[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"pre-exposure-prophylaxis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:pre-exposure-prophylaxis":97},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,8,0,[8,46,82,109,133,160,182,212],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100497164","gathering-online-for-dialogue-and-discussion-to-enhance-social-support-100497164",false,"NCT05753683","Gathering Online for Dialogue and Discussion to Enhance Social Support","GODDESS (Gathering Online for Dialogue and Discussion to Enhance Social Support): Engaging Young African American Women in a Virtual Group App to Address Alcohol Misuse, Sexual Risk, and Pre-exposure Prophylaxis (PrEP) in North Carolina (NC)","GODDESS","Selected Inclusion Criteria:\n\n* identify as Black\u002FAfrican American\n* identify as female\n* be between 18 and 30 years old\n* recent substance use\n* HIV negative and not currently on PrEP\n* have an Android or iOS-based smartphone\n\nSelected Exclusion Criteria:\n\n* test positive for HIV\n* participated in the previous study activities of the current study or previous related studies",true,"ALL","18 Years","30 Years",{"count":22,"type":23},500,"ESTIMATED","INTERVENTIONAL",[26],"NA","The goal of this trial is to test a modified mobile health intervention (with a group component) relative to a mobile health intervention in a two-arm randomized trial with up to 500 young women who are human immunodeficiency virus (HIV)-negative and who misuse alcohol.\n\nThe expected outcomes are to: (1) determine the efficacy of the virtual group component in reducing alcohol use and sexual risk and increasing pre-exposure prophylaxis (PrEP) utilization; and (2) understand selected outcomes for implementation.\n\nParticipants will be randomized to receive either the mHealth app or the mHealth app plus the group component, and followed up at 3- and 6-months post-enrollment.",[29,30,31,32],"Alcohol Misuse","HIV","Sexually Transmitted Infections","Pre-exposure Prophylaxis","RECRUITING","2026-05-15",{"date":36,"type":37},"2026-05-19","ACTUAL",{"date":39,"type":37},"2025-04-07",{"date":41,"type":23},"2027-11",{"name":43,"class":44},"RTI International","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":17,"sex":54,"minAge":55,"maxAge":56,"enrollmentInfo":57,"targetDuration":4,"studyType":24,"phases":59,"briefSummary":61,"conditions":62,"keywords":65,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":45},"100528235","phase-4-uncpm-22314---pregnancy-infant-and-maternal-health-outcomes-study-100528235","NCT06158126","UNCPM 22314 - Pregnancy, Infant and Maternal Health Outcomes Study","UNCPM 22314 - Evaluating the Safety of Pregnancy, Infant and Maternal Health Outcomes Among PrEP Users in Malawi","PrIMO","Inclusion Criteria:\n\nMaternal participants:\n\n* Confirmed pregnancy by urine pregnancy test or ultrasound.\n* Aged 15 years or older\n* PrEP-eligible by Malawi local guidelines\n* Confirmed HIV-negative based on the local HIV testing algorithm\n* Hepatitis B surface antigen (HBsAg) negative\n* Weight \\>35 kg\n* Provided informed consent and expressed willingness to participate in study activities with their infants.\n\nInfant participants: Infant participants will enter the study with their mother as unborn infants. There are no specific eligibility criteria for infant participation otherwise.\n\nExclusion Criteria:\n\nMaternal participants will not be eligible to enter the prospective cohort study if any of the following conditions are identified during the screening process:\n\n* Known to be living with HIV\n* Known allergies to CAB-LA, TDF\u002F3TC or FTC\u002FTDF\n* Other current significant disease process (active or chronic), substance use, or social circumstances that, in the judgment of the site investigator would make participation in the study unsafe.\n* Intention to leave the study site's catchment area of Bwaila before scheduled study exit.","FEMALE","15 Years","55 Years",{"count":58,"type":23},621,[60],"PHASE4","The primary purpose of this study is to assess the safety of long-acting injectable cabotegravir (CAB-LA) and oral pre-expose prophylaxis (PrEP) (FTC\u002FTDF or 3TC\u002FTDF) for the prevention of HIV during pregnancy and breastfeeding among pregnant women and their infants in Malawi. The main question the study aims to answer is:\n\n\\- Do composite adverse pregnancy events, maternal health outcomes, and\u002For infant health outcomes differ between individuals taking oral PrEP and those taking CAB-LA?