[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"premature\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:premature":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,19,0,[8,45,76,104,132,159,196,221,242,270,296,320,342,372,399,425,452,479,503],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100531997","early-dhaara-supplementation-in-growth-restricted-very-preterm-infants-a-randomized-clinical-trial-100531997",false,"NCT06207071","Early DHA\u002FARA Supplementation in Growth-restricted Very Preterm Infants: A Randomized Clinical Trial","Early DHA Supplementation in Growth-restricted Very Preterm Infants: A Randomized Clinical Trial","Inclusion Criteria:\n\n* Gestational ages between 22 0\u002F7 - 32 6\u002F7 weeks gestation\n* \\\u003C 25th centile birthweight\n\nExclusion Criteria:\n\n* Major congenital\u002Fchromosomal anomalies\n* Terminal illness in which decisions to withhold or limit support have been made",true,"ALL","24 Hours","72 Hours",{"count":21,"type":22},152,"ESTIMATED","INTERVENTIONAL",[25],"NA","Growth-restricted very preterm infants (VPT) are born without adequate fat mass (FM) deposits and low docosahexaenoic acid (DHA) concentrations. They often experience further declines in DHA concentrations during the initial three weeks post-birth while advancing enteral feeds and receiving lipid supplementation predominantly through parenteral nutrition. These suboptimal enteral and parenteral nutrition practices significantly heighten the risk of faltering postnatal growth. One promising approach to mitigate these issues is enteral DHA supplementation. However, it remains unclear whether the early administration of DHA through enteral supplementation could lead to a more substantial increase in head growth without affecting FM accretion in growth-restricted VPT infants. To address this question, we propose a masked randomized clinical trial involving 152 VPT infants.",[28,29,30,31],"Infant Malnutrition","Light-For-Dates With Signs of Fetal Malnutrition","Premature","Nutrition Disorder, Infant","RECRUITING","2026-06-11",{"date":35,"type":36},"2026-06-15","ACTUAL",{"date":38,"type":36},"2024-05-20",{"date":40,"type":22},"2027-04",{"name":42,"class":43},"University of Alabama at Birmingham","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":4,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":17,"minAge":52,"maxAge":53,"enrollmentInfo":54,"targetDuration":4,"studyType":23,"phases":56,"briefSummary":57,"conditions":58,"keywords":61,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":44},"100639553","automated-oxygen-control-in-preterms-on-non-invasive-ventilation-100639553","NCT07622563","Automated Oxygen Control in Preterms on Non-invasive Ventilation","Randomised Controlled Trial of Closed-loop Automated Oxygen Control in Preterm Infants Receiving Non-invasive Respiratory Support","Inclusion Criteria:\n\nPreterm infants \\\u003C34 weeks of gestation and at any postnatal age on non-invasive respiratory support including:\n\n* non-invasive positive pressure ventilation (NIPPV)\n* nasal CPAP\n* HHFNC oxygen, either as primary or post extubation respiratory support.\n\nExclusion Criteria:\n\n* Infants with congenital cyanotic heart disease.\n* Infants with other know major congenital abnormalities.","22 Weeks","34 Weeks",{"count":55,"type":22},76,[25],"This randomised controlled trial aims to investigate the effectiveness of closed-loop automated oxygen control (CLAC) in preterm infants receiving non-invasive respiratory support and determine if it reduces the duration of supplementary oxygen treatment and improves achievement of oxygen saturation targets, reduces the incidences of hypoxia and hyperoxia, the number of manual adjustments to the inspired oxygen concentration (FiO2), and adverse outcomes including bronchopulmonary dysplasia (BPD).\n\nThe study will take place at King's College Hospital neonatal intensive care unit (NICU). Parents of preterm infants born at less than 34 weeks of gestation and receiving non-invasive respiratory support will be approached, informed and if appropriate consented to join the trial.\n\nParticipants will be randomised to receiving either automated or manual oxygen control.\n\nThe study will measure outcomes including the duration of supplementary oxygen treatment, the percentage of time spent within oxygen saturation targets, the incidences of hypoxia and hyperoxia, the number of manual FiO2 adjustments required, the overall duration of non-invasive respiratory support and length of neonatal unit stay, and the incidence of BPD at 36 weeks postmenstrual age (PMA). Results will be compared between the two groups.",[59,30,60],"Infant","Airway Morbidity",[62,63,64,65],"automated oxygen control","non-invasive respiratory support","randomised controled trial","neonates","NOT_YET_RECRUITING","2026-05-27",{"date":69,"type":36},"2026-06-03",{"date":71,"type":22},"2026-06-01",{"date":73,"type":22},"2027-09",{"name":75,"class":43},"King's College Hospital NHS Trust",{"id":77,"slug":78,"hasResults":11,"nctId":79,"briefTitle":80,"officialTitle":80,"acronym":4,"eligibilityCriteria":81,"healthyVolunteers":11,"sex":17,"minAge":53,"maxAge":82,"enrollmentInfo":83,"targetDuration":4,"studyType":85,"phases":4,"briefSummary":86,"conditions":87,"keywords":90,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":44},"100609551","predictive-value-of-lung-ultrasound-for-respiratory-decompensation-in-late-preterm-neonates-100609551","NCT07216053","Predictive Value of Lung Ultrasound for Respiratory Decompensation in Late Preterm Neonates","Inclusion Criteria:\n\n* Inborn infants born between 34w0d and 36w6d gestational age\n* In RA or 1 Litre per minute 1LPM NC (room air (RA) or nasal cannula (NC))\n* Admitted to NICU or Well Baby Nursery (WBN)\n\nExclusion Criteria:\n\n* Patients born \\\u003C34 weeks or \\>36w6d\n* Major genetic anomaly or syndromic condition\n* Cardiac or pulmonary structural defects\n* Cord pH \\\u003C7.0 or 5 minute APGAR 5 or less\n* Suspected fetal hemorrhage or other source of significant anemia at birth","36 Weeks",{"count":84,"type":22},300,"OBSERVATIONAL","Respiratory morbidity presents a significant clinical challenge in the neonatal period, and an individual patient's clinical course is often difficult to predict. This is especially true for late-preterm infants, who share some of the same risks of premature babies in terms or respiratory morbidity, but whose births may not always be attended by a neonatologist, or who may be born at hospitals with lower level Neonatal Intensive Care Units (NICUs) and require transfer if they decompensate.\n\nWith this study, the aim is to 1) determine the efficacy of early point of care lung ultrasound (LUS) to predict respiratory decompensation in the first 48 hours of life in late preterm infants and 2) to compare the performance of three lung ultrasound scoring systems, 3 type-of-lung, high risk pattern and total LUS scoring systems.",[88,89,30],"Pre-Term","Respiratory Distress of Newborn",[91,92,93,94],"Lung Ultrasound","Respiratory Decompensation","Late Preterm Neonates","respiratory distress","2026-05-20",{"date":97,"type":36},"2026-05-22",{"date":99,"type":36},"2025-11-06",{"date":101,"type":22},"2027-11",{"name":103,"class":43},"Hackensack Meridian Health",{"id":105,"slug":106,"hasResults":11,"nctId":107,"briefTitle":108,"officialTitle":109,"acronym":110,"eligibilityCriteria":111,"healthyVolunteers":11,"sex":17,"minAge":52,"maxAge":112,"enrollmentInfo":113,"targetDuration":4,"studyType":23,"phases":115,"briefSummary":116,"conditions":117,"keywords":120,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":124,"lastUpdatePostDateStruct":125,"startDateStruct":127,"completionDateStruct":128,"leadSponsor":130,"locationsCount":4},"100635885","effect-of-rectal-administration-of-breast-milk-on-gut-microbiota-in-preterm-infants-100635885","NCT07558499","Effect of Rectal Administration of Breast Milk on Gut Microbiota in Preterm Infants","Effect of Rectal Administration of Human Milk on Gut Microbiota and Clinical Outcomes in Preterm Infants: A Randomized Controlled Study","premic","Inclusion Criteria:\n\nPreterm infants with a gestational age ≤32 weeks and birth weight ≤1500 g\n\nInfants without meconium passage within the first 48 hours of life\n\nInfants whose parents have provided written informed consent\n\nExclusion Criteria:\n\nnfants with major congenital anomalies\n\nInfants with gastrointestinal system anomalies\n\nInfants in whom administration of maternal breast milk is contraindicated\n\nInfants whose parents do not provide consent for participation\n\nInfants who die within the first 72 hours of life","32 Weeks",{"count":114,"type":22},60,[25],"This study aims to evaluate the effect of rectal administration of maternal breast milk on gut microbiota development in preterm infants. Preterm infants are at increased risk of dysbiosis due to immaturity and limited enteral feeding in the early postnatal period. In this randomized controlled study, preterm infants will receive either rectal administration of maternal breast milk or normal saline. The primary objective is to compare gut microbiota composition between the two groups. The findings may provide insight into a novel and non-invasive strategy to support microbiota development in preterm infants.",[30,118,119],"Gut Microbiota Diversity and Composition","NEC - Necrotizing Enterocolitis",[121,122,123],"premature","gut microbiota","preterm morbidities","2026-04-22",{"date":126,"type":36},"2026-04-30",{"date":35,"type":22},{"date":129,"type":22},"2027-08-15",{"name":131,"class":43},"Zekai Tahir Burak Women's Health Research and Education Hospital",{"id":133,"slug":134,"hasResults":11,"nctId":135,"briefTitle":136,"officialTitle":136,"acronym":137,"eligibilityCriteria":138,"healthyVolunteers":11,"sex":17,"minAge":139,"maxAge":140,"enrollmentInfo":141,"targetDuration":4,"studyType":85,"phases":4,"briefSummary":143,"conditions":144,"keywords":145,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":150,"lastUpdatePostDateStruct":151,"startDateStruct":153,"completionDateStruct":155,"leadSponsor":157,"locationsCount":44},"100631056","reactions-to-oro-facial-solicitations--a-predictor-of-eating-difficulties-for-premature-babies-of-36-weeks-gestation-adjusted-age-100631056","NCT07495709","Reactions to Oro-facial Solicitations : a Predictor of Eating Difficulties for Premature Babies of 36 Weeks Gestation Adjusted Age","RESOF-36","Inclusion Criteria:\n\n* Premature babies born between 26 and 27 + 6 weeks of gestation\n* Admitted to the CHSF between 1 May 2025 and 31 March 2026\n* Criteria grid completed upon admission\n* Parents or guardians informed of the study and not opposed to it.