[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"precocious-puberty\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:precocious-puberty":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,45,72,106,143],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":5},"100643082","clinical-study-of-traditional-chinese-medicine-in-the-treatment-of-phlegm-dampness-intrinsic-precocious-puberty-100643082",false,"NCT07637019","Clinical Study of Traditional Chinese Medicine in the Treatment of Phlegm-dampness Intrinsic Precocious Puberty","A Multicenter, Randomized, Double-Blind, Placebo-Controlled Clinical Trial to Evaluate the Efficacy and Safety of Sanghe Jianghuo Granules in the Treatment of Girls Aged 5-8.5 Years With Precocious Puberty and Phlegm-Dampness Internal Accumulation Syndrome According to Traditional Chinese Medicine","SHJG-PP","Inclusion Criteria:\n\n1. Female, aged between 5 and 9 years (inclusive).\n2. Presence of secondary sexual characteristics before 8 years of age, consistent with simple premature thelarche \u002F initial central precocious puberty (CPP) \u002F Tanner stage II.\n3. Traditional Chinese Medicine (TCM) syndrome differentiation: Phlegm-dampness internal accumulation syndrome.\n4. Body mass index (BMI) greater than the 50th percentile for same age and sex.\n5. Initial case, no prior medication for precocious puberty (including but not limited to GnRHa, sex hormones, growth hormones, Zhibai Dihuang Wan, Dabuyin Wan, or traditional Chinese weight-loss medicines) within the last 3 months.\n6. Informed consent signed by the legal guardian(s), with ability to comply with the follow-up schedule.\n\nExclusion Criteria:\n\n1. Secondary precocious puberty due to central nervous system organic lesions, thyroid or adrenal disorders, ovarian tumors, or other underlying conditions.\n2. Severe hepatic or renal dysfunction, or hematological diseases.\n3. Use of sex hormones, growth hormones, Zhibai Dihuang Wan, Dabuyin Wan, or traditional Chinese weight-loss medicines within the last 3 months.\n4. Inability to cooperate with examinations or poor compliance with follow-up visits (e.g., inability to complete ultrasound, blood collection, or scheduled visits).","FEMALE","5 Years","9 Years",{"count":21,"type":22},200,"ESTIMATED","INTERVENTIONAL",[25],"NA","Precocious puberty is characterized by the premature appearance of secondary sexual characteristics. Globally, the timing of puberty onset in children has shown a certain tendency to advance. In China, the incidence of precocious puberty has been increasing year by year. Precocious puberty exerts long-term and systemic impacts on children's health: advanced bone age leads to short stature; earlier sexual development than peers may induce emotional problems such as anxiety and inferiority; it may increase the risk of obesity and type 2 diabetes, posing long-term hazards to cardiovascular health; it may also result in irregular menstruation or dysmenorrhea, exerting indirect effects on reproductive health.\n\nModern traditional Chinese medicine (TCM) holds that: various factors lead to liver-kidney yin deficiency, hyperactivity of ministerial fire, and early arrival of tian gui (the substance responsible for promoting growth, development and reproduction), thereby triggering premature sexual development. The main syndrome types identified in clinical practice include yin deficiency with fire hyperactivity syndrome, liver stagnation transforming into fire syndrome, and phlegm-dampness internal accumulation syndrome.\n\nSince the late 1970s, the investigators' department has taken the lead in treating precocious puberty with TCM diagnostic methods, proposing that the pathogenesis of precocious puberty lies in \"kidney yin deficiency and hyperactivity of ministerial fire\", and adopting the therapy of nourishing yin and purging fire for its treatment. A number of studies have confirmed that TCM medicines with the effects of nourishing yin and purging fire can effectively alleviate the yin deficiency with fire hyperactivity syndrome in children, delay the development of secondary sexual characteristics and bone age.\n\nAt present, central precocious puberty is mostly treated with gonadotropin-releasing hormone analogs (GnRHa). However, this treatment has the drawback of inhibiting the growth axis, yielding limited benefits for children with advanced bone age, overweight or obesity, and may even affect glucose and lipid metabolism. Moreover, some children with precocious puberty complicated with obesity may be intolerant to this therapy. In contrast, TCM therapy and integrated TCM-Western medicine therapy can effectively delay the development of secondary sexual characteristics and advanced bone age, and improve final adult height, thus being widely applied in China.