[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"prefrail-elderly\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:prefrail-elderly":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,50,80],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100619620","non-invasive-brain-stimulation-on-functional-capacity-in-prefrail-older-adults-100619620",false,"NCT07346989","Non-invasive Brain Stimulation on Functional Capacity in Prefrail Older Adults","Effectiveness of Non-invasive Brain Stimulation on Functional Capacity in Prefrail Older Adults","NeuroFit","Inclusion Criteria:\n\n* Age between 65 -90 years old\n* Meet 1-2 frailty criteria, according to Fried's Criteria.\n* Ability to understand instructions (Mini-Mental State Examination \\>23 points).\n* Signing of the informed consent.\n\nExclusion Criteria:\n\n* History of stroke within the past 6 months or hospital admission for any reason within the past 3 months.\n* Alterations of the central or peripheral nervous system\n* Alterations of the vestibular system\n* Concomitant diseases\n* Have a neurological pathology, cardiovascular musculoskeletal that contraindicates physical activity\n* Epilepsy or history, medications that lower the seizure threshold\n* Cardiac pacemaker, endocranial and hearing implants\n* History of severe headaches\n* Uncontrolled intracranial or arterial hypertension\n* Heart and\u002For respiratory failure\n* Implanted medication pump\n* Skin lesions (psoriasis, eczema)\n* Serious head surgeries\n* Completing less than 80% of training sessions","ALL","65 Years","90 Years",{"count":21,"type":22},120,"ESTIMATED","INTERVENTIONAL",[25],"NA","The general objective of this study is to evaluate the effectiveness of non-invasive neuromodulation combined with a therapeutic exercise program on neuroplasticity and, therefore, on variables related to functional capacity and quality of life, in prefrail older adults.",[28],"Prefrail Elderly",[30,31,32,33,34,35,36],"Prefrail","Non-invasive neuromodulation","TMS","TDCS","Virtual running","Functional capacity","Elderly","RECRUITING","2026-06-22",{"date":40,"type":41},"2026-06-25","ACTUAL",{"date":43,"type":41},"2026-01-15",{"date":45,"type":22},"2028-07",{"name":47,"class":48},"University of Valencia","OTHER",1,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":54,"acronym":4,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":17,"minAge":56,"maxAge":4,"enrollmentInfo":57,"targetDuration":4,"studyType":23,"phases":59,"briefSummary":60,"conditions":61,"keywords":65,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":75,"completionDateStruct":76,"leadSponsor":78,"locationsCount":4},"100628162","comparson-of-the-effcacy-of-conventonal-exercse-and-plates-n-pre-fral-and-fral-older-adults-100628162","NCT07458048","Comparıson of the Effıcacy of Conventıonal Exercıse and Pılates ın Pre-fraıl and Fraıl Older Adults","Inclusion Criteria:\n\n* Age 60 years and older Classified as prefrail or frail according to the FRAIL Scale A score of 24 or higher on the Mini-Mental State Examination (MMSE) Provided written informed consent after being informed about the study\n\nExclusion Criteria:\n\nPresence of unstable cardiovascular disease Having received physical therapy and rehabilitation within the past 6 months History of severe neurological disorders History of major surgery affecting mobility within the past 6-12 months Severe musculoskeletal or orthopedic conditions that limit or preventt independent mobility.\n\n\\-","60 Years",{"count":58,"type":22},40,[25],"Brief Summary\n\nThis clinical study aims to compare the effects of a conventional exercise program and a Pilates exercise program in prefrail and frail older adults. A total of 40 participants aged 60 years and older who are classified as prefrail or frail according to the FRAIL Scale will be included in the study.\n\nParticipants will be randomly assigned to either the conventional exercise group or the Pilates group. Both exercise programs will be conducted twice weekly for 6 weeks. The interventions will focus on stretching exercises, balance and perturbation training, and strength exercises targeting major muscle groups.\n\nPrimary outcomes will include changes in frailty status assessed before and after the intervention. Secondary outcomes will include functional mobility and balance assessed by the Timed Up and Go Test, dynamic balance assessed by the Functional Reach Test, lower extremity strength assessed by the 30-Second Sit-to-Stand Test, gait speed assessed by the 10-Meter Walk Test, depressive symptoms and psychological well-being assessed by the Yesavage Geriatric Depression Scale, independence in daily activities assessed by the Lawton Instrumental Activities of Daily Living Scale, cognitive status assessed by the Mini-Mental State Examination, and fatigue assessed by the Modified Borg Scale. Frailty status will be evaluated using the FRAIL Scale.