\n\nExclusion Criteria:\n\n* ENT malformation\n* Neurological pathology\n* Dysplasia or oxygen therapy greater than or equal to 0.3L\u002Fmin (these children are seen systematically)\n* Extreme prematurity (gestational age less than 26 weeks)\n* Genetic syndrome\n* Anoxic-ischaemic encephalopathy\n* Digestive malformation","26 Weeks","28 Weeks",{"count":142,"type":22},80,"The goal of this observational study is to assess the link between reactions to orofacial stimuli observed at 29 weeks of amenorrhoea, and feeding difficulties at 36 weeks of amenorrhoea, in babies born prematurely between 26 and 27 + 6 weeks of gestation, admitted to the CHSF between 1 May 2025 and 31 March 2026. The main questions it aims to answer are : Can reactions to orofacial stimulation in babies born very prematurely be used as a tool for early detection of feeding difficulties before discharge from hospital? Is it possible to establish a predictive score for potential feeding difficulties as early as 29 weeks of gestation corrected, based on reactions to orofacial stimuli ? Participants will have their reactions to orofacial stimulations recorded in the 'Suivi oralité' grid completed by the nurses in the neonatal medicine and intensive care unit, which will then collect.",[30],[121,146,147,148,149],"Early intervention","orofacial stimulation","feeding difficulties","orality","2026-03-24",{"date":152,"type":36},"2026-03-27",{"date":154,"type":22},"2026-04-01",{"date":156,"type":22},"2026-12-31",{"name":158,"class":43},"Centre Hospitalier Sud Francilien",{"id":160,"slug":161,"hasResults":11,"nctId":162,"briefTitle":163,"officialTitle":164,"acronym":165,"eligibilityCriteria":166,"healthyVolunteers":11,"sex":17,"minAge":167,"maxAge":168,"enrollmentInfo":169,"targetDuration":4,"studyType":23,"phases":171,"briefSummary":172,"conditions":173,"keywords":176,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":188,"lastUpdatePostDateStruct":189,"startDateStruct":191,"completionDateStruct":192,"leadSponsor":194,"locationsCount":44},"100628319","premature-infant-oral-motor-intervention-vs-pacifier-for-oral-feeding-transition-in-preterm-infants-100628319","NCT07460089","Premature Infant Oral Motor Intervention vs. Pacifier for Oral Feeding Transition in Preterm Infants","The Effect of the Premature Infant Oral Motor Intervention Versus Pacifier Use in the Transition to Oral Feeding in Preterm Infants","PIOMI","Inclusion Criteria:\n\n1. \\- Preterm infants born at 26-32 weeks of gestational age\n2. \\- Clinically stable (no mechanical ventilation, no major congenital anomalies, no necrotizing enterocolitis)\n3. \\- Birth weight ≥1000 grams\n4. \\- Informed consent obtained from parents or legal guardians\n\nExclusion Criteria:\n\n1. Orofacial malformations (e.g., cleft lip, cleft palate)\n2. Neurological impairment affecting sucking ability (e.g., intraventricular hemorrhage grade III or IV, periventricular leukomalacia)\n3. Infants who received any prior structured oral motor intervention\n4. Major congenital anomalies or genetic syndromes affecting feeding or development\n5. Infants requiring surgical interventions during the study period\n6. Lack of parental consent","1 Day","28 Days",{"count":170,"type":22},150,[25],"This study compares three approaches to help premature babies learn to feed by mouth: a special mouth exercise program (called PIOMI), using a pacifier, and standard care. Premature babies often have difficulty feeding because their sucking, swallowing, and breathing are not yet coordinated, which can lead to longer hospital stays. The study will include 150 premature infants born between 26 and 32 weeks of pregnancy at a hospital in Thi Qar. Babies will be randomly placed into one of three groups: one group will receive a many-day mouth exercise program, another will use a pacifier for many days, and the third will receive routine care. We will measure how quickly each baby learns to feed fully by mouth, how long they stay in the hospital, how much weight they gain, and their feeding skills. The results may help improve care for premature babies and reduce the time they spend in the hospital.",[174,175,30],"Feeding Difficulties","Sucking Behavior",[177,178,179,174,175,165,180,181,182,183,184,185,186,187],"Premature Infant","Preterm Infant","Oral Feeding","Pacifier Use","Non-nutritive Sucking","Oral Motor Intervention","Neonatal Intensive Care","NICU","Feeding Transition","Weight Gain","Length of Hospital Stay","2026-03-06",{"date":190,"type":36},"2026-03-10",{"date":190,"type":22},{"date":193,"type":22},"2026-05-30",{"name":195,"class":43},"University of Baghdad",{"id":197,"slug":198,"hasResults":11,"nctId":199,"briefTitle":200,"officialTitle":201,"acronym":4,"eligibilityCriteria":202,"healthyVolunteers":11,"sex":17,"minAge":203,"maxAge":204,"enrollmentInfo":205,"targetDuration":4,"studyType":23,"phases":207,"briefSummary":208,"conditions":209,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":212,"lastUpdatePostDateStruct":213,"startDateStruct":215,"completionDateStruct":217,"leadSponsor":219,"locationsCount":44},"100599731","effect-of-lactase-enzyme-supplements-on-intolerance-in-preterm-neonates-100599731","NCT07088302","Effect OF Lactase Enzyme Supplements ON Intolerance IN Preterm Neonates","Effect OF Lactase Enzyme Supplements ON Protection Against Feeding Intolerance IN Preterm Neonates","Inclusion criteria will be as follows:\n\n* Preterm neonates ≤ 32 weeks gestational age.\n* Start feeding in the first 72 hours of life. 8. Exclusion criteria\n\nPatients with any of the following will be excluded:\n\n1. Parental consent lacking\u002Frefusal.\n2. Obvious major congenital abnormalities.\n3. Infants more than 72 hours of age at the time of randomization.\n4. Delayed introduction of feeding (beyond three days of life).\n5. Known galactosemia.