[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"postoperative\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:postoperative":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,11,0,[8,49,93,123,150,181,203,227,252,275,302],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":28,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100643965","electrical-impedance-tomography-guided-identification-of-the-optimal-lateral-position-in-postoperative-ards-100643965",false,"NCT07669558","Electrical Impedance Tomography-Guided Identification of the Optimal Lateral Position in Postoperative ARDS","Effect of Left Lateral, Right Lateral, and Supine Positioning on Ventilation-Perfusion Matching Assessed by Electrical Impedance Tomography in Adult Postoperative Abdominal Surgery Patients With ARDS: A Prospective Randomized Crossover Physiological Study","Inclusion Criteria:\n\n* Age ≥18 years\n* Postoperative abdominal surgery patients admitted to the ICU with ARDS (Berlin definition)\n* Considered able to tolerate protocolized position changes by the treating team\n* EIT belt placement and protocol procedures feasible\n* Informed consent obtained from the patient or legally authorized representative\n\nExclusion Criteria:\n\n* Contraindication to lateral positioning (e.g., unstable spine, uncontrolled bleeding, open abdomen, high-risk surgical wound condition)\n* Severe hemodynamic instability or other conditions making participation unsafe\n* High risk of airway\u002Fvascular line\u002Fdrain dislodgement not manageable\n* Pregnancy\n* Refusal of informed consent\n* Any other condition deemed inappropriate by investigators","ALL","18 Years",{"count":19,"type":20},24,"ESTIMATED","INTERVENTIONAL",[23],"NA","This prospective, randomized crossover physiological study evaluates the effects of lateral positioning (left lateral position and right lateral position) versus the supine position on ventilation-perfusion (V\u002FQ) matching in adult postoperative abdominal surgery participants with acute respiratory distress syndrome (ARDS). Bedside electrical impedance tomography (EIT) will be used to quantify regional ventilation and perfusion (perfusion derived from an intravenous tracer bolus administered during a brief breath-hold) and to calculate global \"normal V\u002FQ\" (normal V\u002FQ, %). Oxygenation, respiratory mechanics (when applicable), and hemodynamics will be recorded concurrently. Feasibility and safety of the positioning protocol will also be assessed.",[26,27],"Acute Respiratory Distress Syndrome (ARDS)","Postoperative",[29,30,31,32,33,34,35],"acute respiratory distress syndrome (ARDS)","electrical impedance tomography (EIT","Lateral position","ventilation-perfusion","postoperative abdominal surgery","crossover study","supine position","NOT_YET_RECRUITING","2026-06-22",{"date":39,"type":40},"2026-06-25","ACTUAL",{"date":42,"type":20},"2026-06-16",{"date":44,"type":20},"2026-10-31",{"name":46,"class":47},"Ruijin Hospital","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":4,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":16,"minAge":56,"maxAge":57,"enrollmentInfo":58,"targetDuration":4,"studyType":21,"phases":60,"briefSummary":61,"conditions":62,"keywords":76,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":48},"100592604","dietary-supplements-in-patients-with-coronary-artery-bypass-grafting-for-improving-the-quality-of-healthcare-delivery-100592604","NCT06995586","Dietary Supplements in Patients With Coronary Artery Bypass Grafting for Improving the Quality of Healthcare Delivery.","The Synergistic Action of Vitamins and Dietary Supplements in Patients With Coronary Artery Bypass Grafting for Improving the Quality of Healthcare Delivery.","Inclusion Criteria:\n\n* The subjects will be people 40-80 years old, with coronary artery disease, and mental clarity who will undergo Coronary Aortic Bypass (CABG) in our clinic (Public Cardiothoracic Surgery clinic in Nicosia General Hospital) and will be randomized into 2 groups (intervention group and control group).