[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"prehabilitation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:prehabilitation":35},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,39,0,25,[9,60,93,127,153,184,215,247,290,317,346,372,395,418,444,466,498,526,553,584,608,635,663,689,716],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":16,"eligibilityCriteria":17,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":37,"overallStatus":47,"whyStopped":4,"lastUpdateSubmitDate":48,"lastUpdatePostDateStruct":49,"startDateStruct":52,"completionDateStruct":54,"leadSponsor":56,"locationsCount":59},"100641147","digitally-supported-prehabilitation-before-major-visceral-cancer-surgery-100641147",false,"NCT07658313","Digitally Supported Prehabilitation Before Major Visceral Cancer Surgery","From Prehabilitation to Rehabilitation: A Feasibility Trial for Digitally Supported Prehabilitation in Major Visceral Oncologic Surgery","P2R-OncoVis","Inclusion Criteria:\n\n* Adults aged 18 years or older\n* Clinical diagnosis requiring major surgery of the pancreas, liver, bile ducts, stomach, or esophagus with curative intent\n* Confirmed indication for surgery by the multidisciplinary tumor board\n* Medical stability and physician clearance to participate in a prehabilitation exercise program\n* Willingness and ability to attend center-based prehabilitation exercise sessions three times per week, or once per week with additional tele-prehabilitation if travel time exceeds 40 minutes one way\n* Willingness and ability to perform home-based physical activities\n* Sufficient German language proficiency and digital literacy\n* Access to a smartphone or tablet device with internet connection\n* Provision of written informed consent\n\nExclusion Criteria:\n\n* Age younger than 18 years\n* Physical disability or mental impairment preventing safe participation in the study\n* Health care medical power of attorney not permitting independent consent\n* Non-elective, emergency, or revision surgery\n* Acute medical condition contraindicating participation in a structured prehabilitation program","ALL","18 Years",{"count":21,"type":22},30,"ESTIMATED","INTERVENTIONAL",[25],"NA","Major visceral oncologic surgery is associated with high postoperative morbidity, prolonged hospitalization, delayed recovery, and reduced quality of life. Patients undergoing surgery of the pancreas, liver, bile ducts, stomach, or esophagus frequently present with reduced physical fitness, malnutrition, sarcopenia, and psychological distress, all of which may negatively affect surgical outcomes and rehabilitation. Although prehabilitation has shown potential to improve functional capacity before surgery, structured prehabilitation pathways are currently not routinely implemented in Austria, and the feasibility of digitally supported perioperative care pathways remains insufficiently evaluated.\n\nThe aim of the Prehab2Rehab-OncoVis study is to evaluate the feasibility, acceptability, and safety of a multimodal, digitally supported prehabilitation intervention for patients undergoing major visceral oncologic surgery with curative intent. The study will additionally explore potential effects on clinical recovery, functional capacity, rehabilitation outcomes, and patient-reported outcomes across the perioperative pathway.\n\nPrehab2Rehab-OncoVis is designed as a prospective, single-arm feasibility cohort study conducted at the University Hospital Salzburg and the University Institute of Sports Medicine, Prevention and Rehabilitation, coordinated by the Paracelsus Medical University in cooperation with the Ludwig Boltzmann Institute for Rehabilitation Research and the Ludwig Boltzmann Institute for Digital Health and Prevention within the Prehab2Rehab consortium. Approximately 30 adult patients, with the possibility to include up to 50 participants if feasible, will be consecutively recruited.\n\nThe intervention consists of a four-week multimodal prehabilitation program combining supervised exercise training, promotion of physical activity, nutritional counseling, psycho-oncological distress screening, and health literacy support. Digital tools will support the intervention throughout the perioperative pathway, including the HERO application (Das Herz Reha-Informationstool) for patient education and health literacy, aktivplan as a digital exercise planner and training diary, and the CAATS telecommunication platform for remote supervision and tele-prehabilitation sessions where appropriate.\n\nThe exercise intervention includes supervised center-based sessions and, for participants with longer travel distances, a hybrid model combining center-based and tele-prehabilitation sessions. Nutritional counseling will follow current European Society for Clinical Nutrition and Metabolism (ESPEN) guidelines and includes screening for malnutrition risk. Psycho-oncological distress screening will follow recommendations of the German Cancer Society and includes referral to supportive care when clinically indicated.\n\nParticipants will be assessed throughout the perioperative pathway, including at the beginning and end of prehabilitation (Prehabilitation Assessment 1 \\[PRE1\\] and Prehabilitation Assessment 2 \\[PRE2\\]), during hospitalization and rehabilitation, and at a three-month follow-up after surgery. Primary outcomes focus on feasibility, including recruitment and retention rates, adherence, fidelity, safety, data management feasibility, and acceptability and usability of the digital technologies. Secondary outcomes include clinical recovery indicators, postoperative complications, length of hospital and intensive care stay, functional independence, psychological well-being, quality of life, body composition, cardiorespiratory fitness, functional exercise capacity, and muscle strength.\n\nTo contextualize outcomes, two historical comparator cohorts will be used: a local hospital cohort of patients who previously underwent similar surgery without prehabilitation, and a national rehabilitation cohort derived from routine rehabilitation datasets matched for diagnosis, sex, and age.\n\nThe study is intended to generate feasibility data and preliminary estimates that may support the development of future adequately powered randomized controlled trials evaluating digitally supported prehabilitation and rehabilitation pathways in visceral oncologic surgery.",[28,29,30,31,32,33,34,35,36],"Gastrointestinal Neoplasms","Pancreatic Neoplasms","Liver Neoplasm","Oesophageal Cancer","Gastrointestinal Cancer","Pancreatic Cancer","Liver Cancer","Prehabilitation","Cancer Rehabilitation",[35,38,39,40,41,42,43,44,45,46],"Visceral Surgery","Oncology","Rehabilitation","Digital Health","Exercise Therapy","Teleprehabilitation","Cancer Surgery","Preoperative Care","Functional Recovery","NOT_YET_RECRUITING","2026-06-16",{"date":50,"type":51},"2026-06-18","ACTUAL",{"date":53,"type":22},"2026-06",{"date":55,"type":22},"2027-07",{"name":57,"class":58},"Ludwig Boltzmann Institute for Digital Health and Prevention","OTHER",2,{"id":61,"slug":62,"hasResults":12,"nctId":63,"briefTitle":64,"officialTitle":65,"acronym":66,"eligibilityCriteria":67,"healthyVolunteers":68,"sex":69,"minAge":4,"maxAge":4,"enrollmentInfo":70,"targetDuration":4,"studyType":23,"phases":72,"briefSummary":73,"conditions":74,"keywords":78,"overallStatus":83,"whyStopped":4,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":59},"100539857","prehabilitation-with-resistance-exercise-training-for-breast-cancer-neoadjuvant-therapy-100539857","NCT06309290","Prehabilitation With Resistance-exercise Training for Breast Cancer Neoadjuvant Therapy","Prehabilitation Based on Resistance-exercise Training in Women With Breast Cancer Undergoing Neoadjuvant Therapy: From Molecular Mechanism to Clinical Benefits","NEO STRONG","Inclusion Criteria:\n\n* Postmenopausal women with breast cancer in stages I, II and III with luminal breast tumor, HER2+ or TNBC\n* Indication for neoadjuvant chemotherapy\n* Candidates for curative breast surgery\n* Body mass index: 18.5 \\\u003CBMI \\\u003C30 kg\u002Fm2\n* Sedentary (does not perform scheduled or planned physical activity ≥ 2 times a week)\n* Willingness to participate in the study and follow the proposed prehabilitation scheme.\n\nExclusion Criteria:\n\n* Present comorbidities that interact with the metabolism and mobility of the muscles of the body and that do not allow the (safe) performance of strength exercises (e.g., debilitating arthritis, all neurological disorders, paralysis, among others).\n* Severe or uncontrolled cardiovascular disease, cardiac ejection fraction less than 50%\n* Previous antineoplastic treatment\n* Use of nutritional supplements (leucine, glutamine, casein, whey protein, fatty acids and creatine).",true,"FEMALE",{"count":71,"type":22},68,[25],"Breast cancer stands as the foremost cause of cancer-related deaths among women worldwide, with the highest incidence of any cancer type. The choice of therapeutic interventions hinges upon factors like cancer stage, cell subtype, and tumor size. Consequently, individuals with more aggressive tumors, such as HER+2 and Triple Negative, or larger tumors often undergo neoadjuvant chemotherapy before breast surgery. However, these anticancer treatments come with side effects like cancer-related fatigue, reduced functional capacity, and changes in body composition, notably skeletal muscle atrophy. Skeletal muscle loss correlates with heightened mortality rates, cardiotoxicity, and diminished quality of life, underscoring the need for early therapeutic interventions. One such promising strategy is prehabilitation, which involves resistance-exercise training aimed at bolstering skeletal muscle mass from the outset of the disease, even preceding breast surgery. Resistance-exercise training has shown favorable effects on women undergoing adjuvant therapy or survivors of breast cancer, however, its molecular and clinical effects in women with breast cancer undergoing neoadjuvant therapy are unknown.",[35,75,76,77],"Breast Cancer","Postmenopause","Resistance Training",[35,79,80,81,82],"Breast neoplasm","Strength Training","Skeletal muscle","Muscle strength","RECRUITING","2026-06-10",{"date":86,"type":51},"2026-06-12",{"date":88,"type":51},"2025-01-01",{"date":90,"type":22},"2026-12",{"name":92,"class":58},"Universidad de La Frontera",{"id":94,"slug":95,"hasResults":12,"nctId":96,"briefTitle":97,"officialTitle":98,"acronym":99,"eligibilityCriteria":100,"healthyVolunteers":12,"sex":18,"minAge":101,"maxAge":4,"enrollmentInfo":102,"targetDuration":4,"studyType":23,"phases":104,"briefSummary":105,"conditions":106,"keywords":113,"overallStatus":47,"whyStopped":4,"lastUpdateSubmitDate":117,"lastUpdatePostDateStruct":118,"startDateStruct":120,"completionDateStruct":122,"leadSponsor":124,"locationsCount":126},"100643674","from-exercise-oncology-research-to-clinical-practice-100643674","NCT07635589","From Exercise Oncology Research to Clinical Practice","Bridging the Gap Between Exercise Oncology Research and Its Implementation in Clinical Practice","PAC ICare","Inclusion Criteria:\n\n* Have received a cancer diagnosis (inclusive of primary, recurrent; and\u002For metastatic disease);\n* Over the age of 19 years;\n* Able to participate in mild levels of activity as a minimum;\n* Be pretreatment, or receiving active cancer treatment, or have received cancer treatment within the past six months and are still under active oncology care, or beyond six months if they continue to be under active oncology care;\n* Able to provide informed written consent in English; and\n* Have access to internet service and a device that can support video calling (for online programs).