\n6. Severe IUGR. -","3 Days","1 Month",{"count":206,"type":22},120,[25],"This study aims to study the effect of lactase enzyme in preventing feeding intolerance in preterm neonates in neonatal intensive care unit at Alexandria University Children's Hospital.",[30,210,211],"Feeding Disorders","Lactase Deficiency, Congenital","2026-01-15",{"date":214,"type":36},"2026-01-16",{"date":216,"type":36},"2025-08-30",{"date":218,"type":22},"2026-03-28",{"name":220,"class":43},"Alexandria University",{"id":222,"slug":223,"hasResults":11,"nctId":224,"briefTitle":225,"officialTitle":226,"acronym":4,"eligibilityCriteria":227,"healthyVolunteers":16,"sex":17,"minAge":228,"maxAge":229,"enrollmentInfo":230,"targetDuration":4,"studyType":23,"phases":232,"briefSummary":233,"conditions":234,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":212,"lastUpdatePostDateStruct":236,"startDateStruct":237,"completionDateStruct":239,"leadSponsor":241,"locationsCount":44},"100578531","evaluation-of-placental-transfusion-techniques-in-prevention-of-prematurity-related-complications-and-effect-on-their-hematological-profile-100578531","NCT06812507","Evaluation of Placental Transfusion Techniques in Prevention of Prematurity Related Complications and Effect on Their Hematological Profile","Evaluation of Placental Transfusion Techniques in of Prematurity Related Complications and Hematological Profile","* Inclusion Criteria:\n\n  1. Premature neonates ≤ 32 weeks gestational age regardless birth weight\n  2. patients should be admitted to neonatal intensive care unit in the first day of life of life\n\nExclusion criteria:\n\n* Exclusion Criteria:\n\nPatient with any of the following will be excluded:\n\n1. Major congenital anomalies (complex cyanotic heart disease, major central nervous system anomalies).\n2. Evidence of head trauma causing major intracranial hemorrhage.\n3. placental abnormalities like : abruptions, placenta previa or retroplacental hematoma.\n4. Cord accident, or avulsion at the time of delivery.\n5. Refusal to perform the intervention by the obstetrician","1 Minute","2 Minutes",{"count":231,"type":22},160,[25],"The objective of this study is to evaluate the general course and prognosis associated with different methods of placental transfusion (Intact umbilical cord milking, cut- umbilical cord milking and delayed cord clamping) in premature neonates over the first days of life",[30,235],"Placental Transfusion",{"date":214,"type":36},{"date":238,"type":36},"2025-03-10",{"date":240,"type":22},"2026-04-28",{"name":220,"class":43},{"id":243,"slug":244,"hasResults":11,"nctId":245,"briefTitle":246,"officialTitle":247,"acronym":4,"eligibilityCriteria":248,"healthyVolunteers":11,"sex":17,"minAge":139,"maxAge":249,"enrollmentInfo":250,"targetDuration":4,"studyType":23,"phases":252,"briefSummary":253,"conditions":254,"keywords":258,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":262,"lastUpdatePostDateStruct":263,"startDateStruct":265,"completionDateStruct":266,"leadSponsor":268,"locationsCount":44},"100596778","baby-abs-abdominal-binder-study-100596778","NCT07049900","Baby ABS (Abdominal Binder Study)","Baby ABS (Abdominal Binder Study) : Impact of Abdominal Binder Use on Abdominal Wall Development in Premature Infants Requiring CPAP Support","Inclusion Criteria:\n\n* Premature viable neonates with corrected gestational age of 26-31 weeks\n* Anticipated to require non-invasive continuous positive pressure ventilation including bCPAP, CPAP, and NAVA CPAP for a minimum of 2 weeks either on their first trial of CPAP or after extubation.\n\nExclusion Criteria:\n\n* Outside of gestational age at birth\n* Umbilical lines\n* Genetic condition or neuromuscular anomaly\n* Known abdominal anomaly\n* Non-viable neonates and neonates with uncertain viability who are not anticipated to be able to survive with standard NICU care.\n* Surgical intervention on the abdominal wall, such as gastroschisis or history of surgical NEC\n* Compromised skin integrity of abdominal wall\n* Any condition in the opinion of the investigator that would risk the data integrity or collection of the study","31 Weeks",{"count":251,"type":22},40,[25],"The primary outcome of this study is to determine if the use of the FDA-approved DandleLion NeoBellyBand increases the thickness of the rectus abdominis muscle in premature babies receiving continuous positive pressure ventilation, leading to infants reaching full oral feedings at an earlier corrected gestational age.",[30,255,256,257],"Premature Lungs","Ventilator Lung; Newborn","Rectus Abdominis",[259,260,261],"bCPAP","CPAP","NAVA CPAP","2025-09-22",{"date":264,"type":36},"2025-09-26",{"date":262,"type":36},{"date":267,"type":22},"2027-02-28",{"name":269,"class":43},"University of Minnesota",{"id":271,"slug":272,"hasResults":11,"nctId":273,"briefTitle":274,"officialTitle":275,"acronym":4,"eligibilityCriteria":276,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":82,"enrollmentInfo":277,"targetDuration":4,"studyType":23,"phases":279,"briefSummary":280,"conditions":281,"keywords":282,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":286,"lastUpdatePostDateStruct":287,"startDateStruct":289,"completionDateStruct":291,"leadSponsor":293,"locationsCount":295},"100468486","metabolic-mechanisms-induced-by-enteral-dha-and-ara-supplementation-in-preterm-infants-100468486","NCT05380401","Metabolic Mechanisms Induced by Enteral DHA and ARA Supplementation in Preterm Infants","Metabolic Mechanisms Induced by Enteral Docosahexaenoic Acid (DHA) and Arachidonic Acid (ARA) Supplementation in Preterm Infants","Inclusion Criteria:\n\n* born between 25 0\u002F7 and 29 6\u002F7 weeks of gestation\n* less than 48 hours of age at first lipid dose (The cohort is defined by gestational age rather than birth weight to avoid an over-represented sample of growth-restricted infants in birth weight defined cohorts.)