\n* Signed consent form\n* Ability to adhere to the protocol\n\nExclusion Criteria:\n\n* Any psychiatric, neurological or motor disorder.\n* Hypersensitivity to the components of the supplement.\n* Combined Cardiac Surgery other than CABG and valve or aortic\n* Concurrent participation in other clinical trials.\n* Previous use of any probiotics, prebiotics, adsorbent dietary supplements, Vitamin C and\u002For Omega 3 fatty acids.","40 Years","80 Years",{"count":59,"type":20},108,[23],"Cardiovascular disease (CVD) remains the leading cause of death worldwide. Prevention of CAD by targeting modifiable factors remains a key public health priority. L-Ascorbic Acid (Vitamin C - Vit. C) and Omega 3 fatty acids, Eicosapentaenoic \u002F Docosahexaenoic Acid (EPO\u002FDHA), powerful but also necessary antioxidants for the human body, after observational studies as well as randomized studies seem to have a beneficial effect in the direction of the prevention of CVD with pleiotropic mechanisms. Lignin, a polymer of plant origin that is considered a dietary fiber, has a developed porous structure and can retain exogenous and endogenous toxins, and pathogenic microorganisms. Lactulose considered a prebiotic provides a selective substrate for the metabolism of saccharolytic bacteria with bifidogenic activity and multiple benefits to the host's gut health. Coronary artery bypass grafting (CABG) is an established surgical intervention and treatment of symptoms of myocardial ischemia that improves patient survival Optimal Medical Therapy (OMT) after coronary arterial bypass grafting (CABG) as described in current clinical practice could be made even better by the addition of these beneficial food supplements.\n\nA randomized controlled trial is proposed in an intervention group of 54 post-CABG patients who will be given daily orally in addition to the usual medication, 1000 mg Vitamin C, 840 mg EPO\u002FDHA, 2130 mg Lignin \\& 720 mg Lactulose and a control group of 54 patients (Control Group) in which only usual medication will be administered. The intervention will take place from the 15th postoperative day when CAGB patients are discharged and lasts for 2.5 months (10 weeks) postoperatively. The data will be collected on the 15th, 80-90th postop day in 6 months and 12 months postop and then the statistical analysis of the data will be performed. Considering the number of CABG surgeries performed electively in our clinic, this study is expected to be completed in approximately 2-3 years from the day of initiation.\n\nThe expected knowledge through the expected results such as these will emerge from this study is the potentially beneficial effect of our food supplements administration (intervention), i.e. Vitamin C, EPO\u002FDHA, Lignin \\& Lactulose, on the postoperative course of our patients. Some degree of improvement in the well-being and clinical picture of our patients postoperatively is expected, which will be thoroughly investigated in each phase of the study.",[63,64,65,66,67,68,69,70,71,27,72,73,74,75],"Cardio-pulmonary Bypass","Cardiovascular Diseases","Omega-3 Polyunsaturated Fatty Acids","Omega-3 Supplementation","Vitamin C","Supplements","Postoperative Depression","Antioxidants","Lactulose","Optimal Medical Therapy","CABG","Coronary Artery Bypass Grafting","Prebiotics",[63,64,77,67,70,71,78,68,79,72,73,74,80,81,82,83],"Omega-3 polyunsaturated fatty acids","Omega-3 supplementation","postoperative","postoperative depression","Lignin","adsorbent","prebiotics","2026-05-09",{"date":86,"type":40},"2026-05-13",{"date":88,"type":20},"2026-09-01",{"date":90,"type":20},"2028-12-01",{"name":92,"class":47},"Nicosia General Hospital",{"id":94,"slug":95,"hasResults":11,"nctId":96,"briefTitle":97,"officialTitle":97,"acronym":4,"eligibilityCriteria":98,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":99,"enrollmentInfo":100,"targetDuration":4,"studyType":21,"phases":102,"briefSummary":104,"conditions":105,"keywords":111,"overallStatus":113,"whyStopped":4,"lastUpdateSubmitDate":114,"lastUpdatePostDateStruct":115,"startDateStruct":117,"completionDateStruct":119,"leadSponsor":121,"locationsCount":48},"100578364","early-phase-1-pain-control-and-quality-of-recovery-after-intravenous-methadone-versus-intravenous-remifentanil-in-craniotomy-surgery-100578364","NCT06810336","Pain Control and Quality of Recovery After Intravenous Methadone Versus Intravenous Remifentanil in Craniotomy Surgery","Inclusion Criteria:\n\n1. Adult Patients between ages 18 and 65 years old.