[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"postoperative-stroke\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:postoperative-stroke":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":28,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":41,"lastUpdatePostDateStruct":42,"startDateStruct":45,"completionDateStruct":47,"leadSponsor":49,"locationsCount":52},"100485045","impact-of-personalised-cardiac-anaesthesia-and-cerebral-autoregulation-on-neurological-outcomes-in-patients-undergoing-cardiac-surgery-100485045",false,"NCT05595954","Impact of Personalised Cardiac Anaesthesia and Cerebral Autoregulation on Neurological Outcomes in Patients Undergoing Cardiac Surgery","Impact of Personalised Cardiac Anaesthesia and Cerebral Autoregulation on Neurological Outcomes in Patients Undergoing Cardiac Surgery (PRECISION)","PRECISION","Inclusion Criteria:\n\n* Elective primary or reoperative coronary artery bypass graft and\u002For valvular and\u002For ascending aorta surgery requiring cardiopulmonary bypass.\n\nExclusion Criteria:\n\n* Surgery requiring moderate (28-31.9ºC) or deep (\\\u003C28ºC) hypothermic circulatory arrest;\n* Heart and\u002For lung transplantation;\n* Urgent (within 24 hours) and emergency surgery;\n* Inability to follow procedures or insufficient knowledge in English, German or French;\n* Inability to give consent.\n\nParticipants who undergo cardiac surgery under minimal extracorporeal circulation will also be excluded.","ALL","65 Years",{"count":20,"type":21},500,"ESTIMATED","OBSERVATIONAL","This international, multicentre prospective cohort study will assess whether perioperative duration and magnitude of mean arterial pressure (MAP) outside of an individual's cerebral autoregulation (CA) limits using near-infrared spectroscopy (NIRS) and transcranial Doppler (TCD) are associated with adverse neurological events. It is to investigate whether patients with a higher burden of cerebral haemodynamic insults have an increased incidence or poorer neurological outcomes. Associations between neurologic outcomes, neurobiomarkers and genetic tests will be explored.",[25,26,27],"Postoperative Delirium","Postoperative Stroke","Postoperative Cognitive Dysfunction",[29,30,31,32,33,34,35,36,37,38,39],"cerebral autoregulation","hypotension","neurological outcomes","adverse neurological events","postoperative delirium","postoperative stroke","postoperative cognitive decline","personalised cardiac anaesthesia","cardiac surgery","near-infrared spectroscopy","transcranial Doppler","RECRUITING","2026-06-25",{"date":43,"type":44},"2026-06-30","ACTUAL",{"date":46,"type":44},"2023-01-23",{"date":48,"type":21},"2027-06",{"name":50,"class":51},"University Hospital, Basel, Switzerland","OTHER",4]