\n\nWomen who are already using PrEP at the time of pregnancy diagnosis or those who initiate PrEP during pregnancy will enroll into a Safety Cohort where they will be closely followed up during pregnancy while optimizing their antenatal care (ANC) per the Malawi ANC package. Women will have access to either CAB-LA or oral PrEP and will be given an opportunity to choose one option. Women and their infants will attend a series of follow-up visits through pregnancy, birth, and the postnatal period.\n\nIn addition, the study will contribute to the development of a national PrEP Pregnancy Registry which will be initially rolled out in Lilongwe and Blantyre -the two most populous cities in Malawi-before a nationwide roll out begins under the guidance of the Malawi Ministry of Health.",[32,63,64],"HIV Prevention","Pregnancy Related",[66,67,68,69,70,71,72],"PrEP","Pregnancy","Breastfeeding","Infant health","HIV prevention","Maternal health","Eliminating mother-to-child transmission (EMTCT)","2026-05-01",{"date":75,"type":37},"2026-05-05",{"date":77,"type":37},"2024-04-17",{"date":79,"type":23},"2027-12",{"name":81,"class":44},"University of North Carolina, Chapel Hill",{"id":83,"slug":84,"hasResults":11,"nctId":85,"briefTitle":86,"officialTitle":87,"acronym":88,"eligibilityCriteria":89,"healthyVolunteers":17,"sex":18,"minAge":90,"maxAge":4,"enrollmentInfo":91,"targetDuration":4,"studyType":93,"phases":4,"briefSummary":94,"conditions":95,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":103,"completionDateStruct":105,"leadSponsor":107,"locationsCount":45},"100547451","universal-test-and-connect-for-hiv-service-delivery-in-south-africa-100547451","NCT06408142","Universal Test and Connect for HIV Service Delivery in South Africa","Universal Test and Connect for HIV Service Delivery in South Africa and Baltimore","UTC: SA","Inclusion Criteria for universal testing and connecting:\n\n* Patients attending the Emergency Department\n* Ages \\> or = 12 years old in South Africa\n* For subset that participate in PrEP choice trial, inclusion criteria will be to ensure that they meet PrEP eligibility criteria and do not have any contraindications to PrEP (kidney disease, acute HIV signs or symptoms, already taking PrEP).\n\nExclusion Criteria:\n\n* Patients unable to provide written informed consent - i.e., have a depressed level of consciousness (head trauma or concurrent alcohol\u002Fsubstance abuse), determined as critically ill (triage score of \"emergent\"), or\n* do not speak a language spoken by the study team (English, Afrikaans, and Xhosa).\n\nIn-depth interviews and surveys to providers:\n\nInclusion Criteria:\n\n* Nurses, physicians, or advanced practice providers (APPs) who work regularly in the Emergency Department at one of the clinical sites.\n* Consent to a recorded in-depth interview and\u002For Normalizing Process Theory (NPT) survey\n\nExclusion Criteria:\n\n* Providers who have already been interviewed (if working at both clinical sites)\n* Providers who do not consent to an interview or a survey.","12 Years",{"count":92,"type":23},2000,"OBSERVATIONAL","The goal of this study is to determine how many patients with HIV or at high risk of getting HIV attend the Emergency Department (ED) in South Africa (SA). The investigators will integrate HIV assessment in the ED and see how many people who would be a candidate for a drug that prevents HIV (PrEP). Universal test and connect (UTC) is a strategy that universally tests all patients and connects patients to long-term care, whether HIV positive or negative, including referrals for PrEP. The investigator's goal is to use UTC across two busy 24-hr EDs in Cape Town, SA.",[96,97,98,99],"Human Immunodeficiency Virus","Pre-Exposure Prophylaxis","Emergency Department","South Africa","2026-01-28",{"date":102,"type":37},"2026-01-30",{"date":104,"type":37},"2026-01-19",{"date":106,"type":23},"2027-12-01",{"name":108,"class":44},"Johns