\n\nExclusion Criteria:\n\n* serious congenital anomalies\n* conditions at birth that will require surgery prior to discharge\n* imminent death such that withdrawal of intensive care support is anticipated within the first 72 hours after birth",{"count":278,"type":22},328,[25],"A comprehensive analysis of the impact of exogenous enteral DHA and ARA supplementation on lipid metabolism including the production of downstream derived mediators and how this impacts important biological pathways such as metabolism, inflammation, and organogenic factors.",[30],[283,284,285],"infant, premature","fatty acids","nutrition","2025-09-19",{"date":288,"type":36},"2025-09-24",{"date":290,"type":36},"2023-03-09",{"date":292,"type":22},"2028-04",{"name":294,"class":43},"The University of Texas Health Science Center at San Antonio",7,{"id":297,"slug":298,"hasResults":11,"nctId":299,"briefTitle":300,"officialTitle":301,"acronym":4,"eligibilityCriteria":302,"healthyVolunteers":11,"sex":17,"minAge":303,"maxAge":4,"enrollmentInfo":304,"targetDuration":4,"studyType":85,"phases":4,"briefSummary":306,"conditions":307,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":312,"lastUpdatePostDateStruct":313,"startDateStruct":315,"completionDateStruct":316,"leadSponsor":318,"locationsCount":44},"100604797","triglycerides-glucose-index-on-angiographic-profiling-of-non-diabetic-premature-coronary-artery-disease-patients-100604797","NCT07154186","Triglycerides Glucose Index on Angiographic Profiling of Non-Diabetic Premature Coronary Artery Disease Patients","Impact of Triglycerides Glucose Index on Angiographic Profiling of Non-Diabetic Premature Coronary Artery Disease Patients","Inclusion Criteria:\n\n* Age ≥18 years old.\n* Both sexes.\n* Non-diabetic patients \\[no history of diabetes, hemoglobin A1C (HbA1C) \\\u003C 6.5%, fasting glucose \\\u003C 126 mg\u002FdL\\].\n* Confirmed diagnosis of coronary artery disease (CAD) by coronary angiography.\n\nExclusion Criteria:\n\n* Known diabetes mellitus (type 1 or type 2).\n* Previous history of coronary revascularization.\n* Severe hepatic or renal dysfunction \\[alanine transaminase (ALT)\u002Faspartate aminotransferase (AST) ≥ 5× upper limit of normal (ULN), estimated glomerular filtration rate (eGFR)\\\u003C 30 mL\u002Fmin\u002F1.73 m²\\].\n* Malignant disease, autoimmune disease, or systemic inflammatory disorders.\n* Current use of triglyceride-lowering medications.","18 Years",{"count":305,"type":22},180,"This study aims to evaluate the impact of the triglyceride-glucose (TyG) index on the angiographic profiling of non-diabetic patients with premature coronary artery disease (CAD).",[308,309,310,30,311],"Triglycerides Glucose Index","Angiographic Profiling","Non-Diabetic","Coronary Artery Disease","2025-09-04",{"date":314,"type":36},"2025-09-05",{"date":312,"type":36},{"date":317,"type":22},"2026-02-01",{"name":319,"class":43},"Sohag University",{"id":321,"slug":322,"hasResults":11,"nctId":323,"briefTitle":324,"officialTitle":325,"acronym":4,"eligibilityCriteria":326,"healthyVolunteers":11,"sex":17,"minAge":52,"maxAge":112,"enrollmentInfo":327,"targetDuration":4,"studyType":85,"phases":4,"briefSummary":328,"conditions":329,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":333,"lastUpdatePostDateStruct":334,"startDateStruct":336,"completionDateStruct":338,"leadSponsor":340,"locationsCount":44},"100533456","growing-little-peapods-study-100533456","NCT06226051","Growing Little PEAPODS Study","Growing Little PEAPODS Study: Association Between Prematurity and Body Composition, Nutrition Practices, and Neurodevelopmental Outcomes","Neonate Inclusion Criteria:\n\n* Born inpatient at Meriter Hospital, Inc. at or above 22 gestational weeks. Upper limit is 32 weeks 6 days GA (possible gestational age range from 22w0d-32w6d)\n\nNeonate Exclusion Criteria:\n\n* Known genetic condition that impacts neurodevelopmental outcomes or brain structure development\n* Multiple major congenital anomalies\n* Per the investigator's opinion, the subject will likely require transfer to American Family Children's Hospital (AFCH) before 36 weeks PMA\n\n  * Any neonate who enrolls in the study and then unexpectedly requires transfer to AFCH before 36 weeks PMA will be excluded from the study if they are unable to obtain at least one body composition measurement before transfer. Body composition data points can only be collected at Meriter Hospital due to the location of PEAPOD\n\nBirthing Parent Inclusion Criteria:\n\n* Birthing parent must speak English or Spanish due to consent documents\n* Able to understand and willing to sign a written informed consent document\n* Primary caregiver of a neonate who is eligible to participate in the study\n* Agrees to enroll neonate into the study\n* Willing to comply with all study procedures and be available for the duration of the study\n* Age 15 or older\n\nBirthing Parent Exclusion Criteria:\n\n* Subject is unable to provide informed consent, including subjects in foster care and subjects within state custody\n* Does not plan to maintain custody of the child after birth, such as in instances of adoption or surrogacy",{"count":206,"type":22},"The goal of this clinical trial is to learn more about how the food and nutrition babies receive while in the Neonatal Intensive Care Unit (NICU) influences their ability to gain weight and fat-free mass, and their future growth and development.