[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"posttraumatic-stress-symptoms\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:posttraumatic-stress-symptoms":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,42,87,112],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100634649","impact-of-dog-adoption-and-training-in-veterans-with-post-traumatic-stress-symptoms-andor-other-mental-health-conditions-100634649",false,"NCT07542431","Impact of Dog Adoption and Training in Veterans With Post-traumatic Stress Symptoms and\u002For Other Mental Health Conditions","Assessment of Biopsychosocial Indicators Linked to Canine Intervention Treatment Response in Veterans With Post-traumatic Stress Symptoms and\u002For Other Mental Health Conditions","VCRM","Inclusion Criteria:\n\n* Military veteran with self-reported posttraumatic stress symptoms and\u002For other mental health conditions\n* Over 18 years of age\n* Applied and approved to adopt a shelter dog for training through the Humane Society of Broward County in Fort Lauderdale, Florida\n* English speaker (written and spoken)\n* Home internet access via tablet, computer or smartphone.\n\nExclusion Criteria:\n\n* Fear of dogs\n* Allergies to pet dander\n* Uncorrected hearing or visual impairment.","ALL","18 Years",{"count":20,"type":21},120,"ESTIMATED","INTERVENTIONAL",[24],"NA","The goal of this single-arm study is to learn if a dog adoption and training program can treat, prevent in \\[describe participant population\u002Fprimary condition; could include any of the following: sex\u002Fgender, age groups, healthy volunteers\\]. The main questions it aims to answer are:\n\n* Does the dog adoption and training program decrease posttraumatic stress symptoms in veterans with self-reported posttraumatic stress symptoms?\n* Does the dog adoption and training program decrease stress and improve psychosocial health in veterans with self-reported posttraumatic stress symptoms?\n* Does the dog adoption and training program decrease inflammation, increase oxytocin, and change the structure and resting-state function of specific brain regions in veterans with self-reported posttraumatic stress symptoms?\n\nParticipants will:\n\n* Attend eight one-hour professional dog training sessions within a 10-week period.\n* Visit the clinical research unit four times during the study for data collection.",[27,28],"Posttraumatic Stress Symptoms","Mental Health Conditions","RECRUITING","2026-04-21",{"date":32,"type":33},"2026-04-24","ACTUAL",{"date":35,"type":33},"2026-02-09",{"date":37,"type":21},"2030-12",{"name":39,"class":40},"Florida Atlantic University","OTHER",1,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":4,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":17,"minAge":49,"maxAge":18,"enrollmentInfo":50,"targetDuration":4,"studyType":22,"phases":52,"briefSummary":53,"conditions":54,"keywords":65,"overallStatus":77,"whyStopped":4,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":41},"100630104","comparative-effectiveness-of-sparcs-and-unified-protocol-for-youth-with-chronic-medical-conditions-and-trauma-related-distress-100630104","NCT07483333","Comparative Effectiveness of SPARCS and Unified Protocol for Youth With Chronic Medical Conditions and Trauma-Related Distress","Supporting Purposeful Interventions & Resilience In Trauma (SPIRIT) Program: Implementing Trauma-Specific Screening and Stratified Interventions for Youth With a Chronic Medical Condition","Inclusion Criteria:\n\n* Youth (aged 8-18 years) who received a SPIRIT program psychological trauma screening and were deemed clinically appropriate for SPIRIT group therapy. Clinically appropriate means the youth can historically engage in a group setting (e.g., school, camp, therapy group) without significant disruption to the group process or other participants.\n* Youth and parent\u002Flegal guardian are willing and able to provide informed consent\u002Fassent for randomization.\n* Youth and parent\u002Flegal guardian are fluent in English or Spanish.\n* Youth is not currently engaged in individual therapy at the time of enrollment (per patient\u002Fparent report).\n\nExclusion Criteria:\n\n* Wards of the state or DCFS youth in care.