\n\nExclusion Criteria:\n\n* Severe cognitive, physical, psychiatric, or uncontrolled medical condition(s) resulting in an inability to provide consent and\u002For safely participate in the study.","19 Years",{"count":103,"type":22},500,[25],"Building on previous research that shows the benefits of exercise, this study aims to find out how best to implement exercise in real-world settings. The study will assess the feasibility and acceptability of an embedding an automated referral tool and an exercise professional into standard cancer care impacts clinician referral and patient uptake of exercise programming. The study will assess how effective the exercise program is at improving patients' physical health, quality of life, symptom management, and overall wellbeing during different stages of their cancer journey (e.g., before treatment, on treatment, after treatment).",[107,108,109,110,111,35,112],"Cancer","Exercise","Implementation of Evidence Based Programs","Cost Effectiveness","Rehabilitation Exercise","Survivorship",[107,108,114,115,116,110],"Implementation Science","Mixed-Methods","Effectiveness-Implementation","2026-06-03",{"date":119,"type":51},"2026-06-09",{"date":121,"type":22},"2026-09-01",{"date":123,"type":22},"2029-12",{"name":125,"class":58},"Melanie Keats",1,{"id":128,"slug":129,"hasResults":12,"nctId":130,"briefTitle":131,"officialTitle":132,"acronym":4,"eligibilityCriteria":133,"healthyVolunteers":12,"sex":69,"minAge":19,"maxAge":4,"enrollmentInfo":134,"targetDuration":4,"studyType":23,"phases":136,"briefSummary":137,"conditions":138,"keywords":4,"overallStatus":83,"whyStopped":4,"lastUpdateSubmitDate":144,"lastUpdatePostDateStruct":145,"startDateStruct":147,"completionDateStruct":149,"leadSponsor":151,"locationsCount":126},"100467293","prehabilitation-for-ovarian-cancer-patients-100467293","NCT05364879","Prehabilitation for Ovarian Cancer Patients","The Impact of Prehabilitation Exercise on Frailty and Treatment Outcomes in Ovarian Cancer Patients","Inclusion Criteria:\n\n* 18 years or older\n* Have a confirmed diagnosis of stage III or IV ovarian cancer\n* Scheduled to receive cytoreductive surgery as part of their treatment plan\n* Must have a minimum of 4-weeks between the time of study enrollment and scheduled surgery\n* Be able to attend in-person and\u002For virtual exercise sessions\n* Be fluent in English\n* Have oncologist approval\n\nExclusion Criteria:\n\n* Have already completed surgery\n* Unstable cardiac or respiratory disease, injury or any other co-morbid disease that may make it unsafe for participants to exercise\n* Significant cognitive impairment (e.g., do not have the capacity to consent, unable to follow exercise instructions)",{"count":135,"type":22},108,[25],"Individuals with ovarian cancer have very poor survival rates. This is because the cancer is not usually detected until it has reached advanced stages. How long an individual survives also is determined by the cancer treatment they receive. Although there are best treatment practices to improve survival, some women have other conditions that limit treatment options. One such condition seen in as many as 50% of women with advanced ovarian cancer is frailty (an age-related decline in function and health). This is a major concern as doctors will often have to change how the cancer is treated based on the patient being frail. For example, patients living with frailty are less likely to have their full tumor removed during surgery. They are also more likely to have complications with surgery, stay in the hospital longer, and recover less well from surgery overall. Patients living with frailty also are more likely to experience delays in their chemotherapy starting, receive lower doses of chemotherapy and\u002For receive fewer cycles of chemotherapy. These changes in treatment may decrease how long a patient survives after diagnosis. Thus, research is needed to explore strategies to decrease frailty in patients who require treatment for advanced ovarian cancer. An option gaining more attention is physical exercise (e.g. walking, repeatedly rising from a chair). Exercise performed before surgery, which is called prehabilitation, can improve how well a patient recovers after surgery and increase how long they survive. Research has shown that prehabilitation is very beneficial for patients undergoing surgery for heart disease. However, it is not clear whether prehabilitation works for those with advanced ovarian cancer that are going to have surgery. Therefore, the investigators want to explore how a 4+ week exercise program performed while waiting for surgery for advanced ovarian cancer changes frailty and how a patient recovers after surgery. The investigators will specifically look whether the exercise program: 1) reduces how frail a patient is before surgery; 2) improves how well the patient recovers after surgery; and 3) affects the patient's chemotherapy treatment plan. This study will provide important information about the ability of prehabilitation exercise to improve surgical and treatment outcomes in women with advanced ovarian cancer. Overall, it is believed that exercise has the potential to improve the survival of advanced ovarian cancer patients.",[35,108,139,140,141,142,143],"Frailty","Ovarian Cancer","Surgical Complication","Treatment Outcomes","Enhanced Recovery After Surgery","2026-05-28",{"date":146,"type":51},"2026-06-01",{"date":148,"type":51},"2023-01-03",{"date":150,"type":22},"2027-08-31",{"name":152,"class":58},"Nova Scotia Health Authority",{"id":154,"slug":155,"hasResults":12,"nctId":156,"briefTitle":157,"officialTitle":158,"acronym":159,"eligibilityCriteria":160,"healthyVolunteers":12,"sex":69,"minAge":19,"maxAge":4,"enrollmentInfo":161,"targetDuration":4,"studyType":23,"phases":163,"briefSummary":164,"conditions":165,"keywords":168,"overallStatus":47,"whyStopped":4,"lastUpdateSubmitDate":175,"lastUpdatePostDateStruct":176,"startDateStruct":178,"completionDateStruct":180,"leadSponsor":182,"locationsCount":126},"100640235","evaluating-the-feasibility-of-prehabilitation-delivery-models-for-patients-preparing-for-ovarian-cancer-surgery-100640235","NCT07609082","Evaluating the Feasibility of Prehabilitation Delivery Models for Patients Preparing for Ovarian Cancer Surgery","Assessing Delivery Approaches for Prehabilitation Trials in Ovarian Cancer: A Pilot Feasibility Patient-Preference Trial","ADAPT-OC","Inclusion Criteria:\n\n* Female\n* Aged ≥18 years\n* Scheduled for cytoreductive surgery for an ovarian mass suspected or confirmed of cancer\n* Surgery planned ≥3 weeks from time of booking\n* No contraindications to exercise on the CSEP Get Active Questionnaire\n* Able to provide written informed consent\n* Able to understand and communicate in English\n\nExclusion Criteria:\n\n* Pregnancy\n* Surgery scheduled \\\u003C3 weeks from booking\n* Receiving neoadjuvant chemotherapy\n* Positive contraindications to exercise on the CSEP Get Active Questionnaire\n* End-stage or advanced renal disease limiting safe protein supplementation\n* Malnutrition as assessed by a registered dietician",{"count":162,"type":22},36,[25],"The goal of this clinical trial is to learn whether high-dose multimodal prehabilitation, delivered either in person or remotely with coaching and web application support, is feasible and acceptable for women preparing for ovarian cancer surgery. It will also examine which delivery model patients prefer and the factors influencing patient preferences.\n\nThe main questions ADAPT-OC aims to answer are:\n\n1. Can participants achieve the prescribed aerobic exercise target of at least 10 MET-hours per week before surgery?\n2. Do patients prefer in-person prehabilitation, remote prehabilitation, or education-only care, and what factors influence that preference?\n\nThe researchers will compare in-person prehabilitation, remote prehabilitation, and education-only care to see which delivery approach is most feasible, acceptable, and practical for patients with suspected ovarian cancer.\n\nParticipants will:\n\n* Choose their preferred study group, or be randomly assigned if they have no preference\n* Complete physical assessments, questionnaires, and interviews at baseline, 1-3 days before surgery, and 4 weeks after surgery\n* If assigned to a prehabilitation group, complete aerobic exercise, protein supplementation, and daily breathing exercises before surgery\n* Attend weekly coaching sessions with a trained prehabilitation coach\n* Use the KingstonPrehab web application to track exercise, nutrition, breathing practice, and progress toward activity goals",[35,166,45,140,42,167],"Preoperative Aerobic Training","Postoperative Outcomes",[169,170,171,172,173,174],"postoperative outcomes","prehabilitation","nutritional support","psychological support","exercise therapy","ovarian cancer","2026-05-19",{"date":177,"type":51},"2026-05-27",{"date":179,"type":22},"2026-05-14",{"date":181,"type":22},"2027-05-14",{"name":183,"class":58},"Jordan Leitch",{"id":185,"slug":186,"hasResults":12,"nctId":187,"briefTitle":188,"officialTitle":189,"acronym":190,"eligibilityCriteria":191,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":192,"targetDuration":4,"studyType":23,"phases":194,"briefSummary":195,"conditions":196,"keywords":200,"overallStatus":47,"whyStopped":4,"lastUpdateSubmitDate":206,"lastUpdatePostDateStruct":207,"startDateStruct":209,"completionDateStruct":210,"leadSponsor":212,"locationsCount":214},"100638709","prehabilitation-before-major-surgery-100638709","NCT07590141","Prehabilitation Before Major Surgery","PRehabilitation In Advance of Major Elective Surgery: A Pilot Randomized Controlled Trial (PRIME Pilot)","PRIME","Inclusion Criteria:\n\n* ≥ 18 years of age\n* Undergoing major elective intra-thoracic, intra-abdominal or orthopedic surgery. Major surgery is defined as any operation performed under general and\u002For spinal anesthesia requiring a skin incision extending beyond the subcutaneous tissue\n* More than 3 weeks from the date of scheduled operation\n\nExclusion Criteria:\n\n* Emergency Surgery\n* Operation in less than 3 weeks from time of initial research contact\n* Patients who are pregnant\n* Unable\u002Funwilling to sign written informed consent\n* Physical, cognitive or psychological impairment\n* Unable to understand\u002Fcommunication in English.",{"count":193,"type":22},120,[25],"The goal of this clinical trial is to learn if a virtually monitored, home-based prehabilitation program is feasible and acceptable for adults undergoing major elective surgery. The main questions it aims to answer are:\n\n1. Can researchers successfully recruit and retain participants across multiple sites?