\n\nParticipants will:\n\n* have body growth measurements collected using the PEAPOD device\n* have nutritional information collected, and\n* be followed for neurodevelopmental outcomes\n\nParticipants can expect to be in the study for 36 months.",[330,177,30,331,332],"Premature Birth","Intrauterine Growth Restriction","Small for Gestational Age at Delivery","2025-08-07",{"date":335,"type":36},"2025-08-12",{"date":337,"type":36},"2024-09-04",{"date":339,"type":22},"2028-01",{"name":341,"class":43},"University of Wisconsin, Madison",{"id":343,"slug":344,"hasResults":11,"nctId":345,"briefTitle":346,"officialTitle":347,"acronym":4,"eligibilityCriteria":348,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":168,"enrollmentInfo":349,"targetDuration":4,"studyType":23,"phases":351,"briefSummary":352,"conditions":353,"keywords":356,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":362,"lastUpdatePostDateStruct":363,"startDateStruct":365,"completionDateStruct":367,"leadSponsor":369,"locationsCount":44},"100601672","post-extubation-use-ram-cannula-versus-short-binasal-prong-interfaces-in-preterm-infants-100601672","NCT07113535","Post-extubation Use RAM Cannula Versus Short Binasal Prong Interfaces in Preterm Infants","RAM Cannula Versus Short Binasal Prong Interfaces of Non- Invasive Ventilation for Prevention of Extubating Failure in Preterm Infants: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Inborn preterm neonates ≤ 32 weeks of gestational and\u002For birth weight ≤1500 g with respiratory distress syndrome requiring initial invasive ventilation support for at least 24 hours.\n\nExclusion Criteria:\n\n* Outborn preterm neonates\n* Major congenital malformations.",{"count":350,"type":22},90,[25],"Nowadays, the use of non-invasive ventilation for preterm infants in the NICU has increased to avoid complications associated with prolonged endotracheal intubation. Adequate pressure delivery through non-invasive ventilation is essential, as it enhances the growth and development of premature lungs. Various interfaces have been used to ensure proper sealing. The RAM cannula, used as an interface for non-invasive respiratory support in preterm neonates, is associated with reduced nasal trauma compared to short binasal prongs (SBPs), due to its softer material, making it a safer option. However, the RAM cannula has been shown to deliver lower pharyngeal pressure and, therefore, may not maintain airway pressure as consistently as nasal prongs. Currently, limited data is available regarding the efficacy of nasal prongs compared to the RAM cannula as a post-extubation interface for non-invasive ventilation support in preterm infants. Additionally, we have observed that the use of the RAM cannula for non-invasive ventilation in preterm infants is associated with a longer duration of oxygen therapy compared to SBPs.\n\nThe investigators hypothesize that the RAM cannula provides a lower level of positive end-expiratory pressure compared to SBPs during non-invasive ventilation.\n\nThe investigators aim to assess the efficacy and safety of the RAM cannula versus SBPs as nasal interfaces for post-extubation non-invasive respiratory support in preterm infants.",[30,354,355],"Respiratory Distress Syndrome","Extubation",[357,358,121,359,360,361],"nasal interface","noninvasive respiratory support","RAM cannula","Chest ultrasound","Diaphragm","2025-08-04",{"date":364,"type":36},"2025-08-08",{"date":366,"type":22},"2025-08",{"date":368,"type":22},"2027-12-31",{"name":370,"class":371},"Ministry of Health, Saudi Arabia","OTHER_GOV",{"id":373,"slug":374,"hasResults":11,"nctId":375,"briefTitle":376,"officialTitle":376,"acronym":377,"eligibilityCriteria":378,"healthyVolunteers":16,"sex":17,"minAge":167,"maxAge":4,"enrollmentInfo":379,"targetDuration":4,"studyType":23,"phases":381,"briefSummary":382,"conditions":383,"keywords":387,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":390,"lastUpdatePostDateStruct":391,"startDateStruct":393,"completionDateStruct":395,"leadSponsor":397,"locationsCount":44},"100503481","magnetoencephalography-by-optical-pumping-magnetometer-100503481","NCT05835817","Magnetoencephalography by Optical Pumping Magnetometer","MEG OPM","Inclusion Criteria:\n\n* For healthy adult volunteers\n* Age between 18 and 65\n* No pathology, no treatment\n* No toxicant intake\n* For term newborns\n* Child between 38 and 42 weeks gestational age on the day of registration\n* No pathology, no treatment\n* For children born prematurely\n* Child between 28 and 36 weeks gestational age on the day of registration\n* No pathology, no treatment apart from routine care related to prematurity\n* For pregnant women\n* Pregnant with between 28 to 40 weeks gestational age on the day of registration\n* No pathology, no treatment\n\nExclusion Criteria:\n\n* Subject and Patients \"not compatible\" MEG. Wearers of prosthesis or pacemaker likely to generate artefacts interfering with the measurement. There is no danger to the subject, but the measurement itself may be impossible.\n* Patients who cannot stand to stand still for a few minutes.\n* Newborn on ventilatory assistance or infusion\n* Newborn baby not meeting the age criteria",{"count":380,"type":22},70,[25],"MagnetoEncephaloGraphy (MEG) is a method of recording brain activity with high temporal resolution and good spatial resolution, compared to current recording techniques such as ElectroEncephaloGraphy (EEG). The main limitation of MEG is its cost due to the sensors used, the Super Quantum Interference Devices (SQUID). These require a complex infrastructure from an instrumentation point of view to operate, requiring liquid helium, most often at a loss, at increasing cost. Optical Pumping Magnetometers (OPM) type sensors represent a promising alternative to SQUIDs sensors, especially since they do not require helium cooling.