\n* Youth with reported or observed symptoms that would significantly impair group therapy engagement, including but not limited to: intellectual disability, moderate-to-severe autism spectrum disorder, active suicidal ideation, uncontrolled psychosis, or other acute psychiatric symptoms that could disrupt the group process.\n* Regular use of alcohol or other substances that interfere with participation or disrupt the group process.\n* Youth requiring immediate higher-level psychiatric care (e.g., intensive outpatient programming, partial hospitalization, inpatient psychiatric admission, or residential treatment) at the time of first randomization.","8 Years",{"count":51,"type":21},400,[24],"The goal of this clinical trial is to compare the effectiveness of trauma-focused therapies for improving mental health symptoms and daily functioning in youth with chronic medical conditions who have experienced psychological trauma and trauma-related distress. The study evaluates two evidence-based cognitive-behavioral therapies - Structured Psychotherapy for Adolescents Responding to Chronic Stress (SPARCS) and the Unified Protocol (UP) - delivered in group and individual formats to determine which approach, or combination of approaches, best reduces trauma symptoms and supports coping and adjustment. The study will also help researchers understand how to best support youth who continue to experience distress after an initial round of therapy.\n\nThe main questions it aims to answer are:\n\n* Does SPARCS group therapy or UP group therapy lead to greater improvements in trauma symptoms and functional impairment?\n* For youth who do not show enough improvement after group therapy, does adding SPARCS or UP individual therapy lead to better outcomes?\n* Which sequence of group and individual therapies leads to the greatest improvements in trauma symptoms and functioning?\n\nResearchers will compare two evidence-based therapies currently offered at Ann \\& Robert H. Lurie Children's Hospital of Chicago. Youth will first be randomly assigned to receive either SPARCS or UP in a group format. After completing group therapy, youth who still need additional support will be randomly assigned again to receive individual or family therapy using SPARCS or UP. This stepwise approach will help identify which sequence of therapies leads to the best overall outcomes for youth.\n\nParticipants will:\n\n* Take part in group therapy sessions using either SPARCS or UP\n* For those needing additional support after group therapy, participate in individual SPARCS or UP therapy\n* Complete brief assessments of mental health and daily functioning at enrollment, and every 12 weeks thereafter for 48 weeks, as part of their regular care through Ann \\& Robert H. Lurie Children's Supporting Purposeful Interventions \\& Resilience in Trauma (SPIRIT) program",[55,56,57,58,59,60,61,62,63,27,64],"Trauma Exposure","Trauma","Trauma and Stressor Related Disorder","Mental Health Functioning","Chronic Medical Conditions","Chronic Medical Condition","Chronic Medical Illness","Posttraumatic Stress Disorder PTSD","Posttraumatic Stress Disorders","Posttraumatic Stress",[66,67,68,69,70,71,72,73,74,75,76],"pediatric trauma","posttraumatic stress disorder","chronic medical conditions","pediatrics","trauma symptoms","trauma and stressor related disorder","trauma informed care","Sequential, Multiple Assignment Randomized Trial","Supporting Purposeful Interventions and Resilience in Trauma","Unified Protocol","Structured Psychotherapy for Adolescents Responding to Chronic Stress","NOT_YET_RECRUITING","2026-03-16",{"date":80,"type":33},"2026-03-19",{"date":82,"type":21},"2026-07",{"date":84,"type":21},"2029-09-29",{"name":86,"class":40},"Anthony Vesco",{"id":88,"slug":89,"hasResults":11,"nctId":90,"briefTitle":91,"officialTitle":92,"acronym":4,"eligibilityCriteria":93,"healthyVolunteers":11,"sex":94,"minAge":18,"maxAge":4,"enrollmentInfo":95,"targetDuration":4,"studyType":22,"phases":97,"briefSummary":98,"conditions":99,"keywords":4,"overallStatus":77,"whyStopped":4,"lastUpdateSubmitDate":102,"lastUpdatePostDateStruct":103,"startDateStruct":105,"completionDateStruct":107,"leadSponsor":109,"locationsCount":41},"100604310","a-feasibility-mixed-methods-study-of-the-intervention-take-your-sexuality-back-for-sexually-traumatized-women-100604310","NCT07147855","A Feasibility Mixed Methods Study of the Intervention Take Your Sexuality Back for Sexually Traumatized Women.","Take Your Sexuality Back - a Feasibility Study of a New Intervention for Sexually Traumatized Women: Preliminary Evaluations of Efficacy and Outcome Measurements","Inclusion Criteria:\n\n1. A history of sexual trauma.