\n2. Will participants adhere to the prehabilitation program at a high enough rate to justify a larger trial?\n\nResearchers will compare the prehabilitation program to standard preoperative care to see if the intervention is feasible to implement and whether it may help reduce postoperative complications.\n\nParticipants will:\n\n* Be randomly assigned to receive either the prehabilitation program or usual care\n* Complete questionnaires and physical assessments before and after the intervention\n* (For those in the intervention group) Receive exercise, nutrition, and mindfulness guidance, protein supplements, and use the CloudDX virtual care platform to support their activities",[35,45,197,198,199],"Elective Surgical Procedures","Postoperative Complications","Surgical Procedures, Operative",[201,202,203,42,204,205,167],"Home-based Care","Virtual Care","Remote Health Monitoring","Nutritional Support","Psychological Support","2026-05-10",{"date":208,"type":51},"2026-05-15",{"date":146,"type":22},{"date":211,"type":22},"2028-01-31",{"name":213,"class":58},"Queen's University",3,{"id":216,"slug":217,"hasResults":12,"nctId":218,"briefTitle":219,"officialTitle":220,"acronym":221,"eligibilityCriteria":222,"healthyVolunteers":12,"sex":18,"minAge":223,"maxAge":4,"enrollmentInfo":224,"targetDuration":4,"studyType":23,"phases":226,"briefSummary":227,"conditions":228,"keywords":233,"overallStatus":83,"whyStopped":4,"lastUpdateSubmitDate":237,"lastUpdatePostDateStruct":238,"startDateStruct":240,"completionDateStruct":242,"leadSponsor":244,"locationsCount":246},"100623395","pre-operative-risk-assessment-combined-with-targeted-intervention-in-the-chinese-elderly-with-spine-surgery-ii-100623395","NCT07396077","Pre-operative Risk Assessment Combined With Targeted Intervention in the Chinese Elderly With Spine Surgery II","Multimodal Physiological Reserve Optimizing Prehabilitation Program (PHYSIO-Prehab) in the Chinese Elderly With Spine Surgery","PRACTICE-2","Inclusion Criteria:\n\n1. Aged ≥75 years at the time of screening\n2. Voluntarily sign the informed consent form\n3. Clinically diagnosed with degenerative lumbar spinal disorders with duration of symptoms \\>6 months\n4. Requiring elective lumbar fusion surgery (single-level or multi-level, open or minimally invasive approach)\n5. No severe cognitive impairment (Mini-Mental State Examination score \\> 9)\n6. Scheduled to undergo surgery within 6-8 weeks after screening (allowing completion of the 6-week prehabilitation program)\n\nExclusion Criteria:\n\n1. Scheduled to undergo other emergency surgery or day surgery\n2. Urgent medical conditions requiring priority management before spinal surgery\n3. With spinal disorders other than degenerative diseases (spinal fracture, tumor, metastasis, infection, ankylosing spondylitis, scoliosis with Cobb angle \\>40°)\n4. With contraindications to prehabilitation exercise (New York Heart Association Class IV heart failure, unstable angina, uncontrolled hypertension \\[systolic BP ≥180 mmHg or diastolic BP ≥110 mmHg despite medication\\])\n5. With severe functional disability for other disorders or long-term bedridden status unable to perform basic physical activities\n6. With allergy or intolerance to nutritional supplements used in the prehabilitation program\n7. Participating in another clinical trial involving prehabilitation, perioperative intervention, or spinal surgery within 3 months before screening","75 Years",{"count":225,"type":22},248,[25],"This multicenter, parallel-group, assessor-blinded randomized controlled trial will enroll 248 adults aged ≥75 years with degenerative lumbar spinal diseases scheduled for elective lumbar fusion surgery, and they will be randomized 1:1 into the intervention and usual care groups. The intervention group will receive a 6-week PHYSIO-Prehab multimodal prehabilitation program, including multicomponent exercise, nutritional intervention, comorbidity optimization, and cognitive prehabilitation with brain protection strategies. The control group will receive standard health education provided via a manual, and both groups will receive consistent perioperative Enhanced Recovery After Surgery care. The primary outcome will be the change in Barthel Index (a tool for assessing independence in activities of daily living) from baseline to 30 days postoperatively; secondary outcomes will include pain scores, disability, patient satisfaction, and the 30-day postoperative Comprehensive Complication Index. The trial will initiate recruitment in April 2026 and conclude in December 2027, aiming to evaluate the feasibility and efficacy of PHYSIO-Prehab and provide high-quality evidence for patient-centered perioperative care pathways in this population.",[229,230,231,232,35],"Spine Degeneration","Lumbar Degenerative Disease","Frail Elderly","Enhanced Recovery After Surgery (ERAS) Protocol",[35,234,235,236],"ERAS","lumbar fusion","ADL","2026-04-26",{"date":239,"type":51},"2026-04-28",{"date":241,"type":51},"2026-04-15",{"date":243,"type":22},"2027-12-30",{"name":245,"class":58},"Xuanwu Hospital, Beijing",4,{"id":248,"slug":249,"hasResults":12,"nctId":250,"briefTitle":251,"officialTitle":251,"acronym":4,"eligibilityCriteria":252,"healthyVolunteers":68,"sex":18,"minAge":253,"maxAge":254,"enrollmentInfo":255,"targetDuration":4,"studyType":23,"phases":257,"briefSummary":258,"conditions":259,"keywords":271,"overallStatus":83,"whyStopped":4,"lastUpdateSubmitDate":279,"lastUpdatePostDateStruct":280,"startDateStruct":282,"completionDateStruct":284,"leadSponsor":286,"locationsCount":289},"100636162","develop-and-evaluate-an-artificial-intelligence-assisted-prehabilitation-program-for-returning-to-work-and-cost-effectiveness-analysis-in-patients-with-oral-cancer-100636162","NCT07562100","Develop and Evaluate An Artificial Intelligence Assisted Prehabilitation Program for Returning to Work and Cost-effectiveness Analysis in Patients With Oral Cancer","Inclusion Criteria:\n\n* Adult (\\> 20 years old and younger than 70 years old)\n* Newly diagnosed as OC and scheduled to receive cancer-related treatment\n* Able to use Mobile phone\n* Willing to sign an informed consent form after receiving a detailed explanation of the study's aims and procedures\n* Healthcare professionals involved in patients' care, including doctors, nurses, case managers, dietitians, rehabilitation therapists, and psychologists\n* Family members who are primary caregivers of the participating patients, engaged in different stages of medical care\n\nExclusion Criteria:\n\n* Risk populations for walking or performing exercise\n* Patients with cognitive impairment or psychiatric diseases","20 Years","70 Years",{"count":256,"type":22},650,[25],"The goal of this clinical trial is to develop and evaluate an Artificial Intelligence Assisted Prehabilitation Program (AI APP) for returning to work and cost-effectiveness analysis in patients with oral cancer (OC). The main questions it aims to answer are:\n\n* What kinds of needs are related to returning to work (RTW) in patients with OC from diagnosis to survival that we can incorporate into the development of AI APP to assist this population ?\n* How is the effect of the AI APP that based on findings from the first question for patients with OC on physical and psychological distress, fear of recurrence, self-efficacy in coping with cancer, communication, motor function, quality of life, and RTW?\n* How is the effect of the RTW AI prediction model to identify high-risk groups ? And how is the comprehensive cost effectiveness of benefits and quality of life of the AI APP for OC population?\n\nResearchers will compare patients without using AI APP to see if the AI APP works to assist with coping physical and psychological distress, communication, motor function, quality of life, and RTW issues for individuals with OC?\n\nParticipants will:\n\n* Be asked to fulfill a structural questionnaire, or engage in a semi-structured one-by-one interview or a focus group to assess their physical, psychological, and social support needs in the first stage.\n* Be invited to participant the pilot testing of AI APP in the second stage.\n* Be provided and trained by 3-month AI APP for 3 months or cared as usual in the third stage.\n* Complete a structural questionnaire and follow up one year, including the baseline (before using the AI app) and at 1-2 weeks, 3 months, 6 months, 9 months, and 12 months after the baseline.\n* Engage in one-by-one interview or a focus group to assess user experiences of the AI APP.",[260,261,262,263,264,35,265,266,40,267,110,268,269,270],"Oral Cancer","Psychological Distress","Communication Aids for Disabled","Physiotherapy","Return to Work","Physical Symptom Distress","Motor Function","Quality of Life","Artifical Intelligence","Prediction Model","Case Management, APP(Application)",[272,264,260,261,262,263,35,273,274,40,275,276,277,278],"Artificial Intelligence","Physical symptom distress","motor function","Quality of life","Cost effectiveness","prediction model","case management, APP(Application)","2026-04-24",{"date":281,"type":51},"2026-05-01",{"date":283,"type":51},"2024-09-27",{"date":285,"type":22},"2029-12-01",{"name":287,"class":288},"Taipei Veterans General Hospital, Taiwan","OTHER_GOV",5,{"id":291,"slug":292,"hasResults":12,"nctId":293,"briefTitle":294,"officialTitle":295,"acronym":4,"eligibilityCriteria":296,"healthyVolunteers":12,"sex":18,"minAge":297,"maxAge":298,"enrollmentInfo":299,"targetDuration":4,"studyType":301,"phases":4,"briefSummary":302,"conditions":303,"keywords":305,"overallStatus":47,"whyStopped":4,"lastUpdateSubmitDate":309,"lastUpdatePostDateStruct":310,"startDateStruct":311,"completionDateStruct":313,"leadSponsor":315,"locationsCount":4},"100628077","prehabilitation-to-enhance-preoperative-function-in-elderly-undergoing-abdominal-malignancy-surgery-100628077","NCT07456943","Prehabilitation to Enhance Preoperative Function in Elderly Undergoing Abdominal Malignancy Surgery","Prehabilitation to Enhance Preoperative Function in Elderly Undergoing Abdominal Malignancy Surgery: A Prospective Study at Siriraj Hospital","Inclusion Criteria:\n\n* Diagnosed with intraabdominal malignancy (e.g., colorectal, esophageal, gastric, pancreatic, hepatic, biliary tract, urinary bladder, or endometrial malignancies).\n* Schedules for elective major surgery and formally enrollment in the ERAS program at Siriraj Hospital. (at Siriraj Hospital, patients scheduled for pre-specific elective major surgeries are enrolled into the ERAS program as individual hospital protocols for each ERAS module. All patients are informed about the ERAS program by their surgical team.)\n* Referred to the SiPAP center for prehabilitation in accordance with the ERAS preoperative protocol, with a minimum preoperative time of 14 days before the scheduled surgery date.