[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"premature-ventricular-contractions\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:premature-ventricular-contractions":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,44,69],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100608434","real-time-intracardiac-echocardiography-for-ventricular-arrhythmia-ablation-100608434",false,"NCT07201506","Real-Time Intracardiac Echocardiography for Ventricular Arrhythmia Ablation","Real-Time Intracardiac Echocardiography for Ventricular Arrhythmia Ablation: A Randomized Controlled Trial","REAL-ICE","Inclusion Criteria:\n\n* Patients (≥18y) undergoing a premature ventricular contraction or ventricular tachycardia ablation.\n\nExclusion Criteria:\n\n* Origin of ventricular arrhythmia with high likelihood in the right ventricular outflow tract (left-bundle-inferior axis, \\>V4 transition precordially)\n* Primary epicardial ablation planned\n* Congenital heart disease\n* Presence of a mechanical tricuspid valve prosthesis\n* Unwilling or unable to comply fully with study procedures and followup","ALL","18 Years",{"count":20,"type":21},70,"ESTIMATED","INTERVENTIONAL",[24],"NA","This study is investigating whether using ultrasound directly inside the heart during ablation of heart rhythm disorders in the ventricles can reduce radiation exposure for patients.\n\nDuring an ablation, catheters are guided through the heart to treat the abnormal electrical signals. Usually, X-ray imaging (fluoroscopy) is used to see where the catheters are, which exposes both patients and hospital staff to radiation.\n\nThe study is randomized and controlled: half of the participants will have the ablation with ultrasound inside the heart, and the other half will have the standard ablation without ultrasound during the procedure. The main goal is to compare the amount of X-ray time used during the procedure. Secondary goals are to look at safety, effectiveness, and the total procedure time.\n\nPatients with premature ventricular contractions or ventricular tachycardia can take part. A total of 70 people will be included, 35 in each group. Using ultrasound inside the heart makes it possible to see the catheters and heart structures directly, so many steps can be done without X-rays. This could make ablations safer and reduce radiation exposure.\n\nThe study is being carried out at Inselspital, Bern University Hospital, and at University Hospital Basel. All steps are standardized and data are collected carefully. The results will show whether ultrasound during ablations can significantly reduce radiation and make ablations more efficient and safer.",[27,28,29,30],"Ablation of Arrhythmias","Premature Ventricular Contractions","Ventricular Tachycardia","Ventricular Arrhythmia","RECRUITING","2026-03-26",{"date":34,"type":35},"2026-04-01","ACTUAL",{"date":37,"type":35},"2026-03-25",{"date":39,"type":21},"2027-06-30",{"name":41,"class":42},"Insel Gruppe AG, University Hospital Bern","OTHER",2,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":48,"acronym":49,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":51,"targetDuration":4,"studyType":53,"phases":4,"briefSummary":54,"conditions":55,"keywords":4,"overallStatus":58,"whyStopped":4,"lastUpdateSubmitDate":59,"lastUpdatePostDateStruct":60,"startDateStruct":62,"completionDateStruct":64,"leadSponsor":66,"locationsCount":68},"100451457","myocarditis-causing-premature-ventricular-contractionsinsights-from-the-maveric-registry-100451457","NCT05158751","Myocarditis Causing Premature Ventricular Contractions:Insights From the MAVERIC Registry","MAVERIC","Inclusion Criteria:\n\n* Patients \\> 18 years of age with mono-morphic or polymorphic PVC burden of ≥5000 in 24 hours.\n* Non-sustained VT was defined as ≥3 more consecutive beats lasting \\\u003C30 seconds\n\nExclusion Criteria:\n\n* History of myocardial infarction,\n* Significant flow-limiting coronary artery disease (≥50% stenosis) on invasive coronary angiography or CT angiography,\n* History of revascularization,\n* Significant symptomatic atrial arrhythmias associated with LV dysfunction,\n* Severe valvular disease,\n* Cardiomyopathy attributed to toxins such as alcohol and illicit drugs,\n* History of cardiac arrest,\n* History of channelopathies or inherited arrhythmias.",{"count":52,"type":21},100,"OBSERVATIONAL","To assess potential link between unrecognized myocardial inflammation (myocarditis) and premature ventricular contractions (PVCs) associated with and without reduced Left ventricular ejection fraction (LVEF) through comprehensive diagnostic work up.",[56,28,57],"Myocarditis","Ventricular Tachycardia (VT)","NOT_YET_RECRUITING","2025-08-27",{"date":61,"type":35},"2025-09-04",{"date":63,"type":21},"2026-01",{"date":65,"type":21},"2026-05",{"name":67,"class":42},"Kansas City Heart Rhythm Research Foundation",1,{"id":70,"slug":71,"hasResults":11,"nctId":72,"briefTitle":73,"officialTitle":73,"acronym":74,"eligibilityCriteria":75,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":76,"enrollmentInfo":77,"targetDuration":4,"studyType":22,"phases":79,"briefSummary":81,"conditions":82,"keywords":4,"overallStatus":58,"whyStopped":4,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":4},"100499499","phase-4-prophylactic-frequent-premature-ventricular-complexes-suppression-on-left-ventricular-function-impairment-in-asymptomatic-patients-100499499","NCT05784051","Prophylactic Frequent Premature Ventricular complexeS sUPPression on Left ventriculaR Function impairmEnt in aSymptomatic patientS","SUPPRESS","Inclusion Criteria:\n\nInclusion criteria (all must be present):\n\n1. 18 ≤ Age ≤ 85\n2. PVC burden ≥ to 10% regardless of current or preexisting antiarrhythmic drug intake (for instance, a patient under betablocker therapy because of his PVCs or hypertension can be included)\n3. Asymptomatic status\n4. Normal (\\>or= 55%) LVEF. Patients with underlying cardiomyopathy can be included as long as LV function remains preserved.\n5. Signed informed consent\n\nExclusion criteria (any of them):\n\n1. Pregnant woman or Female of childbearing potential without effective method of birth control or nursing woman.\n2. Patients that can't undergo MRI study\n3. De novo requirement for antiarrhythmic drug prescription for another indication (e.g. atrial fibrillation…)\n4. The physician already decided that the patient requires drug initiation or escalation;\n5. Ischemic cardiomyopathy requiring revascularization (PCI or surgery)\n6. History of LV dysfunction\n7. Participation in another research involving the human person\n8. Patient under legal protection\n9. Non affiliation to a social security scheme","85 Years",{"count":78,"type":21},298,[80],"PHASE4","The main objective of the study is to demonstrate that prophylactic treatment of patients with asymptomatic frequent (\\>10%) PVCs is superior to simple follow-up strategy with no therapy to prevent subsequent LV dysfunction at 24 months. The prophylactic treatment is based on drugs ± ablation (ablation can be performed if the PVC burden remain \\>10% after 2 lines of AAD treatment since the initiation of the study).\n\nThe primary endpoint will be the development of LV dysfunction (PVC-iCMP) defined as a 15% relative LVEF decrease (and\u002For a LVEF \\\u003C50%) within 2 years following randomization, on cardiac magnetic resonance imaging (cMRI) (or transthoracic echocardiography (TTE) when not possible).",[28,83],"Ventricular Dysfunction, Left","2023-09-05",{"date":86,"type":35},"2023-09-06",{"date":88,"type":21},"2023-10-01",{"date":90,"type":21},"2027-06-01",{"name":92,"class":42},"Assistance Publique - Hôpitaux de Paris"]