[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"pre-hypertension\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:pre-hypertension":55},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,44,73,102],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100627816","the-effects-of-brief-periods-of-exercise-on-blood-pressure-100627816",false,"NCT07453550","The Effects of Brief Periods of Exercise on Blood Pressure","Inclusion Criteria:\n\n* 18-55 yrs.\n* 24 hour average BP \\>110\u002F70 mmHg, but \\\u003C 160 systolic blood pressure\n* Able to provide informed consent\n\nExclusion Criteria:\n\n* Currently taking anti-hypertensive medication smokers and alcohol drinkers Inability to undertake exercise intervention (resistance and isometric exercise)\n\nCurrent medical history of any of the following:\n\nhyperaldosteronism Diabetes mellitus (Type 1 or type 2) Heart disease Stroke or transient ischemic attack Peripheral neuropathy Aortic aneurysm and\u002For peripheral arterial disease If female, pregnancy or currently breast feeding Enrolled in another Clinical Trial of an Interventional Medicinal Product or Medical Device or other interventional study Medical condition that, in the opinion of the investigator, would make the participant unsuitable for the study On long term warfarin Allergies to blood pressure cuff materials or ultrasound gel\n\nPrevious medication history of any of the following:\n\nhyperaldosteronism Heart disease Stroke or transient ischemic attack Peripheral neuropathy Aortic aneurysm and\u002For peripheral arterial disease thromboembolism Infection within limb within 3 months On long term warfarin Allergies to blood pressure cuff materials or ultrasound gel",true,"ALL","18 Years","55 Years",{"count":20,"type":21},45,"ESTIMATED","INTERVENTIONAL",[24],"NA","High blood pressure is a common medical condition that affects the body's arteries. It's also called hypertension. Untreated hypertension increases the risk of heart attack, stroke and other serious health problems. Exercise is a promising tool in hypertension management. Regular participation in exercise improves vascular health, heart and lung function, and multisystem health. However, the direct evidence of the treatment effects of a brief period of exercise on blood pressure in individuals with hypertension is limited. A brief period of exercise refers to an exercise protocol that only lasts for a very short period of time, such as 5-10 minutes.",[27,28],"Hypertension (HTN)","Pre Hypertension",[30],"isometric exericse","RECRUITING","2026-04-27",{"date":34,"type":35},"2026-05-01","ACTUAL",{"date":37,"type":35},"2026-02-01",{"date":39,"type":21},"2027-06",{"name":41,"class":42},"University of Hartford","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":48,"acronym":4,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":16,"minAge":50,"maxAge":18,"enrollmentInfo":51,"targetDuration":4,"studyType":22,"phases":52,"briefSummary":53,"conditions":54,"keywords":56,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":43},"100633679","additional-effects-of-pilates-breathing-and-diaphragmatic-breathing-combined-with-moderate-intensity-continuous-treadmill-training-on-blood-pressure-chest-expansion-pulmonary-function-and-quality-of-life-in-pre-hypertensive-patients-100633679","NCT07529821","Additional Effects of Pilates Breathing and Diaphragmatic Breathing Combined With Moderate Intensity Continuous Treadmill Training on Blood Pressure, Chest Expansion, Pulmonary Function and Quality Of Life in Pre-hypertensive Patients","Inclusion Criteria:\n\n* Prehypertensive individuals (SBP 120-139 mmHg or DBP 80-89 mmHg)\n* Age 20-55 years\n* Both male and female\n* Sedentary individuals according to IPAQ\n* Willing to participate and provide informed consent\n\nExclusion Criteria:\n\n* Diagnosed hypertension (≥140\u002F90 mmHg)\n* Cardiopulmonary diseases (COPD, asthma, CAD, heart failure)\n* Musculoskeletal conditions preventing exercise\n* Neurological disorders\n* Pregnancy\n* Participation in structured exercise in last 3 months","20 Years",{"count":20,"type":21},[24],"Pre-hypertension is defined as systolic blood pressure between 120-139mmHg or diastolic blood pressure between 80-89mmHg and is considered a risk factor for developing hypertension. Early lifestyle interventions such as aerobic exercise and breathing techniques may help prevent progression to hypertension. This randomised controlled trial aims to determine the additional effects of pilates breathing and diaphragmatic breathing combined with moderate-intensity continuous treadmill training on blood pressure, chest expansion, pulmonary function and quality of life in pre-hypertensive patients.\n\nA total of 45 participants will be randomly allocated into three groups:\n\ntreadmill training with pilates breathing, tredmill training with diaphragmtic brething and treadmill training alone. The intervention will be conducted for 6 weeks. Outcome measures including blood pressure, pulmonary function, chest expansion and quality of life will be assesed before and after the intervention.",[55],"PRE-HYPERTENSION",[57,58,59,60,61,62,63],"Pre-hypertension","Pilates Breathing","Diaphragmatic Breathing","Treadmill training","Pulmonary Function","Chest expansion","Quality of life","2026-04-07",{"date":66,"type":35},"2026-04-14",{"date":68,"type":35},"2026-02-28",{"date":70,"type":21},"2026-05-15",{"name":72,"class":42},"Foundation University