[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"preserved-ratio-impaired-spirometry\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:preserved-ratio-impaired-spirometry":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,46,68,114],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":28,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100600094","mitigating-chronic-respiratory-disease-through-the-lens-of-multimorbidity-100600094",false,"NCT07093021","Mitigating Chronic Respiratory Disease Through the Lens of Multimorbidity","Feasibility of Implementing the COLA-6 Case-Finding Tool to Identify Chronic Respiratory Disease in Primary Health Care in Brazil","MARES2","Inclusion Criteria:\n\nHCP: providing care to people with NCDs in PHC settings in Brazil. PATIENTS: attending for NCD care at a PHC setting in Brazil.\n\nExclusion Criteria:\n\nHCP: not received training to deliver COLA-6.\n\nPATIENTS:\n\n* not provided informed consent\n* clinically unstable in the past month\n* current pregnancy\n* active tuberculosis or being on treatment for tuberculosis\n* cognitive impairment that would prevent understanding of the case-finding tool\n* contra-indications to lung function testing.","ALL","30 Years",{"count":20,"type":21},1000,"ESTIMATED","OBSERVATIONAL","The investigators aim to evaluate whether it is feasible for healthcare professionals to implement a case-finding tool to identify individuals at high risk for chronic respiratory diseases (CRDs) during routine care for non-communicable diseases (NCDs) in primary healthcare services in Brazil.\n\nThe investigators will complete a cross-sectional observational study involving 20 healthcare professionals (physicians, physiotherapists, community health agents, and nurses) from five primary healthcare services who will apply the COLA-6 tool during routine NCD care. A total sample of 1,000 patients is expected. Qualitative interviews will be conducted with healthcare professionals to explore barriers and facilitators to implementing COLA-6 in clinical practice.",[25,26,27],"Chronic Obstructive Pulmonary Disease (COPD)","Asthma","Preserved Ratio Impaired Spirometry",[29,30,31,32],"case-finding","chronic obstructive pulmonary disease","asthma","multi-morbidity","NOT_YET_RECRUITING","2025-07-28",{"date":36,"type":37},"2025-07-30","ACTUAL",{"date":39,"type":21},"2025-08",{"date":41,"type":21},"2026-12",{"name":43,"class":44},"University College, London","OTHER",2,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":54,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":56,"conditions":57,"keywords":58,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":45},"100596849","mitigating-chronic-respiratory-disease-through-the-lens-of-multi-morbidity-100596849","NCT07050823","Mitigating Chronic Respiratory Disease Through the Lens of Multi-Morbidity","Case-Finding for Chronic Respiratory Diseases in People Living With Other Long-Term Conditions","MARES1","Inclusion Criteria:\n\nAttending primary health care services in Brasil.\n\nDiagnosed with one or more existing, non-respiratory long-term conditions such as cardiovascular disease, diabetes or hypertension.\n\nExclusion Criteria:\n\nClinically unstable in the past month (defined as worsening symptoms requiring emergency care or hospitalization).\n\nCurrent pregnancy.\n\nActive pulmonary tuberculosis or undergoing treatment for pulmonary tuberculosis.\n\nCurrent acute respiratory infection.\n\nCognitive impairment that prevents understanding of the case-finding questionnaire, defined as MMSE score ≤20.\n\nContraindications to spirometry.\n\nDeclines to participate in the study.",{"count":55,"type":21},859,"The investigators aim to make it easier to find people with undiagnosed long-term lung health problems (such as asthma, and chronic obstructive pulmonary disease, COPD, collectively called 'Chronic Respiratory Diseases', CRDs) living in Brasil.\n\nBecause people with undiagnosed CRDs often have other medical problems too, such as heart problems, high blood pressure and diabetes (collectively called 'Long Term Conditions', LTC), the investigators will look for undiagnosed CRD in people with LTC when they are attending appointments at local health centres in the cities of Sao Carlos and Sao Paulo.\n\nTo look for undiagnosed CRDs the investigators will use two questionnaire-based methods called 'COLA' and 'SBQ'. These are quick and simple to do. All participants will also have tests of their lung function completed including spirometry and Fractional Exhaled Nitric Oxide so that the investigators can make a definite diagnosis of CRDs. When the study is complete, the investigators will examine how well the COLA and SBQ questionnaires perform in identifying people with a definite diagnosis of CRD.\n\nIn total, the investigators aim to recruit 859 people.",[25,26,27],[29,30,31,32],"RECRUITING","2025-07-21",{"date":62,"type":37},"2025-07-25",{"date":64,"type":37},"2025-07-01",{"date":66,"type":21},"2027-07",{"name":43,"class":44},{"id":69,"slug":70,"hasResults":11,"nctId":71,"briefTitle":72,"officialTitle":73,"acronym":4,"eligibilityCriteria":74,"healthyVolunteers":75,"sex":17,"minAge":76,"maxAge":77,"enrollmentInfo":78,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":80,"conditions":81,"keywords":97,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":103,"lastUpdatePostDateStruct":104,"startDateStruct":106,"completionDateStruct":108,"leadSponsor":110,"locationsCount":113},"100556693","identification-of-multiple-pulmonary-diseases-using-volatile-organic-compounds-biomarkers-in-human-exhaled-breath-100556693","NCT06528418","Identification of Multiple Pulmonary Diseases Using Volatile Organic Compounds Biomarkers in Human Exhaled Breath","Exploration and Study on the Identification of Various Pulmonary Diseases Using Volatile Organic Compounds Biomarkers in Human Exhaled Breath","Inclusion Criteria:\n\n* Males or females, age must be 18 years old or above.