\n2. Undergoing supratentorial intracranial surgery\n3. American Society of Anesthesiologists (ASA) physiological status I-III\n4. Body Mass Index (BMI) between 18.5 and 45\n5. Ability to understand and read English\n\nExclusion Criteria:\n\n1. Being unable or unwilling to sign a consent\n2. Anticipated discharge within 24 hours after surgery\n3. Patients requiring Emergent Surgery\n4. Preoperative usage of Methadone, or allergy to it.\n5. Patients with chronic pain, requiring daily opioid use at the time of surgery, MME \\>60 as FDA defines opioid tolerant as 60 MME, long-acting forms of opioids such as fentanyl patch, oxycontin\n6. Active or Prior Substance Use Disorder, undergoing active treatment with Medication of Opioid Use Disorder including methadone (once daily dosing), Buprenorphine (any formulation) and Naltrexone\n7. Preoperative chronic renal insufficiency or failure (defined as a serum creatinine more than 2 mg\u002Fdl),\n8. Pregnancy\n9. Significant liver disease (cirrhosis or hepatic failure)\n10. QTc \\>450 on preoperative electrocardiogram\n11. Pulmonary disease necessitating home oxygen therapy\n12. Inability to speak or read the English language","65 Years",{"count":101,"type":20},40,[103],"EARLY_PHASE1","Postoperative pain is prevalent after intracranial surgery. Patients undergoing craniotomy are typically managed with short acting opioids to enable early and reliable post-operative neurological exam as well as avoid the risk of respiratory depression. However, a plethora of studies have shown that a majority of these patients experience moderate to severe pain in first 48 hours after surgery. Suboptimal pain control can lead to complications such as arterial hypertension and post-operative intracranial hemorrhage, and hence, increased morbidity and mortality.\n\nIntravenous (IV) methadone has a long analgesic half-life and has N-methyl-D-aspartate (NMDA) receptor antagonist and serotonin and norepinephrine reuptake inhibitor (SNRI) properties. It has previously been shown to reduce postoperative opioid requirements, postoperative nausea and vomiting (PONV), and postoperative pain scores in patients that underwent orthopedic, abdominal, complex spine, and cardiac surgery. Similar findings have been shown in obstetric patients that underwent caesarean delivery under general anesthesia as well as patients that underwent gynecologic surgery and received IV methadone intraoperatively.\n\nIn a recently published retrospective study, a single intraoperative dose of IV methadone was well tolerated with lower pain scores as well as MME (oral morphine milligram equivalents) requirements for up to 72 hours after elective intracranial surgery.\n\nIV methadone has, however, never been compared with conventional management via IV remifentanil for functional recovery in patients undergoing elective intercranial surgery.\n\nThe investigator's hypothesis is that intravenous (IV) methadone is non-inferior to IV remifentanil in patients who undergo elective intracranial surgery. It offers the advantage of being a single dose noninvasive analgesic modality that may contribute to decreasing MME consumption during the first 72 hours postoperatively, controlling postoperative pain, and improving quality of recovery after surgery.",[106,107,108,109,27,110],"Brain Injury","Brain Tumors","Craniotomy Surgery","Pain","Postoperative Care",[112],"craniotomy","RECRUITING","2026-04-27",{"date":116,"type":40},"2026-05-04",{"date":118,"type":40},"2025-03-10",{"date":120,"type":20},"2027-09-10",{"name":122,"class":47},"University of