Hopkins University",{"id":110,"slug":111,"hasResults":11,"nctId":112,"briefTitle":113,"officialTitle":114,"acronym":4,"eligibilityCriteria":115,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":116,"enrollmentInfo":117,"targetDuration":4,"studyType":24,"phases":119,"briefSummary":120,"conditions":121,"keywords":4,"overallStatus":123,"whyStopped":4,"lastUpdateSubmitDate":124,"lastUpdatePostDateStruct":125,"startDateStruct":127,"completionDateStruct":129,"leadSponsor":131,"locationsCount":45},"100553535","intervention-to-reduce-implicit-bias-in-pharmacies-100553535","NCT06487351","Intervention to Reduce Implicit Bias in Pharmacies","The Impact of an Intervention to Reduce Pharmacists' Racial Bias Towards People of Color at Risk of HIV","Inclusion Criteria:\n\nThree types of participants will be included\n\n1. Pharmacy interns:\n\n   * Pharmacy intern (non-licensed individual undergoing training and preparations for licensure examination).\n   * Currently registered as a regular student in the School of Pharmacy, Bouvé College of Health Sciences at Northeastern University, Boston, MA.\n   * Doing the internship in pharmacies located in cities with the highest average annual rate of HIV infection diagnosis in Suffolk County, MA.\n   * Experience with PrEP (counsel PrEP candidates, complete PrEP continuing education activity, or awareness with current CDC guidelines on PrEP use) OR willingness to prescribe PrEP in the future (will be measured with one Yes\u002FNo question: \"Are you willing to prescribe PrEP in the future?)\n   * Moderate to high preference for White people as measured by the Implicit Association Test.\n2. Pharmacy managers\n\n   * Defined as an individual designated by a pharmacy owner to manage a pharmacy.\n   * Pharmacy managers of pharmacies located in the same areas described above.\n3. Pharmacy policymaker defined as official employee of the Boards of Registration in Pharmacy whose role is directly related to community pharmacy practice (e.g., director of pharmacy compliance).\n\nExclusion Criteria:\n\nInability to provide consent (e.g., intoxication), unwillingness to provide consent","65 Years",{"count":118,"type":23},70,[26],"This study will follow the ADAPT-ITT model to apply the Prejudice Habit Breaking Intervention (PHBI) to pharmacists who have experience with or are willing to prescribe PrEP. We will first collect qualitative data through focus group discussions guided by the Health Equity Implementation Framework (HEIF) on determinants related to the intervention itself, pharmacists, and the community pharmacy context that may impact implementation of the PHBI. Then, we will use this information to adapt the PHBI in an iterative process involving topic experts, pharmacists, and PrEP users. We will then determine the feasibility, acceptability, and preliminary impact of the adapted PHBI to reduce implicit racial bias.",[122,30,32],"Bias, Implicit","NOT_YET_RECRUITING","2025-11-08",{"date":126,"type":37},"2025-11-12",{"date":128,"type":23},"2027-07",{"date":130,"type":23},"2029-07",{"name":132,"class":44},"Massachusetts General Hospital",{"id":134,"slug":135,"hasResults":11,"nctId":136,"briefTitle":137,"officialTitle":138,"acronym":4,"eligibilityCriteria":139,"healthyVolunteers":17,"sex":140,"minAge":19,"maxAge":141,"enrollmentInfo":142,"targetDuration":4,"studyType":24,"phases":144,"briefSummary":145,"conditions":146,"keywords":147,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":150,"lastUpdatePostDateStruct":151,"startDateStruct":153,"completionDateStruct":155,"leadSponsor":157,"locationsCount":159},"100560400","thailand-hiv-and-stigma-reduction-study-100560400","NCT06576648","Thailand HIV and Stigma Reduction Study","Optimizing Mobile Interventions to Overcome Stigma and Promote HIV Prevention","Aim 1 (Formative Research and Beta-Testing) Transgender women\n\nInclusion Criteria:\n\n* Ages between 18 and 29 years\n* Male sex at birth\n* Self-identifies as women, transgender women or culturally identifies with the female spectrum\n* Laboratory-confirmed HIV-negative status\n* Self-reported recent history of condomless sex\n* Able to understand, read and speak Thai\n* Either not started PrEP or currently on PrEP but not adherent (taking ≤3 pills\u002Fweek) in the past month.