\n\nAlthough a large number of relevant studies have been reported in recent years and TCM diagnosis and treatment guidelines for precocious puberty have been formulated, there is still a lack of high-quality evidence-based medical research to support the advantageous aspects of integrated TCM-Western medicine diagnosis and treatment. Additionally, the underlying mechanisms of diagnosis and treatment for different syndrome types of precocious puberty remain insufficiently studied.\n\nIn this study, the investigators will conduct a multicenter, randomized, double-blind, placebo-controlled clinical trial to evaluate the effects of Sanghe Jianghuo Granules on the regulation of the hypothalamic-pituitary-gonadal (HPG) axis, metabolic homeostasis and inflammatory microenvironment, so as to verify its efficacy and safety. Furthermore, combined with transcriptomics, proteomics and network pharmacology, the investigators will identify the key targets and action pathways of Sanghe Jianghuo Granules, and verify its regulatory effect on the HPG axis through in vivo and in vitro experiments.",[28],"Precocious Puberty",[28,30,31,32],"Sanghe Jianghuo Granules","Traditional Chinese Medicine","Phlegm-Dampness Syndrome","NOT_YET_RECRUITING","2026-06-04",{"date":36,"type":37},"2026-06-09","ACTUAL",{"date":39,"type":22},"2026-07-01",{"date":41,"type":22},"2028-06-30",{"name":43,"class":44},"Children's Hospital of Fudan University","OTHER",{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":4,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":17,"minAge":52,"maxAge":19,"enrollmentInfo":53,"targetDuration":4,"studyType":23,"phases":55,"briefSummary":57,"conditions":58,"keywords":4,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":71},"100555336","phase-3-a-trial-of-chinese-traditional-medicine-combining-with-intradermal-acupuncture-for-treating-precocious-puberty-100555336","NCT06510764","A Trial of Chinese Traditional Medicine Combining With Intradermal Acupuncture for Treating Precocious Puberty","A Randomized Controlled Trial of Ziyin-Xiehuo Chinese Medicine Herbs Combined With Intradermal Acupuncture for the Treatment of Girl's Idiopathic Precocious Puberty With Yin Deficiency and Fire Hyperactivity","Inclusion Criteria:\n\n* Girls are diagnosed as Idiopathic precocious puberty, and their age of onset ≤7.5years;\n* Tanner stages of breast in female patients ≤ Tanner III stage, diameters of mammillary nucleus ≤ 3cm; •B-type ultrasonography: the volume of uterus≥ 3ml, the volume of ovary≥1.5ml, the diameter of follicle≥4mm;\n* Bone age: compared the chronological age, the bone age is less than 1 year and the bone age \\\u003C10 years old;\n* No GnRH analogs or Sex hormones were administrated in the past; and All above are needed at the same time.\n\nExclusion Criteria:\n\n* Precocity caused by the central nervous system organic diseases;\n* Precocious precocity caused by congenital hypothyroidism, congenital adrenal hyperplasia, adrenal tumor and ovarian or testicular neoplasms as well as McCune-Albright syndrome, etc;\n* Precocious precocity with a family history of diseases such as tumor, leukemia, diabetes, systemic lupus erythematous;\n* Pseudo sexual precocity and partial precocious puberty.","4 Years",{"count":54,"type":22},170,[56],"PHASE3","A randomized controlled study will be conducted to evaluate the therapeutic effect of traditional Chinese medicine and acupoints stimulation on children with idiopathic precocious puberty.",[28,59,60,61],"Treatment","Alternative Medicine","Acupuncture","RECRUITING","2026-03-13",{"date":65,"type":37},"2026-03-16",{"date":67,"type":37},"2024-09-15",{"date":69,"type":22},"2027-07-01",{"name":43,"class":44},2,{"id":73,"slug":74,"hasResults":11,"nctId":75,"briefTitle":76,"officialTitle":77,"acronym":4,"eligibilityCriteria":78,"healthyVolunteers":11,"sex":79,"minAge":80,"maxAge":81,"enrollmentInfo":82,"targetDuration":4,"studyType":84,"phases":4,"briefSummary":85,"conditions":86,"keywords":91,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":105},"100537667","observation-of-environment-and-reproductive-endocrine-effects-100537667","NCT06280807","Observation of Environment and Reproductive-Endocrine Effects","OBServation of Environment and ReproductiVe Endocrine Effects Study (OBSERVE Study)","* INCLUSION CRITERIA:\n\nIn order to be eligible to participate in this study, an individual must meet all of the following criteria:\n\n1. Male or female, referring to sex assigned at birth (cis gender)\n2. Age \\> 8 years and weight \\>= 12 kg\n3. A diagnosis of hypogonadism, infertility or other reproductive dysfunction\n\n   Some specific diagnoses (as defined in standard guidelines) will include:\n   * Male or female hypogonadism\n\n     * Obesity\u002Fmetabolic syndrome related to hypogonadism.