[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"precancerous-condition\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:precancerous-condition":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,42,74],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100638801","noninvasive-early-diagnosis-of-colorectal-cancer-using-odor-targeted-capture-point-of-care-testing-and-intelligent-analysis-100638801",false,"NCT07620743","Noninvasive Early Diagnosis of Colorectal Cancer Using Odor-Targeted Capture, Point-of-Care Testing, and Intelligent Analysis","Key Technology Research on Non-invasive Early Diagnosis of Colorectal Cancer Based on Odor-targeted Capture, Instant Detection, and Intelligent Analysis","Inclusion Criteria:\n\n* Age 18 to 85 years, male or female\n* Histopathologically or cytologically confirmed colon or rectal cancer (TNM stage I-IV) for colorectal cancer group\n* Histopathologically confirmed adenomatous polyps, sessile serrated lesions, traditional serrated adenomas, or other precancerous lesions for precancerous lesion group\n* No abnormality on colonoscopy within the past year; no personal history of colorectal cancer or other malignancies; no chronic diseases requiring long-term treatment for healthy control group\n* Willing and able to provide signed informed consent\n\nExclusion Criteria:\n\n* Hereditary colorectal cancer syndromes (e.g., familial adenomatous polyposis, hereditary non-polyposis colorectal cancer)\n* Autoimmune diseases (e.g., systemic lupus erythematosus, rheumatoid arthritis)\n* Severe cardiovascular, respiratory, or urinary system diseases\n* Other primary malignant tumors\n* Hematological diseases\n* Unable to comply with study procedures (e.g., sample collection or questionnaires)\n* Planning to become pregnant, pregnant, or breastfeeding\n* Suspected or confirmed alcohol or drug abuse\n* Known allergy to any drug used for colorectal cancer treatment\n* Participation in another interventional drug clinical trial within the past month\n* Any other condition that, in the investigator's judgment, makes the participant unsuitable for the study",true,"ALL","18 Years","85 Years",{"count":21,"type":22},453,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to see whether a new, noninvasive test that analyzes smells (odor) from breath and intestinal gas can help detect colorectal cancer and precancerous growths at an early stage.\n\nThe main questions it aims to answer are:\n\nCan the new odor-based test correctly identify people who have colorectal cancer or precancerous lesions?\n\nHow accurate is the new test compared to the current standard method (colonoscopy with biopsy)?\n\nResearchers will compare the results of the new test with standard diagnostic results.\n\nParticipants will be asked to:\n\nProvide samples of breath, urine, stool, and intestinal gas (collected using a special device or a collection bag)\n\nAllow researchers to review their medical records and colonoscopy results\n\nAnswer questions about their health history and lifestyle\n\nThis study involves no treatments or procedures beyond normal medical care. It only collects samples and data for research purposes.",[26,27,28],"CRC","Precancerous Condition","Healthy","NOT_YET_RECRUITING","2026-05-29",{"date":32,"type":33},"2026-06-02","ACTUAL",{"date":35,"type":22},"2026-06-10",{"date":37,"type":22},"2029-12-31",{"name":39,"class":40},"Beijing University of Chinese Medicine","OTHER",1,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":4,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":49,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":51,"conditions":52,"keywords":57,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":73},"100125361","gastrointestinal-biomarkers-in-tissue-and-biological-fluid-samples-from-colorectal-cancer-patients-100125361","NCT00899626","Gastrointestinal Biomarkers in Tissue and Biological Fluid Samples From Colorectal Cancer Patients","Novel Colon Cancer Markers in Gastrointestinal Tissue and Biofluids","DISEASE CHARACTERISTICS:\n\n* Undergoing colonoscopy or endoscopy for diagnostic or screening purposes at the Vanderbilt University Medical Center or at the Veterans Affairs Medical Center AND\n* Meets 1 of the following criteria:\n\n  * Diagnosis of gastrointestinal (GI) cancer, polyps, or inflammatory bowel disease\n  * History of previously treated GI cancer, polyps, or inflammatory bowel disease\n\nPATIENT CHARACTERISTICS:\n\n* Capable of giving informed consent\n* Not mentally or medically impaired\n* No bleeding disorder\n\nPRIOR CONCURRENT THERAPY:\n\n* See Disease Characteristics",{"count":50,"type":22},5000,"RATIONALE: Studying samples of tissue, blood, urine, stool, and other biological fluids from patients with cancer and from healthy volunteers undergoing colonoscopy or endoscopy may help doctors identify and learn more about biomarkers related to cancer.