Virginia",{"id":124,"slug":125,"hasResults":11,"nctId":126,"briefTitle":127,"officialTitle":128,"acronym":129,"eligibilityCriteria":130,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":131,"targetDuration":4,"studyType":133,"phases":4,"briefSummary":134,"conditions":135,"keywords":137,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":141,"lastUpdatePostDateStruct":142,"startDateStruct":144,"completionDateStruct":146,"leadSponsor":148,"locationsCount":4},"100630976","proteomics-and-physiological-parameters-predicting-complications-after-colorectal-cancer-surgery-100630976","NCT07494669","Proteomics and Physiological Parameters Predicting Complications After Colorectal Cancer Surgery","Towards Precision Perioperative Medicine: Multimodal Prediction of Surgical Complications Using Proteomics and Physiological Monitoring","ProComp","Inclusion Criteria:\n\n* Scheduled for elective colorectal cancer surgery\n\nExclusion Criteria:\n\n\\-",{"count":132,"type":20},210,"OBSERVATIONAL","Study combines physiological data from wearables, continuous glucose montiors and proteomics to better assess risk of complications after colorectal surgery",[136,27],"Observation",[138,139,140],"complications","risk stratification","proteomics","2026-03-20",{"date":143,"type":40},"2026-03-27",{"date":145,"type":20},"2026-04-07",{"date":147,"type":20},"2028-03-30",{"name":149,"class":47},"Region Skane",{"id":151,"slug":152,"hasResults":11,"nctId":153,"briefTitle":154,"officialTitle":155,"acronym":4,"eligibilityCriteria":156,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":157,"enrollmentInfo":158,"targetDuration":4,"studyType":21,"phases":160,"briefSummary":161,"conditions":162,"keywords":167,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":172,"lastUpdatePostDateStruct":173,"startDateStruct":175,"completionDateStruct":177,"leadSponsor":179,"locationsCount":48},"100629597","effect-of-transcutaneous-auricular-vagus-nerve-stimulation-on-postoperative-delirium-and-negative-emotions-in-patients-undergoing-cardiac-surgery-100629597","NCT07476742","Effect of Transcutaneous Auricular Vagus Nerve Stimulation on Postoperative Delirium and Negative Emotions in Patients Undergoing Cardiac Surgery","Effect of Intraoperative Transcutaneous Auricular Vagus Nerve Stimulation on Postoperative Delirium and Negative Emotional States in Patients Undergoing Cardiac Surgery: A Multicenter, Randomized, Double-Blind, Sham-Controlled Trial","Inclusion Criteria:\n\n* Aged 18 to 85 years. Scheduled for elective cardiac surgery (e.g., CABG, valve replacement\u002Frepair). NYHA cardiac function class I-III. Willing and able to provide informed consent. Expected surgery duration ≥ 2 hours.\n\nExclusion Criteria:\n\n* Preoperative MMSE score \\\u003C 24; severe communication barriers. History of diagnosed delirium, dementia, Parkinson's disease, schizophrenia, bipolar disorder, major depressive disorder, or long-term use of psychotropic drugs.\n\nSkin lesions, infection, or deformity of bilateral ears; history of ear surgery or nerve injury; allergy to electrode materials.\n\nSevere arrhythmia; implanted electronic devices (e.g., pacemaker, ICD). Participation in another interventional trial within 3 months. Other conditions deemed unsuitable by investigators.","85 Years",{"count":159,"type":20},270,[23],"A multicenter, randomized, double-blind, sham-controlled trial to investigate the effects of intraoperative transcutaneous auricular vagus nerve stimulation (taVNS) on the incidence of postoperative delirium and negative emotional states (anxiety, depression) in patients undergoing elective cardiac surgery.",[163,27,164,165,166],"Postoperative Delirium (POD)","Anxiety","Depression","Cardiac Surgical Procedures",[168,169,170,165,164,171],"Transcutaneous Vagus Nerve Stimulation","Cardiac Surgery","Postoperative Delirium","Randomized Controlled Trial","2026-03-12",{"date":174,"type":40},"2026-03-17",{"date":176,"type":20},"2026-02-28",{"date":178,"type":20},"2027-02-28",{"name":180,"class":47},"Chinese PLA General