[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"prescribing\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:prescribing":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,48],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":31,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100626096","british-columbia-prescriber-feedback-program---antimicrobial-resistance-100626096",false,"NCT07431190","British Columbia Prescriber Feedback Program - Antimicrobial Resistance","Building a National Framework to Combat Antimicrobial Resistance in Primary Care (CANBuild-AMR): Study Protocol for an Impact Evaluation of the British Columbia Prescriber Feedback Program","Practitioner Inclusion Criteria:\n\nRegistered in 2024 with the BC Medical Services Plan (MSP) with:\n\n* A valid MSP billing number;\n* Status of Salaried, Private Practice, Temporary Licence, or Post Graduate;\n* Prescribed \\>100 dispensed medications in 2024.\n\nExclusion Criteria:\n\n* Previously opted out of the Therapeutics Initiative Portrait program\n\nPatient Exclusion Criteria:\n\n* Age \\\u003C18 years at time of oral antibiotic dispensation;\n* Received PharmaCare benefits through the Palliative Care program at any time during the baseline or study period;\n* Hospitalized within 1 week prior to an antibiotic prescription at any time during the baseline or study period;\n* On chronic suppressive antibiotic therapy (≥90 days' supply of any antibiotic dispensed) during the baseline or study period","ALL","18 Years",{"count":19,"type":20},7626,"ESTIMATED","INTERVENTIONAL",[23],"NA","The goal of this study is to evaluate an educational intervention that aims to reduce the number of unnecessary antibiotics prescribed by family physicians and nurse practitioners in British Columbia, Canada.\n\nThe intervention materials include a confidential personalized prescribing \"portrait\" and an evidence-based educational summary (therapeutics letter), accompanied by an introduction letter.\n\nThe main research questions are:\n\n1. Will the intervention lead to a reduction in the overall number of antibiotics prescriptions started?\n2. Will the intervention lead to a reduction in the proportion of antibiotics prescribed that are likely unnecessary, especially prescriptions for upper respiratory tract infections, acute bronchitis, acute sinusitis?\n\nResearchers will conduct an intervention study with family physicians and nurse practitioners in British Columbia, Canada. Participant clinicians will be randomly assigned to one of two groups. The Early Group will consist of 80% of the participants and will receive the intervention (prescribing portrait, evidence summary, and introduction letter) at the start of the study. The Delayed Group will consist of 20% of participants and will receive the intervention about nine months later. This study design allows most practitioners to receive the intervention early while still allowing time to compare the two groups to assess the impact. To estimate the impact of the intervention, researchers will use administrative health data to compare the prescribing of the Early Group with prescribing of the Delayed Group.",[26,27,28,29,30],"Quality Improvement","Feedback","Prescribing","Antibiotics","Antimicrobial Drug Resistance",[32,33,34,29,35],"Randomized controlled trial","Prescribing feedback","Quality improvement","Antimicrobial resistance","NOT_YET_RECRUITING","2026-02-17",{"date":39,"type":40},"2026-02-24","ACTUAL",{"date":37,"type":20},{"date":43,"type":20},"2028-11-30",{"name":45,"class":46},"University of British Columbia","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":16,"minAge":56,"maxAge":4,"enrollmentInfo":57,"targetDuration":4,"studyType":21,"phases":59,"briefSummary":60,"conditions":61,"keywords":68,"overallStatus":76,"whyStopped":4,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":86},"100572291","improved-prescribing-for-older-nursing-home-patients-100572291","NCT06731361","Improved Prescribing for Older Nursing Home Patients","Improving Medication Prescription in the contExt of Advance Care Planning for paTients Receiving Long Term nUrSing Home Care","IMPETUS","Inclusion Criteria:\n\nNursing home patients:\n\n* Age 65years and above\n* Living at long term care wards in nursing homes\n* Living at a long term care ward for at least 4 weeks before start of the study\n\nExclusion Criteria:\n\n* Temporary nursing home patients (i.e. geriatric rehabilitation or end-of-life\u002Fhospice care)\n* Life expectancy \\\u003C 4 weeks\n* Life expectancy clearly \\> 1.5 - 2 years (i.e. patients with Huntingtons disease)","65 Years",{"count":58,"type":20},450,[23],"Research aim:\n\nTo investigate the effect of training health care professionals in medication assessments on the medication use of nursing home residents with a limited life expectancy (\\\u003C 1.5-2 years).\n\nThe core of the training is to tailor medication use to (palliative) treatment goals of nursing home residents.\n\nDesign:\n\nA cluster randomized controlled trial on long term care wards in nursing homes, with the nursing home care organisations as unit of randomisation. The investigators intent to include 6 organisations and 450 nursing home patients. The research starts in september and lasts 1 year and 3 months. Eligible patients are nursing home patients of 65 years and older with a limited life expectancy (\\\u003C 1.5-2 year) of long term care wards.\n\nIntervention:\n\nThe intervention includes a method in which healthcare professionals (medical practitioner, pharmacist and care worker) are trained to tailor medication to the (palliative) treatment goals of nursing home patients with a limited life expectancy. The training consists of 2 components: 1) medication assessment, and 2) advance care planning (ACP). In the intervention group, healthcare professionals receive the training in combination with supporting tools and educational materials, in the control group care continues as normal. The allocation ratio for control and intervention groups is 1:1. A process evaluation will take place simultaneously with the intervention study. Data collection takes place before the start of the intervention (T0), after 6 months (T1) and after 12 months (T2).\n\nOutcome measures:\n\nThe primary outcome measure is potential under- and over-treatment with medication. The secondary outcome measure is experienced involvement in decision-making (measured with a short questionnaire based on the revised PATD (patients' attitude towards deprescribing)). Tertiary outcome measures are: quality of life, deaths, falls, hospital admissions\u002Facute first aid referrals and pain.\n\nDiscussion:\n\nThe intervention is expected to result in a decrease in chronic and preventive medication prescriptions, an increase in medication for symptom treatment and more involvement (and satisfaction) of the nursing home resident in decision-making, without adverse effects.",[62,63,28,64,65,66,67],"Nursing Home Residents","Older People","Advance Care Planning","Medication Reviews","Decision Making","Prescribing Practices",[69,70,71,72,73,74,75],"limited life expectancy","ReNeWAL criteria (adjusted STOPP\u002FSTART criteria)","decision making involvement","appropriate prescribing","Cluster randomised trial","Educational intervention","Prescribing practices","RECRUITING","2024-12-09",{"date":79,"type":40},"2024-12-12",{"date":81,"type":40},"2024-09-10",{"date":83,"type":20},"2025-12-01",{"name":85,"class":46},"Amsterdam UMC, location VUmc",7]