[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"prenatal-genetic-diagnosis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:prenatal-genetic-diagnosis":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,50],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":30,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100642438","grace---genetic-insights-into-early-pregnancy-loss-using-cell-free-fetal-dna-100642438",false,"NCT07639333","GRACE - Genetic Insights Into Early pRegnancy Loss Using Cell-free fEtal DNA","GRACE - Genetic Insights Into Early pRegnancy Loss: A Prospective Study Using Cell-free fEtal DNA","GRACE","Inclusion Criteria:\n\n* A stopped pregnancy with an intrauterine pregnancy diagnosed by ultrasound (embryo larger than 7 mm corresponding to a gestational age of 6 weeks and 5 days. This is justified by the fact that fetal fragment (FF) detection is possible at 5 weeks of gestation, or 7 weeks and 5 days)\n* Expulsion of a pregnancy within the last 2 hours\n\n  * Patient fluent in French\n  * Enrolled in a social security program\n  * Has received oral and written information about the protocol and has signed a consent form to participate in this research.\n\nExclusion Criteria:\n\n* Diagnosis of an empty gestational sac, ectopic pregnancy, or unknown location\n* Ultrasound findings consistent with a molar pregnancy\n* Identified cause (preimplantation diagnosis, multiple uterine fibroids or a single fibroid \\> 5 cm, uterine malformation affecting the uterine cavity, lupus, and antiphospholipid syndrome)\n* Inability to obtain a blood sample\n* Known current malignant tumor\n* Blood transfusions within the last 3 months\n* Cell therapy or immunotherapy within the last 3 months\n* Previous organ transplant","FEMALE","18 Years","43 Years",{"count":21,"type":22},100,"ESTIMATED","INTERVENTIONAL",[25],"NA","The aim of this study is to assess the impact of non-invasive prenatal testing right after an early isolated miscarriage on mental health and on the patient's subsequent care in the year following the miscarriage",[28,29],"Miscarriage in First Trimester","Prenatal Genetic Diagnosis",[31,32,33,34,35,36],"early miscarriage","miscarriage","prenatal diagnosis","prenatal test","cell free fetal DNA","chromosomal abnomarlities","NOT_YET_RECRUITING","2026-06-10",{"date":40,"type":41},"2026-06-12","ACTUAL",{"date":43,"type":22},"2026-07",{"date":45,"type":22},"2029-01",{"name":47,"class":48},"Rennes University Hospital","OTHER",1,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":54,"acronym":4,"eligibilityCriteria":55,"healthyVolunteers":56,"sex":57,"minAge":18,"maxAge":4,"enrollmentInfo":58,"targetDuration":4,"studyType":60,"phases":4,"briefSummary":61,"conditions":62,"keywords":63,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":75},"100640578","guideseq-genomic-understanding-impact-decision--ethics-in-prenatal-sequencing-100640578","NCT07610590","guideSEQ: Genomic Understanding, Impact, Decision & Ethics in Prenatal Sequencing","Inclusion Criteria:\n\n* Patient planned chorionic villus sampling (CVS) or amniocentesis in the absence of major fetal structural anomalies (minor anomalies are eligible, the HPO (Human Phenotype Ontology) will not be used by the analyst)\n* Certified genetic counselor involved in care\n\nExclusion Criteria:\n\n* A major structural anomaly\n* Maternal or paternal age less than 18 years old\n* Parental unwillingness to participate in 1 year of postnatal follow-up\n* Language barrier (non-English or Spanish speaking)",true,"ALL",{"count":59,"type":22},1042,"OBSERVATIONAL","This study looks at whether genome sequencing should be used more routinely during pregnancy, even when ultrasounds look normal. Genome sequencing can examine nearly all of a baby's genes and may find genetic conditions that standard tests do not detect. Researchers will compare this test with current prenatal testing to see if it provides helpful information for families and doctors. The study will also explore how parents decide what kinds of genetic information they want to receive and how this information affects their experience during pregnancy. The goal is to understand whether genome sequencing can be used in a way that is helpful, responsible, and supportive for families in the future.",[29],[64],"Genome Sequencing","RECRUITING","2026-05-27",{"date":68,"type":41},"2026-05-29",{"date":70,"type":41},"2026-04-29",{"date":72,"type":22},"2029-07-31",{"name":74,"class":48},"Columbia University",3]