Hospital",{"id":182,"slug":183,"hasResults":11,"nctId":184,"briefTitle":185,"officialTitle":186,"acronym":4,"eligibilityCriteria":187,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":188,"targetDuration":4,"studyType":21,"phases":190,"briefSummary":191,"conditions":192,"keywords":194,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":196,"lastUpdatePostDateStruct":197,"startDateStruct":199,"completionDateStruct":200,"leadSponsor":201,"locationsCount":202},"100628208","effect-of-transcutaneous-auricular-vagus-nerve-stimulation-on-perioperative-negative-emotions-in-breast-cancer-surgery-patients-100628208","NCT07458646","Effect of Transcutaneous Auricular Vagus Nerve Stimulation on Perioperative Negative Emotions in Breast Cancer Surgery Patients","Effect of Intraoperative Transcutaneous Auricular Vagus Nerve Stimulation on Perioperative Negative Emotions in Patients Undergoing Breast Cancer Surgery: A Multicenter, Randomized, Double-Blind, Sham-Controlled Trial","Inclusion Criteria:\n\n* Aged ≥18 years. Scheduled for elective breast cancer surgery. ASA physical status I-III. Willing and able to provide informed consent.\n\nExclusion Criteria:\n\n* Preoperative MMSE score \\\u003C 24; severe communication barriers. History of diagnosed dementia, Parkinson's disease, schizophrenia, bipolar disorder, major depressive disorder, or long-term use of psychotropic drugs.\n\nSkin lesions, infection, or deformity of bilateral ears; history of ear surgery or nerve injury; allergy to electrode materials.\n\nSevere arrhythmia; implanted electronic devices (e.g., pacemaker, ICD). Participation in another interventional trial within 3 months. Other conditions deemed unsuitable by investigators.",{"count":189,"type":20},232,[23],"A multicenter, randomized, double-blind, sham-controlled trial to investigate the effects of a single session of intraoperative transcutaneous auricular vagus nerve stimulation (taVNS) on perioperative negative emotions (anxiety and depression), pain, nausea, sleep, and recovery in patients undergoing elective breast cancer surgery.",[165,27,164,193],"Breast Surgery",[168,195,165,164,171],"Breast Cancer Surgery","2026-03-04",{"date":198,"type":40},"2026-03-09",{"date":176,"type":20},{"date":178,"type":20},{"name":180,"class":47},2,{"id":204,"slug":205,"hasResults":11,"nctId":206,"briefTitle":207,"officialTitle":207,"acronym":208,"eligibilityCriteria":209,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":210,"targetDuration":4,"studyType":21,"phases":212,"briefSummary":213,"conditions":214,"keywords":217,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":218,"lastUpdatePostDateStruct":219,"startDateStruct":221,"completionDateStruct":223,"leadSponsor":225,"locationsCount":48},"100616087","app-assisted-swallowing-program-after-oral-cancer-surgery-100616087","NCT07301047","App-Assisted Swallowing Program After Oral Cancer Surgery","AASP","Inclusion Criteria:\n\n* Willing to sign a written informed consent form\n* Diagnosed with oral cancer\n* Hospitalized for first-time oral cancer tumor resection and flap reconstruction surgery\n* Aged 18 years or older\n* Conscious and mentally clear\n* Able to communicate in Mandarin or Taiwanese\n\nExclusion Criteria:\n\n* Diagnosed by a physician with poor postoperative wound healing that prevents participation in oral rehabilitation exercises\n* Unable to perform oral rehabilitation exercises within one week after surgery, as determined by a physician\n\nWithdrawal Criteria:\n\n-Participants who withdraw consent at any time during the study will be excluded from further participation",{"count":211,"type":20},72,[23],"This study aims to examine the effects of a swallowing care program combined with an exercise mobile application (App) on swallowing function, anxiety, and quality of life in patients with oral cancer after flap reconstruction surgery. The goal is to determine whether integrating App-based swallowing exercises into postoperative care can improve rehabilitation outcomes compared with conventional care alone.