\n* Able to understand the study protocol and provide written informed consent.\n\nExclusion Criteria:\n\n* Have emergency surgery\n* Reschedule the surgery for an earlier date, allowing less than 14 days for prehabilitation.\n* Severe cardiopulmonary or musculoskeletal conditions that contraindicate exercise (e.g., unstable angina, decompensated heart failure, severe COPD, or orthopedic disability).\n* Cognitive impairment or psychiatric illness precluding participation in prehabilitation.\n* Refusal to participate.\n* Inability to comply with the protocol.","60 Years","90 Years",{"count":300,"type":22},110,"OBSERVATIONAL","The goal of this observational study is to evaluate the effectiveness of the multimodal prehabilitation program at the Siriraj Integrated Preoperative and Prehabilitation Center (SiPAP) on improving preoperative walking capacity and functional status in patients undergoing elective intraabdominal cancer surgery. The main question it aims to answer is:\n\n\\- Does the prehabilitation program lead to a significant change in 6-minute walk distance (6MWD) at preoperative admission as compared to at baseline assessment? Participants will receive the structured multimodal prehabilitation program, which represents the standard of care for patients in the ERAS protocol at the study site. Outcomes will be measured at preoperative admission and at 1 and 3 months after surgery.",[35,304],"Functional Capacity",[35,306,307,308],"Functional capacity","Preoperative care","Abdominal cancer surgery","2026-04-22",{"date":239,"type":51},{"date":312,"type":22},"2026-05",{"date":314,"type":22},"2027-12",{"name":316,"class":58},"Siriraj Hospital",{"id":318,"slug":319,"hasResults":12,"nctId":320,"briefTitle":321,"officialTitle":322,"acronym":4,"eligibilityCriteria":323,"healthyVolunteers":12,"sex":18,"minAge":254,"maxAge":4,"enrollmentInfo":324,"targetDuration":4,"studyType":23,"phases":326,"briefSummary":327,"conditions":328,"keywords":332,"overallStatus":83,"whyStopped":4,"lastUpdateSubmitDate":337,"lastUpdatePostDateStruct":338,"startDateStruct":340,"completionDateStruct":342,"leadSponsor":344,"locationsCount":126},"100628708","multimodal-prehabilitation-of-frail-patients-undergoing-elective-knee-or-hip-replacement-100628708","NCT07465159","Multimodal Prehabilitation of Frail Patients Undergoing Elective Knee or Hip Replacement","Multimodal Prehabilitation of Frail Patients 70 Years and Older Undergoing Elective Knee or Hip Replacement: A Pilot Randomized Controlled Trial","Inclusion Criteria:\n\n* Patients aged 70 years or older assigned to undergo hip\u002Fknee replacement at Landspítali University Hospital.\n* Inclusion will be offered to patients who have previously presented at the outpatient orthopedic department and been scheduled for an elective (with a waiting period ≥2 months before surgery) hip\u002Fknee replacement.\n* Patients who are willing to participate and sign informed consent and are willing to be randomized to the control or intervention arm.\n\nExclusion Criteria:\n\n* Patients who screen negative for all frailty tools will be excluded from the study.\n* Patients who are already in active physiotherapy, meeting with a physiotherapist \\>1 every month, will also be excluded.\n* In addition, those who do not undergo planned surgery, are undergoing redo hip\u002Fknee prosthesis replacement will be excluded",{"count":325,"type":22},50,[25],"Background: Frailty is a geriatric syndrome of reduced physiologic reserve that increases surgical risk and is common among older adults undergoing hip or knee replacement. While prehabilitation has shown promise in enhancing outcomes, evidence from randomized controlled trials (RCTs) in frail orthopedic patients is limited.\n\nObjective: This study aims to evaluate the feasibility and preliminary data on the effectiveness of a multimodal prehabilitation program for frail patients undergoing elective hip or knee arthroplasty.\n\nMethods: A pilot RCT will be conducted at Landspítali-University Hospital. Patients ≥70 years scheduled for surgery with ≥2 months waiting time will be screened for frailty using PRISMA-7, the Clock Drawing Test, and Timed Up \\& Go. Patients screening positive for any of the three screening tools will be randomized to multimodal prehabilitation or standard of care. The intervention includes comprehensive geriatric assessment, medication review, tailored physiotherapy using the Otago Exercise Programme, and nutritional counseling if at risk of malnutrition. We will conduct an external pilot for feasibility measures (overall enrollment, recruitment, retention, adherence). Secondary outcomes include physical performance, postoperative complications, patient-reported health status (WOMAC scale) and quality of life (EQ-5D-5L ), length of primary hospital stay, discharge location, falls postoperatively, 180-day readmission and 180-day mortality.\n\nSignificance: This trial may aid in the design of larger RCT study and provide a signal of the role of multimodal prehabilitation on outcomes, including quality of life and health status among frail arthroplasty patients.",[329,35,330,331],"Frailty Syndrome","Arthroplasties, Knee Replacement","Arthroplasties, Hip Replacement",[139,333,35,334,335,336],"Arthroplasty","Multimodal prehabilitation","Knee replacement","Hip replacement","2026-04-01",{"date":339,"type":51},"2026-04-07",{"date":341,"type":51},"2026-03-20",{"date":343,"type":22},"2027-12-31",{"name":345,"class":58},"University of Iceland",{"id":347,"slug":348,"hasResults":12,"nctId":349,"briefTitle":350,"officialTitle":351,"acronym":4,"eligibilityCriteria":352,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":353,"targetDuration":4,"studyType":23,"phases":355,"briefSummary":356,"conditions":357,"keywords":359,"overallStatus":83,"whyStopped":4,"lastUpdateSubmitDate":337,"lastUpdatePostDateStruct":364,"startDateStruct":366,"completionDateStruct":368,"leadSponsor":370,"locationsCount":126},"100629708","prehab-for-pancreatic-cancer-surgery-100629708","NCT07478185","Prehab for Pancreatic Cancer Surgery","Multimodal Prehabilitation Prior to Pancreatic Cancer Surgery: A Pilot Study","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Diagnosis of pancreatic ductal adenocarcinoma (PDAC)\n* Planned neoadjuvant chemotherapy prior to planned surgical resection\n* Medically stable and cleared to participate in physical activity\u002Fexercise programming\n* Able to provide informed consent\n* Ability to read, write and understand English\n\nExclusion Criteria:\n\n* Age \\\u003C18 years\n* Pregnant\n* Prisoner\n* Severe cognitive impairment that precludes informed consent or participation\n* Contraindications to physical activity, including unstable cardiac disease, severe pulmonary disease, or recent myocardial infarction",{"count":354,"type":22},20,[25],"The goal of this clinical study is to test whether a structured prehabilitation program can be successfully used by adults with pancreatic cancer who are receiving chemotherapy before planned surgery. Prehabilitation is a program designed to improve a person's physical fitness, nutrition, and symptom control before surgery.\n\nThe study's main hypothesis is that patients with pancreatic cancer can take part in and adhere to a multimodal prehabilitation program during chemotherapy, and that doing so may improve physical function, patient experience, and early recovery after surgery.",[358,35],"Pancreatic Cancer, Adult",[35,360,306,361,362,363],"Nutritional status","Pancreatic cancer","Pancreatectomy","Pancreaticoduodenectomy",{"date":365,"type":51},"2026-04-03",{"date":367,"type":51},"2026-03-31",{"date":369,"type":22},"2028-12",{"name":371,"class":58},"University of Massachusetts, Worcester",{"id":373,"slug":374,"hasResults":12,"nctId":375,"briefTitle":376,"officialTitle":377,"acronym":4,"eligibilityCriteria":378,"healthyVolunteers":68,"sex":69,"minAge":19,"maxAge":254,"enrollmentInfo":379,"targetDuration":4,"studyType":23,"phases":381,"briefSummary":382,"conditions":383,"keywords":4,"overallStatus":47,"whyStopped":4,"lastUpdateSubmitDate":386,"lastUpdatePostDateStruct":387,"startDateStruct":389,"completionDateStruct":391,"leadSponsor":393,"locationsCount":126},"100625261","preoperative-shoulder-exercises-and-postoperative-inflammation-pain-and-function-after-modified-radical-mastectomy-100625261","NCT07420335","Preoperative Shoulder Exercises and Postoperative Inflammation, Pain, and Function After Modified Radical Mastectomy","The Effect of Preoperative Shoulder Range-of-Motion Exercises on C-Reactive Protein (CRP) Levels, Pain, and Shoulder Joint Dysfunction, as Well as Quality of Life in Patients With Locally Advanced Breast Cancer After Modified Radical Mastectomy","Inclusion Criteria:\n\n* Patients with clinically locally advanced breast cancer (stage IIIA-IIIC according to the American Joint Committee on Cancer staging system) who have been scheduled to undergo modified radical mastectomy.\n* Age ≥ 18 years at the time of diagnosis\n* Willing to undergo preoperative rehabilitation for 6-8 weeks and to perform the recommended home-based exercise program.\n* Willing to participate in follow-up via telephone.\n\nExclusion Criteria:\n\n* Inability to understand verbal or written communication, resulting in difficulty following exercise instructions.\n* Intraoperative complications, such as injury to or transection of the thoracodorsal nerve, long thoracic nerve, and\u002For intercostobrachial nerve.\n* Postoperative complications leading to delayed wound healing, defined as incomplete wound healing at one month after surgery, including wound dehiscence, wound infection, or abscess formation.\n* Pre-existing shoulder joint motion limitation diagnosed prior to surgery (e.g., preoperative frozen shoulder).\n* Presence of inflammatory conditions in other body regions at the start of or during the study that may result in elevated leukocyte counts, such as diarrhea, urinary tract infection, or skin infection.\n* Requirement for nonsteroidal anti-inflammatory drugs (NSAIDs) or systemic corticosteroids for the management of inflammation.