\n\nExclusion Criteria:\n\n* Have a serious cognitive or psychiatric problem compromising ability to provide informed consent\n* Have active suicidal ideation or major mental illness at the time of interview (these patients will be referred for treatment)\n* Laboratory or clinical findings that would preclude PrEP initiation (e.g., decreased creatinine clearance)\n* Currently enrolled in another HIV intervention study.\n\nHealthcare providers Inclusion criteria\n\n* Age 18 or above\n* Has provided HIV prevention or treatment services for TGW for at least one year Exclusion criteria\n* None\n\nAim 2 (Pilot RCT) Transgender women Inclusion criteria\n\n* Ages between 18 and 29 years\n* Male sex at birth\n* Self-identifies as women, transgender women or culturally identifies with the female spectrum\n* Laboratory-confirmed HIV-negative status\n* Self-reported recent history of condomless sex\n* Able to understand, read and speak Thai\n* Either not started PrEP or currently on PrEP but not adherent (taking ≤3 pills\u002Fweek) in the past month.\n\nExclusion criteria\n\n* Have a serious cognitive or psychiatric problem compromising ability to provide informed consent\n* Have active suicidal ideation or major mental illness at the time of interview (these patients will be referred for treatment)\n* Laboratory or clinical findings that would preclude PrEP initiation (e.g., decreased creatinine clearance)\n* Currently enrolled in another HIV intervention study.","MALE","29 Years",{"count":143,"type":23},154,[26],"This project will develop a multi-component, technology-delivered intervention designed to reduce HIV and intersectional stigma and improve the use of HIV pre-exposure prophylaxis (PrEP) among HIV-negative Thai vulnerable emerging adults (18-29 years).",[97],[97,63,148,149],"mHealth","Stigma","2025-09-03",{"date":152,"type":37},"2025-09-08",{"date":154,"type":37},"2025-02-20",{"date":156,"type":23},"2027-08-14",{"name":158,"class":44},"University of Massachusetts, Worcester",3,{"id":161,"slug":162,"hasResults":11,"nctId":163,"briefTitle":164,"officialTitle":165,"acronym":166,"eligibilityCriteria":167,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":168,"targetDuration":4,"studyType":24,"phases":170,"briefSummary":171,"conditions":172,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":173,"lastUpdatePostDateStruct":174,"startDateStruct":176,"completionDateStruct":178,"leadSponsor":180,"locationsCount":45},"100451995","stick2prep-cisgender-women-and-trans-individuals-100451995","NCT05165745","Stick2PrEP Cisgender Women and Trans Individuals","Stick2PrEP Women\u002FTrans Individuals: Increasing Pre-Exposure Prophylaxis (PrEP) Uptake, Adherence, and Retention in Care, and Understanding PrEP Preferences Among Predominantly Black and Latinx Cisgender Women and Transgender Individuals","S2P:CWTI","Inclusion Criteria:\n\n* Cisgender women and trans individuals who have an indication for PrEP and have 1) decided to take PrEP, 2) decided not to take PrEP, or 3) decided to discontinue PrEP\n\nExclusion Criteria:\n\n* Cannot provide informed consent\n* Living with HIV",{"count":169,"type":23},175,[26],"Taking a daily anti-HIV pill can protect people from HIV infection. This is called preexposure prophylaxis \\[PrEP\\]. Many cisgender women and trans individuals do not know this medication is available; others struggle to take the pill every day. It is important to understand attitudes and preferences about HIV prevention options, especially as new options become available. This study plans to evaluate preferences over time among cisgender women and trans individuals who are taking medication to prevent HIV, and among cisgender women and trans individuals who are not taking medication but are at risk of HIV. The investigators enroll up to 175 participants who visit the HIV prevention clinic, and the investigators will ask participants to complete questionnaires at regular follow up visits and between visits. This study may help the investigators understand how best to prevent HIV among people at risk.",[63,32],"2025-08-25",{"date":175,"type":37},"2025-09-02",{"date":177,"type":37},"2021-10-25",{"date":179,"type":23},"2026-10-25",{"name":181,"class":44},"Columbia