\n     * Other reproductive dysfunction (e.g., secondary to endocrine dysfunction, thyroid disorders, Cushing syndrome, pharmacotherapy, etc.)\n     * Premature Ovarian Insufficiency\n     * Isolated hypogonadotropic hypogonadism\n   * Polycystic Ovarian Syndrome\n   * Delayed Puberty\n   * Precocious puberty\n   * Perimenopause and post-menopausal states\n   * Androgen Excess States (Nonclassic Congenital Adrenal Hyperplasia, Extreme hyperinsulism, Idiopathic etc.)\n\n   or\n\n   -Exhibiting signs of a diagnosis of hypogonadism, e.g., Bosma arrhinia microphthalmia syndrome (BAMS)\n4. Ability of participant, legal guardian, or Legally Authorized Representative (LAR) to understand and the willingness to sign a written informed consent document.\n\nEXCLUSION CRITERIA:\n\nAn individual who meets any of the following criteria will be excluded from participation in this study:\n\n1. A diagnosis of a serious medical disorder such as malignancy or heart disease will be grounds for exclusion at the discretion of the PI or AI.\n2. Inability to follow up with the research study and\u002For perform study procedures, at the discretion of the PI or AI.\n3. Pregnant participants, less than 18 years of age, for their safety, since there is not a trained doctor on the study to give proper medical care to pregnant individuals less than 18 years of age.\n\nIndividuals who do not meet the criteria for participation in this study (screen failure) because of an acute, reversible or transient medical reason may be rescreened upon reversal, improvement or stabilization of their clinical status. Participants who develop an acute, reversible or transient medical condition during the study may return upon reversal, improvement or stabilization of their clinical status.","ALL","8 Years","99 Years",{"count":83,"type":22},300,"OBSERVATIONAL","Background:\n\nEndocrine disorders occur when the glands that make hormones do not work properly. Hormones levels that are too high or too low can cause problems such as late or early puberty, irregular periods, and infertility. Environmental factors - including pollution; chemical exposure at home and work; foods; medicines; and sleep habits - may cause problems with the endocrine and reproductive systems.\n\nObjective:\n\nTo learn how environmental factors may affect the endocrine and reproductive systems.\n\nEligibility:\n\nMales or females, referring to sex assigned at birth, aged 8 years and older; they must have hypogonadism, infertility, or other reproductive disorders.\n\nDesign:\n\nAdult participants will have 4 to 5 visits in 5 years. Children may have up to 12 visits; they may remain in the study up to the age of 23. Most visits will be less than 3 hours.\n\nParticipants will be screened. They will have a physical exam. They will have blood and urine tests. They will complete questionnaires; they will answer questions about their diet, health, and other topics. Some may be referred for additional tests, such as imaging scans and semen analysis.\n\nSpecific tests conducted during study visits will vary, depending on the participant s diagnosis. In addition to repeated blood and urine tests, these may include:\n\nBody composition measure: Participants will sit in a pod-shaped machine for about 6 minutes. The machines measures the air inside the capsule to record body fat and breathing volume.\n\nResting energy expenditure test: Participants will lie down with a clear dome placed over their head. They will breathe quietly for 30 minutes. This test measures the number of calories their body burns at rest.\n\n...",[87,88,28,89,90],"Hypogonadism","Hypergonadism","Late Puberty","Amenorrhea",[92,93,94],"Endocrine","Reproductive Disorders","Hypothalamic-Pituitary-Gonadal Endocrine Axis","2025-12-20",{"date":97,"type":37},"2025-12-23",{"date":99,"type":37},"2024-07-01",{"date":101,"type":22},"2039-03-31",{"name":103,"class":104},"National Institute of Environmental Health Sciences (NIEHS)","NIH",1,{"id":107,"slug":108,"hasResults":11,"nctId":109,"briefTitle":110,"officialTitle":111,"acronym":4,"eligibilityCriteria":112,"healthyVolunteers":113,"sex":79,"minAge":4,"maxAge":4,"enrollmentInfo":114,"targetDuration":4,"studyType":84,"phases":4,"briefSummary":116,"conditions":117,"keywords":125,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":134,"lastUpdatePostDateStruct":135,"startDateStruct":137,"completionDateStruct":139,"leadSponsor":141,"locationsCount":105},"100178744","genetics-of-reproductive-disorders-including-kallmann-syndrome-and-cleft-lip-andor-palate-100178744","NCT01601171","Genetics