\n\nDrop out criteria:\n\n* incomplete follow up\n* Unwillingness to undergo repeated blood sampling during the study period.",{"count":380,"type":22},52,[25],"This study evaluates whether preoperative shoulder range-of-motion exercises influence postoperative inflammatory response, pain, shoulder function, and quality of life in patients with locally advanced breast cancer undergoing modified radical mastectomy.",[384,385,35],"Locally Advanced Breast Cancer (LABC)","Postoperative Inflammation","2026-02-12",{"date":388,"type":51},"2026-02-19",{"date":390,"type":22},"2026-01-21",{"date":392,"type":22},"2026-12-03",{"name":394,"class":58},"Indonesia University",{"id":396,"slug":397,"hasResults":12,"nctId":398,"briefTitle":399,"officialTitle":400,"acronym":401,"eligibilityCriteria":402,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":403,"enrollmentInfo":404,"targetDuration":4,"studyType":23,"phases":406,"briefSummary":407,"conditions":408,"keywords":4,"overallStatus":47,"whyStopped":4,"lastUpdateSubmitDate":409,"lastUpdatePostDateStruct":410,"startDateStruct":412,"completionDateStruct":414,"leadSponsor":416,"locationsCount":126},"100622909","preoperative-physical-exercise-nutritional-support-and-psychological-intervention-multimodal-prehabilitation-to-strengthen-patients-overall-health-and-reduce-postoperative-complications-100622909","NCT07389746","Preoperative Physical Exercise, Nutritional Support, and Psychological Intervention (Multimodal Prehabilitation) to Strengthen Patients' Overall Health and Reduce Postoperative Complications","Multimodal Prehabilitation Reduces Postoperative Complications in High Risk Patients Undergoing Major Gastrointestinal Cancer Surgery","PREHAB","Inclusion Criteria:\n\n* Candidate to elective major gastrointestinal cancer surgery (pelvic exenteration, cytoreductive surgery, oesophagectomy, transhiatal gastrectomy, hepatectomy, pancreatectomy, rectum resection)\n* High risk for surgical complications defined by presence of comorbid disease such as deconditioning, heart disease, diabetes, renal impairment or morbid obesity\n* Duke Activity Status Index score (DASI) \\\u003C402\n* Schedule allowing for at least 4 weeks for intervention with multimodal prehabilitation prior to surgery \u002F willingness to exercise\n\nExclusion Criteria:\n\n* Non-elective surgery\n* Unstable cardiac or respiratory disease\n* Locomotor limitations precluding exercise training\n* Cognitive deterioration impeding adherence to the programme\n* Enrolment in other research studies affecting study endpoint","80 Years",{"count":405,"type":22},400,[25],"In this prospective, randomized, controlled trial patients undergoing major gastrointestinal cancer surgery will be exercised (intervention group) 4 weeks before surgery with a high-intensity interval training (HIIT). They will also receive a specialized nutrition therapy and psychological support (multimodal prehabilitation). Aim of this study is to find out if the prehabilitation group is more resilient to postoperative complications when compared to the control group that will receive standard of care. Another goal is to unravel the underlying mechanisms that are stimulated by exercise like enhancing vascular function, improving immune system response, strengthen cellular tumor defense and optimizing neurological outcome.",[44,35],"2026-02-10",{"date":411,"type":51},"2026-02-13",{"date":413,"type":22},"2026-07-01",{"date":415,"type":22},"2029-01-01",{"name":417,"class":58},"University Hospital of Cologne",{"id":419,"slug":420,"hasResults":12,"nctId":421,"briefTitle":422,"officialTitle":423,"acronym":424,"eligibilityCriteria":425,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":426,"enrollmentInfo":427,"targetDuration":4,"studyType":23,"phases":429,"briefSummary":430,"conditions":431,"keywords":432,"overallStatus":83,"whyStopped":4,"lastUpdateSubmitDate":435,"lastUpdatePostDateStruct":436,"startDateStruct":438,"completionDateStruct":440,"leadSponsor":442,"locationsCount":126},"100623280","preoperative-optimization-before-total-hip-or-knee-replacement-surgery-100623280","NCT07394582","Preoperative Optimization Before Total Hip or Knee Replacement Surgery","Preoperative Optimization Before Total Hip or Knee Replacement Surgery - a Controlled, Randomized, Single-blind Study","PrOpE","Inclusion Criteria:\n\n* American Society of Anesthesiologists (ASA) physical status classification ≥ 3\n* Age between 18 and 99 years\n* All sexes\n* Elective total hip or knee replacement with a waiting period of ≥ 8 weeks between surgical indication and surgery\n* Ability to understand the nature, content, and procedures of the study and to provide written informed consent\n* Written informed consent obtained prior to any study-related procedure\n\nExclusion Criteria:\n\n* Pregnancy or active breastfeeding\n* Severe trauma or major blood loss within 14 days prior to enrollment\n* Participation in another pharmacological or interventional clinical study\n* Contraindications to physical training\n* Pre-existing diagnosis of moderate to severe dementia","99 Years",{"count":428,"type":22},180,[25],"Preoperative Optimisation prior to Hip and Knee Arthroplasty (PrOpE) Many patients scheduled for planned hip or knee replacement surgery have health conditions that may affect recovery, such as reduced physical fitness, nutritional problems, multiple medications, or increased stress and anxiety. These factors can increase the risk of complications and delay recovery after surgery.\n\nThe PrOpE study examines whether a structured preparation programme before surgery, known as preoperative optimization or prehabilitation, can be safely implemented and may support recovery after hip or knee replacement.\n\nAim of the study The main aim is to assess the feasibility of a comprehensive preoperative optimisation programme and to explore its potential effects on recovery and health outcomes. The results will help improve future care for patients undergoing major orthopaedic surgery.\n\nWho can participate? Adult patients scheduled for elective total hip or knee replacement surgery who are classified as ASA \\>2, aged between 18 and 99 years old and without a severe cognitive impairment. Participation is voluntary.\n\nStudy design\n\nA total of 180 participants will be included and randomly assigned to one of two groups:\n\n• Standard Care Group: Participants receive usual medical care before and after surgery.\n\n• Intervention Group:\n\nIn addition to standard care, participants receive an individualised preparation programme over several weeks before surgery. This programme may include:\n\n* Personalised physical exercise\n* Nutritional assessment and advice\n* Support for stress, pain, and mental well-being\n* Review of regular medications Some elements may be delivered at home or via telemedicine, depending on individual needs.\n\nWhat information is collected? The study evaluates recovery after surgery, including complications, length of hospital stay, physical function, quality of life, and use of health care services. Questionnaires, physical tests, and blood samples are used to better understand health status before and after surgery.\n\nRisks and benefits The study involves low additional risk. All measures are adapted to individual abilities and supervised by trained professionals. The main burden is the additional time required for participation. Participants in the optimisation group may benefit from improved preparation for surgery. The study also contributes to improving care for future patients.",[35,45],[433,434],"Preoperative Optimization","orthopedic surgery","2026-02-09",{"date":437,"type":51},"2026-02-11",{"date":439,"type":22},"2026-02-05",{"date":441,"type":22},"2034-02-05",{"name":443,"class":58},"Medical University Innsbruck",{"id":445,"slug":446,"hasResults":12,"nctId":447,"briefTitle":448,"officialTitle":449,"acronym":450,"eligibilityCriteria":451,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":452,"targetDuration":4,"studyType":23,"phases":453,"briefSummary":454,"conditions":455,"keywords":4,"overallStatus":83,"whyStopped":4,"lastUpdateSubmitDate":457,"lastUpdatePostDateStruct":458,"startDateStruct":460,"completionDateStruct":462,"leadSponsor":464,"locationsCount":126},"100537676","prehab-prior-to-stem-cell-transplantation-in-multiple-myeloma-100537676","NCT06280924","Prehab Prior to Stem Cell Transplantation in Multiple Myeloma","Multiple Myeloma Exercise Prehabilitation for Individuals Awaiting a Stem Cell Transplantation (MOTIVATE): A Randomized Controlled Feasibility Trial","MOTIVATE","Inclusion Criteria:\n\n1. Have a diagnosis of Multiple Myeloma\n2. Be transplant eligible\n3. Be undergoing chemotherapy prior to, or following an autologous stem cell transplant as part of their cancer treatment; or transplant ineligible.\n4. Be an Alberta resident\n5. Be ≥18 years of age\n6. Be able to read and understand English.\n\nExclusion Criteria:\n\n1. Their disease status\u002Fcomorbidities preclude exercise testing or participation\n2. They are unable to commit to the 10-week exercise program and\u002For testing sessions at the Cancer Rehabilitation Clinic at the University of Alberta\n3. They do not have regular access to the internet and\u002For an electronic device in the home.",{"count":21,"type":22},[25],"The primary purpose of this study is to see if individuals with Multiple Myeloma are able and interested in taking part in a tailored exercise program while undergoing their chemotherapy prior to a stem cell transplant. We also hope to learn if this type of program, along with a flexible delivery format (in-person and virtual), helps in maintaining or improving physical fitness, muscle mass and strength, and quality of life during chemotherapy.",[456,108,35],"Multiple Myeloma","2026-02-03",{"date":459,"type":51},"2026-02-06",{"date":461,"type":51},"2024-08-06",{"date":463,"type":22},"2026-07-31",{"name":465,"class":58},"University of Alberta",{"id":467,"slug":468,"hasResults":12,"nctId":469,"briefTitle":470,"officialTitle":471,"acronym":472,"eligibilityCriteria":473,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":298,"enrollmentInfo":474,"targetDuration":4,"studyType":23,"phases":476,"briefSummary":477,"conditions":478,"keywords":483,"overallStatus":83,"whyStopped":4,"lastUpdateSubmitDate":489,"lastUpdatePostDateStruct":490,"startDateStruct":492,"completionDateStruct":494,"leadSponsor":496,"locationsCount":126},"100621011","the-primrose-trial-100621011","NCT07365072","The PRIMROSE Trial","A Randomised Controlled Trial to Evaluate the Impact of Thoracic PRehabilitation With Inspiratory Muscle tRaining cOmpared to Standard prEhabilitation in People With Lung Cancer for Surgical Treatment . The PRIMROSE Trial","PRIMROSE","Inclusion Criteria: Adults with lung cancer with surgically resectable disease who are referred for pre-treatment optimization with Prehab, from the lung cancer Multi-Disciplinary Teams (MDTs).