\n2. Experience trauma-related sexual problems.\n3. Age between 18 and 65 years.\n4. Enough competence in Norwegian to participate in a psychoeducational group.\n\nExclusion Criteria:\n\n1. Acute suicidality.\n2. Serious substance abuse interfering with treatment\n3. Severe dissociative or psychotic disorders.\n4. Current life crisis interfering with treatment.\n5. Living in an abusive relationship. -","FEMALE",{"count":96,"type":21},20,[24],"This study looks at the potential effects of a new group treatment called \"Take Your Sexuality Back\", designed for women who have experienced sexual trauma. Investigators will collect information in two ways-through forms that participants fill out themselves and through ECG measurements during a stress tests. Data will be collected before the treatment, right after it, and again three months later. When all data are collected and analyzed investigators will carry out in-depth interviews with participants and explore how they felt about being tested and how they understand the results -especially if some numbers look unusual or surprising. The goal with this study is to create a strong foundation for a future larger-scale study of the treatment by testing the methods, estimating the size of possible effects and identify outcome measurements that are experienced as meaningful to the participants.",[27,100,101],"Sexual Abuse","Sexual Trauma","2025-09-01",{"date":104,"type":33},"2025-09-08",{"date":106,"type":21},"2025-09",{"date":108,"type":21},"2027-09",{"name":110,"class":111},"Sykehuset Telemark","OTHER_GOV",{"id":113,"slug":114,"hasResults":11,"nctId":115,"briefTitle":116,"officialTitle":116,"acronym":117,"eligibilityCriteria":118,"healthyVolunteers":11,"sex":17,"minAge":119,"maxAge":120,"enrollmentInfo":121,"targetDuration":123,"studyType":124,"phases":4,"briefSummary":125,"conditions":126,"keywords":131,"overallStatus":77,"whyStopped":4,"lastUpdateSubmitDate":137,"lastUpdatePostDateStruct":138,"startDateStruct":140,"completionDateStruct":142,"leadSponsor":144,"locationsCount":41},"100587006","between-the-belly-and-the-brain-distorted-gut-brain-crosstalk-in-early-life-adversity-100587006","NCT06922773","Between the Belly and the Brain: Distorted Gut-brain Crosstalk in Early-life Adversity","BellyBrain","Inclusion Criteria:\n\n* Primary school-aged children (6 to 13 years of age) who have experienced at least one early-life traumatic event, based on the Childhood Trust Events Survey (CTES) questionnaire\n* The child and at least one of his\u002Fher parents (or guardian) speak Dutch sufficiently well to complete all of the questionnaires and the semi-structured child psychiatric interview (SCID-5-Junior)\n\nExclusion Criteria:\n\n* any chronic disorders or diseases known to affect the gut micobiome\n* inablity to complete questionnaires and\u002For semi-structured interview because of linguistic and\u002For cognitive barrier\n* congenital or acquired immunodeficiencies\n* use of medication(s) that affect gastrointestinal function (e.g., antibiotics) within the last 6 weeks, or laxatives within the last 4 weeks, or probiotic or prebiotic supplements within the last 4 weeks\n* current involvement in another clinical or food study","6 Years","13 Years",{"count":122,"type":21},50,"1 Month","OBSERVATIONAL","The goal of this observational study is to learn about the effects of early-life adversity (ELA) on the composition of children's microbiome and on their psychosocial functioning. The main questions it aims to answer are:\n\n* Do children who have experienced ELA have lower gut microbial diversity and\u002For an altered gut microbial composition?\n* Do these microbiome alterations correlate with adverse neurodevelopmental outcomes, including increased levels of stress, social and\u002For affective problems?",[127,128,129,130,27],"Early Life Adversity","Microbiome, Human","Anxiety Symptoms","Depressive Symptoms",[132,133,134,135,136],"early life adversity","gut microbiome","anxiety symptoms","depressive symptoms","posttraumatic stress symptoms","2025-04-03",{"date":139,"type":33},"2025-04-10",{"date":141,"type":21},"2025-05",{"date":143,"type":21},"2026-06",{"name":145,"class":40},"Universitair Ziekenhuis Brussel"]