[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"postsurgical-pain\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:postsurgical-pain":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,48,79,109],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":31,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100616191","comparison-of-the-postoperative-analgesic-efficacy-of-sap-and-spsip-blocks-in-patients-undergoing-mammoplasty-100616191",false,"NCT07302399","Comparison of the Postoperative Analgesic Efficacy of SAP and SPSIP Blocks in Patients Undergoing Mammoplasty","SPSIP","Inclusion Criteria:\n\n* Patients aged 18-85 years\n* Patients undergoing elective mammoplasty\n* ASA physical status I-II\n\nExclusion Criteria:\n\n* Patients who refuse to participate\n* Mentally disabled patients\n* Presence of infection at the injection site\n* Patients with coagulopathy\n* History of allergy or toxicity to local anesthetics\n* Patients with uncontrolled hypertension\n* Patients with uncontrolled diabetes mellitus\n* Patients with hepatic or renal failure\n* Pregnant, breastfeeding women",true,"FEMALE","18 Years","65 Years",{"count":21,"type":22},60,"ESTIMATED","INTERVENTIONAL",[25],"NA","The aim is to compare the postoperative analgesic efficacy of serratus anterior plane block (SAPB) and serratus posterior superior intercostal plane block (SPSIPB) in patients undergoing mammoplasty surgery. To this end, a double-blind, randomized, controlled study has been designed. Female patients aged 18-65 years who will undergo mammoplasty surgery will be included in the study. Postoperative pain levels, opioid consumption, duration of analgesic requirement, and patient satisfaction will be evaluated in patients who receive fascial blocks for analgesic purposes.",[28,29,30],"Postoperative Pain","Postsurgical Pain","Breast Pain",[32,28,33,34],"Mammoplasty","SPSIP Block","SAP Block","NOT_YET_RECRUITING","2026-01-11",{"date":38,"type":39},"2026-01-13","ACTUAL",{"date":41,"type":22},"2026-02-01",{"date":43,"type":22},"2026-12-01",{"name":45,"class":46},"Abant Izzet Baysal University","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":17,"minAge":55,"maxAge":4,"enrollmentInfo":56,"targetDuration":4,"studyType":23,"phases":58,"briefSummary":61,"conditions":62,"keywords":65,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":47},"100542538","phase-2-dinalbuphine-ester-naldebain-for-pain-management-after-cesarean-section-100542538","NCT06344169","Dinalbuphine Ester (Naldebain) for Pain Management After Cesarean Section","Efficacy of Parenteral Injection of an Extended Release Kappa-receptor Opioid Sebacoyl Dinalbuphine Ester for Pain Management After Cesarean Section: a Randomized, Open-label, Non-inferiority Trial","Inclusion Criteria:\n\n* term primipara or multipara who are scheduled for elective cesarean section\n\nExclusion Criteria:\n\n1. Severe pregnancy-induced complication (such as preeclampsia, eclampsia, poorly control pregnancy-induced hypertension and\u002For diabetes)\n2. High risk for postpartum hemorrhage\n3. Contraindicated for neuraxial block\n4. Preterm (gestational age\\\u003C 36 week) delivery\n5. Emergency cesarean section\n6. After-office hour schedule\n7. History of substance abuse\n8. Known allergy to nalbuphine, benzyl benzoate or sesame oil\n9. Eligible parturient who are not willing to follow the assignment of treatment after randomization","20 Years",{"count":57,"type":22},120,[59,60],"PHASE2","PHASE3","Inadequate postoperative pain management can lead to physical and psychological distress in patients as well as impact surgical wound healing and increase the risk of developing postoperative delirium and cardiopulmonary and thromboembolic events. Severe postoperative pain may also result in the development of chronic post-surgical pain (CPSP), which in turn can lead to prolonged use of opioids and increased health-care costs. A descriptive survey study in 60 postpartum women who received cesarean section suggested that the presence of postoperative pain significantly reduced the willingness of breastfeeding and infant care. The incidence of CPSP after cesarean delivery has been reported to vary from 1% to 18% up to 1 year after operation. Intrathecal morphine (ITM) injection