[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"postthrombotic-syndrome\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:postthrombotic-syndrome":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,47,71],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100545703","dvt-burden-and-the-risk-of-post-thrombotic-syndrome-100545703",false,"NCT06385353","DVT Burden and the Risk of Post-thrombotic Syndrome","Baseline Ultrasound Venous Thrombosis Burden and the Risk of Post-thrombotic Syndrome in Patients With a First Acute Episode of Symptomatic Deep Vein Thrombosis of the Lower Limbs - The \"DVT-Burden\" Project -","DVT-Burden","Inclusion Criteria:\n\n1. Age ≥ 18 years\n2. Patients with symptomatic acute deep venous thrombosis of the lower limbs confirmed by ultrasound on the criteria of venous incompressibility and direct image of the thrombus (patients with stable pulmonary embolism associated with a symptomatic deep venous thrombosis can be included)\n3. Affiliates or beneficiaries of a social security scheme.\n\nExclusion Criteria:\n\n1. Pregnant women, women in labour or breastfeeding mothers.\n2. Pulmonary embolism haemodynamically unstable defined by systolic blood pressure \\\u003C 90 mmHg or a drop in systolic blood pressure of at least 40 mmHg during at least 15 min, shock or cardiac arrest.\n3. Asymptomatic venous thrombosis.\n4. Symptomatic venous thrombosis of both lower limbs (patients with bilateral deep venous thrombosis but symptomatic on one side only can be included).\n5. History of ipsilateral or contralateral venous thrombosis of the lower limb.\n6. Fracture or orthopedic surgery of the lower limbs in the last 3 months.\n7. Dependance caused by age or secondary to a chronic affection, going from the inability to stand up or walk alone without help to bed or armchair rest over.\n8. Prophylactic or therapeutic anticoagulant treatment \\> 5 days.\n9. Expected duration of anticoagulant treatment \\\u003C 3 months (all patients must have a minimum treatment of 3 months).\n10. Patient estimated at high risk of bleeding according to investigator clinical judgment (renal, platelet, digestive, hepatic, neurological... origin) .\n11. Indication for interruption of the inferior vena cava or venous recanalisation (endovascular, thrombolysis or surgery).\n12. Refusal or inability to give written informed consent to participate in the study.\n13. Life expectancy \\\u003C 6 months.\n14. Patients under legal protection (guardianship, curatorship, etc.) or safeguard of justice.\n15. Patients taking part in a research project for venous thromboembolism that can interfere with the conduct of DVT-BURDEN research.","ALL","18 Years",{"count":20,"type":21},400,"ESTIMATED","INTERVENTIONAL",[24],"NA","Post-thrombotic syndrome (PTS) is the most common chronic complication of deep vein thrombosis (DVT), with major consequences for patient quality of life and cost of management. Identifying patients at high risk of developing PTS could be useful for its prevention and may lead to more appropriate therapeutic strategies to reduce its incidence and severity.\n\nPrognostic tools for predicting risk are very useful for choosing the optimum treatment and improving patient management and are a preliminary step before developing predictive models useful for determining sensitivity to treatment. At present, although several prognostic markers and models have been proposed, it is still difficult to predict who will develop a PTS or a moderate to severe PTS. The development of PTS is multifactorial and depends largely on the extent and severity of venous obstruction which supports the theory of thrombosis burden (DVT-Burden) as a potential prognostic marker for PTS. It therefore seems important to study the association between thrombosis burden and the occurrence of PTS.\n\nThe Venous Volumetric Index or VVI (Ouriel 1999) will be used for quantifying DVT-Burden. The VVI was constructed by calculating the volume from the diameter and length of 14 venous segments from the calf veins to the inferior vena cava. The VVI has been validated for its ability to discriminate between symptomatic and asymptomatic DVT and has shown superior performance to other methods for quantifying DVT.\n\nThis study aim to assess the performance of baseline DVT-burden estimated by the VVI score on ultrasound for predicting the occurrence and the severity of PTS as assessed by the Villalta scale at 6 months.",[27],"Postthrombotic Syndrome",[29,30,31,32,33],"Venous thrombosis","Thrombus burden","Ultrasonography","Thrombus resolution","Post-thrombotic syndrome","RECRUITING","2026-06-15",{"date":37,"type":38},"2026-06-16","ACTUAL",{"date":40,"type":38},"2024-06-05",{"date":42,"type":21},"2027-06",{"name":44,"class":45},"Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer","OTHER",27,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":55,"enrollmentInfo":56,"targetDuration":4,"studyType":22,"phases":58,"briefSummary":59,"conditions":60,"keywords":4,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":67,"leadSponsor":69,"locationsCount":4},"100637048","acute-or-subacute-iliofemoral-vein-thrombosis-aspiration-for-flow-restoration-versus-standard-anticoagulation-100637048","NCT07573618","Acute