[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"postpartum-obsessive-compulsive-disorder\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:postpartum-obsessive-compulsive-disorder":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":4},"100636861","transcranial-magnetic-stimulation-as-a-treatment-for-postpartum-obsessive-compulsive-disorder-100636861",false,"NCT07571187","Transcranial Magnetic Stimulation as a Treatment for Postpartum Obsessive Compulsive Disorder","Continuous Theta Burst Treatment as a Novel Treatment for Postpartum Obsessive Compulsive Disorder","Project MOM","Inclusion Criteria:\n\n1. Age 18-45\n2. Diagnosis of OCD defined by DSM-V criteria with problematic symptoms in the 12 months following childbirth\n3. YBOCS ≥16\n4. Either currently taking OCD medications at a stable dose for 8 weeks or unmedicated\n5. Concurrent psychotherapy (exposure and response prevention therapy) will be allowed if it was initiated 8 weeks or more before study entry and continues regularly throughout the trial\n6. Ability to read, write and understand English sufficiently well to complete study procedures and provide informed consent.\n\nExclusion Criteria:\n\n1. Past history of a primary psychotic or bipolar disorder\n2. Current acute suicidality or significantly elevated risk of suicide as determined by the investigators\n3. Personal history of moderate traumatic brain injury, epilepsy, or other clinically significant neurological illness except tic disorders\n4. A history of pre-eclampsia during the most recent pregnancy if the patient is less than 8 weeks postpartum\n5. Current, moderate to severe alcohol or illicit substance use disorder in the last 3 months, determined by clinical assessment\n6. Women who are currently pregnant. All participants will be asked to use a reasonable birth control method throughout the study period (barrier, oral contraceptives, etc.). We will not administer pregnancy tests.\n7. current psychotic symptoms\n8. A current seizure disorder\n9. active severe major depressive episode as indicated on the Edinburgh Postnatal Depression Scale (greater than or equal to 19).","FEMALE","18 Years","45 Years",{"count":21,"type":22},15,"ESTIMATED","INTERVENTIONAL",[25],"NA","The goal of this clinical trial is to learn if accelerated transcranial magnetic stimulation (TMS) is a feasible treatment for obsessive compulsive disorder that worsens or starts within 12 months of childbirth. The main questions it aims to answer are:\n\nIs TMS a tolerable and acceptable treatment for postpartum women with OCD?\n\nDoes TMS improve OCD symptoms in postpartum women?\n\nDoes TMS change connectivity between areas of the brain involved in OCD?\n\nParticipants will:\n\n1. Receive 50 sessions of a type of TMS called continuous theta burst stimulation (cTBS) over the course of two weeks.\n2. Complete clinical assessments before and after TMS, as well as at 1 and 3 months post-treatment\n3. Undergo functional magnetic resonance imaging (fMRI) of the brain before and after TMS",[28],"Postpartum Obsessive Compulsive Disorder",[30,31,32,33,34,35],"obsessive compulsive disorder","ocd","postpartum","peripartum","tms","transcranial magnetic stimulation","NOT_YET_RECRUITING","2026-04-30",{"date":39,"type":40},"2026-05-06","ACTUAL",{"date":42,"type":22},"2026-04",{"date":44,"type":22},"2028-06",{"name":46,"class":47},"Butler Hospital","OTHER"]