University",{"id":183,"slug":184,"hasResults":11,"nctId":185,"briefTitle":186,"officialTitle":187,"acronym":188,"eligibilityCriteria":189,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":190,"targetDuration":4,"studyType":24,"phases":192,"briefSummary":193,"conditions":194,"keywords":196,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":203,"lastUpdatePostDateStruct":204,"startDateStruct":206,"completionDateStruct":208,"leadSponsor":210,"locationsCount":45},"100528601","case-management-dyad-100528601","NCT06162897","Case Management Dyad","Implementation of a Triadic Network Case Management Intervention for Individuals Living With or Vulnerable to HIV","CM2","Gap in HIV or PrEP care access in the past 24 months, defined as a gap greater than 6 months or detectable viral load at least one time in the past 24 months\n\nSelf-reported financial or food insecurity",{"count":191,"type":23},180,[26],"The overall goal of this study is to test whether dyadic and focused case management will (1) improve financial wellbeing, (2) improve access to food, (3) increase linkage and retention rates for individuals living with HIV or those taking PrEP (PrEP persistence), and (4) increase the proportion of individuals living with HIV who are virally suppressed (viral suppression) when compared to routine Ryan White Non-Medical Case Management.",[30,32,195],"Case Management",[197,198,199,200,201,202],"linkage to care","viral suppression","case management","retention in care","financial wellbeing","food security","2025-07-09",{"date":205,"type":37},"2025-07-11",{"date":207,"type":37},"2022-09-09",{"date":209,"type":23},"2027-06-30",{"name":211,"class":44},"University of Chicago",{"id":213,"slug":214,"hasResults":11,"nctId":215,"briefTitle":216,"officialTitle":217,"acronym":4,"eligibilityCriteria":218,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":219,"targetDuration":4,"studyType":93,"phases":4,"briefSummary":221,"conditions":222,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":224,"lastUpdatePostDateStruct":225,"startDateStruct":227,"completionDateStruct":229,"leadSponsor":231,"locationsCount":45},"100519632","predictors-of-health-service-utilizations-among-key-population-in-washington-dc-100519632","NCT06046079","Predictors of Health Service Utilizations Among Key Population in Washington DC","A Mixed Methods Study of the Association Between LAI PrEP Initiation and Adherence, and Utilization of Health and Social Support Services Among Key Populations in Washington DC","Inclusion Criteria:\n\n* age of 18 years or above;\n* confirmed HIV-negative status;\n* residence in the Washington, DC metropolitan area;\n* one of the following PrEP profiles (PrEP naïve \\[no history of any PrEP use in the past\\] currently on daily oral PrEP or receiving LAI-PrEP).\n\nExclusion Criteria:\n\n* being younger than18 years of age\n* being unable to speak and\u002For read English\n* a reported residence outside of the defined Washington, DC metropolitan area\n* being unable or unwilling to provide written informed consent\n* being unable to comply with the requirements of the protocol (i.e. persons with mental health conditions, persons who are intoxicated or incoherent for other reasons)\n* evidence of suspected hepatoxicity",{"count":220,"type":23},100,"The primary objective of the proposed study is to investigate how PrEP use might result in an increase in the utilization of health and social services offered at a local community-based organization. Our primary hypothesis is that the investigators will observe higher utilization of sexual health (STI screenings), psychosocial health (psychotherapy, and substance use treatment) and other social services (emergency cash assistance, food pantry, transportation assistance, clothing,and housing resources) among PrEP users (LAI-PrEP or daily oral) compared to participants who are PrEP naïve over the 12-month follow-up period.",[32,30,223],"Health Behavior","2025-03-05",{"date":226,"type":37},"2025-03-10",{"date":228,"type":37},"2023-08-25",{"date":230,"type":23},"2026-01-01",{"name":232,"class":44},"Us Helping Us, People Into Living, Inc."]