[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"pregnancy-disease\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:pregnancy-disease":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,44,76],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":23,"studyType":24,"phases":4,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100640629","fertility-outcomes-after-antibiotic-treatment-in-women-with-chronic-endometritis-100640629",false,"NCT07603492","Fertility Outcomes After Antibiotic Treatment In Women With Chronic Endometritis","Monitoring of Reproductive Outcomes in Women With Chronic Endometritis: A Prospective Cohort Study on the Impact of Antibiotic Treatment on Fertility and Obstetric Outcomes","MORE","Inclusion Criteria\n\n* Female participants aged 18-40 years.\n* Diagnosis of infertility (primary or secondary infertility).\n* Indication for diagnostic hysteroscopy with endometrial biopsy as part of infertility evaluation.\n* Suspected or confirmed chronic endometritis.\n* Ability and willingness to provide written informed consent prior to any study-related procedures.\n* Willingness to undergo protocol-defined antibiotic treatment.\n* Willingness to comply with study procedures and follow-up assessments.\n* Agreement to reproductive outcome monitoring following treatment, including spontaneous conception and pregnancies achieved through assisted reproductive technologies (ART).\n\nExclusion Criteria\n\n* Age \\>40 years.\n* Current pregnancy.\n* Known hypersensitivity or contraindication to tetracycline antibiotics or other study-related antibiotic therapy without a suitable alternative treatment option.\n* Severe systemic disease or medical condition that, in the opinion of the investigator, could interfere with study participation, safety, or interpretation of study results.\n* Active malignant disease requiring systemic treatment.\n* HIV infection or other severe immunodeficiency disorder.\n* Acute pelvic inflammatory disease or clinically significant active genital tract infection requiring immediate treatment.\n* Previous participation in this study.\n* Inability to undergo planned hysteroscopy or endometrial biopsy.\n* Inability or unwillingness to comply with study procedures or follow-up requirements.\n* Failure or refusal to provide written informed consent.","FEMALE","18 Years","40 Years",{"count":21,"type":22},100,"ESTIMATED","2 Years","OBSERVATIONAL","Chronic endometritis (CE) is a long-lasting inflammation of the lining of the uterus. Many women with CE do not have symptoms, but the condition may affect fertility, embryo implantation, and pregnancy outcomes. CE is usually diagnosed during hysteroscopy, a procedure that allows doctors to look inside the uterus and collect a small tissue sample for laboratory testing.\n\nThe goal of this prospective cohort study is to learn how common CE is in women with infertility and to determine whether antibiotic treatment improves reproductive outcomes. The study will also examine whether hysteroscopic findings match laboratory-confirmed CE and whether certain findings can help doctors diagnose CE more accurately. In addition, researchers will study the types of bacteria found in the uterine lining and their possible relationship to fertility and pregnancy outcomes.\n\nThe main questions the study aims to answer are:\n\n* How common is chronic endometritis in women undergoing infertility evaluation?\n* Does antibiotic treatment improve fertility and pregnancy outcomes in women with CE?\n* Can hysteroscopic findings reliably predict CE confirmed by laboratory testing?\n* Are specific bacteria associated with poorer reproductive outcomes? Researchers will enroll approximately 100 women aged 18 to 40 years with diagnosed infertility who are scheduled for hysteroscopy and endometrial biopsy as part of infertility evaluation. Participants with severe systemic disease, pregnancy, inability to undergo hysteroscopy or antibiotic treatment, or allergy to study antibiotics without a suitable alternative will not be included.\n\nParticipants will:\n\n* Undergo diagnostic hysteroscopy and endometrial biopsy\n* Have tissue samples examined using histopathology and immunohistochemistry to identify CE\n* Receive standardized antibiotic treatment if CE is confirmed\n* Be followed for up to 12 months after treatment to monitor fertility outcomes\n* Continue follow-up during pregnancy, if pregnancy occurs, to assess pregnancy and delivery outcomes Researchers will evaluate spontaneous pregnancies, embryo transfer success, implantation rates, miscarriage rates, time to pregnancy, and live birth outcomes. Pregnancy complications such as preeclampsia, placental disorders, premature rupture of membranes, and preterm birth will also be recorded.