\n\nThe purpose of this project is to Identify biomarkers in Magnetoencephalography of normal brain development in healthy adults, premature and term newborns from \"a priori\" obtained by the classical technique of High Resolution EEG performed.",[384,385,386,30],"Magnetoencephalography","Optical Pump Magnetometer","Neonate",[384,388,389,30],"optical pump magnetometer","neonate","2025-05-22",{"date":392,"type":36},"2025-05-28",{"date":394,"type":36},"2023-04-11",{"date":396,"type":22},"2026-04",{"name":398,"class":43},"Centre Hospitalier Universitaire, Amiens",{"id":400,"slug":401,"hasResults":11,"nctId":402,"briefTitle":403,"officialTitle":403,"acronym":404,"eligibilityCriteria":405,"healthyVolunteers":11,"sex":17,"minAge":167,"maxAge":4,"enrollmentInfo":406,"targetDuration":4,"studyType":23,"phases":407,"briefSummary":408,"conditions":409,"keywords":414,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":416,"lastUpdatePostDateStruct":417,"startDateStruct":419,"completionDateStruct":421,"leadSponsor":423,"locationsCount":44},"100567801","impact-of-standardized-skin-to-skin-care-on-clinical-outcomes-in-infants-born--32-weeks-a-multicenter-study-100567801","NCT06672913","Impact of Standardized Skin-to-Skin Care on Clinical Outcomes in Infants Born ≤ 32 Weeks: A Multicenter Study","TR-SSCinNICU","Inclusion Criteria:\n\n* Infants born at gestational age ≤ 32 weeks\n\nExclusion Criteria:\n\n* Death before NICU discharge\n* Abdominal wall defects",{"count":206,"type":22},[25],"This study is a multi-center, prospective pre-post clinical study conducted under the leadership of the Turkish Neonatal Society. It aims to investigate the effects of a standardized skin-to-skin care in NICU, initiated early and applied regularly, on recieving exclusive mothers' milk at discharge and clinical outcomes for preterm infants born ≤ 32 weeks of gestation.\n\n1. Primary Objective: To evaluate the rate of receiving exclusive mothers' milk at discharge for infants born ≤ 32 weeks of gestation who have received skin-to-skin care in accordance with the study protocol.\n2. Secondary Objective: To evaluate the rates of neonatal sepsis, intraventricular hemorrhage, and necrotizing enterocolitis (stage 2 and above) as well as the length of hospital stay for infants born at or below 32 weeks of gestation who have received skin-to-skin care in accordance with the study protocol.",[30,410,411,412,413],"Skin to Skin Contact","Breast Feeding","Necrotizing Enterocolitis","Retinopathy of Prematurity",[30,415,411,412,413],"Skin to skin contact","2024-11-01",{"date":418,"type":36},"2024-11-04",{"date":420,"type":36},"2024-09-01",{"date":422,"type":22},"2025-06-01",{"name":424,"class":43},"Baskent University Ankara Hospital",{"id":426,"slug":427,"hasResults":11,"nctId":428,"briefTitle":429,"officialTitle":430,"acronym":431,"eligibilityCriteria":432,"healthyVolunteers":11,"sex":17,"minAge":433,"maxAge":434,"enrollmentInfo":435,"targetDuration":4,"studyType":23,"phases":437,"briefSummary":439,"conditions":440,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":443,"lastUpdatePostDateStruct":444,"startDateStruct":446,"completionDateStruct":448,"leadSponsor":450,"locationsCount":44},"100444109","phase-3-protecting-preterm-infants-from-respiratory-tract-infections-and-wheeze-by-using-bacterial-lysates-100444109","NCT05063149","Protecting Preterm Infants From Respiratory Tract Infections and Wheeze by Using Bacterial Lysates.","Protecting Late-moderate Preterm Infants From Respiratory Tract Infections and Wheeze in Their First Years of Life by Using Bacterial Lysates.","PROTEA","Inclusion Criteria:\n\n* Gestational age at delivery between 30+0 and 35+6 weeks\n* Postnatal age at least 6 weeks at randomization \\& postmenstrual age at least 37 weeks\n* Written informed consent by both parents or formal caregivers\n\nExclusion Criteria:\n\n* Underlying other severe respiratory disease such as broncho-pulmonary dysplasia (unexpected in this group); hemodynamic significant cardiac disease; immunodefi-ciency; severe failure to thrive; birth asphyxia with predicted poor neurological out-come; syndrome or serious congenital disorder.\n* Lower RTI before randomization\n* Dysmaturity and\u002For weight \\\u003C 2.5 kg at age of randomization.\n* Maternal TNF-alpha inhibitors or other immunosuppression during pregnancy and\u002For breastfeeding\n* Parents unable to speak and read Dutch\u002FEnglish language\n* Known allergic hypersensitivity to the active ingredients\u002Fsubstance or to any of the excipients.","6 Weeks","10 Weeks",{"count":436,"type":22},500,[438],"PHASE3","The primary objective of this study is to reduce respiratory tract infections and wheezing in moderate-late preterms in the first years of life by bacterial lysate administration. Next to determine the correlation of biological markers with respiratory symptoms, immune protection and treatment effect.",[441,442,30],"Wheezing","LRTI","2024-08-20",{"date":445,"type":36},"2024-08-22",{"date":447,"type":36},"2022-01-18",{"date":449,"type":22},"2026-12",{"name":451,"class":43},"Franciscus Gasthuis",{"id":453,"slug":454,"hasResults":11,"nctId":455,"briefTitle":456,"officialTitle":457,"acronym":4,"eligibilityCriteria":458,"healthyVolunteers":11,"sex":17,"minAge":459,"maxAge":460,"enrollmentInfo":461,"targetDuration":4,"studyType":85,"phases":4,"briefSummary":463,"conditions":464,"keywords":465,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":470,"lastUpdatePostDateStruct":471,"startDateStruct":473,"completionDateStruct":475,"leadSponsor":477,"locationsCount":44},"100505791","dtdi-during-a-sbt-to-predict-extubation-failure-in-preterm-infants-100505791","NCT05865977","dTDI During a SBT to Predict Extubation Failure in Preterm Infants","Diaphragmatic Tissue Doppler Imaging During a Spontaneous Breathing Trial to Predict Extubation Failure in Preterm Infants","Inclusion Criteria:\n\n* premature infants with gestational age \\\u003C32 weeks and supported by invasive mechanical ventilation ≥48 hours\n* All the indications for extubation are met：cough or vomiting due to spontaneous breathing and sputum aspiration; ventilator parameters in recent 24 hours: MAP \\\u003C 8cmH2O, RR \\\u003C 30 times\u002Fmin, FiO2 \\\u003C 30%; Arterial blood gas: pH \\> 7.25, (PaCO2\\\u003C 60mmHg, BE \\\u003C 