[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"prehypertension-elevated-blood-pressure-or-hypertension\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:prehypertension-elevated-blood-pressure-or-hypertension":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,54],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":28,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":42,"lastUpdatePostDateStruct":43,"startDateStruct":46,"completionDateStruct":48,"leadSponsor":50,"locationsCount":53},"100567555","evaluation-of-physical-fitness-and-hemodynamics-across-a-diverse-population-100567555",false,"NCT06669715","Evaluation of Physical Fitness and Hemodynamics Across a Diverse Population","Validation of an Interval Test for Monitoring Cardiovascular Function for Individuals With Different Levels of Physical Fitness","ACT-ON-s1","Inclusion Criteria:\n\n* Adults (18 + years of age) without restriction on sex, health status or physical fitness.\n\nExclusion Criteria:\n\n* Inability to walk without assistance\n* Presence of acute injuries and\u002For illnesses that limit maximal exertion during physical fitness testing\n* Lower extremity injury or surgery within the past 2 years (if not fully rehabilitated)",true,"ALL","18 Years",{"count":21,"type":22},30,"ESTIMATED","OBSERVATIONAL","In this study, investigators will use the IFT 30-15 test, a six-minute walking test, and a treadmill test to assess the participants' cardiorespiratory fitness. For the treadmill cardiopulmonary exercise test (CPET), we will measure indirect gas exchange using a CPET device (K5). Maximum heart rate (HRmax) will be measured with a Polar heart rate monitor (model H10). The six-minute walking test will follow standardized procedures, and the treadmill test will follow a protocol of gradually increasing speed each minute.\n\nThe study will involve two groups of participants: healthy individuals and pre-hypertensive individuals. While the IFT 30-15 test has been validated on a diverse range of athletes and physically active individuals, it has not yet been validated in individuals with similar characteristics to our participants (BMI \\> 30 and limited cardiovascular function). Additionally, a variety of hemodynamic measures and other physical function measures such as sit-to-stand and push-ups will be assessed for all participants.",[26,27],"Prehypertension (Elevated Blood Pressure) or Hypertension","Obesity and Obesity-related Medical Conditions",[29,30,31,32,33,34,35,36,37,38,39,40],"cardiovascular fitness","CRF","physical fitness testing","vascular function","heamodynamics","blood pressure","prehypertension","aerobic capacity","arterial stiffness","endothelial function","post-occlusive reactive hyperemia","PORH","RECRUITING","2026-05-07",{"date":44,"type":45},"2026-05-12","ACTUAL",{"date":47,"type":45},"2024-11-04",{"date":49,"type":22},"2027-10-30",{"name":51,"class":52},"University of Ljubljana","OTHER",1,{"id":55,"slug":56,"hasResults":11,"nctId":57,"briefTitle":58,"officialTitle":58,"acronym":59,"eligibilityCriteria":60,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":61,"enrollmentInfo":62,"targetDuration":4,"studyType":64,"phases":65,"briefSummary":67,"conditions":68,"keywords":70,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":53},"100596672","difference-in-acute-responses-of-vascular-function-to-moderate-intensity-and-high-intensity-interval-training-in-healthy-and-prehypertensive-individuals-100596672","NCT07048509","Difference in Acute Responses of Vascular Function to Moderate-intensity and High-intensity Interval Training in Healthy and Prehypertensive Individuals","ACT-ON-ACUTE","Inclusion Criteria:\n\nNormotensive participants inclusion criteria:\n\n* 18 - 50 years of age, BMI \\\u003C 30, blood pressure (BP) within the optimal range according to the latest ESH guidelines (\\\u003C 120 mmHg systolic and\u002For \\\u003C 80 mmHg diastolic BP)\n* Sedentary or low active according to the Global Physical Activity Questionnaire (GPAQ) (Armstrong \\& Bull, 2006; Lim et al., 2012)\n* No prescribed medication and absence of chronic diseases\n\nInclusion criteria for prehypertensive individuals:\n\n* 18 - 50 years of age, BMI \\\u003C 30\n* Diagnosed prehypertension by a clinican from the Hypertension clinic, University clinical centre of Ljubljana using established criteria\n* Sedentary or low or moderately active according to the Global Physical Activity Questionnaire (GPAQ)\n* No prescribed medication and absence of chronic diseases\n\nExclusion Criteria:\n\n* Blood pressure out of the optimal range (normotensives)\n* High level of phyisical activity (moderate or high active according to GPAQ)\n* Hypotension\n* Chronic diseases\n* Prescribed medication\n* Lower extremity injury in the last six months\n* Menopause\n* Absence of normal menstrual cycle\n* Pregnancy\n* Smoking","50 Years",{"count":63,"type":22},45,"INTERVENTIONAL",[66],"NA","In this study, the investigators will evaluate acute changes in vascular function measures after moderate-intensity continuous and high-intensity interval exercise in healthy and prehypertensive individuals. Participants will be subjected to three separate visits: control condition (30 min rest), moderate-intensity continuous exercise, and high-intensity interval exercise. The investigators will measure aerobic capacity using a cardiopulmonary exercise test (CPET) using indirect gas-exchange to derive subsequent exercise intensity and maximal oxygen uptake. The investigators will evaluate different measures of vascular function (Pulse-wave velocity, Flow-mediated slowing, microvascular function) before and after each condition.\n\nThe study will involve two groups of participants: healthy individuals and prehypertensive individuals. The investigators aim to establish the reliability and validity of less-established methods of vascular function assessment (flow-mediated slowing and microvascular function) against established measures (pulse-wave velocity). The acute response of vascular function to different exercise intensities has not yet been thoroughly researched using the aforementioned measures in individuals with similar characteristics to the proposed study cohort.",[26,69],"Healthy",[71,32,35],"aerobic exercise","2025-12-15",{"date":74,"type":45},"2025-12-22",{"date":76,"type":45},"2025-06-24",{"date":78,"type":22},"2026-06",{"name":51,"class":52}]