\n\nA purposive sampling method will be used to recruit 72 participants from the surgical wards of a medical center in northern Taiwan. Eligible patients scheduled for oral cancer tumor resection and flap reconstruction will be identified through consultation with plastic surgeons. After screening and informed consent, participants will be assigned to a control group or an experimental group, with approximately 36 patients in each group.\n\nThe control group will receive routine ward education and standard postoperative nursing care, while the experimental group will receive the same care plus an additional intervention using a swallowing exercise App. The intervention will begin on postoperative day 7, guided by the researcher. Follow-up assessments will be conducted during outpatient visits at postoperative week 4 and week 12. To minimize potential interference between participants, data collection will be performed sequentially-first for the control group, followed by the experimental group.\n\nData will be collected through self-administered questionnaires or researcher-assisted interviews, including a demographic survey, the Postoperative Oral Dysfunction-10 (POD-10), the Functional Oral Intake Scale (FOIS), a Visual Analog Scale for Anxiety, and the EORTC QLQ-H\\&N35 questionnaire for quality of life. Each assessment will take approximately 20-30 minutes. Participants may withdraw from the study at any time without penalty.\n\nDescriptive statistics will be used to summarize participant characteristics. The chi-square test and independent t-test will be used to examine group homogeneity. Paired t-tests will be applied to evaluate within-group changes in swallowing function, anxiety, and quality of life before and after the intervention. The results of this study are expected to provide empirical evidence on the effectiveness of App-assisted swallowing rehabilitation for patients with oral cancer following reconstructive surgery, supporting the development of innovative, technology-based postoperative care models.",[215,216,27],"Oral Cancer","Reconstructive Surgery",[215,27,216],"2025-12-23",{"date":220,"type":40},"2025-12-24",{"date":222,"type":20},"2026-01-01",{"date":224,"type":20},"2026-12-31",{"name":226,"class":47},"Chang Gung Memorial Hospital",{"id":228,"slug":229,"hasResults":11,"nctId":230,"briefTitle":231,"officialTitle":231,"acronym":4,"eligibilityCriteria":232,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":57,"enrollmentInfo":233,"targetDuration":4,"studyType":21,"phases":235,"briefSummary":236,"conditions":237,"keywords":238,"overallStatus":113,"whyStopped":4,"lastUpdateSubmitDate":243,"lastUpdatePostDateStruct":244,"startDateStruct":246,"completionDateStruct":248,"leadSponsor":250,"locationsCount":48},"100412142","effect-of-erector-spinae-esp-block-on-opioid-reduction-and-enhanced-recovery-after-posterior-cervical-spine-surgery-100412142","NCT04646707","Effect of Erector Spinae (ESP) Block on Opioid Reduction and Enhanced Recovery After Posterior Cervical Spine Surgery","Inclusion Criteria:\n\nAll adult patients aged 18-80 years with ASA class I - III undergoing posterior cervical (C3-T2) decompression and instrumented fusion for cervical stenosis in prone position.\n\nExclusion Criteria:\n\n1. In patients who are allergic to local anesthetics.\n2. ASA IV patients\n3. Lack of informed consent\n4. Pregnant patient.\n5. Fracture cervical spine\n6. Extradural or intradural cervical tumors\n7. Surgery of C1 and C2 spine",{"count":234,"type":20},52,[23],"Patients undergoing spine surgery frequently experience significant pain after surgery. This can limit patient activity and hinder rehabilitation. If inadequately treated, severe pain can result in emotional and psychological distress and ultimately impact long-term function, and increase the risk of developing pain that lasts longer than six months associated with depression, anxiety and disability.