\n\nThe study is expected to run from January 2026 through December 2029. Data collected during the study may help improve the diagnosis and treatment of chronic endometritis in women with infertility and may support better reproductive outcomes in clinical practice.",[27,28,29,30],"Endometritis","Infertility","Hysteroscopy","Pregnancy Disease","RECRUITING","2026-05-22",{"date":34,"type":35},"2026-05-27","ACTUAL",{"date":37,"type":35},"2026-01-01",{"date":39,"type":22},"2030-01-01",{"name":41,"class":42},"Faculty Hospital Kralovske Vinohrady","OTHER_GOV",2,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":50,"eligibilityCriteria":51,"healthyVolunteers":52,"sex":17,"minAge":18,"maxAge":53,"enrollmentInfo":54,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":56,"conditions":57,"keywords":60,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":75},"100534479","dietary-salicylates-and-preeclampsia-100534479","NCT06239363","Dietary Salicylates and Preeclampsia","Nutritional Sources of Salicylates and Disorders of Placental Angiogenesis in Preeclampsia","PreSal","Inclusion Criteria:\n\n* age 18-45 years\n* healthy women with no previous adverse medical history and women with diagnosed preeclampsia\n* singleton pregnancy\n* people who have the full ability to give informed consent.\n\nExclusion Criteria:\n\n* pregnancies with detectable fetal defects, chromosomal abnormalities, genetic syndromes\n* infections\n* history of chronic hypertension, metabolic disorder before or during pregnancy, or the presence of high-risk factors such as heart diseases, diabetes, and renal diseases.",true,"45 Years",{"count":55,"type":22},500,"Preeclampsia (PE) is an important pregnancy complication and cause of maternal and perinatal mortality and morbidity. The underlying etiology and pathophysiology of preeclampsia is incompletely understood but it involves dysfunctional cytotrophoblastic invasion, placental ischemia, and release of inflammatory and endothelial mediators. Placenta dysfunction in PE is related to angiogenic balance. Currently, therapeutic options for the prevention and treatment of PE are limited. It is known that the risk of PE is reduced by low-dose aspirin. Therefore, the influence of salicylates on the development of PE seems to need to be investigated. This project plans to examine the preventive effects of food sources of salicylic acid and compare their effects with aspirin. Therefore, the aim of the present study is thus answer the following questions. whether the maternal dietary intake of salicylates is related to placental angiogenesis; 2. whether naturally occurring salicylates have the same effects on preeclampsia development and placental angiogenesis as aspirin. To answer these questions we plan to carry out a human study with pregnant women.\n\nDue to the above the planned research aims to determine the association between maternal dietary intake of salicylates and placental angiogenesis and the risk of preeclampsia development.\n\nAlthough PE remains an incurable disease, the results of this project will enable the development of dietary recommendations for the prevention and treatment of preeclampsia. Moreover, the results of this study may be useful in lowering the cost of maternal and fetal complications from preeclampsia and the cost of their hospitalization.",[30,58,59],"Preeclampsia","Diet Habit",[61,62,63,64],"pregnancy","preeclampsia","angiogenesis","salicylates","2026-03-26",{"date":67,"type":35},"2026-04-01",{"date":69,"type":35},"2024-01-08",{"date":71,"type":22},"2028-09-30",{"name":73,"class":74},"Poznan University of Life Sciences","OTHER",1,{"id":77,"slug":78,"hasResults":11,"nctId":79,"briefTitle":80,"officialTitle":80,"acronym":81,"eligibilityCriteria":82,"healthyVolunteers":11,"sex":83,"minAge":18,"maxAge":4,"enrollmentInfo":84,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":86,"conditions":87,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":43},"100499195","prospective-observational-study-to-characterize-patients-treated-at-internal-medicine-clinics-100499195","NCT05780099","Prospective Observational Study to Characterize Patients Treated at Internal Medicine Clinics","MED-Cli","Inclusion Criteria:\n\n* Receving treatment at internal medicine departments (inpatient, outopatient, day hospital) of San Raffaele Hospital\n* at least one suspected or confirmed diagnosis among:\n\n  1. immune mediated disorder\n  2. respiratory disorder\n  3. metabolic disorder\n  4. sepsis\n  5. rare disorder (according to Italian Ministry of Health list)\n  6. pregnancy-related disorder\n  7. frailty defined as: either ≥2 CIRS (Cumulative Illness Rating Scale) Severity Index 10 or ≤70% Karnofsky scale\n\nExclusion Criteria:\n\n* refusal to participate\n* enrolment in other intervantional study","ALL",{"count":85,"type":22},50000,"Patients referred to internal medicine wards are becoming increasingly complex and fragile. Despite deep knowledge of their specific disorders, steps are required to improve overall management of their acute and chronic conditions. The main objective of the study is to identify demographic, clinical, laboratory and radiological markers of disease severity and activity in patients with diseases treated at general medicine wards (respiratory disease, immune-mediated disease, sepsis, metabolic disease, rare disease, frailty, pregnancy pathology) in order to improve their diagnosis, monitoring and treatment processes.",[88,89,90,91,92,30,93,94],"Respiratory Disease","Cardiovascular Diseases","Infectious Disease","Critical Illness","Immunological Disease","Metabolic Syndrome","Chronic Disease","2025-06-17",{"date":97,"type":35},"2025-06-22",{"date":99,"type":35},"2022-06-24",{"date":101,"type":22},"2032-09-10",{"name":103,"class":74},"IRCCS San Raffaele"]