[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"premature-ovarian-failure\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:premature-ovarian-failure":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,41,73],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":40},"100392462","is-there-a-role-for-mechanical-stimulation-in-ovarian-follicular-activation-100392462",false,"NCT04390308","Is There A Role For Mechanical Stimulation In Ovarian Follicular Activation?","Is There A Role For Mechanical Stimulation In Ovarian Follicular Activation? A Randomized Control Trial.","Inclusion Criteria:\n\n* Signed and dated informed consent\n* Women 40 years of age and younger with documented primary ovarian insufficiency (12).\n* Normal Karyotype\n* BMI \\\u003C\u002F= 35 kg\u002Fm2\n* Oligo\u002Famenorrhea for at least 4 months\n* FSH \\> 25 IU\u002FmL\n* AMH \\\u003C\u002F= 0,1 ng\u002Fml\n* No evidence of follicles \\> 4mm\n* Must have two ovaries of approximately equal volume.\n* Willingness to undergo further fertility treatment, including IVF if there is evidence of response\n* A transvaginal scan including Doppler for arteria ovarica will be performed previously to the surgical procedure.\n\nExclusion Criteria:\n\n* Premature ovarian failure due to a genetic origin, such as Turner's Syndrome or chromosomal abnormality.\n* Oncological diseases (specially, skeletal system and blood).\n* Autoimmune diseases, for example, lupus erythematosus, etc.\n* Previous treatments including radiotherapy or chemotherapy.\n* Other conditions not suitable for surgical procedures and\u002For anesthesia.\n* Anticoagulant or antiaggregant treatment.\n* Acute and chronic infectious diseases.\n* Active substance abuse or dependence.\n* Major Mental health disorder.","FEMALE","18 Years","40 Years",{"count":20,"type":21},70,"ESTIMATED","OBSERVATIONAL","Premature ovarian failure (POI) is a loss of normal function before age 40, leading to infertility and hypoestrogenism. About 1% of women younger than 40 years old and 0.1% before 30 are affected. Most patients already had impaired or complete loss of fecundity when diagnosed. Hence, the treatment of POI is particularly tough. Currently, no optimal regimen exists to ameliorate ovarian function.",[25,26,27],"Infertility, Female","Premature Ovarian Failure","IVF","RECRUITING","2025-02-17",{"date":31,"type":32},"2025-02-19","ACTUAL",{"date":34,"type":32},"2021-06-02",{"date":36,"type":21},"2025-12-31",{"name":38,"class":39},"ART Fertility Clinics LLC","OTHER",1,{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":47,"eligibilityCriteria":48,"healthyVolunteers":49,"sex":16,"minAge":50,"maxAge":51,"enrollmentInfo":52,"targetDuration":4,"studyType":54,"phases":55,"briefSummary":58,"conditions":59,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":40},"100364916","phase-2-autologous-prp-infusion-may-restore-ovarian-function-and-may-promote-folliculogenesis-in-poi-patients-100364916","NCT04031456","Autologous PRP Infusion May Restore Ovarian Function and May Promote Folliculogenesis in POI Patients","Investigating Reactivation of Ovarian Function Following Autologous PRP Intra-ovarian Infusion in POI Patients","PRP","Inclusion Criteria:\n\n* Age \\\u003C 40 years, presenting with amenorrhea or menstrual cycle irregularities for at least four months, and elevated FSH levels \\>25 IU\u002FL recorded on two occasions \\>4 weeks apart\n* Normal Karyotype: 46, XX\n* Discontinuation of any complementary\u002Fadjuvant treatment including hormone replacement, acupuncture, and botanotherapy, for at least three months prior to recruitment.\n* Willing to comply with study requirements\n\nExclusion Criteria:\n\n* Any pathological disorder related to reproductive system anatomy\n* AMH \\> 8 pmol\u002FL\n* Endometriosis\n* Adenomyosis\n* Fibroids and adhesions\n* Infections in reproductive system\n* Current or previous diagnosis of cancer in reproductive system\n* History of familiar cancer in reproductive system\n* Severe male factor infertility\n* Prior referral for PGT\n* Ovarian inaccessibility\n* Endocrinological disorders (Hypothalamus-Pituitary disorders, thyroid dysfunction, diabetes mellitus, metabolic syndrome)\n* BMI\\>30 kg\u002Fm2 or BMI\\\u003C18.5 kg\u002Fm2\n* Systematic autoimmune disorders",true,"25 Years","39 Years",{"count":53,"type":21},100,"INTERVENTIONAL",[56,57],"PHASE2","PHASE3","Autologous PRP intra ovarian infusion may restore ovarian function, may promote folliculogenesis and may improve patients' hormonal profile in patients presenting with POI.",[60,61,62,26,63],"Menopause, Premature","Menopause Related Conditions","Menopausal Syndrome","Ovarian Failure, Premature","2024-12-20",{"date":66,"type":32},"2024-12-24",{"date":68,"type":32},"2019-07-30",{"date":70,"type":21},"2026-07-30",{"name":72,"class":39},"Genesis Athens Clinic",{"id":74,"slug":75,"hasResults":11,"nctId":76,"briefTitle":77,"officialTitle":77,"acronym":78,"eligibilityCriteria":79,"healthyVolunteers":49,"sex":16,"minAge":80,"maxAge":81,"enrollmentInfo":82,"targetDuration":4,"studyType":54,"phases":83,"briefSummary":85,"conditions":86,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":40},"100496157","the-danish-turner-cryopreservation-study-100496157","NCT05740579","The Danish TURNER Cryopreservation Study","DANTE","Inclusion Criteria:\n\n* 45,X karyotype or other Turner variant karyotypes (45,X\u002F46,XX mosaicism, ring X mosaicism, isochromosome X)\n* Age 2-17 years old\n* Ability to participate in a physical examination including a cardiac examination.\n* Signed consent from both parents.\n\nExclusion Criteria:\n\n* Severe cardiac disease which inhibits safe surgery and pregnancy.\n* Karyotype with Y chromosome material\n* Mental retardation","2 Years","17 Years",{"count":53,"type":21},[84],"NA","The goal of this clinical trial is to investigate if cryopreservation of ovarian tissue in girls with Turner syndrome can improve their fertility and lead to increased number of liveborn babies of Turner syndrome mothers. Women with Turner syndrome suffer from premature ovarian insufficiency which leads to infertility and lack of estrogen.\n\nThe main questions it aims to answer are:\n\n* Does the number of pregnancies and liveborn children increase after cryopreservation of ovarian tissue in turner syndrome?\n* Is the possible to predict when a girl with Turner syndrome reach menopause using monitoring of sex hormones?\n* Is it possible to identify any genes causing ovarian failure in Turner syndrome females?\n\nParticipants between 2-18 years old will be asked to participate in a laparoscopic surgery and removal of one ovary in order to cryopreserve the tissue until adulthood. The the cortical tissue will be autotransplanted in order to preserve fertility. The participant will during the study period be monitored using sex hormones.\n\nFurthermore, the investigators wish to investigate the ovarian tissue using RNA sequencing and DNA methylation analysis.\n\nNo comparison group is present.",[87,88,26],"Fertility Disorders","Turner Syndrome","2024-05-23",{"date":91,"type":32},"2024-05-24",{"date":93,"type":32},"2023-01-01",{"date":95,"type":21},"2051-01-01",{"name":97,"class":39},"University of Aarhus"]