[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"pregnancy-loss-early\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:pregnancy-loss-early":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,50],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":25,"conditions":26,"keywords":33,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100633895","microbiome-and-metabolome-profiles-in-couples-undergoing-ivf-and-reproductive-outcomes-100633895",false,"NCT07532629","Microbiome and Metabolome Profiles in Couples Undergoing IVF and Reproductive Outcomes","Microbiome and Metabolome Profiles in Couples Undergoing IVF and Their Association With Reproductive Outcomes in a Prospective Longitudinal Cohort Study","Mi IVF","Inclusion Criteria:\n\n* Women aged 18 to 40 years at enrolment.\n* Men aged between 18 to 56 years at enrolment.\n* Couples planning to undergo IVF treatment at a participating centre.\n* Sufficient understanding of spoken and written Swedish or English to provide informed consent and complete the web-based questionnaire.\n\nExclusion Criteria:\n\n* Pregnancy at the time of enrolment (confirmed or suspected).\n* Recent systemic antibiotic use within the past 4 weeks\n* Active vaginal or genital tract infection at the time of sampling",true,"ALL","18 Years","40 Years",{"count":22,"type":23},1000,"ESTIMATED","OBSERVATIONAL","This prospective observational cohort study investigates the role of the microbiome and metabolome in couples undergoing in vitro fertilization. Biological samples will be collected from both female and male partners, including semen, vaginal, and blood samples, to characterize microbial composition and metabolic profiles. The study aims to examine how these biological profiles are associated with reproductive outcomes such as fertilization, pregnancy, miscarriage, and live birth. Participants will be followed longitudinally, and reproductive and obstetric outcomes will be obtained through linkage with national health registers.",[27,28,29,30,31,32],"Infertility","Assisted Reproductive Technology","Pregnancy Complications","Pregnancy Loss, Early","Metabolome","Microbiome",[34,32,31,35,36],"IVF","Male fertility","Pregnancy outcome","RECRUITING","2026-04-13",{"date":40,"type":41},"2026-04-16","ACTUAL",{"date":43,"type":41},"2022-06-10",{"date":45,"type":23},"2029-03-01",{"name":47,"class":48},"Karolinska Institutet","OTHER",3,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":4,"eligibilityCriteria":56,"healthyVolunteers":11,"sex":57,"minAge":19,"maxAge":58,"enrollmentInfo":59,"targetDuration":4,"studyType":61,"phases":62,"briefSummary":64,"conditions":65,"keywords":67,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":5},"100603981","comparison-of-surgical-management-of-early-pregnancy-loss-by-suction-curettage-versus-hysteroscopy-in-patients-undergoing-in-vitro-fertilization-ivf-100603981","NCT07143578","Comparison of Surgical Management of Early Pregnancy Loss by Suction Curettage Versus Hysteroscopy in Patients Undergoing In-vitro Fertilization (IVF)","Comparison Of Surgical Management Of Early Pregnancy Loss By Suction Curettage Versus Hysteroscopy In Patients Undergoing In-Vitro Fertilization (IVF)","Inclusion Criteria:\n\n1. Diagnosis of early pregnancy loss up to 10 weeks' gestation, based on last menstrual period or ultrasound.\n2. Pregnancy conceived through assisted reproductive techniques (in vitro fertilization, IVF).\n3. Ability to provide informed consent, and proficiency in reading and writing Hebrew.\n\nExclusion Criteria:\n\n1. Heavy vaginal bleeding or diagnosis of incomplete abortion.\n2. Signs of infection and\u002For suspicion of septic abortion\n3. Known uterine anomalies- including septate, bicornuate, unicornuate, or didelphys uterus.\n4. Prior medical or surgical treatment during the current pregnancy\n5. History of intrauterine adhesions\n6. History of ≥ 3 prior miscarriages.\n7. History of ≥ 3 prior cesarean sections.\n8. History of myomectomy via abdominal or hysteroscopic approach.","FEMALE","50 Years",{"count":60,"type":23},50,"INTERVENTIONAL",[63],"NA","Early pregnancy loss occurs in \\~15% of pregnancies. The treatment options include surgical uterine evacuation by suction curettage, medical management with misoprostol, or conservative management without interventions. The advantages of surgical management include quick resolution of the pregnancy and avoidance of heavy vaginal bleeding, while the disadvantages include retained products of conception and intrauterine adhesion formation which could affect future fertility. With the aim of reducing the complications of suction curettage, uterine evacuation using operative hysteroscopy has been suggested.\n\nIn a previous study, the investigators compared suction curettage with operative hysteroscopy for the surgical management of early pregnancy loss up to 10 weeks of gestation. The results showed significantly reduced adhesions rate (4.2% in the hysteroscopy group vs. 45.2% in the suction group, p \\\u003C 0.01), although the operative time was significantly longer for the hysteroscopy.\n\nIn this follow-up study, the investigators will compare the outcomes of hysteroscopy and suction curettage in a select group of patients with early pregnancy loss following conception by in-vitro fertilization. These patients are at risk for adhesions and therefore candidates for the hysteroscopic intervention. The study will include 50 patients randomized to 2 intervention arms - hysteroscopy using a tissue removal device versus the standard suction curettage. Post-operative adhesions will be assessed by office hysteroscopy after 6-8 weeks.",[66,30],"Early Abortion",[68,69,70,71,72,73],"hysteroscopy","pregnancy loss","early missed abortion","spontaneous abortion","suction curettage","intrauterine adhesions","2026-01-25",{"date":76,"type":41},"2026-01-27",{"date":78,"type":41},"2025-08-20",{"date":80,"type":23},"2027-08-30",{"name":82,"class":83},"Assaf-Harofeh Medical Center","OTHER_GOV"]