is considered as the standard pain management strategy for post-cesarean pain. However, the overall analgesic effect of ITM is about 8-12h and it is associated with pruritus, nausea\u002Fvomiting, urinary retention, constipation, mental status change, and respiratory depression. Therefore, the development of a safe, conveniently operated, and long-lasting analgesic strategy, which serves as background pain control modality up to several days after cesarean section should provide clinically beneficial advantages in the management of acute postoperative pain and prevention of CPSP in postpartum women. Naldebain® is prodrug of nalbuphine, which was approved by the Taiwan FDA in 2017. Naldebain® is rapidly hydrolyzed by tissue of plasma esterase to release nalbuphine. The bioavailability of nalbuphine following intramuscular injection Naldebain® was 85.4%, and it took approximately 6 days for the complete release of Naldebain® into the blood circulation. Therefore, a single parenteral injection of Naldebain® could provide long lasting analgesic effect in several phase II trials. However, Naldebain® has not been tested in the pain control after cesarean section. Therefore, this PI-initiated prospective, randomized, open-label, non-inferiority trial aims to investigate the clinical efficacy of Naldebain® in management of acute postoperative pain in term parturient who receive elective cesarean section to provide analgesic effect that is not inferior to the standard ITM and prevent the development of CPSP.",[29,63,64],"Cesarean Section","Chronic Post-surgical Pain",[66,67,68],"kappa agonist","mu agonist","Intrathecal morphine","RECRUITING","2025-05-06",{"date":72,"type":39},"2025-05-09",{"date":74,"type":39},"2024-05-06",{"date":76,"type":22},"2026-06-14",{"name":78,"class":46},"Dalin Tzu Chi General Hospital",{"id":80,"slug":81,"hasResults":11,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":4,"eligibilityCriteria":85,"healthyVolunteers":11,"sex":86,"minAge":87,"maxAge":4,"enrollmentInfo":88,"targetDuration":4,"studyType":23,"phases":89,"briefSummary":90,"conditions":91,"keywords":92,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":108},"100454106","phase-2-sustained-release-lidocaine-for-the-treatment-of-postoperative-pain-100454106","NCT05193227","Sustained Release Lidocaine for the Treatment of Postoperative Pain","A Randomized Phase 2 Trial of ST-01 (Sustained-release Lidocaine Polymer Solution for Injection) in Subjects Undergoing Pelvic Surgery","Inclusion Criteria:\n\n* Any sex, aged ≥ 19 years\n* Indication to undergo an operation with a planned pelvic incision\n* Able and willing to provide informed consent\n* Stated willingness to comply with all study procedures and availability for the duration of the study\n* If sexually active, is willing to use adequate birth control methods to prevent pregnancy over the course of the study\n\nExclusion Criteria:\n\n* History of chronic pain conditions associated with the use of opioids or steroids\n* Known allergic reactions to any components of the investigational product\n* Active infection involving the surgical site\n* Any contraindication to local anesthesia with lidocaine (e.g., known hypersensitivity to anesthetics of the amide type, known hypokalemia, complete heart block, anticoagulants (ASA permitted) antiarrhythmic medication)\n* Use of prohibited medications (quinidine, procainamide, disopyramide, lidocaine, mexiletine, flecainide, propafenone, amiodarone, dronedarone, ibutilide, dofetilide, sotalol, vernakalant)\n* Has participated in another clinical trial within 3 months prior to the Screening Visit or is planning to participate in another clinical trial during this trial period\n* Has any other surgical or medical condition that, in the judgment of the clinical Investigator might warrant exclusion or be contraindicated for safety reason","ALL","19 Years",{"count":57,"type":22},[59],"In this study, the investigators are testing a new formulation of lidocaine for its suitability in managing postoperative pain after pelvic (circumcision, inguinal, scrotal), perineal (hemorrhoidectomy) or perianal (fistulotomy) incisions. The new formulation ST-01 is a sustained release lidocaine formulation and is expected to provide pain relief