\n* Patients must meet the CT imaging diagnostic criteria for different lung diseases, and patients must be able to provide electronic versions of CT image data.\n* Patients must have a clear clinical diagnosis.\n* All participants must sign a written informed consent form.\n\nExclusion Criteria:\n\n* Pregnant women.\n* Individuals with a history of cancer other than lung disease.\n* Individuals who have undergone organ transplants or non-autologous (allogeneic) bone marrow or stem cell transplants.\n* Individuals with other severe organic diseases or mental illnesses.\n* Individuals with metabolic diseases such as diabetes, hyperlipidemia, etc.\n* Any other condition that researchers deem unsuitable for participation in this clinical trial.",true,"18 Years","100 Years",{"count":79,"type":21},10000,"The goal of this observational study is to develop an advanced expiratory algorithm model utilizing exhaled breath volatile organic compound (VOC) marker molecules. This model aims to accurately diagnose mutiple pulmonary diseases. The primary objectives it strives to accomplish are:\n\n1. To assess the diagnostic accuracy of an exhaled breath VOC-assisted diagnostic artificial intelligence (AI) model in diagnose several common pulmonary diseases.\n2. To assess the diagnostic accuracy of an exhaled breath VOC-assisted diagnostic artificial intelligence (AI) model in diagnose more pulmonary diseases.",[82,83,84,85,86,87,88,89,90,91,92,93,94,95,96,27],"Lung Cancer","Lung Infection","COPD","Bronchitis","Pulmonary Fibrosis","Pulmonary Embolism","Pulmonary Arterial Hypertension","Pulmonary Tuberculosis","Pulmonary Abscess","Emphysema","Lung Injury","Cystic Fibrosis of the Lung","Bronchial Asthma","Bronchiectasis","Interstitial Lung Disease",[98,99,100,101,102],"Pulmonary Disease","Volatile Organic Compounds","Human Exhaled Breath","micro Gas Chromatography-photoionisation","detector (μGC-PID) system","2025-03-23",{"date":105,"type":37},"2025-03-26",{"date":107,"type":37},"2024-06-30",{"date":109,"type":21},"2027-06-30",{"name":111,"class":112},"ChromX Health","INDUSTRY",1,{"id":115,"slug":116,"hasResults":11,"nctId":117,"briefTitle":118,"officialTitle":119,"acronym":4,"eligibilityCriteria":120,"healthyVolunteers":11,"sex":17,"minAge":76,"maxAge":121,"enrollmentInfo":122,"targetDuration":4,"studyType":124,"phases":125,"briefSummary":127,"conditions":128,"keywords":129,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":133,"lastUpdatePostDateStruct":134,"startDateStruct":136,"completionDateStruct":138,"leadSponsor":140,"locationsCount":4},"100544971","bufei-recipe-reduces-the-incidence-rate-of-copd-100544971","NCT06375824","Bufei Recipe Reduces the Incidence Rate of COPD","Bufei Recipe Reduces the Incidence Rate of COPD: A Multicenter, Randomized, Double Blind, Placebo Controlled Study","Inclusion Criteria:\n\n1. Risk factors for chronic obstructive pulmonary disease. Having one item from a, b, and c (risk factors will be further optimized based on the screening results of high-risk populations):\n\n   1. smoking history (including previous and current smokers);\n   2. 1 year or more of exposure to dust or chemical toxins;\n   3. Indoor air pollution for 1 year or more (use of contaminated fuels, passive smoking, exposure) Oil fumes, etc.\n2. Have a history of chronic bronchitis and\u002For emphysema, and have one of the following chronic respiratory symptoms:\n\n   1. Cough (more than 3 months per year, continuous for 2 years or more);\n   2. Coughing phlegm (more than 3 months per year, continuous for 2 years or more);\n   3. Difficulty breathing (more than 3 months per year, continuous for 2 years or more).\n3. The lung function test meets the following criteria: forced expiratory volume in one second (FEV1)\u002Fforced vital capacity (FVC) ≥ 70% and FEV1 accounting for%\\\u003C80% of the expected value.\n4. Meets the diagnostic criteria for lung qi deficiency syndrome.\n5. Age range from 18 to 80 years old.\n6. Voluntarily participate in the study and sign an informed consent form.\n\nExclusion Criteria:\n\n* Pregnant and planned pregnancy, lactating women.\n* Dementia and various mental illness patients.\n* Other diseases with chronic cough, sputum production, or difficulty breathing.\n* Merge tumors.\n* Merge severe cardiovascular and cerebrovascular diseases.\n* Concomitant severe liver and kidney diseases.\n* Participants in clinical trials of other drugs.\n* Allergies to intervention drugs.","80 Years",{"count":123,"type":21},1100,"INTERVENTIONAL",[126],"NA","Establish early TCM prevention and treatment program to reduce the incidence rate of COPD.",[27],[130,131,132],"Bufei Recipe","PRISm","incidence rate","2024-04-16",{"date":135,"type":37},"2024-04-19",{"date":137,"type":21},"2024-05-01",{"date":139,"type":21},"2027-10-31",{"name":141,"class":44},"Henan University of Traditional Chinese Medicine"]