\n\nThe referral criteria for Prehab is below:\n\n* ≥1 Medical Research Council (MRC) dyspnoea score\n* ≥1 World Health Organization (WHO) performance status (PS)\n* Age ≥ 70 years\n* Frailty index \\>3\n* Borderline or poor pulmonary function (forced expiratory volume in one second (FEV1) \\\u003C 50% or diffusion capacity for carbon monoxide (DLCO) \\\u003C50%)\n* Sedentary people despite having adequate FEV1 or DLCO\n* People who are eligible for surgical procedures, including endobronchial excision of tumour, or lobectomy, segmental resection, pneumonectomy or wedge resection, either via a minimally invasive approach or a standard thoracotomy approach\n\nAdditionally:\n\n* Participants will be included in the trial if they are capable of providing verbal and written consent for Prehab, and written consent for undergoing a surgical procedure for lung cancer\n* People over 18 years of age\n* All people will be considered regardless of their baseline respiratory muscle strength\n\nExclusion Criteria: Inclusion criteria not met\n\n* People diagnosed with other cancers namely, metastatic lung cancer, mesothelioma, sarcoma, mediastinal tumours, or benign diseases\n* People who decline Prehab\n* People who do not consent to Prehab, and do not attend Prehab. People who do not consent to surgery\n* People with a high cardiovascular risk for Prehab and awaiting investigations or interventions (including unstable angina and syncope)\n* People with a serious concomitant disorder that would compromise safety during Prehab\n* People with an abdominal hernia or recent abdominal surgery\n* People with a history of spontaneous pneumothorax and\u002For evidence of large bullae on radiological imaging\n* People with an inability to understand written and\u002For spoken English (only if carers are able to translate)\n* People with a perforated ear drum\n* People with worsening heart failure signs and symptoms after IMT\n* People with pulmonary hypertension\n* People who have suffered from or likely to suffer from costochondritis\n* If a participant was involved in a similar study, with potential to cause bias or conflict of interest then they will be excluded",{"count":475,"type":22},100,[25],"Smoking is a major cause for developing lung cancer. People diagnosed with lung cancer, may be offered surgery which offers a complete cure. Smoking also damages the lungs and compromises a person's lung function, resulting in shortness of breath. Breathlessness limits the ability to carry out daily physical activities and exercise and makes people vulnerable to developing post procedure complications and even death. Some people with surgically treatable lung cancer have a poor ability to exercise and compromised lung function and are not fit for surgery. They will instead be referred for radiation therapy, chemotherapy or palliative care. Surgery is the preferred treatment option.\n\nThe pulmonary rehabilitation program (Prehab) improves fitness levels. In addition, it improves the level of breathlessness, exercise capacity and vulnerability of people with lung cancer, with the aim of making them fit for safe surgery. By adding a breathing training device to the Prehab program, the investigators aim to further improve participants fitness for surgery, lower their risk of developing complications and the time spent in hospital after the procedure. The breathing training device is called an inspiratory muscle training device. The hand-held device helps to train and strengthen the breathing muscles, which are then able to work more effectively. After the procedure, participants may be able to breathe and exercise more easily reducing their risk of developing complications and improving outcomes.\n\nThe study will compare two groups of people with lung cancer having surgical removal of part of the lung, at a specialist hospital . One group will receive standard Prehab and inspiratory muscle training with the device prior to the procedure; patients in the second group with receive standard Prehab prior to the procedure. Participants will be followed up for twelve months.",[107,479,480,35,481,482],"Lung Resection","Inspiratory Muscle Training","Respiratory Complications","Length of Hospital Stay",[484,107,485,35,486,487,488],"Inspiratory muscle training","Lung resection","Lung surgery","Randomised control trial","length of hospital stay","2026-01-28",{"date":491,"type":51},"2026-01-30",{"date":493,"type":51},"2025-05-01",{"date":495,"type":22},"2027-05-01",{"name":497,"class":58},"Swansea Bay University Health Board",{"id":499,"slug":500,"hasResults":12,"nctId":501,"briefTitle":502,"officialTitle":503,"acronym":504,"eligibilityCriteria":505,"healthyVolunteers":12,"sex":69,"minAge":19,"maxAge":4,"enrollmentInfo":506,"targetDuration":4,"studyType":23,"phases":508,"briefSummary":509,"conditions":510,"keywords":512,"overallStatus":83,"whyStopped":4,"lastUpdateSubmitDate":517,"lastUpdatePostDateStruct":518,"startDateStruct":520,"completionDateStruct":522,"leadSponsor":524,"locationsCount":126},"100601215","multimodal-prehabilitation-program-that-combines-physical-exercise-psychological-intervention-and-nutritional-support-to-improve-the-response-to-neoadjuvant-chemoterhapy-in-early-breast-cancer-patients-100601215","NCT07107594","Multimodal Prehabilitation Program That Combines Physical Exercise, Psychological Intervention and Nutritional Support to Improve the Response to Neoadjuvant Chemoterhapy in Early Breast Cancer Patients","Multimodal Intervention During Neoadjuvant Chemotherapy in Patients With Early-breast Cancer as a Strategy to Improve Treatment Response: DIANA Trial (Multimodal Prehabilitation: DIet, ANxiety Control Psychotherapy, Physical Activity)","DIANA","Inclusion Criteria:\n\n* Histologically confirmed diagnosis of non-metastatic breast cancer: stages cT1-T4, cN0-N3, M0, and candidates for neoadjuvant chemotherapy (NAC).\n* Age ≥ 18 years.\n* Signed informed consent.\n\nExclusion Criteria:\n\n* Contraindication or physical inability to perform moderate-to-high intensity physical exercise.\n* Pregnant or breastfeeding patients.\n* Presence of other active synchronous neoplasms.\n* Metastatic breast cancer (stage IV).\n* Patients already engaging in regular physical exercise: more than 150 minutes of moderate or intense aerobic exercise per week.\n* Male breast cancer patients.\n* Personal history of a previous malignancy treated with chemotherapy.\n* Severe or poorly controlled psychiatric illness (including uncontrolled active substance abuse).",{"count":507,"type":22},214,[25],"The aim of this clinical trial is to evaluate whether following a multimodal prehabilitation program including physical exercise, nutritional support and psychological intervention during neoadjuvant chemotherapy in breast cancer patients could improve the pathological response to chemotherapy.\n\n214 women with non-metastatic breast cancer with indication of chemotherapy before surgery will be eligible to participate. Patients will be randomly assigned to either the intervention group or the control group.\n\n* Patients assigned to the intervention group (107 women) will undergo a directed multimodal prehabilitation program during the chemotherapy (4-6 months), including structured physical exercise, psychological intervention and nutritional guidance.\n* Patients assigned to the control group (107 women) will undergo standard clinical management for their disease without multimodal prehabilitation.\n\nThe response to chemotherapy between the two groups will be evaluated and compared. It is expected that multimodal prehabilitation will increase the response to chemotherapy and will improve the postoperative recovery of patients and their quality of life, as well as reducing the number of complications from surgery and chemotherapy treatment. Changes in the tumor microenvironment are also expected after prehabilitation.",[511,35],"Breast Cancer Early Stage Breast Cancer (Stage 1-3)",[513,514,35,334,515,516,275],"Breast cancer","Early breast cancer","Neoadjuvant chemotherapy","Lifestyle","2026-01-14",{"date":519,"type":51},"2026-01-15",{"date":521,"type":51},"2025-01-14",{"date":523,"type":22},"2028-03",{"name":525,"class":58},"Hospital Clinic of Barcelona",{"id":527,"slug":528,"hasResults":12,"nctId":529,"briefTitle":530,"officialTitle":531,"acronym":532,"eligibilityCriteria":533,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":534,"targetDuration":4,"studyType":23,"phases":536,"briefSummary":537,"conditions":538,"keywords":541,"overallStatus":83,"whyStopped":4,"lastUpdateSubmitDate":545,"lastUpdatePostDateStruct":546,"startDateStruct":548,"completionDateStruct":550,"leadSponsor":551,"locationsCount":126},"100614363","virtual-group-prehabilitation-education-surgery-school-feasibility-trial-100614363","NCT07278622","Virtual Group Prehabilitation Education (Surgery School) Feasibility Trial","Feasibility Testing and Process Evaluation of a Virtual Group Preoperative Prehabilitation Education Intervention (GoPREPARE)","GoPREPARE","Inclusion Criteria:\n\n* Adults undergoing elective surgery for any body cavity cancer with curative intent.\n* Adults with more than 3 weeks before planned surgery\n* Adults without previous experience of prehabilitation.\n\nExclusion Criteria:\n\n* Children\n* Adults who lack mental capacity.\n* Adults who do not understand spoken English.\n* Previous experience of prehabilitation.\n* Previous surgery for cancer\n* Pregnancy",{"count":535,"type":22},24,[25],"One in four patients requiring planned major surgery have complications. Prehabilitation; which involves increasing physical activity, improving nutrition and supporting emotional well-being prior to surgery can reduce these complications and improve recovery. Group preoperative prehabilitation classes (surgery schools) are advocated by the Centre for Perioperative Care and are standard care in many hospitals, despite a lack of evidence for their effectiveness in improving patient outcomes. In phase 1 an 2 of this research investigators used patient experiences and co-participatory methods to optimise an existing intervention to make it as acceptable and as engaging as possible. The resulting education package is called 'GoPREPARE'\n\nInvestigators now intend to test the practicalities of trialing GoPREPARE on preoperative patients with cancer. 24 patients awaiting surgery will be recruited from University Hospital Plymouth and randomly allocated equally to: Group - GoPREPARE and Group 2- standard care. Participants will complete lifestyle questionnaires before during and after their hospital stay. To evaluate the experience, \\~8 participants will be interviewed. 