[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"preoxygenation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:preoxygenation":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,49],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":30,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100636312","physiological-effects-of-different-preoxygenation-strategies-100636312",false,"NCT07564050","Physiological Effects of Different Preoxygenation Strategies","Physiological Effects of Different Preoxygenation Strategies in Adults and Children: A Comparative Study of NRM and BVM With and Without PEEP","PREOXY II","Inclusion Criteria:\n\n* Adults with an American Society of Anesthesiologists (ASA) physical status score ≤ 2\n* Children aged 5 to 12 years with an ASA physical status score ≤ 2\n* Ability (or legal guardian ability) to provide written informed consent\n\nExclusion Criteria:\n\n* Children aged \\\u003C 5 years or 13 to 18 years\n* ASA physical status score \\> 2\n* Body mass index (BMI) ≥ 30 kg\u002Fm²\n* Known airway pathology or anatomical abnormality that could affect mask fit, ventilation, or oxygenation\n* Presence of an active airway infection at the time of the study\n* Pregnancy\n* Refusal or inability to provide informed consent",true,"ALL","5 Years","75 Years",{"count":22,"type":23},30,"ESTIMATED","INTERVENTIONAL",[26],"NA","The goal of this clinical trial is to evaluate the performance and physiological effects of different preoxygenation devices in healthy adult and pediatric volunteers (children aged 5-12 years). The study aims to determine how these devices influence oxygen delivery, airway pressure, and cardiopulmonary physiology during preoxygenation.\n\nThe main questions it aims to answer are:\n\n* What fraction of inspired oxygen (FiO₂) is delivered by non-rebreather masks (NRM) compared to bag-valve masks (BVM) with and without positive end-expiratory pressure (PEEP)?\n* How do these devices differ in terms of generated PEEP, inspiratory effort, and their effects on lung ventilation and cardiac function?\n\nResearchers will compare NRM, BVM without PEEP, and BVM with PEEP (each with or without supplemental oxygen via nasal cannula) to evaluate differences in oxygenation and physiological effects.\n\nParticipants will:\n\n* Complete multiple 3-minute preoxygenation sessions using each device in randomized order\n* Breathe spontaneously through each device, with or without additional oxygen via nasal cannula\n* Undergo non-invasive monitoring of oxygen concentration (FiO₂), respiratory parameters, airway pressures, and ultrasound assessment of the lungs, diaphragm, and heart\n* Perform a brief breath-holding maneuver to assess airway pressure generation",[29],"Preoxygenation",[29,31,32,33,34,35],"Bag-valve mask (BVM)","Non-rebreather mask (NRM)","Positive end-expiratory pressure (PEEP)","Fraction of inspired oxygen (FiO₂)","Respiratory physiology","RECRUITING","2026-05-06",{"date":39,"type":40},"2026-05-08","ACTUAL",{"date":42,"type":23},"2026-05-23",{"date":44,"type":23},"2026-06-30",{"name":46,"class":47},"Institute of Mountain Emergency Medicine","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":4,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":18,"minAge":56,"maxAge":4,"enrollmentInfo":57,"targetDuration":4,"studyType":59,"phases":4,"briefSummary":60,"conditions":61,"keywords":4,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":48},"100581235","comparison-of-the-time-to-reach-end-tidal-oxygen-value-of-90-and-oxygen-reserve-index-decline-times-during-preoxygenation-in-sarcopenic-and-non-sarcopenic-patients-100581235","NCT06847672","Comparison of the Time to Reach End-Tidal Oxygen Value of 90 and Oxygen Reserve Index Decline Times During Preoxygenation in Sarcopenic and Non-Sarcopenic Patients","Comparison of the Time to Reach End-Tidal Oxygen Value of 90 and Oxygen Reserve Index Decline Times During Preoxygenation in Sarcopenic and Non-Sarcopenic Patients Using the 6-Minute Walk Test","Inclusion Criteria:\n\n* Patients who agree to participate in the study.\n* Patients scheduled for major abdominal oncologic surgery.\n\nExclusion Criteria:\n\n* Patients with severe cardiopulmonary disease.\n* Patients with walking disabilities.","18 Years",{"count":58,"type":23},80,"OBSERVATIONAL","The purpose of this study is to compare the time required to reach an end-tidal oxygen (EtO2) value of 90% and the time until the Oxygen Reserve Index (ORI) drops below 0.55 during preoxygenation in sarcopenic and non-sarcopenic patients. The study aims to investigate the impact of sarcopenia on the oxygenation process.",[62,29,63],"Sarcopenia","Oxygen Reserve Index","NOT_YET_RECRUITING","2025-02-21",{"date":67,"type":40},"2025-02-26",{"date":69,"type":23},"2025-03-01",{"date":71,"type":23},"2025-08-31",{"name":73,"class":47},"Ankara City Hospital Bilkent"]