8mmol\u002FL, oxygen saturation \\> 90%\n* a successful SBT\n* parents or legal guardians sign informed consent to attend this study\n\nExclusion Criteria:\n\n* accidental extubation\n* chest CT or bronchoscopy during hospitalization indicated congenital airway dysplasia\n* complex congenital heart disease\n* congenital metabolic diseases, neuromuscular diseases\n* severe brain injury\n* surgical mechanical ventilation\n* give up before extubation;\n* pneumothorax or pleural effusion\n* no consent is signed","2 Days","6 Months",{"count":462,"type":22},100,"Weaning from mechanical ventilation is a critical issue and the diaphragmatic disfunction has been demonstrated to play an important role in extubation failure. the aim of present investigation is to evaluate diaphragmatic excursion velocity during in patients undergoing spontaneous breathing trial through tissue Doppler analysis in both inspiration and expiration.",[30],[466,467,468,469],"tissue Doppler imaging","Premature infants","extubation","diaphragm","2024-07-13",{"date":472,"type":36},"2024-07-16",{"date":474,"type":36},"2023-02-25",{"date":476,"type":22},"2024-12-25",{"name":478,"class":43},"Wang Jianhui",{"id":480,"slug":481,"hasResults":11,"nctId":482,"briefTitle":483,"officialTitle":484,"acronym":4,"eligibilityCriteria":485,"healthyVolunteers":16,"sex":17,"minAge":486,"maxAge":487,"enrollmentInfo":488,"targetDuration":4,"studyType":23,"phases":489,"briefSummary":490,"conditions":491,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":494,"lastUpdatePostDateStruct":495,"startDateStruct":497,"completionDateStruct":499,"leadSponsor":501,"locationsCount":44},"100521671","enteral-feeding-of-premature-babies-and-olive-oil-supplementation-100521671","NCT06072625","Enteral Feeding of Premature Babies and Olive Oil Supplementation","The Effect of Enteral Organic Extra Virgin Olive Oil Supplementation in Premature Babies on Postnatal Growth and Premature Morbidities","Inclusion Criteria:\n\n* Premature babies born at 32 weeks or less\n* Babies who tolerate full enteral feeding at the before end of the second week\n* Babies given consent by their parents -\n\nExclusion Criteria:\n\n* Having a congenital or genetic anomaly","14 Days","40 Days",{"count":142,"type":22},[25],"It is a two-arm prospective interventional study. 40 babies in both groups will be enrolment in the study. In the intervention group, babies will take 1 ml\u002Fkg\u002Fday of the study product (ULTRA PREMIUM) after full enteral feeding.\n\nSupplementation will continue until discharge or the 36th week. Blood samples will be taken for serum Total antioxidant capacity and Malondialdehyde levels before the intervention and on the 14th day of the control group. At the end of the study, serum will be taken again for control values.\n\nDaily lipid intake amounts will be recorded through breast milk analysis. Lipid profile will be monitored weekly The growth parameters of babies will be monitored daily It will be evaluated at the end of the study in terms of ROP, BPD, and NEC. At the end of the study, the data of babies in both groups will be compared.",[30,492,493],"Olive Oil","Enteral Feeding","2024-07-12",{"date":496,"type":36},"2024-07-15",{"date":498,"type":36},"2023-10-01",{"date":500,"type":22},"2025-03-31",{"name":502,"class":371},"Bursa City Hospital",{"id":504,"slug":505,"hasResults":11,"nctId":506,"briefTitle":507,"officialTitle":508,"acronym":165,"eligibilityCriteria":509,"healthyVolunteers":11,"sex":17,"minAge":510,"maxAge":511,"enrollmentInfo":512,"targetDuration":4,"studyType":23,"phases":514,"briefSummary":515,"conditions":516,"keywords":519,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":526,"lastUpdatePostDateStruct":527,"startDateStruct":529,"completionDateStruct":531,"leadSponsor":533,"locationsCount":44},"100546466","effects-of-the-application-of-piomi-in-the-oral-feeding-of-premature-100546466","NCT06395298","Effects of the Application of PIOMI in the Oral Feeding of Premature","Effects of the Application of PIOMI (Premature Oral Motor Intervention) in the Oral Feeding of the Premature: Randomized Clinical Trial","Inclusion Criteria:\n\n* Neonates born at the Sant Joan de Déu Hospital with a gestational age between 29-30 weeks carrying an external feeding device due to the difficulty of oral feeding and that the medical team in charge considers clinically stable.\n\nExclusion Criteria:\n\n* Endotracheal intubation or high-flow ventilatory support.\n* Exclusive parenteral nutrition.\n* Hyporeactive due to the use of sedative drugs.\n* Condition of prematurity associated with other pathologies (syndromes, acquired brain damage, gastrointestinal malformations, airway and craniofacial malformations).","29 Weeks","30 Weeks",{"count":513,"type":22},35,[25],"The goal of this clinical trial is assess whether the application of the premature oral motor intervention (PIOMI) combined with the Newborn Individualized Developmental Care and Assessment Program (NIDCAP), allows withdrawal of the external feeding device with guarantees of the patient's nutritional status, determining breastfeeding rates at hospital discharge and swallowing safety earlier than if only the care activity corresponding to the NIDCAP model is carried out, as well as the applicability of this standardised protocol in the neonatal intensive care unit of a tertiary hospital.",[517,518,30],"Dysphagia","Disorder; Feeding, Newborn",[520,521,522,523,524,525,175],"Swallowing","Swallowing disorders","Nutritional support","Feeding disorders","Preterm","Neonates","2024-04-29",{"date":528,"type":36},"2024-05-02",{"date":530,"type":36},"2023-02-13",{"date":532,"type":22},"2026-12-30",{"name":534,"class":43},"Fundació Sant Joan de Déu"]