5 clinical staff involved in the trial will also take part in a focus group. The information collected will be analysed to assess if it is feasible to conduct a larger trial.",[44,539,540,35],"Elective Surgery","Patient Education",[542,170,543,544],"surgery school","patient education","perioperative care","2025-12-11",{"date":547,"type":51},"2025-12-12",{"date":549,"type":51},"2025-09-02",{"date":413,"type":22},{"name":552,"class":58},"University Hospital Southampton NHS Foundation Trust",{"id":554,"slug":555,"hasResults":12,"nctId":556,"briefTitle":557,"officialTitle":558,"acronym":4,"eligibilityCriteria":559,"healthyVolunteers":12,"sex":18,"minAge":560,"maxAge":4,"enrollmentInfo":561,"targetDuration":4,"studyType":23,"phases":563,"briefSummary":564,"conditions":565,"keywords":572,"overallStatus":83,"whyStopped":4,"lastUpdateSubmitDate":575,"lastUpdatePostDateStruct":576,"startDateStruct":578,"completionDateStruct":580,"leadSponsor":582,"locationsCount":126},"100555754","auricular-acupressure-in-prehabilitation-100555754","NCT06516198","Auricular Acupressure in Prehabilitation","A Pilot Study of the Utility of Auricular Acupressure in Enhancing Prehabilitation Benefits in Candidates for Thoracic Surgery.","Inclusion Criteria\n\n* Being considered for major lung surgery\n* Surgery is not scheduled for at least 2 weeks\n* Age ≥ 50 years\n* Able to understand English at a 4th grade level\n* No known contraindications to prehabilitation (strength, endurance, balance exercises)\n* Able to provide informed consent for participation\n* Has an adult care partner who will be available and capable of placing seeds\n* Has access to smart phone for communication and image sharing\n* Underwent frailty screening (given any score)\n* Able to perform spirometry testing in clinic\n\nExclusion Criteria:\n\n* Allergy to Vaccaria seeds\n* Medical condition affecting either ear preventing use of auricular acupressure such as eczema, frostbite, sunburn","50 Years",{"count":562,"type":22},40,[25],"Complementary medicine is recognized for its ability to enhance appetite, increase energy, reduce anxiety, decrease pain, and improve sleep, among many other benefits. Acupuncture is among the most frequent types of complementary medicine practiced in the US, and Medicare currently includes back pain as a reimbursable indication for this therapy. Acupuncture-related therapies may enhance efforts at prehabilitation in candidates for major lung resection.",[139,566,35,567,568,569,570,571],"Thoracic","Lung Surgery","Wedge Resection","Segmentectomy","Lobectomy","Pneumonectomy; Status",[573,574],"accupressure","vaccaria seeds","2025-12-02",{"date":577,"type":51},"2025-12-09",{"date":579,"type":51},"2025-07-21",{"date":581,"type":22},"2027-06-20",{"name":583,"class":58},"University of Chicago",{"id":585,"slug":586,"hasResults":12,"nctId":587,"briefTitle":588,"officialTitle":589,"acronym":590,"eligibilityCriteria":591,"healthyVolunteers":12,"sex":18,"minAge":101,"maxAge":4,"enrollmentInfo":592,"targetDuration":4,"studyType":23,"phases":594,"briefSummary":595,"conditions":596,"keywords":597,"overallStatus":47,"whyStopped":4,"lastUpdateSubmitDate":600,"lastUpdatePostDateStruct":601,"startDateStruct":603,"completionDateStruct":605,"leadSponsor":606,"locationsCount":126},"100607472","patient-centered-rehabilitation-program-to-advance-recovery-100607472","NCT07189000","Patient-centered REhabilitation Program to Advance REcovery","A Patient-centered Prehabilitation Program to Enhance Postoperative Recovery in Patients With Malignant Cancer","PREPARE-CAN","Inclusion Criteria:\n\n* Adults ≥18 years.\n* Elective cancer surgery planned under general anesthesia at a participating site (e.g., gastrointestinal, hepatobiliary-pancreatic, thoracic, gynecologic, or other site-approved cancer operations).\n* Ambulatory: able to walk independently (assistive device such as a cane is allowed) and deemed safe to perform a six-minute walk test (6MWT) per investigator judgment.\n* Smartphone access and app use: owns\u002Fhas regular access to a smartphone capable of running the study app and agrees to use the app (notifications, weekly home 6MWT logging, brief daily check-ins).\n* Preoperative lead-in: expected interval of ≈14 days or more between consent\u002Frandomization and surgery to allow prehabilitation exposure (shorter intervals may be screened but must allow minimum onboarding and at least one home 6MWT).\n* Able to understand study procedures and provide written informed consent (Korean or English literacy sufficient to follow app instructions).\n\nExclusion Criteria:\n\n* Emergency surgery or surgery date that cannot accommodate even minimal prehabilitation onboarding.\n* ASA IV or higher, or any unstable\u002Fcritical condition that, in the investigator's opinion, makes participation unsafe.\n* Contraindications to 6MWT\u002Flight walking, including but not limited to: unstable angina, recent myocardial infarction (≤30 days), decompensated heart failure, uncontrolled clinically significant arrhythmia, severe symptomatic aortic stenosis, severe uncontrolled pulmonary disease, or investigator-judged safety concerns (e.g., resting severe hypoxemia, high fall risk).\n* Non-ambulatory status or musculoskeletal\u002Fneurologic conditions that preclude performing a 6MWT.\n* Cognitive impairment or psychiatric\u002Fbehavioral conditions that preclude informed consent or reliable app use.\n* Inability or unwillingness to install\u002Fuse the study app (or lack of regular smartphone access).\n* Concurrent enrollment in another interventional clinical trial that would confound outcomes or burden participants (per investigator judgment).\n* Any other medical or logistical condition that, in the opinion of the investigator, would interfere with protocol adherence, outcome assessment on the preoperative day, or the routine postoperative follow-up visit.",{"count":593,"type":22},60,[25],"The goal of this clinical trial is to learn whether an app-based, patient-centered prehabilitation program improves preoperative functional capacity in adults scheduled for elective cancer surgery. The main questions it aims to answer are:\n\nDoes the program increase the six-minute walk distance (6MWD) measured on the preoperative day (within 24-48 hours before surgery)?\n\nCompared with usual care, does the program improve preoperative adherence to home 6MWT practice and patient-reported anxiety\u002Fdepression (HADS)?\n\nResearchers will compare an app-based prehabilitation program to usual care to see if the program improves preoperative functional capacity.\n\nParticipants will:\n\nUse a study app to perform weekly home six-minute walk tests (6MWT) and complete brief daily check-ins (exercise, nutrition, psychological status) before surgery.\n\nAttend routine preoperative admission (no extra visit) for in-hospital 6MWT (primary endpoint) and brief assessments (grip strength, Timed Up \\& Go, HADS, skeletal muscle mass by InBody where available\u002Ffee-free).\n\nAttend one routine postoperative outpatient visit at 3 or 6 months (site-standard timing) for follow-up assessments.\n\nNo additional study-specific clinic visits are required outside usual care.",[107,139,35],[170,598,599],"frailty","cancer","2025-09-16",{"date":602,"type":51},"2025-09-23",{"date":604,"type":22},"2026-01-01",{"date":343,"type":22},{"name":607,"class":58},"Korea University Anam Hospital",{"id":609,"slug":610,"hasResults":12,"nctId":611,"briefTitle":612,"officialTitle":613,"acronym":614,"eligibilityCriteria":615,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":616,"targetDuration":4,"studyType":301,"phases":4,"briefSummary":618,"conditions":619,"keywords":623,"overallStatus":47,"whyStopped":4,"lastUpdateSubmitDate":626,"lastUpdatePostDateStruct":627,"startDateStruct":629,"completionDateStruct":631,"leadSponsor":633,"locationsCount":4},"100605222","evaluation-of-seismocardiographyscg-for-assessing-fitness-and-predicting-outcomes-in-oesophageal-cancer-surgery-100605222","NCT07159711","Evaluation of Seismocardiography(SCG) for Assessing Fitness and Predicting Outcomes in Oesophageal Cancer Surgery","Evaluation of Seismocardiography (SCG) as a Tool for Assessing Fitness and Predicting Outcomes in Oesophageal Cancer Surgery","SEISMIC","Inclusion Criteria:\n\n* Age \\>=18\n* Diagnosis of Oesophageal cancer (T0-4 N0-3 M0, Oesophageal \u002F Gastro-Oesophageal Junction (GOJ) type 1-2 adenocarcinoma\n* Patients being considered for curative treatment (i.e. due to undergo NAC and Oesophagectomy \u002F Oesophago-Gastrectomy \\[open \u002F MIO \u002F hybrid \u002F robotic\\])\n* Patients able to give informed consent\n\nExclusion Criteria:\n\n* Pregnant patients.\n* Patients under the age of 18.\n* Patients undergoing primary Oesophagectomy +\u002F- Oesophago-Gastrectomy with no neoadjuvant therapy.\n* Patients undergoing Neoadjuvant chemoradiotherapy.\n* Patient's being treated with curative intent for Oesophageal Squamous cell carcinoma\n* Patients that are deemed not fit or suitable for Oesophagogastric cancer resection as part of a Multi-Disciplinary Team meeting decision.\n* Patients with implanted devices such as pacemakers or cardioverter-defibrillators.",{"count":617,"type":22},164,"Oesophageal cancer is a common cause of cancer death worldwide. Curative treatment involves chemotherapy and surgery but has significant risks. Therefore, patient selection and improving physical fitness to withstand such major treatment is important to reduce the risk of complications. Physical fitness is traditionally measured by a specialised exercise test called Cardiopulmonary exercise testing (CPET), which can take up to one hour and requires specialised staff and expensive equipment such as a graded exercise bike or treadmill. Seismofit is a small device (smaller than a smartphone) used to estimate fitness in patients in under three minutes while lying down at rest. It measures the vibrations generated by the heart and, together with patient height, weight, age, and gender, accurately estimates fitness using an algorithm developed in healthy patients. The device has never been tested in a large group of oesophageal cancer patients to see if it can be used to predict complications in patients undergoing cancer treatment.\n\nIn this study, patients undergoing Oesophageal cancer treatment with chemotherapy or chemoradiotherapy and surgery will have Seismofit measurements at various points during their treatment to see if we can predict complications and hospital stay. Secondly, this study will also evaluate the accuracy of Seismofit compared to the gold standard CPET results in cancer patients.",[31,620,35,621,622],"Oesophageal Adenocarcinoma","Oesophagectomy","Neoadjuvant Chemotherapy",[624,621,625,35,515],"oesophageal cancer","Fitness","2025-08-29",{"date":628,"type":51},"2025-09-08",{"date":630,"type":22},"2025-09-15",{"date":632,"type":22},"2027-06",{"name":634,"class":58},"Guy's and St Thomas' NHS Foundation Trust",{"id":636,"slug":637,"hasResults":12,"nctId":638,"briefTitle":639,"officialTitle":640,"acronym":641,"eligibilityCriteria":642,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":643,"targetDuration":4,"studyType":23,"phases":645,"briefSummary":646,"conditions":647,"keywords":649,"overallStatus":47,"whyStopped":4,"lastUpdateSubmitDate":655,"lastUpdatePostDateStruct":656,"startDateStruct":658,"completionDateStruct":659,"leadSponsor":661,"locationsCount":126},"100604069","prehabilitation-program-for-patients-awaiting-elective-heart-surgery-at-increased-risk-of-postoperative-complications-feasibility-and-potential-clinical-outcomes-100604069","NCT07144722","Prehabilitation Program for Patients Awaiting Elective Heart Surgery at Increased Risk of Postoperative Complications: Feasibility and Potential Clinical Outcomes","Preliminary Evaluation of a Prehabilitation Program for Adults Awaiting Elective Heart Surgery and at Increased Risk of Postoperative Complications","PRÉAD-CARDIAQU","Inclusion Criteria:\n\n* A high risk of perioperative and postoperative complications. This risk is determined based on the predictive thresholds for postoperative complications.\n* A waiting period of at least 8 weeks.\n* Access to a smartphone, tablet, or computer for videoconference visits.\n\nExclusion Criteria:\n\n* Unstable angina, malignant arrhythmias, active endocarditis\u002Fmyocarditis, myocardial infarction within the last 2 weeks, left main coronary artery disease ≥ 50% on coronary angiography, severe aortic stenosis, severe mitral insufficiency, and decompensated heart failure.