[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"preterm-and-term-infants\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:preterm-and-term-infants":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,45],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":27,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100604296","fnirs-grasping-task-in-infants-100604296",false,"NCT07147673","fNIRS Grasping Task in Infants","Brain Function During Grasping Task in Three to Nine Months Infants Using fNIRS , the Difference Between Full and Preterm Born Infants","Inclusion Criteria:\n\n* 3-9 months old\n* can tolerate the fNIRS cap\n* performs at least 2 grapsing attempts with one hand within one minute when prompting the hand with a toy\n\nExclusion Criteria:\n\n* history of periferal neurological lesion such as plexus brachialis lesion\n* presence of epilepsia, congenital brain malformation,\n* no informed consent\n* severe visual impairments\n* syndromal or genetical diseases resulting into developmental delay",true,"ALL","3 Months","9 Months",{"count":21,"type":22},100,"ESTIMATED","OBSERVATIONAL","This study aims to investigate the neural mechanisms involved in the development of reach-to-grasp function in infants. Reaching and grasping are crucial motor skills that develop early in infancy and are essential for later motor and cognitive milestones. Understanding how these skills emerge and the underlying neural processes can provide valuable insights into both typical and atypical development.\n\nThe study will focus on infants aged 3 to 9 months, a critical period for the development of reach-to-grasp skills. A total of 100 infants will be recruited, including 50 full-term infants and 50 preterm infants (born \\\u003C36 weeks gestational age). Reach-to-grasp function will be evaluated through a cross-sectional assessment at a single time point. Functional near-infrared spectroscopy (fNIRS) will be used as the brain imaging technique to measure brain activity during the reach-to-grasp task. The use of fNIRS will allow for a non-invasive assessment of neural activity in real time, providing insights into the brain mechanisms supporting the development of motor skills. The findings may offer important information about the neural basis of motor development in infancy, particularly in the context of preterm birth.",[26],"Preterm and Term Infants",[28,29,30,31],"fNIRS","grasping","infants","preterm infants","RECRUITING","2025-08-22",{"date":35,"type":36},"2025-08-29","ACTUAL",{"date":38,"type":36},"2022-09-26",{"date":40,"type":22},"2027-09-30",{"name":42,"class":43},"University Ghent","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":4,"eligibilityCriteria":51,"healthyVolunteers":16,"sex":17,"minAge":4,"maxAge":52,"enrollmentInfo":53,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":54,"conditions":55,"keywords":61,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":5},"100577805","investigation-of-the-mechanisms-of-the-tendency-to-hypothermia-in-newborns-and-premature-neonates-100577805","NCT06803069","Investigation of the Mechanisms of the Tendency to Hypothermia in Newborns and Premature Neonates","Investigation of the Mechanisms of the Tendency to Hypothermia in Newborns and Premature Infants During Surgical Interventions and in the Intensive Care Unit (Non-Interventional, Single-Center, Prospective Clinical Research)","Inclusion Criteria:\n\n* For Substudy 1: Patients admitted to the Neonatal Intensive Care Unit at the University of Pécs, Department of Obstetrics and Gynaecology (premature infants or those in neonatal intensive care).\n* For Substudy 2: Patients under 2 years of age undergoing elective surgery lasting more than 30 minutes at the University of Pécs, Department of Paediatrics.\n* For both substudies: Written consent for participation in the study has been provided by the patient's parent, guardian, or legal representative.\n\nExclusion Criteria:\n\n* For both substudies: If the patient cannot be mobilized (e.g., during the post-operative phase of abdominal or thoracic surgery; presence of chest tubes for pneumothorax or other reasons; hemodynamic instability; need for continuous electrocardiogram (ECG) monitoring; or use of an external pacemaker).\n* The patient's parent, guardian, or legal representative does not consent to the study or withdraws their consent at any point.\n* For Substudy 2: if the patient is older than 2 years.","2 Years",{"count":21,"type":22},"Newborns have thermoregulatory mechanisms that differ from those of adults. Instead of producing heat through shivering, newborns primarily rely on non-shivering thermogenesis by the brown adipose tissue. The development of this thermogenic tissue starts around the 26th gestational week and continues until shortly before birth, after which no further growth occurs. As a result, premature infants, who have less developed brown fat, are more prone to reduced heat production and are at higher risk for hypothermia. There are few human studies examining the thermoregulatory differences and mechanisms between full-term and premature neonates, and the findings remain inconclusive.\n\nIn this study, the investigators aim to conduct a prospective, observational research. Researchers will compare body temperature, brown adipose tissue activity, and specific plasma markers between full-term and premature neonates in insensive care units and during elective surgeries.",[56,57,26,58,59,60],"Neonatal Hypothermia","Brown Adipose Tissue","Neonate","Thermogenesis","Blood Markers",[62,63,64,65,66,67,68],"brown adipose tissue","neonate","neonatal hypothermia","preterm","nonshivering thermogenesis","infant","newborn","2025-02-18",{"date":71,"type":36},"2025-02-19",{"date":73,"type":36},"2024-07-01",{"date":75,"type":22},"2029-07-01",{"name":77,"class":43},"University of Pecs"]