuration":4,"studyType":23,"phases":87,"briefSummary":88,"conditions":89,"keywords":93,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":102,"completionDateStruct":103,"leadSponsor":105,"locationsCount":77},"100582175","phase-4-dexmedetomidine-esketamine-combination-and-sleep-disturbances-after-major-noncardiac-surgery-100582175","NCT06859892","Dexmedetomidine-Esketamine Combination and Sleep Disturbances After Major Noncardiac Surgery","Effect of Dexmedetomidine-esketamine Combination on Sleep Disturbances After Major Noncardiac Surgery: a Single-center, Randomised, Double-blind, Placebo-controlled Trial","Inclusion Criteria:\n\n1. Aged ≥18 years.\n2. Scheduled for major noncardiac surgery (≥60 minutes) under general anesthesia with an expected end of surgery no later than 18:00 pm.\n3. Required patient-controlled intravenous analgesia after surgery.\n\nExclusion Criteria:\n\n1. Emergency surgery, transurethral surgery, organ transplantation.\n2. Pregnant or lactating women.\n3. Patients who need hypnotics for sleep disturbance or antidepressants for depression prior to surgery.\n4. History of schizophrenia, epilepsy, Parkinson's disease, or myasthenia gravis.\n5. Inability to communicate due to coma, severe dementia, or speech disorders, endured hypoxic encephalopathy or traumatic brain injury, or after neurosurgery.\n6. Comorbid with hyperthyroidism and pheochromocytoma.\n7. Preoperative left ventricular ejection fraction \\\u003C30%, sick sinus syndrome, severe sinus bradycardia (heart rate \\\u003C50 beats\u002Fmin), atrioventricular block of degree II or higher without pacemaker implantation, or systolic blood pressure below 90 mmHg despite use of vasopressors.\n8. Diagnosed as sleep apnea, or judged to be at high risk of moderate-to-severe sleep apnea as assessed by STOP-Bang.\n9. Severe hepatic dysfunction (Child-Pugh class C), severe renal dysfunction (on dialysis), or ASA classification ≥IV.\n10. Hypersensitive to dexmedetomidine and\u002For esketamine.\n11. Other conditions that are deemed unsuitable for study participation.",{"count":86,"type":22},476,[54],"Sleep disturbances are common early after major surgery, and are associated with delayed recovery. A previous study showed that dexmedetomidine-esketamine combination as a supplement to patient-controlled intravenous analgesia improved postoperative analgesia and subjective sleep quality in patients after scoliosis correction surgery. The purpose of this trial is to test the hypothesis that dexmedetomidine-esketamine combination used as a supplement during general anesthesia and postoperative intravenous analgesia may reduce sleep disturbances in adult after major noncardiac surgery.",[90,91,67,92,28],"Adults","Major Noncardiac Surgery","Esketamine",[94,95,96,97,98],"adults","major noncardiac surgery","dexmedetomidine","esketamine","postoperative sleep disturbances","2025-03-18",{"date":101,"type":34},"2025-03-19",{"date":99,"type":34},{"date":104,"type":22},"2026-12",{"name":106,"class":41},"Peking University First Hospital"]