\n* Any other acute condition affecting vital signs or causing significant symptoms.\n* Physical or cognitive impairment limiting the ability to participate in the program.",{"count":644,"type":22},45,[25],"The goal of this study is to learn if an exercise-based prehabilitation program can help people who are waiting for heart surgery and are at higher risk of complications recover better.\n\nThe main questions it aims to answer are:\n\nCan a home-based prehabilitation program prescribed by a physiotherapist be done safely and realistically before heart surgery?\n\nParticipants will:\n\nTake part in a personalized exercise program for a 8 to 16 weeks before surgery\n\nDo breathing muscle training at home\n\nMeet with a physiotherapist once a week, either in person or by video call\n\nBe assessed before and after the program\n\nResearchers will compare the postoperative results with those of patients who received usual care only.",[648,35,198],"Cardiac Surgery",[650,651,652,653,654],"exercise-based prehabilitation","pulmonary postoperative complications","teleprehabilitation","elective surgery","cardiac procedures","2025-08-20",{"date":657,"type":51},"2025-08-27",{"date":630,"type":22},{"date":660,"type":22},"2026-06-15",{"name":662,"class":58},"Montreal Heart Institute",{"id":664,"slug":665,"hasResults":12,"nctId":666,"briefTitle":667,"officialTitle":668,"acronym":4,"eligibilityCriteria":669,"healthyVolunteers":12,"sex":670,"minAge":297,"maxAge":298,"enrollmentInfo":671,"targetDuration":4,"studyType":23,"phases":673,"briefSummary":674,"conditions":675,"keywords":678,"overallStatus":47,"whyStopped":4,"lastUpdateSubmitDate":681,"lastUpdatePostDateStruct":682,"startDateStruct":684,"completionDateStruct":686,"leadSponsor":687,"locationsCount":126},"100483571","enhanced-recovery-after-surgery-eras-pathway-in-patients-undergoing-robot-assisted-laparoscopic-radical-prostatectomy-100483571","NCT05576766","Enhanced Recovery After Surgery (ERAS) Pathway in Patients Undergoing Robot-Assisted Laparoscopic Radical Prostatectomy","Impact of Enhanced Recovery After Surgery (ERAS) Pathway on Outcomes in Patients Undergoing Robot-Assisted Laparoscopic Radical Prostatectomy: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Aged 60 years or over but below 90 years.\n* Scheduled to undergo robot-assisted laparoscopic radical prostatectomy (RARP) for prostate cancer.\n* Agree to participate in this study and give written informed consent.\n\nExclusion Criteria:\n\n* Scheduled to undergo combined surgery, including RARP combined with pelvic lymph node dissection or other procedures.\n* American Society of Anesthesiologists (ASA) physical classification ≥IV.\n* Inability to receive preoperative aerobic exercise because of severe cardiovascular disease, motor system diseases (arthritis, lumbar vertebrae disease), or central nervous system diseases (epilepsy, parkinsonism).\n* Inability to communicate in the preoperative period because of profound dementia, deafness, or language barriers.\n* History of schizophrenia, anxiety or depressive disorders, or other mental disorders.","MALE",{"count":672,"type":22},54,[25],"Prostate cancer ranks second among all malignances in men and has become a significant threat to men's health. Robot-assisted laparoscopic radical prostatectomy (RARP) has become a standard treatment for prostate cancer. How to improve recovery following RARP surgery is worth investigating. The enhanced recovery after surgery (ERAS) pathway involves a series of evidence-based procedures. It is aimed to reduce the systemic stress response to surgery and shorten the length of hospital stay. This randomized trial aims to investigate the impact of Enhanced Recovery After Surgery (ERAS) Pathway on early outcomes after RARP surgery.",[676,677,232,35,482],"Prostate Cancer","Robot-Assisted Laparoscopic Radical Prostatectomy",[676,677,679,143,234,35,680],"RARP","Length of hospital stay","2025-08-15",{"date":683,"type":51},"2025-08-21",{"date":685,"type":22},"2025-09",{"date":90,"type":22},{"name":688,"class":58},"Peking University First Hospital",{"id":690,"slug":691,"hasResults":12,"nctId":692,"briefTitle":693,"officialTitle":694,"acronym":4,"eligibilityCriteria":695,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":696,"targetDuration":4,"studyType":23,"phases":697,"briefSummary":698,"conditions":699,"keywords":705,"overallStatus":83,"whyStopped":4,"lastUpdateSubmitDate":707,"lastUpdatePostDateStruct":708,"startDateStruct":710,"completionDateStruct":712,"leadSponsor":714,"locationsCount":126},"100595647","cabgprehab---a-feasibility-study-protocol-100595647","NCT07035171","CABGpreHAB - a Feasibility Study Protocol","CABGpreHAB- Home-based Multimodal Prehabilitation (CABGpreHAB) for Elective Patients Awaiting CABG-surgery - a Feasibility Study Protocol","Inclusion Criteria:\n\n* Planned to have elective isolated first-time CABG surgery.\n* 18 years or older\n* Two weeks or more before surgery\n* Speaks and understands Danish.\n* Gives written informed consent.\n\nExclusion Criteria:\n\n* Patient with unstable angina pectoris and\u002F or MI during the last two weeks.\n* Left main stem stenosis \\>50%\n* Left ventricular ejection fraction \\\u003C 35%\n* Significant ventricular arrhythmia\n* Orthopedic or neurologic preconditions precluding exercise training.\n* Inability to attend the prehabilitation program due to physical limitations.\n* Patients who have cognitive deficits that would disqualify prehabilitation.\n* Severe heart failure, NYHA Class IV\n* Lack of capacity to consent",{"count":325,"type":22},[25],"Patients with ischemic heart disease (IHD) awaiting coronary artery bypass graft (CABG) surgery often face challenges like advanced age, frailty, comorbidities, and physical inactivity. These factors, combined with the physiological and psychological stress of surgery, can hinder postoperative recovery. Traditionally, strategies to improve surgical outcomes focus on the intra- and postoperative periods. However, the pre-surgery waiting period offers a \"window of opportunity\" for prehabilitation, which aims to enhance patients' functional capacity through exercise, nutrition, and psychological support.\n\nThe CABGpreHAB feasibility study evaluates the feasibility of a home-based multimodal prehabilitation intervention for patients awaiting elective CABG surgery. This randomized pilot study compares the intervention plus usual care to usual care alone, assessing feasibility outcomes like recruitment, retention, attrition, fidelity, and adherence. The study aims to optimize a subsequent full-scale randomized controlled trial (RCT) and improve patient outcomes by leveraging the pre-surgery period for prehabilitation.",[700,35,701,702,703,704],"Ischaemic Heart Disease","Coronary Artery Bypass","Feasibility Studies","Multimodal Intervention","Adult",[706],"Prehabilitation, CABG surgery, adult, preoperative,homebased","2025-06-25",{"date":709,"type":51},"2025-06-29",{"date":711,"type":51},"2025-06-24",{"date":713,"type":22},"2026-07-18",{"name":715,"class":58},"Rigshospitalet, Denmark",{"id":717,"slug":718,"hasResults":12,"nctId":719,"briefTitle":720,"officialTitle":720,"acronym":4,"eligibilityCriteria":721,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":722,"targetDuration":723,"studyType":301,"phases":4,"briefSummary":724,"conditions":725,"keywords":730,"overallStatus":83,"whyStopped":4,"lastUpdateSubmitDate":734,"lastUpdatePostDateStruct":735,"startDateStruct":737,"completionDateStruct":739,"leadSponsor":741,"locationsCount":59},"100582028","patients-database-prepare-for-your-surgery-program-100582028","NCT06857981","Patient's Database: Prepare for Your Surgery Program","Inclusion Criteria:\n\n* Patients referred to the Prepare for Your Surgery program\n* Patients characterized as frail according to the Clinical Frailty Scale (score ≥ 4), FRAIL scale or FRIED frailty phenotype or the clinical judgment of the referring surgeon, with at least 4 weeks to receive surgery\n* Elective surgery to be performed at Hospital Clinico Red de Salud UC-Christus\n\nExclusion Criteria:\n\n* Patients who will not undergo elective surgery at Hospital Clínico Red de Salud UC-Christus.\n* Patients who require emergency surgery\n* Patients who for various reasons cannot comply with the interventions proposed for this preparation.",{"count":193,"type":22},"3 Months","Frailty is a multidimensional syndrome that predominantly affects older people and people with long-term treatments such as cancer and chronic pain. This results in an increased risk of disability, reduced resistance and greater vulnerability to stressors.\n\nThese factors culminate in worse postoperative outcomes, including higher rates of complications and mortality. With the current demographic shift towards an aging population in Latin America and Chile, the prevalence of frailty among surgical patients is increasing.\n\nDespite the clear association between frailty and adverse postoperative effects, in Chile there are few centers that routinely perform objective preoperative frailty assessment before to surgery. This is due to logistical challenges, the need for specialized training, and assessment tools. As a result, frailty remains an underestimated syndrome in the perioperative setting.\n\nVarious interventions have been proposed to improve the care of fragile surgical patients. Prehabilitation, a multidisciplinary program designed to prepare patients for surgery and improve their resilience to surgical stress, has emerged as a promising intervention. Recent studies indicate that prehabilitation may lead to shorter hospital length of stay (LOS) and fewer complications.\n\nRecognizing the vital role that frailty plays in surgical outcomes and the paucity of research on prehabilitation, a prehabilitation or timely presurgical conditioning program (Prepare for Your Surgery Program) has been implemented at our center. This proposal seeks to optimize the patient before a surgical intervention in order to reduce frailty and complications, thus improving recovery and medium-term results.\n\nThe program consists of interventions 4 to 6 weeks before surgery focused on: nursing assessment, screening and follow-up, geriatric and\u002For internal medicine assessment and intervention, physiotherapy assessment and intervention, nutrition assessment and intervention, psychological assessment and intervention, and preoperative anesthesiology intervention.\n\nFor this purpose, it has been proposed to create a prospective database of patients from the Prepare for Your Surgery Program, who undergo elective surgery at Hospital Clinico Red Salud UC-Christus.",[726,727,728,729,35],"Frailty in Adult Surgery","Frail Elderly Syndrome","Database","Perioperative Care",[728,731,732,139,733,35],"Perioperative care","Prospective Studies","Follow-Up Studies","2025-06-05",{"date":736,"type":51},"2025-06-10",{"date":738,"type":51},"2025-05-21",{"date":740,"type":22},"2026-06-30",{"name":742,"class":58},"Pontificia Universidad Catolica de Chile"]