\n\nMore specifically, Erector Spinae Plane (ESP) block is a recently described plane block designed to block the dorsal and ventral rami of the thoracic spinal nerves. It has shown to be an effective modality for postoperative pain management as a part of multimodal analgesia in spinal surgery.",[27,109],[239,240,241,27,242],"Opioid","Reduction","Enhanced","Recovery","2025-01-29",{"date":245,"type":40},"2025-01-30",{"date":247,"type":40},"2020-02-17",{"date":249,"type":20},"2025-12-30",{"name":251,"class":47},"University Health Network, Toronto",{"id":253,"slug":254,"hasResults":11,"nctId":255,"briefTitle":256,"officialTitle":256,"acronym":4,"eligibilityCriteria":257,"healthyVolunteers":11,"sex":16,"minAge":258,"maxAge":4,"enrollmentInfo":259,"targetDuration":4,"studyType":133,"phases":4,"briefSummary":261,"conditions":262,"keywords":4,"overallStatus":113,"whyStopped":4,"lastUpdateSubmitDate":266,"lastUpdatePostDateStruct":267,"startDateStruct":269,"completionDateStruct":271,"leadSponsor":273,"locationsCount":48},"100570454","postoperative-clinical-and-neurophysiological-assessment-of-patients-after-open-heart-surgery-100570454","NCT06707454","Postoperative Clinical and Neurophysiological Assessment of Patients After Open Heart Surgery","Inclusion Criteria:\n\n* Patient ≥ 60 years.\n* Both sexes.\n* Patients who are scheduled for on-pump open heart surgery either isolated coronary artery bypass grafting (CABG) or combined CABG and valve surgery.\n\nExclusion Criteria:\n\n* Patients with a past history of CNS disease (e.g. Epilepsy, brain tumors, or Dementia).\n* Patients with metabolic disturbance.\n* Illiterate patient.\n* Patient with sever cognitive impairment on Mini-mental state Examination (MMSE) and\u002For Montreal Cognitive Assessment (MoCA)\n* Patients who cannot undergo DEEG recordings (eg, uncooperative).\n* Patients with abnormal brain images except for small vessel disease.","60 Years",{"count":260,"type":20},80,"This study aims to investigate postoperative clinical, cognitive and neurophysiological assessment of patients after open heart surgery among sample of Egyptian patients.",[27,263,264,265],"Clinical","Neurophysiological Assessment","Open Heart Surgery","2024-11-24",{"date":268,"type":40},"2024-11-27",{"date":270,"type":40},"2023-06-01",{"date":272,"type":20},"2025-05-01",{"name":274,"class":47},"Ain Shams University",{"id":276,"slug":277,"hasResults":11,"nctId":278,"briefTitle":279,"officialTitle":280,"acronym":281,"eligibilityCriteria":282,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":99,"enrollmentInfo":283,"targetDuration":4,"studyType":21,"phases":285,"briefSummary":286,"conditions":287,"keywords":290,"overallStatus":113,"whyStopped":4,"lastUpdateSubmitDate":292,"lastUpdatePostDateStruct":293,"startDateStruct":295,"completionDateStruct":297,"leadSponsor":299,"locationsCount":301},"100420382","transfusion-requirements-in-younger-patients-undergoing-cardiac-surgery-100420382","NCT04754022","Transfusion Requirements in Younger Patients Undergoing Cardiac Surgery","An International, Multi-centre, Randomized Controlled Trial to Assess Transfusion Thresholds in Younger Patients Undergoing Cardiac Surgery","TRICS-IV","Inclusion Criteria:\n\n1. ≥18 and ≤65 years of age\n2. Planned cardiac surgery using cardiopulmonary bypass\n3. Informed consent obtained\n4. Preoperative European System for Cardiac Operative Risk Evaluation (EuroSCORE I) of 6 or more\n\nExclusion Criteria:\n\n1. Patients who refuse participation\n2. Patients who are unable to receive or who refuse blood products\n3. Patients who are involved in a preoperative autologous pre-donation program\n4. Patients who are having a heart transplant or having surgery solely for an insertion of a ventricular assist device\n5. Pregnancy or lactation (a negative pregnancy test must be obtained prior to randomization for women of childbearing potential)",{"count":284,"type":20},1440,[23],"TRICS-IV is an international, multi-centre, open-label randomized controlled trial of two commonly used transfusion strategies in moderate to high risk patients who are 65 years of age or younger undergoing cardiac surgery on cardiopulmonary bypass, using a superiority trial design.",[288,289,27,169],"Disorder","Heart",[169,291],"Transfusion","2024-11-18",{"date":294,"type":40},"2024-11-21",{"date":296,"type":40},"2021-11-01",{"date":298,"type":20},"2026-06",{"name":300,"class":47},"Unity