[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"preoperative-anxiety-experienced-by-the-pediatric-patient\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:preoperative-anxiety-experienced-by-the-pediatric-patient":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,50],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":27,"conditions":28,"keywords":33,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":4},"100606787","phase-1-children-of-age-2-6years-undergoing-elective-surgery-will-be-divided-into-two-groups-randomly-this-study-aims-to-evaluate-if-intranasal-dexmedetomidine-is-better-than-intranasal-ketamine-in-producing-sedation-and-reducing-parent-separation-anxiety-before-surgery-100606787",false,"NCT07180095","Children of Age 2-6years Undergoing Elective Surgery Will be Divided Into Two Groups Randomly. This Study Aims to Evaluate if Intranasal Dexmedetomidine is Better Than Intranasal Ketamine in Producing Sedation and Reducing Parent Separation Anxiety Before Surgery.","Intranasal Dexmedetomidine Versus Intranasal Ketamine for Preoperative Sedation in Pediatrics","DREAM-Kids","Inclusion Criteria:\n\n* American society of Anesthesiologist (ASA) class-I and II\n* Children 2-6 years of age undergoing elective surgery\n\nExclusion Criteria:\n\n* Known hypersensitivity to study drugs\n* Refusal of consent\n* Known renal, hepatic or cardiac dysfunction\n* Nasal deformity or pathology\n* Recent upper respiratory infection (within 2 weeks)\n* Children undergoing neurosurgery or ophthalmic surgery","ALL","2 Years","6 Years",{"count":21,"type":22},60,"ESTIMATED","INTERVENTIONAL",[25,26],"PHASE1","PHASE2","This study aims to compare intranasal dexmedetomidine versus intranasal ketamine as a premedication in children undergoing surgery in our population. Hypothesis is Intranal dexmedetomidine is better than intranasal ketamine in producing preoperative sedation in pediatric patients undergoing surgery under general anesthesia.",[29,30,31,32],"Sedation","Preoperative Anxiety Experienced by the Pediatric Patient","Anxiolytic Effect","Sedation and Analgesia",[34,35,36,37],"Preoperative Sedation","Hemodynamic changes","Dexmedetomidine","Dexmedetomidine vs Ketamine","NOT_YET_RECRUITING","2025-09-11",{"date":41,"type":42},"2025-09-18","ACTUAL",{"date":44,"type":22},"2026-01-01",{"date":46,"type":22},"2026-07-30",{"name":48,"class":49},"Liaquat National Hospital & Medical College","OTHER",{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":4,"eligibilityCriteria":56,"healthyVolunteers":11,"sex":17,"minAge":57,"maxAge":58,"enrollmentInfo":59,"targetDuration":4,"studyType":23,"phases":60,"briefSummary":61,"conditions":62,"keywords":64,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":5},"100591389","phase-2-comparing-two-doses-of-midazolam-with-added-dexmedetomidine-for-kids-before-surgery-100591389","NCT06979791","Comparing Two Doses of Midazolam With Added Dexmedetomidine for Kids Before Surgery","Comparison Between the Effects of Adding Intranasal Dexmedetomidine to Two Different Doses of Midazolam as a Premedication in Pediatrics Undergoing Elective Surgery: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Pediatric patients aged 1 to 8 years\n* Scheduled for elective surgery under general anesthesia\n* Surgery duration \\\u003C 1 hour\n* ASA physical status I or II\n* Parent or legal guardian able to provide informed consent\n\nExclusion Criteria:\n\n* Refusal to participate by parent\u002Fguardian\n* Nasal infections, pathology, or epistaxis\n* Runny nose or upper respiratory tract infection\n* Enlarged adenoids\n* BMI \\> 30\n* Known allergy to dexmedetomidine or midazolam\n* Fever on day of surgery\n* Coagulopathy\n* Scheduled for cardiothoracic or neurosurgical procedures\n* Congenital heart disease\n* Neurological or mental disorders\n* Pre-existing sedation (MOASS \\\u003C 5) on the day of surgery","1 Year","8 Years",{"count":21,"type":22},[26],"The goal of this this randomized controlled trial is to investigate if adding intranasal dexmedetomidine to two different doses of intranasal midazolam provides effective sedation with fewer side effects in pediatric patients aged 1 to 8 years undergoing elective surgeries. The main questions it aims to answer are:\n\nDoes combining intranasal dexmedetomidine with a reduced dose of midazolam achieve adequate sedation while minimizing adverse effects?\n\nHow do different dosing regimens affect mask acceptance, parent separation, sedation levels, recovery times, and perioperative adverse events?\n\nResearchers will compare two groups: one receiving dexmedetomidine plus a higher dose of midazolam (0.4 mg\u002Fkg) and another receiving dexmedetomidine plus a lower dose of midazolam (0.2 mg\u002Fkg) to see if the reduced dose maintains sedation effectiveness while reducing side effects.\n\nParticipants will:\n\nReceive intranasal dexmedetomidine (2 mcg\u002Fkg) combined with either 0.4 mg\u002Fkg or 0.2 mg\u002Fkg of intranasal midazolam.\n\nUndergo sedation scoring at 15 and 30 minutes after drug administration.\n\nBe assessed for ease of separation from parents and acceptance of anesthesia mask.\n\nBe monitored for vital signs, recovery times, and any perioperative adverse events.",[30,63],"Preoperative Anxiety",[65],""pediatric premedication" "dexmedetomidine" "midazolam" "sedation" "mask acceptance"","2025-05-16",{"date":68,"type":42},"2025-05-20",{"date":70,"type":22},"2025-06-01",{"date":72,"type":22},"2025-12",{"name":74,"class":49},"Cairo University"]