of Reproductive Disorders (Including Kallmann Syndrome) and Cleft Lip and\u002For Palate","The Genetics of Neuroendocrine Reproductive Disorders and of the Cleft Lip and\u002For Palate","Inclusion Criteria:(any of the following conditions)\n\n* hypogonadotropic hypogonadism\n* Kallmann syndrome\n* adult-onset hypogonadotropic hypogonadism\n* hypothalamic amenorrhea\n* polycystic ovarian syndrome\n* primary gonadal failure\n* precocious puberty\n* cleft lip\u002Fpalate\n* family members of the above groups\n\nExclusion Criteria:\n\n* acute illness\u002Fhospitalization\n* pituitary tumors\n* iron overload (hemochromatosis)\n* infiltrative diseases (sarcoidosis)\n* chronic alcohol abuse\n* illicit drug use\n* anabolic steroid abuse",true,{"count":115,"type":22},2000,"The purpose of this study is to explore the genetic basis of reproductive disorders and cleft lip and\u002For palate.",[118,119,120,121,28,122,123,124],"Kallmann Syndrome","Hypogonadotropic Hypogonadism","Hypothalamic Amenorrhea","Polycystic Ovarian Syndrome","Cleft Lip and Palate","Cleft Palate","Cleft Lip",[126,127,128,129,130,131,132,133],"GnRH deficiency","hypogonadism","anosmia","infertility","cleft lip","cleft palate","cryptorchidism","microphallus","2022-06-17",{"date":136,"type":37},"2022-06-21",{"date":138,"type":4},"2012-03",{"date":140,"type":22},"2030-03",{"name":142,"class":44},"Centre Hospitalier Universitaire Vaudois",{"id":144,"slug":145,"hasResults":11,"nctId":146,"briefTitle":147,"officialTitle":148,"acronym":4,"eligibilityCriteria":149,"healthyVolunteers":11,"sex":79,"minAge":150,"maxAge":151,"enrollmentInfo":152,"targetDuration":4,"studyType":84,"phases":4,"briefSummary":154,"conditions":155,"keywords":157,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":162,"lastUpdatePostDateStruct":163,"startDateStruct":165,"completionDateStruct":167,"leadSponsor":169,"locationsCount":105},"100371184","overweight-and-obesity-and-puberty-development-cohort-study-100371184","NCT04113070","Overweight and Obesity and Puberty Development Cohort Study","The Effect of Childhood Overweight and Obesity and Genetic Factors on Puberty Development: a Prospective Cohort Study","Inclusion Criteria:\n\n* Children over 6 years old from grade 1, 2 and 3 in selected primary schools in Zhongshan, Qufu and Huhhot since 2019\n\nExclusion Criteria:\n\n* Children with overweight or obesity had a history of hormone drug treatment last for 6 months","6 Years","12 Years",{"count":153,"type":22},14100,"Precocious puberty and childhood overweight and obesity are important public health problems that both had adverse effects, which including psychological symptom in childhood, short final height or reproductive dysfunction in adulthood, on children's physical and psychological development.The prevalence of precocious puberty and childhood overweight and obesity are both high, and a growing body of epidemiological studies suggested that there was a close relationship of childhood overweight and obesity with puberty development, especially in girls. However, the underlying mechanism between them is unclear. Existing evidence shows that the occurrence of precocious puberty and overweight and obesity are the result of interaction of multiple factors, which consists growth environment and genetics, and many previous studies provided that more overlapping genes existed between obesity and precocious puberty patients, suggesting that common genes may result in these diseases. Therefore, based on a case control study, which will investigate the associations between obesity pleiotropic genes and early puberty, the researchers will collect information related to obesity, growth environment factors and risk genes in this study to evaluate the relationships of these related factors and precocious puberty, and to further explore whether there exists biological interaction effects of these risk factors on sexual precocity. This project has been approved by the Ethics Committee of Shanghai Children's Medical Center.",[28,156],"Overweight and Obesity",[158,159,160,161],"Child health care","Weight status","Environment","puberty","2020-02-03",{"date":164,"type":37},"2020-02-05",{"date":166,"type":37},"2019-10-11",{"date":168,"type":22},"2026-12-30",{"name":170,"class":44},"Shanghai Jiao Tong University School of Medicine"]