Health Toronto",54,{"id":303,"slug":304,"hasResults":11,"nctId":305,"briefTitle":306,"officialTitle":307,"acronym":4,"eligibilityCriteria":308,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":57,"enrollmentInfo":309,"targetDuration":4,"studyType":21,"phases":311,"briefSummary":313,"conditions":314,"keywords":319,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":324,"lastUpdatePostDateStruct":325,"startDateStruct":327,"completionDateStruct":329,"leadSponsor":331,"locationsCount":48},"100550278","phase-4-efficacy-and-safety-of-oxycodone-hydrochloride-for-long-term-analgesia-in-icu-patients-100550278","NCT06444997","Efficacy and Safety of Oxycodone Hydrochloride for Long-term Analgesia in ICU Patients","Efficacy and Safety of Oxycodone Hydrochloride and Remifentanil for Long-term Analgesia During Invasive Mechanical Ventilation in Postoperative Patients: A Pilot Study","Inclusion Criteria:\n\n* 18 ≤ Age ≤ 80\n* Intubated and mechanically ventilated \\< 3 days prior to enrollment\n* Expected need for continuous mechanical ventilation ≥ 24 hours\n\nExclusion Criteria:\n\n* Patients requiring deep sedation (e.g., mechanical ventilation patients with severe man-machine dyssynchrony, respiratory distress due to severe respiratory failure, application of neuromuscular blockers, status epilepticus, surgical procedures requiring strict immobilization, mild hypothermia treatment, etc.);\n* Chronic kidney disease, severe liver dysfunction (Child-Pugh Class C)\n* Severe shock requiring norepinephrine ≥ 0.5 µg\u002Fkg\u002Fmin\n* American Society of Anesthesiologists (ASA) Class 5 patients (near death)\n* Nerve injury or organic pathological changes in the brain\n* Need for designated sedatives or anesthetics other than study drug during treatment\n* Patients with chronic pain, frequently taking strong opioids, such as morphine\n* History of alcohol or drug abuse\n* Participation in other opioid studies within 30 days\n* Pregnant or lactating women\n* Patients with study drug allergy and contraindications Patients who are not suitable for inclusion in the study as judged by the investigator",{"count":310,"type":20},60,[312],"PHASE4","The goal of this clinical trial is to learn if oxycodone hydrochloride works to manage pain in patients requiring mechanical ventilation. It will also assess the safety of oxycodone hydrochloride. The main questions it aims to answer are:\n\n1. Does oxycodone hydrochloride effectively lower the CPOT (Critical Care Pain Observation Tool) score in mechanically ventilated patients?\n2. What medical problems do participants have when using oxycodone hydrochloride? Researchers will compare oxycodone hydrochloride to remifentanil to see if oxycodone works better to manage pain in these patients.\n\nParticipants will:\n\n* Receive either oxycodone hydrochloride injection at a dose of 0.03-0.2 mg\u002Fkg\u002Fh or remifentanil injection at a dose of 2-9 μg\u002Fkg\u002Fh.\n* Have their pain scores assessed every 15 minutes until the CPOT score is less than 3. After reaching the target pain score, assessments will be done every 4 hours.\n* Have their vital signs and monitoring data recorded.\n* Have analgesia and sedation scores recorded from days 1 to 7 after administration, with drug dosages adjusted based on pain scores.\n* Have the incidence of adverse reactions and changes in gastrointestinal function observed and recorded from days 1 to 7 after administration.\n* If extubated within 7 days, relevant data will be collected based on the time of extubation.\n* Be followed up on day 28 through the electronic medical record system to gather data on the extubation success rate and incidence of complications within the 28-day period.",[315,316,317,27,318],"Oxycodone","Analgesia","Mechanical Ventilation","Remifentanil",[315,320,321,316,317,318,322,323],"oxycodone hydrochloride","long term analgesic","Pilot Study","ICU","2024-06-05",{"date":326,"type":40},"2024-06-06",{"date":328,"type":20},"2024-06-01",{"date":330,"type":20},"2025-12-31",{"name":332,"class":47},"Shanghai Zhongshan Hospital"]