Islamabad",{"id":74,"slug":75,"hasResults":11,"nctId":76,"briefTitle":77,"officialTitle":78,"acronym":79,"eligibilityCriteria":80,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":81,"enrollmentInfo":82,"targetDuration":4,"studyType":22,"phases":84,"briefSummary":85,"conditions":86,"keywords":88,"overallStatus":91,"whyStopped":4,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":101},"100586619","breathing-exercises-of-cardiobreath-application-on-autonomic-and-vascular-function-in-hypertension-100586619","NCT06917729","Breathing Exercises of CardioBreath Application on Autonomic and Vascular Function in Hypertension","Responses on Arterial Stiffness and Cardiac Vagal Modulation to Breathing Exercises Through the Use of CardioBreath Application in Hypertension and Pre Hypertension; a Randomized Clinical Trial","CardioBreath","Inclusion Criteria:\n\n* BP\\>130mmHg X 80mmHg or previous medical diagnosis of pre- hypertension or hypertension\n\nExclusion Criteria:\n\n* use of beta-blockers\n* drugs that depress the central nervous system\n* clinical conditions that prevent participation after evaluation by the team\n* individuals without a cell phone or tablet (which would make the proposed study unfeasible","60 Years",{"count":83,"type":21},66,[24],"Hypertension is one of the greatest public health challenges, affecting more than one billion people worldwide and representing a significant financial and public health burden. It is responsible for a high number of cardiovascular events, such as heart attacks and strokes. Although pharmacological treatment is effective, non-pharmacological interventions are essential for the sustainable management of blood pressure, especially in its early stages. Respiratory exercises have shown potential in reducing blood pressure and improving cardiac vagal modulation, promoting cardiovascular health benefits.\n\nThis study aims to evaluate the effectiveness of guided respiratory exercises using the CardioBreath app in improving vagal modulation and reducing arterial stiffness in adults with prehypertension or hypertension over six weeks. This is a randomized clinical trial involving adults with prehypertension or hypertension, divided into intervention and control groups. The intervention group will use CardioBreath to perform daily breathing exercises, with weekly remote monitoring. Assessments will include heart rate variability parameters, baroreflex sensitivity, pulse wave velocity, and quality of life.\n\nIt is expected that the use of the app will significantly improve vagal modulation and arterial stiffness, demonstrating the potential of this intervention for the non-pharmacological management of hypertension. The use of CardioBreath may offer an accessible and effective alternative for blood pressure control, with the potential to be integrated into public health programs focused on low-cost, highly accessible interventions for the prevention and management of hypertension.",[87,28],"Hypertension",[87,89,90],"Breathing Exercises","Blood Pressure","NOT_YET_RECRUITING","2025-04-02",{"date":94,"type":35},"2025-04-08",{"date":96,"type":21},"2025-08-01",{"date":98,"type":21},"2027-09-20",{"name":100,"class":42},"Instituto de Cardiologia do Rio Grande do Sul",2,{"id":103,"slug":104,"hasResults":11,"nctId":105,"briefTitle":106,"officialTitle":107,"acronym":4,"eligibilityCriteria":108,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":109,"targetDuration":4,"studyType":22,"phases":111,"briefSummary":112,"conditions":113,"keywords":114,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":118,"lastUpdatePostDateStruct":119,"startDateStruct":121,"completionDateStruct":122,"leadSponsor":124,"locationsCount":43},"100544009","impact-of-sex-in-the-effect-of-dietary-capsaicin-on-cardiovascular-health-100544009","NCT06363305","Impact of Sex in the Effect of Dietary Capsaicin on Cardiovascular Health","Impact of Sex in the Effect of Dietary Capsaicin on Cardiovascular Health: A Randomized Controlled Trial","Inclusion Criteria:\n\n* relatively healthy (other than elevated blood pressure) non-smoking men and women over the age of 18 from the local community\n\nExclusion Criteria:\n\n* Women who are without a period (not due to a birth control method, intrauterine device or menopause), are pregnant, attempting to conceive, or are breastfeeding will be excluded.\n* uncontrolled hypertension\n* Anyone with severe illness or compromised or suppressed immune system (e.g. taking immune suppressants, chronic viral infection or treatment).\n* Any participants with excessive sensitivity to spicy foods or fiber (psyllium husk) will be excluded\n* Participants with food allergies will be excluded\n* Participants who have difficulty swallowing or swallowing pills may be excluded.\n* Participants who suffer from heartburn, hiatal hernia, gastritis, or peptic ulcer disease may be excluded.",{"count":110,"type":21},80,[24],"The investigators long-term goal is to better understand novel interventions to promote cardiovascular health in humans. The goal of the proposed research is to investigate whether there is sex-specificity in the effects of dietary capsaicin on mechanisms regulating nitric oxide (NO) bioavailability, its effect on key markers of cardiovascular (CV) health, including BP, macro- and microvascular function, and arterial stiffness. This knowledge will provide critical insight into the effects of dietary capsaicin on CV health and will guide future trials.",[28,87],[115,116,117],"vascular stiffness","blood pressure","vascular function","2024-07-08",{"date":120,"type":35},"2024-07-10",{"date":118,"type":35},{"date":123,"type":21},"2025-12-31",{"name":125,"class":42},"Skidmore College"]