[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"premature-birth-of-newborn\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:premature-birth-of-newborn":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,49],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100631374","synchronous-vs-asynchronous-telerehabilitation-for-high-risk-infants-100631374",false,"NCT07499843","Synchronous vs. Asynchronous Telerehabilitation for High-Risk Infants","Family-Centered Early Intervention Program Under Physiotherapist Coaching for High-Risk Infants: A Comparison of Synchronous and Asynchronous Telerehabilitation Models","Inclusion Criteria:\n\n* Gestational age ≤32 weeks and\u002For birth weight ≤1500 grams.\n* Corrected age between 6 and 9 months at the time of enrollment.\n* Referral to a pediatric neurology clinic and\u002For current follow-up by a pediatric neurologist due to developmental risk.\n* A total score of ≤73 on the Hammersmith Infant Neurological Examination (HINE) (Romeo et al., 2021; Novak et al., 2017).\n* A score ≤5th percentile on the Alberta Infant Motor Scale (AIMS) (Fuentefria et al., 2017).\n* Parental willingness to participate and signing of the \"Informed Consent Form.\"\n* Access to the minimum technological infrastructure required for telerehabilitation (smartphone, tablet, or computer with video calling capability and active internet access).\n\nExclusion Criteria:\n\n* Presence of diagnosed genetic syndromes or metabolic diseases known to directly affect neuro-motor development.\n* Major congenital malformations causing significant movement restriction or exercise intolerance.\n* History of symptomatic hypoglycemia associated with severe brain injury during the neonatal period.\n* Sensory impairments (bilateral blindness or severe bilateral hearing loss not correctable with hearing aids) that prevent participation in assessments and exercises based on visual and auditory stimuli.\n* Acute or unstable clinical conditions that preclude the safe conduct of the intervention (e.g., continuous mechanical ventilation, hemodynamic instability, uncontrolled seizures, or active acute infections).\n* Non-adherence to the study protocol, defined as missing more than 6 intervention sessions.","ALL","6 Months","9 Months",{"count":20,"type":21},48,"ESTIMATED","INTERVENTIONAL",[24],"NA","Premature birth, low birth weight, and a history of neonatal intensive care history are significant risk factors associated with long-term neurodevelopmental adverse outcomes in infants. Family-centered early intervention programs play a critical role in minimizing the impact of these risks and optimizing developmental potential. Currently, telerehabilitation (TR) has emerged as a cost-effective solution that facilitates access to early intervention services. However, there is limited literature directly comparing the efficacy and feasibility of synchronous (real-time) and asynchronous (store-and-forward) parent coaching-based TR models specifically within the at-risk infant population.\n\nThe primary objective of this project is to comparatively examine the effects of synchronous and asynchronous TR programs on motor development levels, individualized goal attainment, and parental self-efficacy in infants aged 6-9 months (corrected age) at risk of developmental delay, against a standard home program (control group). Designed as a randomized controlled trial, the study will include 45 high-risk infants meeting the inclusion criteria, who will be randomly allocated into three groups: Synchronous TR, Asynchronous TR, and Control. In the Synchronous group, parents will receive real-time coaching via video conferencing for 12 weeks, whereas the Asynchronous group process will be managed through video analysis and delayed feedback mechanisms. The Control group will be provided with standard digital educational materials.\n\nThe primary outcome measures of the study include Goal Attainment Scaling (GAS) scores, the Parental Self-Efficacy Instrument, and the Parenting Stress Index. Secondary measures will include the Bayley Scales of Infant and Toddler Development (Bayley-IV), the Alberta Infant Motor Scale (AIMS), and the Hammersmith Infant Neurological Examination (HINE). Data will be collected at baseline (T0) and post-intervention (T1) by an assessor blinded to group allocation. The findings obtained from this study aim to demonstrate the clinical efficacy of different TR models, thereby providing guidance for the planning and dissemination of remote healthcare services for high-risk infants.",[27,28,29],"Risky Baby","Premature Birth of Newborn","Motor Delay",[31,32,33,34,35],"At-risk infant","Early intervention","Telerehabilitation","Parent coaching","Motor development","NOT_YET_RECRUITING","2026-03-25",{"date":39,"type":40},"2026-03-30","ACTUAL",{"date":42,"type":21},"2026-05-04",{"date":44,"type":21},"2027-07-04",{"name":46,"class":47},"Biruni University","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":56,"targetDuration":4,"studyType":58,"phases":4,"briefSummary":59,"conditions":60,"keywords":63,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":48},"100572135","a-multicenter-and-prospective-study-of-screening-retinopathy-of-prematurity-in-china-100572135","NCT06729333","A Multicenter and Prospective Study of Screening Retinopathy of Prematurity in China","SChiROP","Inclusion Criteria:\n\nFrom December 2024 to May 2025, preterm infants (gestational age \\\u003C37 weeks) or low birth weight infants (birth weight \\\u003C2500 g) who receive their first ROP screening at Xinhua Hospital or partner institutions will be included.\n\nExclusion Criteria:\n\n1. Death before the first screening;\n2. Death or loss to follow-up before complete retinal vascularization;\n3. Presence of other diseases causing incomplete retinal vascularization, such as familial exudative vitreoretinopathy, incontinentia pigmenti, or Coats disease;\n4. Coexisting conditions affecting the classification or staging of ROP, such as corneal opacity, congenital cataract, persistent fetal vasculature, retinoblastoma, anophthalmia, Terson syndrome, or other ocular infections or diseases;\n5. Poor systemic condition preventing fundus examination;\n6. History of ocular trauma or surgery (excluding treatments for ROP);\n7. Poor-quality fundus images;\n8. Other conditions deemed exclusionary by the investigators.",{"count":57,"type":21},5000,"OBSERVATIONAL","The purpose of the study is to explore the current incidence rate of retinopathy of prematurity (ROP) in China and to explore more appropriate screening criteria for ROP.",[28,61,62],"Retinopathy of Prematurity (ROP)","Low Birthweight Infant",[64,65,66],"retinopathy of prematurity","incidence rate","screening","2024-12-06",{"date":69,"type":40},"2024-12-11",{"date":71,"type":21},"2024-12-15",{"date":73,"type":21},"2026-06-14",{"name":75,"class":47},"Xinhua Hospital, Shanghai Jiao Tong University School of Medicine"]