\n\nPURPOSE: This research study is looking at gastrointestinal biomarkers in tissue and biological fluid samples from patients and participants undergoing colonoscopy, endoscopy, or surgery.",[53,54,55,56,27],"Colorectal Cancer","Esophageal Cancer","Gastric Cancer","Pancreatic Cancer",[58,59,60,61,62],"colon cancer","gastric cancer","pancreatic cancer","esophageal cancer","adenomatous polyp","RECRUITING","2026-03-02",{"date":66,"type":33},"2026-03-05",{"date":68,"type":4},"2002-06",{"date":70,"type":22},"2045-10",{"name":72,"class":40},"Vanderbilt University Medical Center",2,{"id":75,"slug":76,"hasResults":11,"nctId":77,"briefTitle":78,"officialTitle":79,"acronym":4,"eligibilityCriteria":80,"healthyVolunteers":11,"sex":17,"minAge":81,"maxAge":82,"enrollmentInfo":83,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":85,"conditions":86,"keywords":89,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":103,"lastUpdatePostDateStruct":104,"startDateStruct":106,"completionDateStruct":108,"leadSponsor":110,"locationsCount":41},"100125416","biomarkers-in-patients-with-respiratory-tract-dysplasia-or-lung-cancer-head-and-neck-cancer-or-aerodigestive-tract-cancer-and-in-normal-volunteers-100125416","NCT00900419","Biomarkers in Patients With Respiratory Tract Dysplasia or Lung Cancer, Head and Neck Cancer, or Aerodigestive Tract Cancer and in Normal Volunteers","Biomarkers and Dysplastic Respiratory Epithelium","Inclusion Criteria:\n\n* Diagnosis of extensive and severe dysplasia of the respiratory epithelium\n* Those without dysplasia of the respiratory epithelium\n\n  * Recruited from the SPORE Tissue Procurement Screening Project or by private or academic physicians (for patients with moderate or severe dysplasia)\n* Survived 1 or more aerodigestive system carcinoma for ≥ 1 year\n* Completely resected stage I non-small cell cancer\n* Undergoing any of the following procedures:\n\n  * Routine panendoscopy for patients with head and neck cancer\n  * Resection of a bronchogenic carcinoma\n  * Bronchoscopy for diagnosis or staging of suspected lung cancer\n  * Subsequent bronchoscopy for surveillance or monitoring of response to endobronchial treatment in patients with prior high-grade dysplasia or worse\n  * No asthma\n  * No lung disease\n  * No respiratory illness within the past 2 weeks Patients suspected of or at risk for neoplastic lung disease who are undergoing a bronchoscopy in which differential diagnostic considerations may include multiple other etiologies such as infection and other processes.\n  * Patients without dysplasia will be: patients undergoing clinically indicated bronchoscopy for conditions other than suspected lung cancer.\n\nPATIENT CHARACTERISTICS:\n\n* No clinically apparent bleeding diathesis\n* No known bleeding disorder\n* No anginal\n* No clinically active coronary artery disease\n* No multifocal premature ventricular contractions\n* No poorly controlled congestive heart failure\n* No myocardial infarction within the past 6 weeks\n* No cardiac dysrhythmia that is potentially life threatening\n* Well-controlled atrial fibrillation or rare (\\\u003C 2\u002Fmin) premature ventricular contractions allowed\n* No ventricular tachycardia or supraventricular tachycardia with a rapid ventricular response\n* No other serious medical condition that would preclude a patient from undergoing a bronchoscopy\n* No acute bronchitis or pneumonia within the past 8 weeks except when clinically proven as a possible result of lung cancer\n* No hypoxemia (i.e., \\\u003C 90% saturation with supplemental oxygen) before bronchoscopy\n\nPRIOR CONCURRENT THERAPY:\n\n* See Disease Characteristics","21 Years","90 Years",{"count":84,"type":22},700,"RATIONALE: Studying samples of sputum and tissue in the laboratory from patients with dysplasia or cancer may help doctors identify and learn more about biomarkers related to cancer. It may also help the study of cancer in the future.\n\nPURPOSE: This laboratory study is looking at biomarkers in patients with respiratory tract dysplasia or lung cancer, head and neck cancer, or aerodigestive tract cancer.",[54,87,88,27],"Head and Neck Cancer","Lung Cancer",[90,91,92,93,94,95,96,97,98,99,100,61,101,102],"non-small cell lung cancer","small cell lung cancer","squamous lung dysplasia","hypopharyngeal cancer","laryngeal cancer","lip and oral cavity cancer","metastatic squamous neck cancer with occult primary","nasopharyngeal cancer","oropharyngeal cancer","paranasal sinus and nasal cavity cancer","salivary gland cancer","pulmonary carcinoid tumor","tongue cancer","2025-09-16",{"date":105,"type":33},"2025-09-22",{"date":107,"type":33},"2001-05-03",{"date":109,"type":22},"2027-09-30",{"name":111,"class":40},"University of Colorado, Denver"]