[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"pregnacy\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:pregnacy":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":30,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100545889","acute-beetroot-juice-supplementation-in-pre-eclampsia-pregnancies-100545889",false,"NCT06387784","Acute Beetroot Juice Supplementation in Pre-eclampsia Pregnancies","Acute Effect of Beetroot Juice Supplementation in Pregnant Women With Pre-eclampsia: a Single-Blind Randomized Placebo-Controlled Trial","BEET_PE","1. Pre-eclampsia pregnat women\n\n   Inclusion Criteria:\n   * Pregnant women at or beyond the 20th week of gestation.\n   * Hospitalized at Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto.\n   * Diagnosed with early-onset pre-eclampsia confirmed by a medical professional.\n   * Capacity to provide written informed consent for study participation.\n\n   Exclusion Criteria:\n   * Multiple pregnancies.\n   * Uncontrolled arterial hypertension (Systolic Blood Pressure \\> 160 mmHg or Diastolic Blood Pressure \\> 100 mmHg).\n   * Pregnant women with a body mass index \\> 40 kg\u002Fm²\n   * Severe gestational complications.\n   * History of food allergy with hypersensitivity to beetroot.\n   * Smokers.\n   * Chronic alcohol consumption.\n   * Medications such as non-steroidal anti-inflammatory drugs, nasal decongestants, users of proton pump inhibitors and H2 receptor antagonists or any other medication that interferes with stomach pH.\n   * Diagnosis of renal or hepatic disease affecting nitrate metabolism.\n   * Cardiac conditions such as moderate to severe congestive heart failure and coronary artery disease.\n   * Pre-existing type 1 or type 2 diabetes.\n2. Healthy Pregnant Women\n\nInclusion Criteria:\n\n* Healthy pregnant women at or beyond the 20th week of gestation.\n* Absence of pre-eclampsia diagnosis or other obstetric complications.\n* Willingness and ability to remain admitted at the Clinical Research Unit for the - period required by the study.\n* Capacity to provide written informed consent for study participation.\n\nExclusion Criteria:\n\n\\- The same exclusion criteria from Pre-eclampsia group apply.","FEMALE","18 Years","40 Years",{"count":21,"type":22},60,"ESTIMATED","INTERVENTIONAL",[25],"NA","Pre-eclampsia is a serious condition that typically affects pregnant women after the 20th week of pregnancy, characterized by high blood pressure and damage to organs such as the kidneys and liver. Currently, treatment options are limited, which has prompted researchers to explore alternative approaches. One such promising alternative is dietary nitrate found in vegetables like beetroot, as nitrate can be converted into nitric oxide in the body, which helps lower blood pressure. This study aims to determine the acute effects of nitrate-rich beetroot juice on blood pressure, several blood and salivary markers in pregnant women with pre-eclampsia and healthy pregnant. Furthermore, the study will assess fetal blood flow using Doppler ultrasound. We want to understand the kinetics of nitrate and nitric oxide metabolites and assess the temporal dependency of the hypotensive response. Through this investigation, we seek evidence of nitrate-enriched beetroot juice as an adjunct therapy in managing pre-eclampsia.",[28,29],"Pre-Eclampsia","Pregnacy",[31,32,33,34],"Pre-eclampsia","Pregnancy","Beetroot Juice","Nitric Oxide","NOT_YET_RECRUITING","2026-04-15",{"date":38,"type":39},"2026-04-21","ACTUAL",{"date":41,"type":22},"2026-05-18",{"date":43,"type":22},"2028-07",{"name":45,"class":46},"University of Sao Paulo","OTHER",2]