over multiple days. Currently, the drug lidocaine is not available as an injectable slow-release formulation.",[28,29],[93,94,95,96,97,98],"pelvic surgery","scrotal surgery","inguinal incision","circumcision","hemorrhoidectomy","fistulotomy","2025-02-04",{"date":101,"type":39},"2025-02-07",{"date":103,"type":39},"2021-10-27",{"date":105,"type":22},"2026-05-27",{"name":107,"class":46},"University of British Columbia",2,{"id":110,"slug":111,"hasResults":11,"nctId":112,"briefTitle":113,"officialTitle":114,"acronym":115,"eligibilityCriteria":116,"healthyVolunteers":16,"sex":17,"minAge":117,"maxAge":118,"enrollmentInfo":119,"targetDuration":4,"studyType":121,"phases":4,"briefSummary":122,"conditions":123,"keywords":126,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":128,"lastUpdatePostDateStruct":129,"startDateStruct":131,"completionDateStruct":133,"leadSponsor":135,"locationsCount":47},"100572339","the-follow-up-after-shorter-tapes-study-effectiveness-and-safety-of-shorter-trans-obturator-tapes-100572339","NCT06731985","The Follow-up After Shorter Tapes Study. Effectiveness and Safety of Shorter Trans-obturator Tapes.","The FAST- Study: The Follow-up After Shorter Tapes Study Effectiveness and Safety of Shorter Trans-obturator Tapes: A Prospective Observational Study From the Norwegian Female Incontinence Registry","FAST","Inclusion Criteria:\n\n* All women operated for stress-urinary incontinence with TVT-O Abbrevo of Ajust incontinence sling between 2009 and 2020.\n\nExclusion Criteria:\n\n* Women operated with other incontinence operations or slings.","25 Years","90 Years",{"count":120,"type":22},750,"OBSERVATIONAL","Urinary incontinence after pregnancy and labor affects 1 in 3 women and has a negative impact on quality of life (QOL), limiting women's physical activity and impairing sexual function. The traditional surgical method treating female urinary incontinence is to implant a sub-urethral synthetic sling, the currently preferred method in Norway. The majority of women treated with synthetic slings obtain great improvement in QOL, but a few experience severe complications including chronic pelvic pain. Several countries, therefore, have reverted to older, less effective surgical methods to avoid synthetic material. Awareness of severe complications has, in some Norwegian hospitals, led to a shift in technique towards shorter slings. With shorter slings, the goal is to achieve the same grade of continence as traditional slings, but with fewer serious complications. The long-term results and complications of these shorter slings are mostly unknown. Akershus University Hospital (AHUS) shifted to shorter slings early, in 2009, using a single incision mini-sling (SIMS) Ajust. Due to costs, AHUS changed to the intermediate sling TVT-O Abbrevo in 2016.\n\nThrough this study, we hope to establish if shorter slings have the same long-term results as traditional slings, and to investigate if shorter slings are safer than traditional slings, with less long-term complications, such as chronic pelvic pain. We plan to perform a long-term follow-up of women having had surgery with shorter slings at AHUS.\n\nAll patients operated with either SIMS Ajust or TVT-O Abbrevo at AHUS between 2009 and 2020 will be invited to a long-term follow-up. The study participants will be asked to fill in validated questionnaires regarding symptoms of urine leakage, QOL, any chronic pain related to the surgery, debut of pain, level of pain and any treatments for the pain. All women treated with the current used sling Abbrevo is invited to a physical examination including testing of their voiding function and a gynecologic examination to check for complications.\n\n2D- and 3D ultrasound scans will be done on the TVT-O Abbrevo group to evaluate the position-, attachment- and any misplacement of the sling.\n\nWomen experiencing insufficient long-term results, such as chronic pain, will be offered a full examination and treatment.",[124,29,125],"Stress Urinary Incontinence","Follow-Up Studies",[127],"Long-term Follow-Up of shorter incontinence tapes","2024-12-09",{"date":130,"type":39},"2024-12-13",{"date":132,"type":39},"2024-10-24",{"date":134,"type":22},"2026-10-31",{"name":136,"class":46},"University Hospital, Akershus"]