\n\nThroughout the study, participant safety will be monitored, and any adverse events, such as injuries or discomfort occurring during exercise sessions, will be recorded and managed appropriately.\n\nThis study is expected to provide valuable clinical evidence regarding the effectiveness of conventional exercise and Pilates programs in improving physical health and reducing frailty in prefrail and frail older adults, thereby contributing to the identification of best practice approaches for the management of this vulnerable population.",[62,28,63,64],"Frailty Syndrome","Frail Elderly","Geriatric",[66,67,68,69,70,71],"Pilates","geriatric","conventional","frailty","exercises","prefrail","NOT_YET_RECRUITING","2026-06-20",{"date":40,"type":41},{"date":38,"type":22},{"date":77,"type":22},"2027-02",{"name":79,"class":48},"Istanbul University - Cerrahpasa",{"id":81,"slug":82,"hasResults":11,"nctId":83,"briefTitle":84,"officialTitle":84,"acronym":85,"eligibilityCriteria":86,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":87,"targetDuration":4,"studyType":23,"phases":89,"briefSummary":90,"conditions":91,"keywords":94,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":105,"lastUpdatePostDateStruct":106,"startDateStruct":108,"completionDateStruct":110,"leadSponsor":112,"locationsCount":4},"100636079","high-technology-telerehabilitation-for-the-treatment-of-the-fragile-patient-100636079","NCT07561021","High-technology TeleRehabilitation for the Treatment of the FRAgile Patient","TeleRiab4Fra","Inclusion Criteria:\n\n* Age 65 years or older.\n* Diagnosis of chronic heart failure for at least 6 months, on stable optimal medical therapy for at least 1 month, regardless of systolic function classification (HFrEF, HFmrEF, or HFpEF), and in NYHA class I-III.\n* Pre-frailty or frailty documented by validated instruments, defined by at least one of the following: Fried phenotype: pre-frailty (1-2 criteria) or frailty (3 or more criteria); Italian Frailty Index (IFI): score ≥1;\n\nShort Physical Performance Battery (SPPB):\n\ntotal score 5-9\u002F12, consistent with functional frailty; or total score 10\u002F12, consistent with pre-frailty if the reduction is attributable to the sit-to-stand test, as documented in the case report form.\n\n* Ability to provide written informed consent, or availability of a legally authorized representative when applicable.\n* Availability of a caregiver, when required for participation in the rehabilitation program.\n\nExclusion Criteria:\n\n* Age younger than 65 years.\n* NYHA class IV and\u002For high likelihood of heart transplantation or ventricular assist device (VAD) implantation within 6 months after screening.\n* Absence of pre-frailty\u002Ffrailty, defined as:\n\nFried phenotype = 0 criteria, and IFI = 0, and SPPB ≥ 11\u002F12 (or 10\u002F12 without evidence of impairment in the sit-to-stand component according to the predefined criterion).\n\n* Severe renal impairment (estimated glomerular filtration rate eGFR \\\u003C30 mL\u002Fmin\u002F1.73 m²) or dialysis.\n* Inability to walk independently, even with assistive devices. SPPB total score \\\u003C5\u002F12, indicating severe functional impairment not compatible with safe execution of the study protocol, regardless of IFI or Fried criteria.\n* Other serious diseases substantially limiting life expectancy (for example, end-stage cancer or end-stage lung disease).\n* Severe visual impairment preventing completion of study procedures even with caregiver support and reasonable accommodations.\n* Current or suspected pregnancy.",{"count":88,"type":22},70,[25],"The aim of this randomized controlled clinical trial is to evaluate the efficacy of an 8-week sensorimotor and cognitive telerehabilitation program in frail and pre-frail older adults with stable chronic heart failure. The study will compare a synchronous telerehabilitation intervention with a caregiver-supervised home exercise program. The primary question is whether telerehabilitation improves functional capacity, measured by change in peak oxygen uptake (VO₂peak) on cardiopulmonary exercise testing, more than the control intervention. A key secondary question is whether telerehabilitation improves frailty status, measured by the Italian Frailty Index (IFI), compared with the control group. Secondary outcomes include quality of life, physical performance, cognitive function, treatment adherence, caregiver burden and stress, and selected biomarkers related to heart failure and frailty. Participants will undergo baseline and follow-up clinical, functional, cognitive, and laboratory assessments and will be followed for up to 24 weeks.",[92,28,93],"Heart Failure","Frail Elderly Syndrome",[95,96,97,98,99,100,101,102,103,104],"Chronic Heart Failure","Cardiac Rehabilitation","Tele-rehabilitation","Telemedicine","Exercise Training","Remote Monitoring","mHealth","Wearable Sensors","Home-based Rehabilitation","Digital Health","2026-05-01",{"date":107,"type":41},"2026-05-07",{"date":109,"type":22},"2026-05-15",{"date":111,"type":22},"2027-03-15",{"name":113,"class":48},"University of Salerno"]