or Subacute Iliofemoral Vein Thrombosis: Aspiration for Flow Restoration Versus Standard Anticoagulation","Vascular Surgery Department of Beijing Tsinghua ChangGung Hospital","IF-FLOW","Inclusion Criteria:\n\n* Age 18-80, gender unrestricted;\n* Diagnosed as acute or subacute proximal deep venous thrombosis of the lower extremities through lower extremity venous ultrasound or enhanced CT of the lower extremity veins, with involvement of at least the common iliac vein, external iliac vein, or common femoral vein;\n* The subjects met the criteria for standard anticoagulation therapy combined with thrombus aspiration along with standard anticoagulation therapy;\n* The patient fully understands and voluntarily signs a written informed consent form;\n* Willing and able to comply with all the visit, treatment, and assessment procedures specified in the study protocol.\n\nExclusion Criteria:\n\n* Bilateral deep iliofemoral vein thrombosis;\n* Femoral edema or femoral white swelling;\n* Inferior vena cava thrombosis;\n* History of deep vein thrombosis with a diagnosis of moderate to severe post-thrombotic syndrome;\n* The affected limb has previously had a venous stent implanted;\n* There are anatomical abnormalities affecting the intervention pathway, such as hypoplasia or dysplasia of the inferior vena cava, or other malformations of the iliac or inferior vena cava;\n* Presence of active major bleeding or clinically significant bleeding risk (hemoglobin \\\u003C80g\u002FL or platelet count \\\u003C50×109\u002FL);\n* Severe coagulation dysfunction, with an international normalized ratio \\>1.7;\n* Uncontrolled severe hypertension (systolic blood pressure \\>180 mmHg or diastolic blood pressure \\>105 mmHg after medication);\n* Severe renal impairment, with a glomerular filtration rate \\\u003C30 mL\u002Fmin\u002F1.73m²;\n* Any interventional treatment for the target deep vein thrombosis within 30 days prior to enrollment;\n* Female patients in pregnancy or lactation;\n* Known history of allergies to drugs used during the study (such as contrast agents, anticoagulants, etc.);\n* Active malignant tumor;\n* In the judgment of the researchers, there are any other comorbidities, conditions, or poor adherence that may affect the study evaluation or place the patient at high risk.","80 Years",{"count":57,"type":21},104,[24],"This trial is a prospective, multicenter, randomized controlled, superiority study. According to the inclusion and exclusion criteria for clinical research subjects, 104 patients with acute deep vein thrombosis involving the iliac and femoral veins were recruited. Qualified subjects were randomly (1:1) assigned to either the experimental group or the control group. The experimental group received thrombus aspiration, with or without balloon dilation, stent implantation, and other accompanying surgical treatments, combined with standard anticoagulant therapy, while the control group received only standard anticoagulant therapy. The efficacy and safety of the experimental group in treating acute iliac and femoral vein thrombosis were compared. The main efficacy endpoint of this study is the 24 month postoperative composite endpoint, with the following hierarchical order: 1. in-hospital mortality or treatment upgrade; 2. Recurrent venous thrombosis or newly developed pulmonary embolism of the target lesion within 24 months; 3. Severity of Villalta score at 24 months; 4. Change in VEINES score after 24 months. Simultaneously observe other secondary efficacy endpoints and safety endpoints. Clinical follow-up was conducted before discharge, 30 days after surgery, 6 months after surgery, 12 months after surgery, and 24 months after surgery.",[61,27],"Deep Vein Thrombosis of Lower Limb","NOT_YET_RECRUITING","2026-05-01",{"date":65,"type":38},"2026-05-07",{"date":63,"type":21},{"date":68,"type":21},"2030-04-30",{"name":70,"class":45},"Weiwei Wu",{"id":72,"slug":73,"hasResults":11,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":77,"eligibilityCriteria":78,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":79,"targetDuration":81,"studyType":82,"phases":4,"briefSummary":83,"conditions":84,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":98},"100353396","ongoing-registry-of-treatment-of-venous-thromboembolism-100353396","NCT03881345","Ongoing Registry of Treatment of Venous Thromboembolism","Russian Registry of Treatment of Venous Thromboembolism","RRT VTE","Inclusion Criteria:\n\n* case of venous thrombosis of a limb or pulmonary embolus\n\nExclusion Criteria:\n\n* no exclusion criteria",{"count":80,"type":21},5000,"12 Months","OBSERVATIONAL","Ongoing registration of patients with venous thromboembolism treated by means of antithrombotic therapy, thrombolisys, open surgery, endovenous desobstruction and stenting.",[85,86,87,27,88],"Deep Vein Thrombosis","Thromboses, Venous","Thrombosis Embolism","Pulmonary Embolism","2025-05-05",{"date":91,"type":38},"2025-05-08",{"date":93,"type":38},"2019-04-01",{"date":95,"type":21},"2036-03-01",{"name":97,"class":45},"Medalp Private Surgery Clinic",1]